Rptor (regulatory associated protein of MTOR, complex 1) - Rat Genome Database

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Gene: Rptor (regulatory associated protein of MTOR, complex 1) Rattus norvegicus
Analyze
Symbol: Rptor
Name: regulatory associated protein of MTOR, complex 1
RGD ID: 1311784
Description: Enables protein kinase binding activity. Involved in positive regulation of endothelial cell proliferation. Located in dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to human RPTOR (regulatory associated protein of MTOR complex 1); PARTICIPATES IN mTOR signaling pathway; insulin signaling pathway; INTERACTS WITH bafilomycin A1; bisphenol A; carbon disulfide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC287871; raptor; regulatory-associated protein of mTOR; RGD1311784; similar to p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810105,376,943 - 105,675,416 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10105,376,943 - 105,675,413 (+)EnsemblGRCr8
mRatBN7.210104,878,487 - 105,176,986 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10104,878,487 - 105,176,983 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10109,981,892 - 110,280,534 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010109,444,928 - 109,743,567 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010104,799,071 - 105,097,542 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010108,750,620 - 109,058,691 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10108,750,620 - 109,058,691 (+)Ensemblrn6Rnor6.0
Rnor_5.010108,353,697 - 108,658,916 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410109,000,666 - 109,302,700 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera10103,425,303 - 103,722,658 (+)NCBICelera
RGSC_v3.110109,015,970 - 109,317,386 (+)NCBI
Cytogenetic Map10q32.3NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,1'-azobis(N,N-dimethylformamide)  (ISO)
1,4-phenylenediamine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,4,6-tribromophenol  (ISO)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-pinene  (ISO)
amino acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
bafilomycin A1  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon disulfide  (EXP)
cholesterol  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
dimercaprol  (ISO)
disodium selenite  (ISO)
dorsomorphin  (EXP,ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenthion  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
ginsenoside Rg1  (ISO)
glycerol 2-phosphate  (ISO)
glyphosate  (EXP,ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lidocaine  (EXP)
linuron  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mechlorethamine  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methoxychlor  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
ochratoxin A  (EXP)
okadaic acid  (ISO)
orotic acid  (ISO)
ozone  (ISO)
perfluorohexanesulfonic acid  (ISO)
pevonedistat  (ISO)
phenylarsine oxide  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
tetrathiomolybdate(2-)  (ISO)
titanium dioxide  (ISO)
torin 1  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
cytoplasmic stress granule  (IEA,ISO)
cytosol  (IEA,ISO)
dendrite  (IDA)
lysosomal membrane  (IEA,ISO)
lysosome  (IEA,ISO)
neuronal cell body  (IDA)
TORC1 complex  (IBA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. mTOR signaling in growth control and disease. Laplante M and Sabatini DM, Cell. 2012 Apr 13;149(2):274-93. doi: 10.1016/j.cell.2012.03.017.
3. Hypoxia-induced endothelial proliferation requires both mTORC1 and mTORC2. Li W, etal., Circ Res. 2007 Jan 5;100(1):79-87. Epub 2006 Nov 16.
4. Molecular mechanisms of mTOR-mediated translational control. Ma XM and Blenis J, Nat Rev Mol Cell Biol. 2009 May;10(5):307-18. Epub 2009 Apr 2.
5. Role of insulin, adipocyte hormones, and nutrient-sensing pathways in regulating fuel metabolism and energy homeostasis: a nutritional perspective of diabetes, obesity, and cancer. Marshall S Sci STKE. 2006 Aug 1;2006(346):re7.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites. Takei N, etal., J Neurosci. 2004 Nov 3;24(44):9760-9.
12. mTORC1 and mTORC2 differentially promote natural killer cell development. Yang C, etal., Elife. 2018 May 29;7. pii: 35619. doi: 10.7554/eLife.35619.
Additional References at PubMed
PMID:12150925   PMID:12150926   PMID:12718876   PMID:15467718   PMID:17897319   PMID:18426977   PMID:18439900   PMID:19211835   PMID:20233713   PMID:20381137   PMID:20543138   PMID:21613227  
PMID:21779001   PMID:22424946   PMID:23092880   PMID:24036451   PMID:25940091   PMID:27006450  


Genomics

Comparative Map Data
Rptor
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810105,376,943 - 105,675,416 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10105,376,943 - 105,675,413 (+)EnsemblGRCr8
mRatBN7.210104,878,487 - 105,176,986 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10104,878,487 - 105,176,983 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10109,981,892 - 110,280,534 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010109,444,928 - 109,743,567 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010104,799,071 - 105,097,542 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010108,750,620 - 109,058,691 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10108,750,620 - 109,058,691 (+)Ensemblrn6Rnor6.0
Rnor_5.010108,353,697 - 108,658,916 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410109,000,666 - 109,302,700 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera10103,425,303 - 103,722,658 (+)NCBICelera
RGSC_v3.110109,015,970 - 109,317,386 (+)NCBI
Cytogenetic Map10q32.3NCBI
RPTOR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381780,544,838 - 80,966,368 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1780,544,819 - 80,966,371 (+)Ensemblhg38GRCh38
GRCh371778,518,638 - 78,940,168 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361776,133,220 - 76,554,768 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1775,147,295 - 75,567,674 (+)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1773,954,508 - 74,378,467 (+)NCBIHuRef
CHM1_11778,604,958 - 79,026,514 (+)NCBICHM1_1
T2T-CHM13v2.01781,446,296 - 81,873,303 (+)NCBIT2T-CHM13v2.0
Rptor
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911119,493,731 - 119,790,417 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11119,493,731 - 119,790,402 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3811119,602,905 - 119,899,591 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11119,602,905 - 119,899,576 (+)Ensemblmm10GRCm38
MGSCv3711119,464,309 - 119,760,905 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611119,419,900 - 119,713,572 (+)NCBIMGSCv36mm8
Celera11131,343,545 - 131,633,430 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1183.96NCBI
Rptor
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555062,008,044 - 2,401,775 (-)Ensembl
ChiLan1.0NW_0049555062,009,422 - 2,401,775 (-)NCBIChiLan1.0ChiLan1.0
RPTOR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21997,125,522 - 97,543,425 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117102,025,309 - 102,442,783 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01774,973,420 - 75,389,339 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11780,705,544 - 81,118,708 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1780,705,544 - 81,118,708 (+)EnsemblpanPan2panpan1.1
RPTOR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.191,012,512 - 1,345,872 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl91,013,603 - 1,344,148 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha91,630,245 - 1,963,406 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.091,621,864 - 1,955,230 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl91,621,871 - 1,953,491 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.191,645,842 - 1,978,909 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.091,771,374 - 2,104,386 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.091,852,046 - 2,185,237 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rptor
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056021,653,875 - 1,984,718 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365944,427,169 - 4,760,120 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365944,427,225 - 4,758,081 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RPTOR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl121,709,128 - 1,991,574 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1121,709,121 - 1,991,844 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2121,614,075 - 1,710,327 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RPTOR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11672,513,593 - 72,916,950 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1672,513,619 - 72,918,416 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607743,826,714 - 44,287,049 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rptor
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248019,677,307 - 10,048,719 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248019,676,965 - 10,053,311 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Rptor
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1964,118,897 - 64,412,297 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rptor
1945 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:256
Count of miRNA genes:163
Interacting mature miRNAs:202
Transcripts:ENSRNOT00000005337
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093723381107556066Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1097202388107556066Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1097202388107556066Rat

Markers in Region
D10Rat108  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210104,926,165 - 104,926,367 (+)MAPPERmRatBN7.2
Rnor_6.010108,798,298 - 108,798,497NCBIRnor6.0
Rnor_5.010108,401,375 - 108,401,574UniSTSRnor5.0
RGSC_v3.410109,048,343 - 109,048,543RGDRGSC3.4
RGSC_v3.410109,048,344 - 109,048,543UniSTSRGSC3.4
Celera10103,472,978 - 103,473,177UniSTS
RGSC_v3.110109,062,847 - 109,063,047RGD
SHRSP x BN Map1092.75RGD
SHRSP x BN Map1092.75UniSTS
Cytogenetic Map10q32.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 94 59 6 359 194 12 145 82 92 31 18 18

Sequence


Ensembl Acc Id: ENSRNOT00000005337   ⟹   ENSRNOP00000005337
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10105,376,943 - 105,675,413 (+)Ensembl
mRatBN7.2 Ensembl10104,878,487 - 105,176,983 (+)Ensembl
Rnor_6.0 Ensembl10108,750,620 - 109,058,691 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101121   ⟹   ENSRNOP00000098000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10105,376,943 - 105,675,413 (+)Ensembl
mRatBN7.2 Ensembl10104,878,487 - 105,176,983 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111480   ⟹   ENSRNOP00000092487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10105,376,943 - 105,675,413 (+)Ensembl
mRatBN7.2 Ensembl10104,878,487 - 105,176,983 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000162479   ⟹   ENSRNOP00000101888
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10105,376,943 - 105,675,413 (+)Ensembl
RefSeq Acc Id: NM_001134499   ⟹   NP_001127971
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810105,376,943 - 105,675,413 (+)NCBI
mRatBN7.210104,878,487 - 105,176,983 (+)NCBI
Rnor_6.010108,750,620 - 109,058,691 (+)NCBI
Rnor_5.010108,353,697 - 108,658,916 (+)NCBI
RGSC_v3.410109,000,666 - 109,302,700 (+)RGD
Celera10103,425,303 - 103,722,658 (+)RGD
Sequence:
RefSeq Acc Id: XM_039085689   ⟹   XP_038941617
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810105,377,824 - 105,675,416 (+)NCBI
mRatBN7.210104,879,344 - 105,176,986 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001127971 (Get FASTA)   NCBI Sequence Viewer  
  XP_038941617 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM06799 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005337
  ENSRNOP00000005337.6
  ENSRNOP00000092487.1
  ENSRNOP00000098000
  ENSRNOP00000098000.1
  ENSRNOP00000101888.1
RefSeq Acc Id: NP_001127971   ⟸   NM_001134499
- UniProtKB: D3ZDU2 (UniProtKB/TrEMBL),   A6HL94 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005337   ⟸   ENSRNOT00000005337
RefSeq Acc Id: XP_038941617   ⟸   XM_039085689
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ANV2 (UniProtKB/TrEMBL),   A6HL94 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000098000   ⟸   ENSRNOT00000101121
Ensembl Acc Id: ENSRNOP00000092487   ⟸   ENSRNOT00000111480
Ensembl Acc Id: ENSRNOP00000101888   ⟸   ENSRNOT00000162479
Protein Domains
Raptor N-terminal CASPase-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZDU2-F1-model_v2 AlphaFold D3ZDU2 1-1335 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697946
Promoter ID:EPDNEW_R8471
Type:initiation region
Name:Rptor_1
Description:regulatory associated protein of MTOR, complex 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010108,750,703 - 108,750,763EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311784 AgrOrtholog
BioCyc Gene G2FUF-22475 BioCyc
Ensembl Genes ENSRNOG00000003821 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005337 ENTREZGENE
  ENSRNOT00000005337.8 UniProtKB/TrEMBL
  ENSRNOT00000101121 ENTREZGENE
  ENSRNOT00000101121.2 UniProtKB/TrEMBL
  ENSRNOT00000111480.2 UniProtKB/TrEMBL
  ENSRNOT00000162479.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  HEAT UniProtKB/TrEMBL
  Raptor UniProtKB/TrEMBL
  Raptor_N UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
KEGG Report rno:287871 UniProtKB/TrEMBL
NCBI Gene 287871 ENTREZGENE
PANTHER Raptor UniProtKB/TrEMBL
  REGULATORY-ASSOCIATED PROTEIN OF MTOR UniProtKB/TrEMBL
Pfam HEAT UniProtKB/TrEMBL
  Raptor_N UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
PhenoGen Rptor PhenoGen
PRINTS YEAST176DUF UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003821 RatGTEx
SMART Raptor_N UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
  WD40_like UniProtKB/TrEMBL
UniProt A0A8I6AHQ2_RAT UniProtKB/TrEMBL
  A0A8I6ANV2 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LJY4_RAT UniProtKB/TrEMBL
  A6HL94 ENTREZGENE, UniProtKB/TrEMBL
  D3ZDU2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-06-12 Rptor  regulatory associated protein of MTOR, complex 1  RGD1311784  similar to p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1311784  similar to p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats   RGD1311784_predicted  similar to p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1311784_predicted  similar to p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats (predicted)  LOC287871_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC287871_predicted  similar to p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL