Cbl (Cbl proto-oncogene) - Rat Genome Database

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Gene: Cbl (Cbl proto-oncogene) Rattus norvegicus
Analyze
Symbol: Cbl
Name: Cbl proto-oncogene
RGD ID: 1561386
Description: Enables several functions, including SH3 domain binding activity; phosphatidylinositol 3-kinase regulatory subunit binding activity; and protein tyrosine kinase binding activity. Involved in several processes, including cellular response to platelet-derived growth factor stimulus; mast cell degranulation; and protein ubiquitination. Located in focal adhesion; growth cone; and perinuclear region of cytoplasm. Used to study transient cerebral ischemia. Biomarker of congenital diaphragmatic hernia; hyperglycemia; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in acute myeloid leukemia; congestive heart failure; juvenile myelomonocytic leukemia; lung non-small cell carcinoma; and myeloid neoplasm. Orthologous to human CBL (Cbl proto-oncogene); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: c-Cbl; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B-lineage lymphoma; Cbl proto-oncogene, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase CBL; LOC500985; RGD1561386; similar to CBL E3 ubiquitin protein ligase (Signal transduction protein CBL); similar to CBL E3 ubiquitin protein ligase (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto-oncogene)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8853,384,656 - 53,468,067 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl853,384,656 - 53,468,067 (-)EnsemblGRCr8
mRatBN7.2844,487,824 - 44,571,620 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl844,489,410 - 44,571,176 (-)EnsemblmRatBN7.2
Rnor_6.0848,481,256 - 48,564,775 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl848,489,036 - 48,564,722 (-)Ensemblrn6Rnor6.0
Rnor_5.0847,105,710 - 47,183,347 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4847,135,357 - 47,211,889 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera844,074,668 - 44,158,034 (-)NCBICelera
Cytogenetic Map8q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
2-naphthylamine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amphetamine  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
bisphenol F  (ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
fipronil  (EXP)
flutamide  (EXP,ISO)
FR900359  (ISO)
geldanamycin  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP)
mercury dichloride  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
phenobarbital  (ISO)
phosphane  (EXP)
resveratrol  (ISO)
retinyl acetate  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
torcetrapib  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
axon  (IDA)
cilium  (IEA,ISO)
cytoplasm  (IEA)
cytosol  (IEA,ISO,TAS)
flotillin complex  (IEA,ISO)
focal adhesion  (IDA)
Golgi apparatus  (IEA,ISO)
growth cone  (IDA)
membrane raft  (IBA)
perinuclear region of cytoplasm  (IDA)
plasma membrane  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Intraarticular interferon-beta gene therapy ameliorates adjuvant arthritis in rats. Adriaansen J, etal., Hum Gene Ther. 2006 Oct;17(10):985-96.
2. CBL mutations in myeloproliferative neoplasms are also found in the gene's proline-rich domain and in patients with the V617FJAK2. Aranaz P, etal., Haematologica. 2012 Aug;97(8):1234-41. doi: 10.3324/haematol.2011.052605. Epub 2012 Feb 7.
3. Exercise training increases components of the c-Cbl-associated protein/c-Cbl signaling cascade in muscle of obese Zucker rats. Bernard JR, etal., Metabolism. 2008 Jun;57(6):858-66. doi: 10.1016/j.metabol.2008.01.035.
4. SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins. Borinstein SC, etal., Cell Signal 2000 Dec;12(11-12):769-79.
5. Loss of c-Cbl expression correlates with de-differentiation status and lymphatic metastasis in gastric cancer. Chen C, etal., Indian J Pathol Microbiol. 2019 Oct-Dec;62(4):549-555. doi: 10.4103/IJPM.IJPM_824_18.
6. EGF-ERBB signalling: towards the systems level. Citri A and Yarden Y, Nat Rev Mol Cell Biol. 2006 Jul;7(7):505-16.
7. Androgen-dependent apoptosis in male germ cells is regulated through the proto-oncoprotein Cbl. El Chami N, etal., J Cell Biol. 2005 Nov 21;171(4):651-61.
8. [Expression down-regulation of c-Cbl and Cbl-b genes in peripheral blood mononuclear cells from multiple myeloma patients]. Fang S, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013 Aug;29(8):842-5.
9. Decreased pulmonary c-Cbl expression and tyrosine phosphorylation in the nitrofen-induced rat model of congenital diaphragmatic hernia. Friedmacher F, etal., Pediatr Surg Int. 2013 Jan;29(1):19-24. doi: 10.1007/s00383-012-3191-6.
10. Syk-dependent regulation of Hrs phosphorylation and ubiquitination upon FcepsilonRI engagement: impact on Hrs membrane/cytosol localization. Gasparrini F, etal., Eur J Immunol. 2012 Oct;42(10):2744-53. doi: 10.1002/eji.201142278. Epub 2012 Jul 25.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. The Met tyrosine kinase receptor in development and cancer. Gentile A, etal., Cancer Metastasis Rev. 2008 Mar;27(1):85-94.
13. Evidence of a functional role for mast cells in the development of type 1 diabetes mellitus in the BioBreeding rat. Geoffrey R, etal., J Immunol. 2006 Nov 15;177(10):7275-86.
14. Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms. Grand FH, etal., Blood. 2009 Jun 11;113(24):6182-92. doi: 10.1182/blood-2008-12-194548. Epub 2009 Apr 22.
15. Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites. Haglund K, etal., J Cell Sci. 2004 May 15;117(Pt 12):2557-68. Epub 2004 May 5.
16. Phosphorylation of cbl after stimulation of Nb2 cells with prolactin and its association with phosphatidylinositol 3-kinase. Hunter S, etal., Mol Endocrinol. 1997 Aug;11(9):1213-22.
17. Evidence for functional roles of Crk-II in insulin and epidermal growth factor signaling in Rat-1 fibroblasts overexpressing insulin receptors. Ishiki M, etal., Endocrinology. 1997 Nov;138(11):4950-8.
18. Increased expression of the Cbl family of E3 ubiquitin ligases decreases Interleukin-2 production in a rat model of peripheral neuropathy. Jeong JS, etal., BMC Anesthesiol. 2018 Jul 18;18(1):87. doi: 10.1186/s12871-018-0555-z.
19. A high occurrence of acquisition and/or expansion of C-CBL mutant clones in the progression of high-risk myelodysplastic syndrome to acute myeloid leukemia. Kao HW, etal., Neoplasia. 2011 Nov;13(11):1035-42.
20. Full spectrum of clonal haematopoiesis-driver mutations in chronic heart failure and their associations with mortality. Kiefer KC, etal., ESC Heart Fail. 2021 Jun;8(3):1873-1884. doi: 10.1002/ehf2.13297. Epub 2021 Mar 28.
21. c-Cbl Expression Correlates with Human Colorectal Cancer Survival and Its Wnt/β-Catenin Suppressor Function Is Regulated by Tyr371 Phosphorylation. Kumaradevan S, etal., Am J Pathol. 2018 Aug;188(8):1921-1933. doi: 10.1016/j.ajpath.2018.05.007. Epub 2018 Jul 17.
22. An E3 ubiquitin ligase: c-Cbl: a new therapeutic target of lung cancer. Lo FY, etal., Cancer. 2011 Dec 1;117(23):5344-50. doi: 10.1002/cncr.26153. Epub 2011 May 23.
23. Mutations in CBL occur frequently in juvenile myelomonocytic leukemia. Loh ML, etal., Blood. 2009 Aug 27;114(9):1859-63. doi: 10.1182/blood-2009-01-198416. Epub 2009 Jul 1.
24. Evidence for a role of the ubiquitin-proteasome pathway in pancreatic islets. López-Avalos MD, etal., Diabetes. 2006 May;55(5):1223-31.
25. Is the c-Cbl proto-oncogene involved in chronic lymphocytic leukemia? Mankai A, etal., Ann N Y Acad Sci. 2007 Jun;1107:193-205.
26. Phosphorylation of c-Cbl protooncogene product following ethanol administration in rat cerebellum: possible involvement of Fyn kinase. Nishio H, etal., Brain Res 2002 Sep 20;950(1-2):203-9.
27. The leukocyte receptor CD84 inhibits Fc epsilon RI-mediated signaling through homophilic interaction in transfected RBL-2H3 cells. Oliver-Vila I, etal., Mol Immunol. 2008 Apr;45(8):2138-49. doi: 10.1016/j.molimm.2007.12.006. Epub 2008 Feb 19.
28. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
29. Characterization of Cbl tyrosine phosphorylation and a Cbl-Syk complex in RBL-2H3 cells. Ota Y, etal., J Exp Med. 1996 Nov 1;184(5):1713-23.
30. RAFTK/Pyk2 regulates EGF-induced PC12 cell spreading and movement. Park SY, etal., Cell Signal. 2007 Feb;19(2):289-300. Epub 2006 Aug 30.
31. The adaptor molecule CIN85 regulates Syk tyrosine kinase level by activating the ubiquitin-proteasome degradation pathway. Peruzzi G, etal., J Immunol. 2007 Aug 15;179(4):2089-96.
32. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
33. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
34. c-Cbl inhibition improves cardiac function and survival in response to myocardial ischemia. Rafiq K, etal., Circulation. 2014 May 20;129(20):2031-43. doi: 10.1161/CIRCULATIONAHA.113.007004. Epub 2014 Feb 28.
35. c-Cbl ubiquitin ligase regulates focal adhesion protein turnover and myofibril degeneration induced by neutrophil protease cathepsin G. Rafiq K, etal., J Biol Chem. 2012 Feb 17;287(8):5327-39. doi: 10.1074/jbc.M111.307009. Epub 2011 Dec 27.
36. c-Cbl deficiency leads to diminished lymphocyte development and functions in an age-dependent manner. Rathinam C and Flavell RA, Proc Natl Acad Sci U S A. 2010 May 4;107(18):8316-21. doi: 10.1073/pnas.0914496107. Epub 2010 Apr 19.
37. Myeloid leukemia development in c-Cbl RING finger mutant mice is dependent on FLT3 signaling. Rathinam C, etal., Cancer Cell. 2010 Oct 19;18(4):341-52. doi: 10.1016/j.ccr.2010.09.008.
38. GOA pipeline RGD automated data pipeline
39. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. Activation of atypical protein kinase Czeta toward TC10 is regulated by high-fat diet and aerobic exercise in skeletal muscle. Saito M, etal., Metabolism. 2008 Sep;57(9):1173-80. doi: 10.1016/j.metabol.2008.03.023.
42. Rho GTPases in insulin-stimulated glucose uptake. Satoh T Small GTPases. 2014;5:e28102. doi: 10.4161/sgtp.28102. Epub 2014 Mar 10.
43. Decreased insulin-dependent glucose transport by chronic ethanol feeding is associated with dysregulation of the Cbl/TC10 pathway in rat adipocytes. Sebastian BM and Nagy LE, Am J Physiol Endocrinol Metab. 2005 Dec;289(6):E1077-84. Epub 2005 Aug 16.
44. Cbl negatively regulates JNK activation and cell death. Sproul AA, etal., Cell Res. 2009 Aug;19(8):950-61. doi: 10.1038/cr.2009.74.
45. Abrogating Cbl-b in effector CD8(+) T cells improves the efficacy of adoptive therapy of leukemia in mice. Stromnes IM, etal., J Clin Invest. 2010 Oct;120(10):3722-34. doi: 10.1172/JCI41991. Epub 2010 Sep 20.
46. Targeting the E3 ubiquitin casitas B-lineage lymphoma decreases osteosarcoma cell growth and survival and reduces tumorigenesis. Sévère N, etal., J Bone Miner Res. 2012 Oct;27(10):2108-17. doi: 10.1002/jbmr.1667.
47. CBL is frequently altered in lung cancers: its relationship to mutations in MET and EGFR tyrosine kinases. Tan YH, etal., PLoS One. 2010 Jan 29;5(1):e8972. doi: 10.1371/journal.pone.0008972.
48. Suppression of c-Cbl tyrosine phosphorylation inhibits neointimal formation in balloon-injured rat arteries. Tang Z, etal., Circulation. 2008 Aug 12;118(7):764-72. doi: 10.1161/CIRCULATIONAHA.107.761932. Epub 2008 Jul 28.
49. Regulation of Cbl-associated protein/Cbl pathway in muscle and adipose tissues of two animal models of insulin resistance. Thirone AC, etal., Endocrinology. 2004 Jan;145(1):281-93. Epub 2003 Oct 2.
50. Dual inhibitory roles of geldanamycin on the c-Jun NH2-terminal kinase 3 signal pathway through suppressing the expression of mixed-lineage kinase 3 and attenuating the activation of apoptosis signal-regulating kinase 1 via facilitating the activation of Akt in ischemic brain injury. Wen XR, etal., Neuroscience. 2008 Oct 15;156(3):483-97. Epub 2008 Aug 12.
51. Peritumoral Cbl is a strong independent prognostic marker after curative resection of hepatocellular carcinoma. Zhang JB, etal., Oncotarget. 2015 Nov 24;6(37):40223-34. doi: 10.18632/oncotarget.5540.
52. Cbl-b and PI3K/Akt pathway are differently involved in oxygen-glucose deprivation preconditioning in PC12 cells. Zhang W, etal., Chin Med J (Engl). 2013 Nov;126(21):4132-8.
Additional References at PubMed
PMID:8550620   PMID:8627181   PMID:9447983   PMID:9918770   PMID:11001060   PMID:11146548   PMID:12671687   PMID:14531861   PMID:15001553   PMID:15465819   PMID:15708858   PMID:16177060  
PMID:16525057   PMID:16751776   PMID:17003487   PMID:18034775   PMID:18070883   PMID:19116150   PMID:19546233   PMID:20029031   PMID:25178484   PMID:25450678   PMID:25468996   PMID:28131823  
PMID:29237719   PMID:31315051   PMID:37199660  


Genomics

Comparative Map Data
Cbl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8853,384,656 - 53,468,067 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl853,384,656 - 53,468,067 (-)EnsemblGRCr8
mRatBN7.2844,487,824 - 44,571,620 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl844,489,410 - 44,571,176 (-)EnsemblmRatBN7.2
Rnor_6.0848,481,256 - 48,564,775 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl848,489,036 - 48,564,722 (-)Ensemblrn6Rnor6.0
Rnor_5.0847,105,710 - 47,183,347 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4847,135,357 - 47,211,889 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera844,074,668 - 44,158,034 (-)NCBICelera
Cytogenetic Map8q22NCBI
CBL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811119,206,339 - 119,308,149 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11119,206,298 - 119,313,926 (+)Ensemblhg38GRCh38
GRCh3711119,077,049 - 119,178,859 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611118,582,200 - 118,684,069 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3411118,582,199 - 118,684,068NCBI
Celera11116,236,024 - 116,339,059 (+)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11115,017,373 - 115,119,562 (+)NCBIHuRef
CHM1_111118,963,252 - 119,065,411 (+)NCBICHM1_1
T2T-CHM13v2.011119,226,712 - 119,328,785 (+)NCBIT2T-CHM13v2.0
Cbl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39944,054,273 - 44,145,556 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl944,054,273 - 44,145,346 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38944,142,976 - 44,234,259 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl944,142,976 - 44,234,049 (-)Ensemblmm10GRCm38
MGSCv37943,957,345 - 44,042,129 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36943,900,257 - 43,985,041 (-)NCBIMGSCv36mm8
Celera941,406,821 - 41,486,735 (-)NCBICelera
Cytogenetic Map9A5.1- A5.2NCBI
cM Map924.72NCBI
Cbl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541220,307,011 - 20,388,539 (+)Ensembl
ChiLan1.0NW_00495541220,307,011 - 20,388,539 (+)NCBIChiLan1.0ChiLan1.0
CBL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29119,911,371 - 120,015,890 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111121,015,030 - 121,119,390 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011114,044,996 - 114,149,204 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111117,973,187 - 118,076,459 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11117,973,187 - 118,074,671 (+)EnsemblpanPan2panpan1.1
CBL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1514,600,409 - 14,676,974 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl514,607,013 - 14,676,956 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha514,653,516 - 14,730,936 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0514,543,644 - 14,621,193 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl514,549,582 - 14,620,322 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1514,681,808 - 14,759,290 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0514,585,944 - 14,663,491 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0514,626,100 - 14,703,693 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cbl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947101,214,875 - 101,314,342 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365424,136,511 - 4,228,288 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365424,136,389 - 4,235,746 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CBL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl946,416,938 - 46,512,834 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1946,416,937 - 46,512,855 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2951,452,262 - 51,549,181 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CBL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11110,581,049 - 110,679,284 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1110,581,143 - 110,674,481 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604315,352,300 - 15,453,239 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cbl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478414,577,515 - 14,667,575 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478414,577,582 - 14,671,816 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cbl
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1838,711,551 - 38,790,998 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cbl
686 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:36
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000067902
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
5684993Bmd84Bone mineral density QTL 844.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)85158969958991895Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83776085958991895Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83776085961459705Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84961020468373388Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)85076395167219641Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)83412590255607752Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat

Markers in Region
D8Got62  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2844,531,430 - 44,531,654 (+)MAPPERmRatBN7.2
Rnor_6.0848,524,940 - 48,525,163NCBIRnor6.0
Rnor_5.0847,143,390 - 47,143,613UniSTSRnor5.0
RGSC_v3.4847,171,833 - 47,172,057RGDRGSC3.4
RGSC_v3.4847,171,834 - 47,172,057UniSTSRGSC3.4
Celera844,118,223 - 44,118,440UniSTS
RGSC_v3.1847,180,600 - 47,180,823RGD
RH 3.4 Map8430.8UniSTS
RH 3.4 Map8430.8RGD
RH 2.0 Map8335.4RGD
Cytogenetic Map8q22UniSTS
D8Got63  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2844,509,806 - 44,509,994 (+)MAPPERmRatBN7.2
Rnor_6.0848,503,237 - 48,503,424NCBIRnor6.0
Rnor_5.0847,121,863 - 47,122,050UniSTSRnor5.0
RGSC_v3.4847,150,172 - 47,150,360RGDRGSC3.4
RGSC_v3.4847,150,173 - 47,150,360UniSTSRGSC3.4
Celera844,096,649 - 44,096,836UniSTS
RGSC_v3.1847,158,939 - 47,159,126RGD
RH 3.4 Map8440.2RGD
RH 3.4 Map8440.2UniSTS
Cytogenetic Map8q22UniSTS
RH142755  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2844,494,096 - 44,494,238 (+)MAPPERmRatBN7.2
Rnor_6.0848,487,526 - 48,487,667NCBIRnor6.0
Rnor_5.0847,106,152 - 47,106,293UniSTSRnor5.0
RGSC_v3.4847,134,458 - 47,134,599UniSTSRGSC3.4
Celera844,080,939 - 44,081,080UniSTS
RH 3.4 Map8428.9UniSTS
Cytogenetic Map8q22UniSTS
RH139032  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2844,495,380 - 44,495,535 (+)MAPPERmRatBN7.2
Rnor_6.0848,488,810 - 48,488,964NCBIRnor6.0
Rnor_5.0847,107,436 - 47,107,590UniSTSRnor5.0
RGSC_v3.4847,135,742 - 47,135,896UniSTSRGSC3.4
Celera844,082,223 - 44,082,377UniSTS
RH 3.4 Map8426.0UniSTS
Cytogenetic Map8q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000067902   ⟹   ENSRNOP00000063226
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl853,386,242 - 53,468,067 (-)Ensembl
mRatBN7.2 Ensembl844,489,410 - 44,571,176 (-)Ensembl
Rnor_6.0 Ensembl848,489,036 - 48,564,722 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101607   ⟹   ENSRNOP00000079790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl853,384,656 - 53,468,067 (-)Ensembl
mRatBN7.2 Ensembl844,493,655 - 44,571,176 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107395   ⟹   ENSRNOP00000092398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl844,493,647 - 44,571,176 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113140   ⟹   ENSRNOP00000095952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl853,384,656 - 53,468,067 (-)Ensembl
mRatBN7.2 Ensembl844,493,655 - 44,571,176 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113781   ⟹   ENSRNOP00000082958
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl853,384,656 - 53,468,067 (-)Ensembl
mRatBN7.2 Ensembl844,493,655 - 44,571,176 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117376   ⟹   ENSRNOP00000083557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl853,384,656 - 53,468,067 (-)Ensembl
mRatBN7.2 Ensembl844,493,655 - 44,571,176 (-)Ensembl
RefSeq Acc Id: NM_001419955   ⟹   NP_001406884
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8853,384,656 - 53,468,067 (-)NCBI
mRatBN7.2844,487,824 - 44,571,244 (-)NCBI
RefSeq Acc Id: XM_006242965   ⟹   XP_006243027
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8853,384,658 - 53,467,959 (-)NCBI
mRatBN7.2844,487,824 - 44,571,620 (-)NCBI
Rnor_6.0848,481,256 - 48,564,775 (-)NCBI
Rnor_5.0847,105,710 - 47,183,347 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039082332   ⟹   XP_038938260
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8853,384,658 - 53,467,595 (-)NCBI
mRatBN7.2844,487,824 - 44,570,767 (-)NCBI
RefSeq Acc Id: XP_006243027   ⟸   XM_006242965
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G861 (UniProtKB/TrEMBL),   A0A0U1ZFN5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063226   ⟸   ENSRNOT00000067902
RefSeq Acc Id: XP_038938260   ⟸   XM_039082332
- Peptide Label: isoform X2
- UniProtKB: A6J3W2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082958   ⟸   ENSRNOT00000113781
Ensembl Acc Id: ENSRNOP00000092398   ⟸   ENSRNOT00000107395
Ensembl Acc Id: ENSRNOP00000083557   ⟸   ENSRNOT00000117376
Ensembl Acc Id: ENSRNOP00000079790   ⟸   ENSRNOT00000101607
Ensembl Acc Id: ENSRNOP00000095952   ⟸   ENSRNOT00000113140
RefSeq Acc Id: NP_001406884   ⟸   NM_001419955
- UniProtKB: A0A8I6G3R2 (UniProtKB/TrEMBL),   A0A0U1ZFN5 (UniProtKB/TrEMBL)
Protein Domains
Cbl-PTB   RING-type   UBA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZV15-F1-model_v2 AlphaFold D3ZV15 1-914 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695886
Promoter ID:EPDNEW_R6409
Type:initiation region
Name:Cbl_1
Description:Cbl proto-oncogene
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0848,564,731 - 48,564,791EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561386 AgrOrtholog
BioCyc Gene G2FUF-30733 BioCyc
Ensembl Genes ENSRNOG00000008444 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067902.5 UniProtKB/TrEMBL
  ENSRNOT00000101607 ENTREZGENE
  ENSRNOT00000101607.2 UniProtKB/TrEMBL
  ENSRNOT00000113140.2 UniProtKB/TrEMBL
  ENSRNOT00000113781 ENTREZGENE
  ENSRNOT00000113781.2 UniProtKB/TrEMBL
  ENSRNOT00000117376.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.930.20 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
InterPro Adaptor_Cbl UniProtKB/TrEMBL
  Adaptor_Cbl_EF_hand-like UniProtKB/TrEMBL
  Adaptor_Cbl_N_dom_sf UniProtKB/TrEMBL
  Adaptor_Cbl_N_hlx UniProtKB/TrEMBL
  Adaptor_Cbl_SH2-like UniProtKB/TrEMBL
  Cbl_PTB UniProtKB/TrEMBL
  EF-hand-like_dom UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  UBA-like UniProtKB/TrEMBL
  UBA/transl_elong_EF1B_N_euk UniProtKB/TrEMBL
  Znf_C3HC4_RING-type UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/TrEMBL
NCBI Gene 500985 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE CBL UniProtKB/TrEMBL
  PTHR23007 UniProtKB/TrEMBL
Pfam Cbl_N UniProtKB/TrEMBL
  Cbl_N2 UniProtKB/TrEMBL
  Cbl_N3 UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
  zf-C3HC4 UniProtKB/TrEMBL
PhenoGen Cbl PhenoGen
PROSITE CBL_PTB UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008444 RatGTEx
SMART RING UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
Superfamily-SCOP Adaptor_Cbl_N UniProtKB/TrEMBL
  RING/U-box UniProtKB/TrEMBL
  SSF47473 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
  UBA_like UniProtKB/TrEMBL
UniProt A0A0U1ZFN5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZWU2_RAT UniProtKB/TrEMBL
  A0A8I6G3R2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G861 ENTREZGENE, UniProtKB/TrEMBL
  A6J3W2 ENTREZGENE, UniProtKB/TrEMBL
  D3ZV15_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-05 Cbl  Cbl proto-oncogene  Cbl  Casitas B-lineage lymphoma  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-05-04 Cbl  Casitas B-lineage lymphoma  Cbl  Cbl proto-oncogene, E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-13 Cbl  Cbl proto-oncogene, E3 ubiquitin protein ligase  Cbl  Cas-Br-M (murine) ecotropic retroviral transforming sequence  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Cbl  Cas-Br-M (murine) ecotropic retroviral transforming sequence  Cbl  Casitas B-lineage lymphoma  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-29 Cbl  Casitas B-lineage lymphoma  RGD1561386_predicted  similar to CBL E3 ubiquitin protein ligase (Signal transduction protein CBL) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-10 RGD1561386_predicted  similar to CBL E3 ubiquitin protein ligase (Signal transduction protein CBL) (predicted)    similar to CBL E3 ubiquitin protein ligase (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto-oncogene) (predicted)  Name updated 1299863 APPROVED
2006-03-07 RGD1561386_predicted  similar to CBL E3 ubiquitin protein ligase (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto-oncogene) (predicted)  LOC500985  similar to CBL E3 ubiquitin protein ligase (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto-oncogene)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC500985  similar to CBL E3 ubiquitin protein ligase (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto-oncogene)      Symbol and Name status set to provisional 70820 PROVISIONAL