Fes (FES proto-oncogene, tyrosine kinase) - Rat Genome Database

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Gene: Fes (FES proto-oncogene, tyrosine kinase) Rattus norvegicus
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Symbol: Fes
Name: FES proto-oncogene, tyrosine kinase
RGD ID: 1564385
Description: Predicted to enable several functions, including immunoglobulin receptor binding activity; microtubule binding activity; and non-membrane spanning protein tyrosine kinase activity. Involved in cardiac muscle cell proliferation and myoblast proliferation. Predicted to be located in several cellular components, including cytoplasmic side of plasma membrane; focal adhesion; and microtubule cytoskeleton. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human FES (FES proto-oncogene, tyrosine kinase); PARTICIPATES IN interleukin-4 signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: feline sarcoma oncogene; LOC361597; RGD1564385; similar to tyrosine kinase Fps/Fes; tyrosine-protein kinase Fes/Fps
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,746,945 - 143,756,181 (-)NCBIGRCr8
mRatBN7.21134,337,698 - 134,346,934 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,337,698 - 134,346,934 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1142,246,565 - 142,255,805 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01149,415,959 - 149,425,199 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01142,333,966 - 142,343,206 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01142,174,648 - 142,183,884 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1142,174,648 - 142,183,884 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01143,127,277 - 143,136,513 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41136,199,523 - 136,208,759 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1126,397,304 - 126,406,534 (-)NCBICelera
Cytogenetic Map1q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
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Original Reference(s)
FesRatesophagus squamous cell carcinoma exacerbatesISOFES (Homo sapiens)153323298DNA:hypermethylation: (human)RGD 
FesRatfemale breast cancer onsetISOFes (Mus musculus)153323296 RGD 
FesRathepatocellular carcinoma exacerbatesISOFES (Homo sapiens)153323297DNA:hypermethylation:promoter (human)RGD 
FesRatlung adenocarcinoma treatmentISOFES (Homo sapiens)153323295human cells in a mouse modelRGD 
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Original Reference(s)
FesRatBloom syndrome  ISOFES (Homo sapiens)8554872ClinVar Annotator: match by term: Bloom syndromeClinVarPMID:28492532
FesRatD-2-hydroxyglutaric aciduria 2  ISOFES (Homo sapiens)8554872ClinVar Annotator: match by term: D-2-hydroxyglutaric aciduria 2ClinVarPMID:28492532
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FesRatcoronary artery disease  ISOFES (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:34961328

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Original Reference(s)
FesRat1,2-dichloroethane increases expressionISOFes (Mus musculus)6480464ethylene dichloride results in increased expression of FES mRNACTDPMID:28960355
FesRat1,2-dimethylhydrazine multiple interactionsISOFes (Mus musculus)6480464Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of FES mRNA]CTDPMID:22206623
FesRat1,2-dimethylhydrazine increases expressionISOFes (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of FES mRNACTDPMID:22206623
FesRat17beta-estradiol decreases expressionISOFes (Mus musculus)6480464Estradiol results in decreased expression of FES mRNACTDPMID:39298647
FesRat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISOFES (Homo sapiens)64804642 more ...CTDPMID:23146750
FesRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOFes (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of FES mRNACTDPMID:19770486
FesRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of FES mRNACTDPMID:34747641
FesRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOFes (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of FES mRNACTDPMID:21570461
FesRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOFES (Homo sapiens)6480464Tetrachlorodibenzodioxin affects the expression of FES mRNACTDPMID:22298810
FesRat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOFES (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FES mRNACTDPMID:28628672
FesRat4,4'-sulfonyldiphenol decreases expressionISOFes (Mus musculus)6480464bisphenol S results in decreased expression of FES mRNACTDPMID:39298647
FesRat4,4'-sulfonyldiphenol affects methylationISOFes (Mus musculus)6480464bisphenol S affects the methylation of FES geneCTDPMID:31683443
FesRat4,4'-sulfonyldiphenol decreases methylationISOFes (Mus musculus)6480464bisphenol S results in decreased methylation of FES exonCTDPMID:33297965
FesRat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of FES mRNACTDPMID:33150595
FesRat6-propyl-2-thiouracil increases methylationEXP 6480464Propylthiouracil results in increased methylation of FES promoterCTDPMID:33150595
FesRatacetamide increases expressionEXP 6480464acetamide results in increased expression of FES mRNACTDPMID:31881176
FesRataflatoxin B1 decreases expressionISOFES (Homo sapiens)6480464Aflatoxin B1 results in decreased expression of FES mRNACTDPMID:27153756
FesRatall-trans-retinoic acid increases expressionISOFES (Homo sapiens)6480464Tretinoin results in increased expression of FES mRNACTDPMID:15498508
FesRatamphetamine increases expressionEXP 6480464Amphetamine results in increased expression of FES mRNACTDPMID:30779732
FesRataristolochic acid A increases expressionISOFES (Homo sapiens)6480464aristolochic acid I results in increased expression of FES mRNACTDPMID:33212167

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Biological Process
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Original Reference(s)
FesRatcardiac muscle cell proliferation  IEP 151665807 RGD 
FesRatcell adhesion involved_inIBAMGI:105917 and PANTHER:PTN0007007751600115GO_REF:0000033GO_CentralGO_REF:0000033
FesRatcellular response to vitamin D involved_inISOFES (Homo sapiens)1624291 PMID:28389358RGDPMID:28389358
FesRatcellular response to vitamin D involved_inIEAUniProtKB:P07332 and ensembl:ENSP000003315041600115GO_REF:0000107EnsemblGO_REF:0000107
FesRatcentrosome cycle acts_upstream_of_or_withinISOFes (Mus musculus)1624291 PMID:14551201RGDPMID:14551201
FesRatcentrosome cycle acts_upstream_of_or_withinIEAUniProtKB:P16879 and ensembl:ENSMUSP000000797331600115GO_REF:0000107EnsemblGO_REF:0000107
FesRatchemotaxis involved_inIBAMGI:105917 and PANTHER:PTN0007007751600115GO_REF:0000033GO_CentralGO_REF:0000033
FesRatmicrotubule bundle formation acts_upstream_of_or_withinIEAUniProtKB:P16879 and ensembl:ENSMUSP000000797331600115GO_REF:0000107EnsemblGO_REF:0000107
FesRatmicrotubule bundle formation acts_upstream_of_or_withinISOFes (Mus musculus)1624291 PMID:14551201RGDPMID:14551201
FesRatmyoblast proliferation  IEP 151667421 RGD 
FesRatpeptidyl-tyrosine phosphorylation involved_inISOFES (Homo sapiens)1624291 PMID:11509660 and PMID:15485904RGDPMID:11509660 and PMID:15485904
FesRatpositive regulation of microtubule polymerization involved_inISOFES (Homo sapiens)1624291 PMID:15485904RGDPMID:15485904
FesRatpositive regulation of microtubule polymerization involved_inIEAUniProtKB:P07332 and ensembl:ENSP000003315041600115GO_REF:0000107EnsemblGO_REF:0000107
FesRatpositive regulation of monocyte differentiation involved_inISOFES (Homo sapiens)1624291 PMID:28389358RGDPMID:28389358
FesRatpositive regulation of monocyte differentiation involved_inIEAUniProtKB:P07332 and ensembl:ENSP000003315041600115GO_REF:0000107EnsemblGO_REF:0000107
FesRatpositive regulation of myeloid cell differentiation involved_inISOFES (Homo sapiens)1624291 PMID:2656706RGDPMID:2656706
FesRatpositive regulation of myeloid cell differentiation involved_inIEAUniProtKB:P07332 and ensembl:ENSP000003315041600115GO_REF:0000107EnsemblGO_REF:0000107
FesRatpositive regulation of neuron projection development involved_inISOFES (Homo sapiens)1624291 PMID:15302586RGDPMID:15302586
FesRatpositive regulation of neuron projection development involved_inIEAUniProtKB:P07332 and ensembl:ENSP000003315041600115GO_REF:0000107EnsemblGO_REF:0000107
FesRatprotein autophosphorylation involved_inISOFES (Homo sapiens)1624291 PMID:7687763RGDPMID:7687763
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Cellular Component
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Original Reference(s)
FesRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
FesRatcytoplasm located_inIEAUniProtKB:P07332 and ensembl:ENSP000003315041600115GO_REF:0000107EnsemblGO_REF:0000107
FesRatcytoplasm located_inISOFES (Homo sapiens)1624291 PMID:11339827RGDPMID:11339827
FesRatcytoplasmic side of plasma membrane located_inISOFES (Homo sapiens)1624291 PMID:18046454 and PMID:19001085RGDPMID:18046454 and PMID:19001085
FesRatcytoplasmic side of plasma membrane located_inIEAUniProtKB:P07332 and ensembl:ENSP000003315041600115GO_REF:0000107EnsemblGO_REF:0000107
FesRatcytoplasmic vesicle located_inISOFES (Homo sapiens)1624291 PMID:11339827RGDPMID:11339827
FesRatcytoplasmic vesicle located_inIEAUniProtKB:P07332 and ensembl:ENSP000003315041600115GO_REF:0000107EnsemblGO_REF:0000107
FesRatcytoskeleton located_inIEAUniProtKB-KW:KW-02061600115GO_REF:0000043UniProtGO_REF:0000043
FesRatcytoskeleton located_inIEAUniProtKB-SubCell:SL-00901600115GO_REF:0000044UniProtGO_REF:0000044
FesRatfocal adhesion located_inISOFES (Homo sapiens)1624291 PMID:18046454RGDPMID:18046454
FesRatfocal adhesion located_inIEAUniProtKB:P07332 and ensembl:ENSP000003315041600115GO_REF:0000107EnsemblGO_REF:0000107
FesRatmicrotubule cytoskeleton located_inISOFES (Homo sapiens)1624291 PMID:15485904RGDPMID:15485904
FesRatmicrotubule cytoskeleton located_inIEAUniProtKB:P16879 and ensembl:ENSMUSP000000797331600115GO_REF:0000107EnsemblGO_REF:0000107
FesRatmicrotubule cytoskeleton located_inIEAUniProtKB:P07332 and ensembl:ENSP000003315041600115GO_REF:0000107EnsemblGO_REF:0000107
FesRatmicrotubule cytoskeleton located_inISOFes (Mus musculus)1624291 PMID:14551201RGDPMID:14551201
FesRatplasma membrane is_active_inIBAFB:FBgn0000017 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
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Molecular Function
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Original Reference(s)
FesRatATP binding enablesIEAUniRule:UR0015033411600115GO_REF:0000104UniProtGO_REF:0000104
FesRatATP binding enablesIEAInterPro:IPR000719 and InterPro:IPR0174411600115GO_REF:0000002InterProGO_REF:0000002
FesRatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
FesRatimmunoglobulin receptor binding enablesISOFES (Homo sapiens)1624291 PMID:19001085RGDPMID:19001085
FesRatimmunoglobulin receptor binding enablesIEAUniProtKB:P07332 and ensembl:ENSP000003315041600115GO_REF:0000107EnsemblGO_REF:0000107
FesRatkinase activity enablesIEAUniProtKB-KW:KW-04181600115GO_REF:0000043UniProtGO_REF:0000043
FesRatmicrotubule binding enablesISOFes (Mus musculus)1624291 PMID:14551201RGDPMID:14551201
FesRatmicrotubule binding enablesIEAUniProtKB:P16879 and ensembl:ENSMUSP000000797331600115GO_REF:0000107EnsemblGO_REF:0000107
FesRatnon-membrane spanning protein tyrosine kinase activity enablesISOFES (Homo sapiens)1624291 PMID:15485904RGDPMID:15485904
FesRatnon-membrane spanning protein tyrosine kinase activity enablesIEAInterPro:IPR0162501600115GO_REF:0000002InterProGO_REF:0000002
FesRatnon-membrane spanning protein tyrosine kinase activity enablesIEAUniProtKB:P07332 and ensembl:ENSP000003315041600115GO_REF:0000107EnsemblGO_REF:0000107
FesRatnon-membrane spanning protein tyrosine kinase activity enablesIEAEC:2.7.10.21600115GO_REF:0000003UniProtGO_REF:0000003
FesRatnucleotide binding enablesIEAUniRule:UR0015033411600115GO_REF:0000104UniProtGO_REF:0000104
FesRatnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
FesRatphosphatidylinositol binding enablesISOFES (Homo sapiens)1624291 PMID:19001085RGDPMID:19001085
FesRatphosphatidylinositol binding enablesIEAUniProtKB:P07332 and ensembl:ENSP000003315041600115GO_REF:0000107EnsemblGO_REF:0000107
FesRatprotein binding enablesISOFES (Homo sapiens)1624291UniProtKB:P10275 more ...RGDPMID:18046454 more ...
FesRatprotein binding enablesISOFes (Mus musculus)1624291UniProtKB:P01901 more ...RGDPMID:22522491
FesRatprotein kinase activity enablesIEAInterPro:IPR000719 more ...1600115GO_REF:0000002InterProGO_REF:0000002
FesRatprotein kinase activity enablesIEAUniProtKB:P16879 and ensembl:ENSMUSP000000797331600115GO_REF:0000107EnsemblGO_REF:0000107
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Imported Annotations - PID (archival)

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FesRatinterleukin-4 signaling pathway  ISOFES (Homo sapiens)6484113 PIDPID:200022
FesRatvascular endothelial growth factor signaling pathway   ISOFES (Homo sapiens)6484113 PIDPID:200188

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Reference Title
Reference Citation
1. Proto-oncogene expression in proliferating and differentiating cardiac and skeletal muscle. Claycomb WC and Lanson NA, Biochem J. 1987 Nov 1;247(3):701-6. doi: 10.1042/bj2470701.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Identification of FES as a Novel Radiosensitizing Target in Human Cancers. Kim BH, etal., Clin Cancer Res. 2020 Jan 1;26(1):265-273. doi: 10.1158/1078-0432.CCR-19-0610. Epub 2019 Oct 1.
4. Prognostic CpG methylation biomarkers identified by methylation array in esophageal squamous cell carcinoma patients. Kuo IY, etal., Int J Med Sci. 2014 May 30;11(8):779-87. doi: 10.7150/ijms.7405. eCollection 2014.
5. Differential expression of protooncogenes related to transformation and cancer progression in rat myoblasts. Leibovitch SA, etal., Cancer Res. 1986 Aug;46(8):4097-103.
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. An identity crisis for fps/fes: oncogene or tumor suppressor? Sangrar W, etal., Cancer Res. 2005 May 1;65(9):3518-22. doi: 10.1158/0008-5472.CAN-04-3468.
10. Epigenomic profiling of DNA methylation for hepatocellular carcinoma diagnosis and prognosis prediction. Zhang C, etal., J Gastroenterol Hepatol. 2019 Oct;34(10):1869-1877. doi: 10.1111/jgh.14694. Epub 2019 Jun 20.
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PMID:2656706   PMID:7687763   PMID:11339827   PMID:11509660   PMID:12093729   PMID:12192036   PMID:12477932   PMID:14551201   PMID:15302586   PMID:15485904   PMID:18046454   PMID:19001085  
PMID:28389358  



Fes
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,746,945 - 143,756,181 (-)NCBIGRCr8
mRatBN7.21134,337,698 - 134,346,934 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,337,698 - 134,346,934 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1142,246,565 - 142,255,805 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01149,415,959 - 149,425,199 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01142,333,966 - 142,343,206 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01142,174,648 - 142,183,884 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1142,174,648 - 142,183,884 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01143,127,277 - 143,136,513 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41136,199,523 - 136,208,759 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1126,397,304 - 126,406,534 (-)NCBICelera
Cytogenetic Map1q31NCBI
FES
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381590,884,504 - 90,895,776 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1590,883,695 - 90,895,776 (+)EnsemblGRCh38hg38GRCh38
GRCh371591,427,734 - 91,439,006 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361589,228,713 - 89,240,010 (+)NCBINCBI36Build 36hg18NCBI36
Build 341589,228,712 - 89,240,010NCBI
Celera1567,836,636 - 67,847,969 (+)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1567,539,170 - 67,550,515 (+)NCBIHuRef
CHM1_11591,269,239 - 91,280,594 (+)NCBICHM1_1
T2T-CHM13v2.01588,643,915 - 88,655,365 (+)NCBIT2T-CHM13v2.0
Fes
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39780,027,506 - 80,037,702 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl780,027,504 - 80,037,694 (-)EnsemblGRCm39 Ensembl
GRCm38780,377,758 - 80,387,954 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl780,377,756 - 80,387,946 (-)EnsemblGRCm38mm10GRCm38
MGSCv37787,522,644 - 87,532,832 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36780,251,286 - 80,260,905 (-)NCBIMGSCv36mm8
Celera777,777,722 - 77,787,907 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.65NCBI
Fes
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541614,948,123 - 14,960,005 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541614,948,121 - 14,959,035 (+)NCBIChiLan1.0ChiLan1.0
FES
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21680,437,700 - 80,449,677 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11584,135,731 - 84,147,865 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01569,576,936 - 69,588,834 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11588,774,967 - 88,786,965 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1588,774,965 - 88,786,965 (+)Ensemblpanpan1.1panPan2
FES
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,346,975 - 53,356,547 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,347,012 - 53,356,516 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha355,984,668 - 55,994,302 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0353,763,060 - 53,772,711 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl353,763,067 - 53,772,745 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1353,282,201 - 53,291,832 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0353,493,421 - 53,503,070 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0353,833,898 - 53,843,534 (-)NCBIUU_Cfam_GSD_1.0
Fes
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640130,199,476 - 130,210,580 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648316,123,779 - 16,135,044 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648316,123,938 - 16,135,044 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FES
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl753,472,947 - 53,485,082 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1753,472,947 - 53,485,084 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2758,504,744 - 58,516,272 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FES
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1298,967,542 - 8,979,475 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl298,965,997 - 8,979,361 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605937,746,110 - 37,758,650 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fes
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476817,359,196 - 17,372,712 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476817,360,602 - 17,372,563 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Fes
36 total Variants

Predicted Target Of
Summary Value
Count of predictions:172
Count of miRNA genes:133
Interacting mature miRNAs:146
Transcripts:ENSRNOT00000016032
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 61 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat

1 to 10 of 61 rows
RH132075  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,337,740 - 134,337,924 (+)MAPPERmRatBN7.2
Rnor_6.01142,174,691 - 142,174,874NCBIRnor6.0
Rnor_5.01143,127,320 - 143,127,503UniSTSRnor5.0
RGSC_v3.41136,199,566 - 136,199,749UniSTSRGSC3.4
Celera1126,397,347 - 126,397,530UniSTS
RH 3.4 Map11070.8UniSTS
Cytogenetic Map1q31UniSTS
D1Bda27  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,348,264 - 134,348,555 (+)MAPPERmRatBN7.2
Rnor_6.01142,185,215 - 142,185,505NCBIRnor6.0
Rnor_5.01143,137,844 - 143,138,134UniSTSRnor5.0
RGSC_v3.41136,210,090 - 136,210,380UniSTSRGSC3.4
Celera1126,407,865 - 126,408,155UniSTS
Cytogenetic Map1q31UniSTS
RH94589  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,348,147 - 134,348,343 (+)MAPPERmRatBN7.2
Rnor_6.01142,185,098 - 142,185,293NCBIRnor6.0
Rnor_5.01143,137,727 - 143,137,922UniSTSRnor5.0
RGSC_v3.41136,209,973 - 136,210,168UniSTSRGSC3.4
Celera1126,407,748 - 126,407,943UniSTS
RH 3.4 Map11074.0UniSTS
Cytogenetic Map1q31UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000016032   ⟹   ENSRNOP00000016032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1134,337,698 - 134,346,934 (-)Ensembl
Rnor_6.0 Ensembl1142,174,648 - 142,183,884 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114248   ⟹   ENSRNOP00000082184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1134,337,703 - 134,346,934 (-)Ensembl
RefSeq Acc Id: NM_001108488   ⟹   NP_001101958
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,746,945 - 143,756,181 (-)NCBI
mRatBN7.21134,337,698 - 134,346,934 (-)NCBI
Rnor_6.01142,174,648 - 142,183,884 (-)NCBI
Rnor_5.01143,127,277 - 143,136,513 (-)NCBI
RGSC_v3.41136,199,523 - 136,208,759 (-)RGD
Celera1126,397,304 - 126,406,534 (-)RGD
Sequence:
RefSeq Acc Id: XM_039082331   ⟹   XP_038938259
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,750,825 - 143,755,550 (-)NCBI
mRatBN7.21134,341,588 - 134,346,850 (-)NCBI
RefSeq Acc Id: XM_063266933   ⟹   XP_063123003
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,749,848 - 143,755,550 (-)NCBI
RefSeq Acc Id: XM_063266941   ⟹   XP_063123011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,751,286 - 143,755,550 (-)NCBI
RefSeq Acc Id: XR_005488133
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,750,817 - 143,755,550 (-)NCBI
mRatBN7.21134,341,570 - 134,346,850 (-)NCBI
RefSeq Acc Id: XR_005488136
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,750,855 - 143,755,550 (-)NCBI
mRatBN7.21134,341,623 - 134,346,850 (-)NCBI
RefSeq Acc Id: XR_350521
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,747,548 - 143,755,550 (-)NCBI
mRatBN7.21134,337,698 - 134,346,850 (-)NCBI
Rnor_6.01142,174,648 - 142,183,866 (-)NCBI
Rnor_5.01143,127,277 - 143,136,513 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001101958   ⟸   NM_001108488
- UniProtKB: D4A584 (UniProtKB/TrEMBL),   A6JCB2 (UniProtKB/TrEMBL),   A0A8I5ZWJ2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016032   ⟸   ENSRNOT00000016032
RefSeq Acc Id: XP_038938259   ⟸   XM_039082331
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000082184   ⟸   ENSRNOT00000114248
RefSeq Acc Id: XP_063123003   ⟸   XM_063266933
- Peptide Label: isoform X1
- UniProtKB: A6JCB7 (UniProtKB/TrEMBL)
F-BAR   Protein kinase   SH2

Name Modeler Protein Id AA Range Protein Structure
AF-D4A584-F1-model_v2 AlphaFold D4A584 1-822 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690146
Promoter ID:EPDNEW_R670
Type:initiation region
Name:Fes_1
Description:FES proto-oncogene, tyrosine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01142,183,819 - 142,183,879EPDNEW


1 to 40 of 58 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-58734 BioCyc
Ensembl Genes ENSRNOG00000011683 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016032 ENTREZGENE
  ENSRNOT00000016032.6 UniProtKB/TrEMBL
  ENSRNOT00000114248.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.60 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
  HR1 repeat UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7104787 IMAGE-MGC_LOAD
InterPro AH/BAR-dom UniProtKB/TrEMBL
  F_BAR UniProtKB/TrEMBL
  FCH UniProtKB/TrEMBL
  Fes/Fps/Fer_SH2 UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Non-receptor_tyrosine_kinases UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr-Pkinase UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2-Ras-GEF_adapter UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  Tyr_kinase_non-rcpt_Fes_subgr UniProtKB/TrEMBL
  Tyr_Pkinase_cat_dom UniProtKB/TrEMBL
  Tyr_prot_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:361597 UniProtKB/TrEMBL
MGC_CLONE MGC:187993 IMAGE-MGC_LOAD
NCBI Gene 361597 ENTREZGENE
PANTHER BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN UniProtKB/TrEMBL
  FCH AND DOUBLE SH3 DOMAINS PROTEIN UniProtKB/TrEMBL
  HIGH OSMOLARITY SIGNALING PROTEIN SHO1 UniProtKB/TrEMBL
  SH2 DOMAIN-CONTAINING PROTEIN 3A UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE UniProtKB/TrEMBL
Pfam FCH UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
PhenoGen Fes PhenoGen
PIRSF TyrPK_fps UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
1 to 40 of 58 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-09 Fes  FES proto-oncogene, tyrosine kinase  Fes  feline sarcoma oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Fes  feline sarcoma oncogene  RGD1564385_predicted  similar to tyrosine kinase Fps/Fes (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564385_predicted  similar to tyrosine kinase Fps/Fes (predicted)  LOC361597  similar to tyrosine kinase Fps/Fes  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC361597  similar to tyrosine kinase Fps/Fes      Symbol and Name status set to provisional 70820 PROVISIONAL