RGD Reference Report - [Expression down-regulation of c-Cbl and Cbl-b genes in peripheral blood mononuclear cells from multiple myeloma patients]. - Rat Genome Database

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[Expression down-regulation of c-Cbl and Cbl-b genes in peripheral blood mononuclear cells from multiple myeloma patients].

Authors: Fang, S  Guo, X  Leng, X  Li, B  Niu, Y  Chen, S  Yang, L  Li, Y 
Citation: Fang S, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013 Aug;29(8):842-5.
RGD ID: 11038794
Pubmed: PMID:23948411   (View Abstract at PubMed)

OBJECTIVE: To investigate c-Cbl and Cbl-b gene expressions in peripheral blood mononuclear cells (PBMCs) from multiple myeloma (MM) patients. METHODS: SYBR(R); Green PCR technique was used to detect c-Cbl and Cbl-b gene expressions in PBMCs from 23 MM patients and 22 healthy individuals, and RT-PCR and DNA sequence analysis were performed to analyze the mutations of 7-10 exons of c-Cbl. RESULTS: The expression of c-Cbl gene in MM patients (median: 0.798%) significantly decreased as compared with that in healthy controls (median: 2.443%) (P<0.05). The expression of Cbl-b gene in MM patients (median: 0.714%) also dropped significantly as compared with that in healthy controls (median: 2.179%) (P<0.05). The 7-10 exons of c-Cbl gene had two different sizes of fragments in 2 MM patients: 483 bp and 148 bp which were wild-type and deletion mutants type of c-Cbl gene. c-Cbl gene mutations were not found in all MM patients. CONCLUSION: The expressions of c-Cbl and Cbl-b genes in PBMCs from MM patients are down-regulated.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CBLHumanmultiple myeloma  IEP mRNA:decreased expression:mononuclear cell:RGD 
CblMousemultiple myeloma  ISOCBL (Homo sapiens)mRNA:decreased expression:mononuclear cell:RGD 
CblRatmultiple myeloma  ISOCBL (Homo sapiens)mRNA:decreased expression:mononuclear cell:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cbl  (Cbl proto-oncogene)

Genes (Mus musculus)
Cbl  (Casitas B-lineage lymphoma)

Genes (Homo sapiens)
CBL  (Cbl proto-oncogene)


Additional Information