Irf3 (interferon regulatory factor 3) - Rat Genome Database

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Gene: Irf3 (interferon regulatory factor 3) Rattus norvegicus
Analyze
Symbol: Irf3
Name: interferon regulatory factor 3
RGD ID: 1549774
Description: Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; promoter-specific chromatin binding activity; and protein homodimerization activity. Involved in cellular response to exogenous dsRNA; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of cytokine production. Predicted to be located in mitochondrion. Predicted to be active in chromatin; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human IRF3 (interferon regulatory factor 3); PARTICIPATES IN Toll-like receptor signaling pathway; hepatitis C pathway; influenza A pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC94729
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,616,608 - 104,621,402 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1104,616,469 - 104,621,401 (+)EnsemblGRCr8
mRatBN7.2195,479,966 - 95,484,926 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,479,821 - 95,484,935 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1100,865,527 - 100,870,321 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,338,193 - 109,342,987 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,628,586 - 102,633,382 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01100,992,244 - 100,997,202 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,992,405 - 100,997,198 (+)Ensemblrn6Rnor6.0
Rnor_5.01102,056,847 - 102,061,805 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4195,470,284 - 95,475,078 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera189,741,455 - 89,746,249 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (EXP,ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
amlexanox  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
auranofin  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
chrysin  (ISO)
Cirsimarin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
coumarin  (ISO)
cudratricusxanthone A  (ISO)
curcumin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
disodium selenite  (ISO)
elemental selenium  (ISO)
eriodictyol  (ISO)
ethanol  (ISO)
ferroheme b  (ISO)
folic acid  (ISO)
fructose  (ISO)
galactose  (EXP,ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
heme b  (ISO)
hexadecanoic acid  (EXP,ISO)
hydroquinone  (ISO)
hydroxychloroquine  (ISO)
ivermectin  (ISO)
linuron  (ISO)
lipopolysaccharide  (ISO)
luteolin  (ISO)
lycopene  (ISO)
metam  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monodansylcadaverine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel dichloride  (ISO)
nitrates  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorooctanoic acid  (EXP)
Phytolaccoside E  (ISO)
pirinixic acid  (EXP,ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
poly(I:C)  (ISO)
pravastatin  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
scoparone  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
thioacetamide  (EXP)
thymoquinone  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
vadimezan  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zingerone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antiviral innate immune response  (ISO)
cell surface receptor signaling pathway  (IEA)
cellular response to exogenous dsRNA  (IEP)
cellular response to lipopolysaccharide  (ISO)
cellular response to virus  (IEA,ISO)
cytoplasmic pattern recognition receptor signaling pathway  (IEA,ISO)
defense response to virus  (IEA,ISO)
DNA-templated transcription  (IEA)
immune system process  (IBA,IEA)
innate immune response  (IEA)
lipopolysaccharide-mediated signaling pathway  (ISO)
mRNA transcription  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (IMP)
positive regulation of cytokine production  (IMP)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of innate immune response  (IEA)
positive regulation of interferon-alpha production  (ISO)
positive regulation of interferon-beta production  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of type I interferon production  (IEA,ISO)
positive regulation of type I interferon-mediated signaling pathway  (ISO)
programmed cell death  (IEA)
programmed necrotic cell death  (ISO)
regulation of apoptotic process  (IEA,ISO)
regulation of DNA-templated transcription  (IEA)
regulation of gene expression  (ISO)
regulation of inflammatory response  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
response to bacterium  (ISO)
response to exogenous dsRNA  (ISO)
response to lipopolysaccharide  (ISO)
toll-like receptor 4 signaling pathway  (IEA,ISO)
TRIF-dependent toll-like receptor signaling pathway  (IEA,ISO)
type I interferon-mediated signaling pathway  (ISO)

Cellular Component
chromatin  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytosol  (IEA,ISO)
mitochondrion  (IEA,ISO)
nucleus  (IBA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. IFN regulatory factor 3 contributes to the host response during Pseudomonas aeruginosa lung infection in mice. Carrigan SO, etal., J Immunol. 2010 Sep 15;185(6):3602-9. Epub 2010 Aug 18.
2. Double-stranded RNA induces pancreatic beta-cell apoptosis by activation of the toll-like receptor 3 and interferon regulatory factor 3 pathways. Dogusan Z, etal., Diabetes. 2008 May;57(5):1236-45. Epub 2008 Jan 25.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Paramyxovirus Sendai virus V protein counteracts innate virus clearance through IRF-3 activation, but not via interferon, in mice. Kiyotani K, etal., Virology. 2007 Mar 1;359(1):82-91. Epub 2006 Oct 6.
5. Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients. Kong SL, etal., Virus Res. 2009 Nov;145(2):260-9. Epub 2009 Jul 25.
6. Pathogen recognition by the innate immune system. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
7. C-reactive protein triggers inflammatory responses partly via TLR4/IRF3/NF-kappaB signaling pathway in rat vascular smooth muscle cells. Liu N, etal., Life Sci. 2010 Sep 11;87(11-12):367-74. Epub 2010 Aug 4.
8. Interferon response factor 3 is essential for house dust mite-induced airway allergy. Marichal T, etal., J Allergy Clin Immunol. 2010 Oct;126(4):836-844.e13. Epub 2010 Jul 31.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:9660935   PMID:11583620   PMID:12062447   PMID:12855817   PMID:12872135   PMID:14556004   PMID:15661922   PMID:15800576   PMID:15841462   PMID:16301520   PMID:17079289   PMID:17560375  
PMID:17618271   PMID:18562536   PMID:18725644   PMID:18818105   PMID:18851954   PMID:19416887   PMID:19454348   PMID:19805092   PMID:19890330   PMID:20403326   PMID:20451243   PMID:20581830  
PMID:21102435   PMID:21606371   PMID:21782231   PMID:22000020   PMID:22394562   PMID:22728658   PMID:23160154   PMID:23332764   PMID:23729669   PMID:23746807   PMID:23770239   PMID:24627105  
PMID:24696485   PMID:25169970   PMID:25609649   PMID:25636800   PMID:27129230   PMID:27447882   PMID:27448985   PMID:28069950   PMID:28122305   PMID:28849230   PMID:36964897   PMID:37935918  


Genomics

Comparative Map Data
Irf3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,616,608 - 104,621,402 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1104,616,469 - 104,621,401 (+)EnsemblGRCr8
mRatBN7.2195,479,966 - 95,484,926 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,479,821 - 95,484,935 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1100,865,527 - 100,870,321 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,338,193 - 109,342,987 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,628,586 - 102,633,382 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01100,992,244 - 100,997,202 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,992,405 - 100,997,198 (+)Ensemblrn6Rnor6.0
Rnor_5.01102,056,847 - 102,061,805 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4195,470,284 - 95,475,078 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera189,741,455 - 89,746,249 (+)NCBICelera
Cytogenetic Map1q22NCBI
IRF3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381949,659,572 - 49,665,857 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1949,659,569 - 49,665,861 (-)Ensemblhg38GRCh38
GRCh371950,162,829 - 50,169,114 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,854,641 - 54,860,936 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341954,854,641 - 54,860,926NCBI
Celera1947,032,161 - 47,038,466 (-)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1946,539,596 - 46,545,904 (-)NCBIHuRef
CHM1_11950,164,615 - 50,170,921 (-)NCBICHM1_1
T2T-CHM13v2.01952,659,601 - 52,665,933 (-)NCBIT2T-CHM13v2.0
Irf3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39744,647,072 - 44,652,272 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl744,647,072 - 44,652,272 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38744,997,648 - 45,002,848 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl744,997,648 - 45,002,848 (+)Ensemblmm10GRCm38
MGSCv37752,253,030 - 52,258,218 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36744,865,702 - 44,870,890 (+)NCBIMGSCv36mm8
Celera740,449,220 - 40,454,417 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.07NCBI
Irf3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,224,874 - 1,228,624 (+)Ensembl
ChiLan1.0NW_0049555591,223,986 - 1,228,671 (+)NCBIChiLan1.0ChiLan1.0
IRF3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22055,776,859 - 55,783,043 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11957,697,602 - 57,703,818 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01946,674,193 - 46,680,464 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11955,593,627 - 55,599,903 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1955,593,627 - 55,599,903 (-)EnsemblpanPan2panpan1.1
IRF3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11106,875,016 - 106,879,065 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1106,875,118 - 106,879,065 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1106,457,016 - 106,462,843 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01107,394,678 - 107,400,508 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,394,687 - 107,400,506 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,066,914 - 107,072,739 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01106,709,002 - 106,714,828 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01107,550,123 - 107,555,958 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Irf3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,859,560 - 21,863,357 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366643,475,543 - 3,481,533 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366643,477,750 - 3,482,489 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRF3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,701,668 - 54,707,151 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1654,701,733 - 54,706,079 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,430,689 - 50,441,627 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IRF3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,835,285 - 42,841,487 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl642,831,203 - 42,840,796 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607322,779,185 - 22,785,813 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Irf3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248324,612,374 - 4,616,276 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248324,611,445 - 4,616,319 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Irf3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12154,542,631 - 154,547,472 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Irf3
126 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:104
Count of miRNA genes:91
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000027786
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000027786   ⟹   ENSRNOP00000027786
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1104,616,469 - 104,621,401 (+)Ensembl
mRatBN7.2 Ensembl195,479,821 - 95,484,935 (+)Ensembl
Rnor_6.0 Ensembl1100,992,405 - 100,997,198 (+)Ensembl
RefSeq Acc Id: NM_001006969   ⟹   NP_001006970
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,616,608 - 104,621,402 (+)NCBI
mRatBN7.2195,480,127 - 95,484,923 (+)NCBI
Rnor_6.01100,992,405 - 100,997,199 (+)NCBI
Rnor_5.01102,056,847 - 102,061,805 (+)NCBI
RGSC_v3.4195,470,284 - 95,475,078 (+)RGD
Celera189,741,455 - 89,746,249 (+)RGD
Sequence:
RefSeq Acc Id: XM_006229021   ⟹   XP_006229083
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,617,012 - 104,621,399 (+)NCBI
mRatBN7.2195,479,966 - 95,484,926 (+)NCBI
Rnor_6.01100,992,244 - 100,997,202 (+)NCBI
Rnor_5.01102,056,847 - 102,061,805 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229022   ⟹   XP_006229084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,617,012 - 104,621,399 (+)NCBI
mRatBN7.2195,479,987 - 95,484,926 (+)NCBI
Rnor_6.01100,992,258 - 100,997,202 (+)NCBI
Rnor_5.01102,056,847 - 102,061,805 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008759337   ⟹   XP_008757559
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,617,500 - 104,621,399 (+)NCBI
mRatBN7.2195,479,987 - 95,484,926 (+)NCBI
Rnor_6.01100,992,257 - 100,997,202 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001006970   ⟸   NM_001006969
- UniProtKB: Q5XIB0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229083   ⟸   XM_006229021
- Peptide Label: isoform X1
- UniProtKB: F7EXX5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229084   ⟸   XM_006229022
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008757559   ⟸   XM_008759337
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSRNOP00000027786   ⟸   ENSRNOT00000027786
Protein Domains
Interferon regulatory factor-3   IRF tryptophan pentad repeat

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XIB0-F1-model_v2 AlphaFold Q5XIB0 1-421 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1549774 AgrOrtholog
BioCyc Gene G2FUF-59735 BioCyc
Ensembl Genes ENSRNOG00000043388 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027786 ENTREZGENE
  ENSRNOT00000027786.8 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  2.60.200.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7193483 IMAGE-MGC_LOAD
InterPro Interferon_regulatory_fac_CS UniProtKB/TrEMBL
  Interferon_regulatory_factor UniProtKB/TrEMBL
  Interferon_regulatory_factor-3 UniProtKB/TrEMBL
  SMAD_dom-like UniProtKB/TrEMBL
  SMAD_FHA_domain UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report rno:292892 UniProtKB/TrEMBL
MGC_CLONE MGC:94729 IMAGE-MGC_LOAD
NCBI Gene 292892 ENTREZGENE
PANTHER INTERFERON REGULATORY FACTOR UniProtKB/TrEMBL
  INTERFERON REGULATORY FACTOR 3 UniProtKB/TrEMBL
Pfam IRF UniProtKB/TrEMBL
  IRF-3 UniProtKB/TrEMBL
PhenoGen Irf3 PhenoGen
PRINTS INTFRNREGFCT UniProtKB/TrEMBL
PROSITE IRF UniProtKB/TrEMBL
  IRF_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000043388 RatGTEx
SMART IRF UniProtKB/TrEMBL
  IRF-3 UniProtKB/TrEMBL
Superfamily-SCOP SMAD_FHA UniProtKB/TrEMBL
  SSF46785 UniProtKB/TrEMBL
UniProt A6JAV4_RAT UniProtKB/TrEMBL
  A6JAV5_RAT UniProtKB/TrEMBL
  F7EXX5 ENTREZGENE, UniProtKB/TrEMBL
  Q5XIB0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Irf3  interferon regulatory factor 3      Symbol and Name status set to approved 1299863 APPROVED
2005-09-15 Irf3  interferon regulatory factor 3      Symbol and Name status set to provisional 70820 PROVISIONAL