C4b (complement C4B) - Rat Genome Database

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Gene: C4b (complement C4B) Rattus norvegicus
Analyze
Symbol: C4b
Name: complement C4B
RGD ID: 1591983
Description: Predicted to enable carbohydrate binding activity and complement component C1q complex binding activity. Predicted to be involved in complement activation and positive regulation of apoptotic cell clearance. Predicted to act upstream of or within immunoglobulin mediated immune response. Located in extracellular space. Human ortholog(s) of this gene implicated in autistic disorder; autoimmune disease (multiple); complement component 4b deficiency; and renal cell carcinoma. Orthologous to several human genes including C4B (complement C4B (Chido/Rodgers blood group)); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Staphylococcus aureus infection pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C4-2; C4l; complement C4-like protein; complement C4B (Chido blood group); complement component 4, gene 2; complement component 4B (Chido blood group)
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,201,979 - 4,216,292 (+)NCBIGRCr8
mRatBN7.2204,197,371 - 4,211,684 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,197,366 - 4,211,681 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,903,172 - 4,917,487 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,264,923 - 4,279,238 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,799,242 - 4,813,541 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,302,344 - 4,316,752 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,302,344 - 4,316,715 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,381,700 - 6,396,108 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,300,687 - 4,315,882 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera203,819,383 - 3,833,684 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-aminothiophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
aldehydo-D-glucose  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
carnosic acid  (ISO)
choline  (ISO)
clofibrate  (ISO)
clopidogrel  (ISO)
coenzyme Q10  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP)
cylindrospermopsin  (ISO)
cyproconazole  (ISO)
D-glucose  (ISO)
D-penicillamine  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
diuron  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fenthion  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fructose  (ISO)
furan  (EXP)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (ISO)
inulin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
kainic acid  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
levofloxacin  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
lycopene  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methylmercury chloride  (EXP)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
O-acetyl-L-carnitine  (ISO)
olanzapine  (ISO)
ozone  (ISO)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
propiconazole  (ISO)
resveratrol  (ISO)
senecionine  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
SU6656  (ISO)
sulindac  (EXP)
tacrolimus hydrate  (EXP)
tauroursodeoxycholic acid  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
triptonide  (ISO)
vanadyl sulfate  (EXP)
vancomycin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Complement C4 protein expression by rat hepatic stellate cells. Fimmel CJ, etal., J Immunol. 1996 Sep 15;157(6):2601-9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. [Enzyme immunoassay of masked complement component C4 deficiency in patients with urogenital Chlamydia infection]. Gora NV, etal., Zh Mikrobiol Epidemiol Immunobiol. 2011 May-Jun;(3):76-80.
4. [Masked deficiency of C4 component of complement in patients with chronic gastrointestinal tract diseases of different etiology]. Kozlov LV, etal., Zh Mikrobiol Epidemiol Immunobiol. 2011 Jul-Aug;(4):61-5.
5. Differential expression of complement proteins in cerebrospinal fluid from active multiple sclerosis patients. Li Y, etal., J Cell Biochem. 2011 Jul;112(7):1930-7. doi: 10.1002/jcb.23113.
6. Association between copy number variation of complement component C4 and Graves' disease. Liu YH, etal., J Biomed Sci. 2011 Sep 26;18:71.
7. The link of C4B null allele to autism and to a family history of autoimmunity in Egyptian autistic children. Mostafa GA and Shehab AA, J Neuroimmunol. 2010 Jun;223(1-2):115-9. Epub 2010 May 10.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Increased frequency of complement C4B deficiency in rheumatoid arthritis. Rigby WF, etal., Arthritis Rheum. 2011 Nov 10. doi: 10.1002/art.33472.
14. The rat expresses two complement factor C4 proteins, but only one isotype is expressed in the liver. Roos C, etal., J Immunol. 2005 Jan 15;174(2):970-5.
15. Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European Americans. Yang Y, etal., Am J Hum Genet. 2007 Jun;80(6):1037-54. Epub 2007 Apr 26.
16. Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma. Zafar GI, etal., J Urol. 2009 Mar;181(3):1028-34; discussion 1034. Epub 2009 Jan 16.
Additional References at PubMed
PMID:2395880   PMID:3023818   PMID:12136338   PMID:12421924   PMID:15060004   PMID:16502470   PMID:19302245   PMID:22333221   PMID:22516433   PMID:23376485   PMID:23533145   PMID:25645918  
PMID:26814963  


Genomics

Comparative Map Data
C4b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,201,979 - 4,216,292 (+)NCBIGRCr8
mRatBN7.2204,197,371 - 4,211,684 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,197,366 - 4,211,681 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,903,172 - 4,917,487 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,264,923 - 4,279,238 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,799,242 - 4,813,541 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,302,344 - 4,316,752 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,302,344 - 4,316,715 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,381,700 - 6,396,108 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,300,687 - 4,315,882 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera203,819,383 - 3,833,684 (-)NCBICelera
Cytogenetic Map20p12NCBI
C4B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38632,014,795 - 32,035,418 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl632,014,795 - 32,035,418 (+)EnsemblGRCh38hg38GRCh38
GRCh37631,982,572 - 32,003,195 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,057,813 - 32,078,435 (+)NCBINCBI36Build 36hg18NCBI36
Celera633,549,596 - 33,570,219 (+)NCBICelera
Cytogenetic Map6p21.33NCBI
CHM1_1631,984,848 - 32,005,386 (+)NCBICHM1_1
T2T-CHM13v2.0631,868,001 - 31,888,625 (+)NCBIT2T-CHM13v2.0
C4b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,947,249 - 34,962,876 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,947,354 - 34,962,856 (-)EnsemblGRCm39 Ensembl
GRCm381734,728,139 - 34,743,902 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,728,380 - 34,743,882 (-)EnsemblGRCm38mm10GRCm38
MGSCv371734,865,325 - 34,880,842 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,336,443 - 34,351,939 (-)NCBIMGSCv36mm8
Celera1737,826,575 - 37,840,058 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.29NCBI
LOC481722
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,433,185 - 1,448,056 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,568,269 - 1,582,800 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,575,361 - 1,589,884 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1121,433,082 - 1,447,359 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,501,274 - 1,515,547 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,567,611 - 1,582,146 (+)NCBIUU_Cfam_GSD_1.0
C4A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl724,068,013 - 24,083,065 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1724,068,019 - 24,083,060 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2727,729,081 - 27,744,181 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in C4b
196 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:96
Count of miRNA genes:79
Interacting mature miRNAs:86
Transcripts:ENSRNOT00000031704
Prediction methods:Microtar, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2026463954597031Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126123605Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2026463954597031Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
737973Pia21Pristane induced arthritis QTL 214.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2036216564606812Rat

Markers in Region
D20Yum64  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,201,495 - 4,201,649 (-)MAPPERmRatBN7.2
Rnor_6.0204,312,474 - 4,312,627NCBIRnor6.0
Rnor_5.0206,391,830 - 6,391,983UniSTSRnor5.0
RGSC_v3.4204,304,812 - 4,304,965UniSTSRGSC3.4
Celera203,829,406 - 3,829,559UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 37 101 91 90 59 25 59 6 201 85 81 40 55 31

Sequence


Ensembl Acc Id: ENSRNOT00000031704   ⟹   ENSRNOP00000037902
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,197,366 - 4,211,681 (+)Ensembl
Rnor_6.0 Ensembl204,302,344 - 4,316,715 (-)Ensembl
RefSeq Acc Id: NM_001002805   ⟹   NP_001002805
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,201,979 - 4,216,292 (+)NCBI
mRatBN7.2204,197,371 - 4,211,684 (+)NCBI
Rnor_6.0204,302,344 - 4,316,752 (-)NCBI
Rnor_5.0206,381,700 - 6,396,108 (-)NCBI
RGSC_v3.4204,300,687 - 4,315,882 (+)RGD
Celera203,819,383 - 3,833,684 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001002805 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA91231 (Get FASTA)   NCBI Sequence Viewer  
  CAE83956 (Get FASTA)   NCBI Sequence Viewer  
  EDL83375 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000037902.5
RefSeq Acc Id: NP_001002805   ⟸   NM_001002805
- Peptide Label: precursor
- UniProtKB: Q8R403 (UniProtKB/Swiss-Prot),   Q62895 (UniProtKB/Swiss-Prot),   P08649 (UniProtKB/Swiss-Prot),   Q6MG90 (UniProtKB/TrEMBL),   E9PSV0 (UniProtKB/TrEMBL),   A0A9K3Y872 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000037902   ⟸   ENSRNOT00000031704
Protein Domains
Anaphylatoxin-like   NTR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6MG90-F1-model_v2 AlphaFold Q6MG90 1-1737 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701336
Promoter ID:EPDNEW_R11860
Type:multiple initiation site
Name:C4b_1
Description:complement C4B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0204,316,770 - 4,316,830EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1591983 AgrOrtholog
BioCyc Gene G2FUF-4579 BioCyc
Ensembl Genes ENSRNOG00000030729 Ensembl
  ENSRNOG00000070397 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031704.7 UniProtKB/TrEMBL
Gene3D-CATH 1.50.10.20 UniProtKB/TrEMBL
  2.20.130.20 UniProtKB/TrEMBL
  2.40.50.120 UniProtKB/TrEMBL
  2.60.120.1540 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  2.60.40.1930 UniProtKB/TrEMBL
  2.60.40.1940 UniProtKB/TrEMBL
  2.60.40.690 UniProtKB/TrEMBL
  6.20.50.160 UniProtKB/TrEMBL
  Anaphylotoxins (complement system) UniProtKB/TrEMBL
InterPro A-macroglobulin_rcpt-bd UniProtKB/TrEMBL
  A-macroglobulin_rcpt-bd_sf UniProtKB/TrEMBL
  A2M/Complement_sys UniProtKB/TrEMBL
  A2M_comp UniProtKB/TrEMBL
  A2M_N UniProtKB/TrEMBL
  A2M_N_2 UniProtKB/TrEMBL
  Alpha-macroglob_thiol-ester_cl UniProtKB/TrEMBL
  Anaphylatoxin/fibulin UniProtKB/TrEMBL
  Anaphylatoxin_ UniProtKB/TrEMBL
  Anaphylatoxn UniProtKB/TrEMBL
  C4_MG1 UniProtKB/TrEMBL
  CO4A-B_CUB_C UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Macroglobln_a2 UniProtKB/TrEMBL
  MacrogloblnA2_CS UniProtKB/TrEMBL
  MG3 UniProtKB/TrEMBL
  MG4 UniProtKB/TrEMBL
  Netrin_domain UniProtKB/TrEMBL
  Netrin_module_non-TIMP UniProtKB/TrEMBL
  Terpenoid_cyclase/PrenylTrfase UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/TrEMBL
KEGG Report rno:406161 UniProtKB/TrEMBL
NCBI Gene 406161 ENTREZGENE
PANTHER MACROGLOBULIN / COMPLEMENT UniProtKB/TrEMBL
  PTHR11412:SF86 UniProtKB/TrEMBL
Pfam A2M UniProtKB/TrEMBL
  A2M_comp UniProtKB/TrEMBL
  A2M_N UniProtKB/TrEMBL
  A2M_N_2 UniProtKB/TrEMBL
  A2M_recep UniProtKB/TrEMBL
  ANATO UniProtKB/TrEMBL
  C4_MG1 UniProtKB/TrEMBL
  CO4A-B_CUB_C UniProtKB/TrEMBL
  MG3 UniProtKB/TrEMBL
  MG4 UniProtKB/TrEMBL
  NTR UniProtKB/TrEMBL
PhenoGen C4b PhenoGen
PRINTS ANAPHYLATOXN UniProtKB/TrEMBL
PROSITE ALPHA_2_MACROGLOBULIN UniProtKB/TrEMBL
  ANAPHYLATOXIN_1 UniProtKB/TrEMBL
  ANAPHYLATOXIN_2 UniProtKB/TrEMBL
  NTR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000030729 RatGTEx
  ENSRNOG00000070397 RatGTEx
SMART A2M UniProtKB/TrEMBL
  A2M_N_2 UniProtKB/TrEMBL
  A2M_recep UniProtKB/TrEMBL
  ANATO UniProtKB/TrEMBL
  C345C UniProtKB/TrEMBL
  Thiol-ester_cl UniProtKB/TrEMBL
Superfamily-SCOP AM_receptor_bind UniProtKB/TrEMBL
  Anaphylatoxin UniProtKB/TrEMBL
  Terp_cyc_toroid UniProtKB/TrEMBL
  TIMP_like UniProtKB/TrEMBL
UniProt A0A9K3Y872 ENTREZGENE, UniProtKB/TrEMBL
  E9PSV0 ENTREZGENE
  P08649 ENTREZGENE
  Q62895 ENTREZGENE
  Q6MG90 ENTREZGENE, UniProtKB/TrEMBL
  Q8R403 ENTREZGENE
UniProt Secondary E9PSV0 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-01-02 C4b  complement C4B  C4b  complement C4B (Chido blood group)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-08-18 C4b  complement C4B (Chido blood group)  C4b  complement component 4B (Chido blood group)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 C4-2  complement component 4, gene 2      Symbol and Name status set to provisional 70820 PROVISIONAL