Apoh (apolipoprotein H) - Rat Genome Database

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Gene: Apoh (apolipoprotein H) Rattus norvegicus
Analyze
Symbol: Apoh
Name: apolipoprotein H
RGD ID: 1310625
Description: Enables lipid binding activity. Involved in several processes, including negative regulation of respiratory burst; positive regulation of triglyceride catabolic process; and triglyceride transport. Located in cell surface and extracellular space. Used to study myocardial infarction and thrombosis. Human ortholog(s) of this gene implicated in antiphospholipid syndrome; myocardial infarction; and peripheral vascular disease. Orthologous to human APOH (apolipoprotein H); PARTICIPATES IN coagulation cascade pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: apo-H; apolipoprotein H (beta-2-glycoprotein I); B2GPI; beta(2)GPI; beta-2-glycoprotein 1; beta-2-glycoprotein I; LOC287774
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81093,841,992 - 93,855,897 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1093,841,966 - 93,857,127 (+)EnsemblGRCr8
mRatBN7.21093,342,435 - 93,356,334 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1093,310,977 - 93,356,329 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1098,400,040 - 98,413,944 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01097,863,118 - 97,877,037 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01093,267,097 - 93,280,941 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01096,640,013 - 96,653,939 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1096,639,924 - 96,653,938 (+)Ensemblrn6Rnor6.0
Rnor_5.01096,364,217 - 96,378,118 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41097,725,088 - 97,739,213 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1092,007,324 - 92,020,973 (+)NCBICelera
RGSC_v3.11097,739,457 - 97,753,582 (+)NCBI
Cytogenetic Map10q32.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-methoxyethanol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carnosic acid  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diisopropyl fluorophosphate  (EXP)
diquat  (ISO)
dorsomorphin  (ISO)
gamma-linolenic acid  (ISO)
gemcitabine  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
L-ethionine  (EXP)
menadione  (ISO)
methidathion  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosomorpholine  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
olanzapine  (ISO)
omeprazole  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
pirinixic acid  (EXP)
potassium dichromate  (ISO)
propanal  (ISO)
quercetin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 431542  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
tetrachloromethane  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A non-complement-fixing antibody to beta2 glycoprotein I as a novel therapy for antiphospholipid syndrome. Agostinis C, etal., Blood. 2014 May 29;123(22):3478-87. doi: 10.1182/blood-2013-11-537704. Epub 2014 Mar 18.
2. Beta2-glycoprotein I-dependent and -independent anticardiolipin antibody in non-obese diabetic (NOD) mice. Anzai K, etal., Clin Exp Immunol. 1998 Jan;111(1):173-80.
3. Beta-2-glycoprotein I is growth regulated and plays a role as survival factor for hepatocytes. Averna M, etal., Int J Biochem Cell Biol. 2004 Jul;36(7):1297-305.
4. Relation of preexisting anti-beta2GPI antibodies to infarct size in a rat model. Barshack I, etal., Cardiovasc Pathol. 2003 Jul-Aug;12(4):195-201.
5. Anti-beta 2-glycoprotein I antibodies bind to central nervous system. Caronti B, etal., J Neurol Sci. 1998 Apr 1;156(2):211-9.
6. Apolipoprotein H is increased in type 2 diabetic patients with microalbuminuria. Cavallo Perin P, etal., Nutr Metab Cardiovasc Dis. 2000 Dec;10(6):311-4.
7. Thrombus formation induced by antibodies to beta2-glycoprotein I is complement dependent and requires a priming factor. Fischetti F, etal., Blood. 2005 Oct 1;106(7):2340-6. Epub 2005 Jun 14.
8. Autoantibodies to the atheroma component beta2-glycoprotein I and risk of symptomatic peripheral artery disease. Franck M, etal., Angiology. 2007 Jun-Jul;58(3):295-302.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. beta 2-glycoprotein I (apolipoprotein H) modulates uptake and endocytosis associated chemiluminescence in rat Kupffer cells. Gomes LF, etal., Free Radic Res. 2002 Jul;36(7):741-7.
11. Oxidized low-density lipoprotein/beta2-glycoprotein I complexes and autoantibodies in patients with type 2 diabetes mellitus. Lopez LR, etal., Ann N Y Acad Sci. 2005 Jun;1051:97-103.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Beta 2 glycoprotein I--function in health and disease. Miyakis S, etal., Thromb Res. 2004;114(5-6):335-46.
14. [Beta 2 glycoprotein I analysis in patients with hyperlipoproteinemia, arteriosclerotic occlusive disease and diabetes mellitus] Muller G, etal., Z Gesamte Inn Med. 1983 May 15;38(10):282-4.
15. Identification of novel liver-specific mRNAs in plasma for biomarkers of drug-induced liver injury and quantitative evaluation in rats treated with various hepatotoxic compounds. Okubo S, etal., Toxicol Sci. 2013 Mar;132(1):21-31. doi: 10.1093/toxsci/kfs340. Epub 2013 Jan 3.
16. Proteomic analysis of vitreous from diabetic macular edema. Ouchi M, etal., Exp Eye Res. 2005 Aug;81(2):176-82.
17. Investigations on beta 2-glycoprotein-I in the rat: isolation from serum and demonstration in lipoprotein density fractions. Polz E, etal., Int J Biochem. 1980;11(3-4):265-70.
18. Anti-beta2-glycoprotein I antibodies as risk factors for acute myocardial infarction. Ranzolin A, etal., Arq Bras Cardiol. 2004 Aug;83(2):141-4; 137-40. Epub 2004 Aug 17.
19. GOA pipeline RGD automated data pipeline
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Influence of APOH protein polymorphism on apoH levels in normal and diabetic subjects. Ruiu G, etal., Clin Genet. 1997 Sep;52(3):167-72.
22. Dietary oil modifies the plasma proteome during aging in the rat. Santos-Gonzalez M, etal., Age (Dordr). 2011 Apr 7.
23. Elevation of apolipoprotein A-I and apolipoprotein H levels in the vitreous fluid and overexpression in the retina of diabetic patients. Simo R, etal., Arch Ophthalmol. 2008 Aug;126(8):1076-81.
24. Antibodies to the atherosclerotic plaque components beta2-glycoprotein I and heat-shock proteins as risk factors for acute cerebral ischemia. Staub HL, etal., Arq Neuropsiquiatr. 2003 Sep;61(3B):757-63. Epub 2003 Oct 28.
25. Beta 2-glycoprotein I is a good indicator of certain adverse pregnancy conditions. Ulcova-Gallova Z, etal., Int J Fertil Womens Med. 2001 Nov-Dec;46(6):304-8.
26. Studies on the possible function of beta 2-glycoprotein-I: influence in the triglyceride metabolism in the rat. Wurm H, etal., Metabolism. 1982 May;31(5):484-6.
27. The role of beta2-glycoprotein I in liposome-hepatocyte interaction. Yan X, etal., Biochim Biophys Acta. 2004 Dec 15;1667(2):208-14.
Additional References at PubMed
PMID:222615   PMID:2771654   PMID:4052628   PMID:7417307   PMID:11145969   PMID:12477932   PMID:14726399   PMID:15486070   PMID:15534879   PMID:16480936   PMID:16502470   PMID:17872974  
PMID:18822289   PMID:19805618   PMID:19895376   PMID:20551380   PMID:23376485   PMID:23533145   PMID:27068509   PMID:27559042   PMID:30442725  


Genomics

Comparative Map Data
Apoh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81093,841,992 - 93,855,897 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1093,841,966 - 93,857,127 (+)EnsemblGRCr8
mRatBN7.21093,342,435 - 93,356,334 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1093,310,977 - 93,356,329 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1098,400,040 - 98,413,944 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01097,863,118 - 97,877,037 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01093,267,097 - 93,280,941 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01096,640,013 - 96,653,939 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1096,639,924 - 96,653,938 (+)Ensemblrn6Rnor6.0
Rnor_5.01096,364,217 - 96,378,118 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41097,725,088 - 97,739,213 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1092,007,324 - 92,020,973 (+)NCBICelera
RGSC_v3.11097,739,457 - 97,753,582 (+)NCBI
Cytogenetic Map10q32.1NCBI
APOH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381766,212,033 - 66,229,415 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1766,211,595 - 66,256,525 (-)Ensemblhg38GRCh38
GRCh371764,208,151 - 64,225,533 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361761,638,609 - 61,656,018 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341761,638,613 - 61,655,992NCBI
Celera1760,780,183 - 60,797,591 (-)NCBICelera
Cytogenetic Map17q24.2NCBI
HuRef1759,599,926 - 59,617,004 (-)NCBIHuRef
CHM1_11764,272,419 - 64,289,828 (-)NCBICHM1_1
T2T-CHM13v2.01767,082,811 - 67,100,218 (-)NCBIT2T-CHM13v2.0
Apoh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911108,286,123 - 108,305,222 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11108,234,180 - 108,305,222 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3811108,395,297 - 108,414,396 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11108,343,354 - 108,414,396 (+)Ensemblmm10GRCm38
MGSCv3711108,256,611 - 108,275,710 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611108,211,403 - 108,230,481 (+)NCBIMGSCv36mm8
Celera11120,134,821 - 120,148,689 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1171.8NCBI
Apoh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554785,610,164 - 5,626,020 (-)Ensembl
ChiLan1.0NW_0049554785,612,258 - 5,626,061 (-)NCBIChiLan1.0ChiLan1.0
APOH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21982,247,480 - 82,339,338 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11787,066,978 - 87,158,996 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01760,154,389 - 60,171,762 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11765,365,250 - 65,382,483 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1765,365,250 - 65,382,483 (-)EnsemblpanPan2panpan1.1
APOH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1914,082,648 - 14,095,186 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl914,082,541 - 14,095,185 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha914,976,443 - 14,988,978 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0915,744,714 - 15,757,283 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl915,744,709 - 15,757,972 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1914,691,324 - 14,703,853 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0912,829,414 - 12,841,962 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0912,830,254 - 12,842,800 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Apoh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560212,499,435 - 12,511,134 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365416,683,534 - 6,695,066 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365416,683,483 - 6,695,094 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1212,827,201 - 12,839,175 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11212,827,195 - 12,839,172 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21213,142,347 - 13,154,323 (-)NCBISscrofa10.2Sscrofa10.2susScr3
APOH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11655,209,142 - 55,231,176 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607726,257,256 - 26,290,880 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apoh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248702,081,968 - 2,099,517 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248702,082,050 - 2,096,220 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Apoh
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1970,728,623 - 70,741,993 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Apoh
91 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:71
Count of miRNA genes:65
Interacting mature miRNAs:68
Transcripts:ENSRNOT00000004756
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093723381107556066Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)109090424595604677Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108780775896620484Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)109112727095604677Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)9090424595604677Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)9090424595604677Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)109090424595604677Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)109090424595604677Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)109090424595604677Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)108890050196620484Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108450348796432422Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108450348796432422Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 11 23 104 87 86 59 25 59 5 221 73 6 89 69 61 27 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001009626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AM071386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000004756   ⟹   ENSRNOP00000004756
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1093,841,966 - 93,855,896 (+)Ensembl
mRatBN7.2 Ensembl1093,310,977 - 93,356,329 (+)Ensembl
Rnor_6.0 Ensembl1096,639,924 - 96,653,938 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000151332   ⟹   ENSRNOP00000107954
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1093,841,966 - 93,857,127 (+)Ensembl
RefSeq Acc Id: NM_001009626   ⟹   NP_001009626
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81093,841,992 - 93,855,897 (+)NCBI
mRatBN7.21093,342,435 - 93,356,334 (+)NCBI
Rnor_6.01096,640,013 - 96,653,939 (+)NCBI
Rnor_5.01096,364,217 - 96,378,118 (+)NCBI
RGSC_v3.41097,725,088 - 97,739,213 (+)RGD
Celera1092,007,324 - 92,020,973 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001009626 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88180 (Get FASTA)   NCBI Sequence Viewer  
  CAJ29887 (Get FASTA)   NCBI Sequence Viewer  
  EDM06447 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000107954
GenBank Protein P26644 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001009626   ⟸   NM_001009626
- Peptide Label: precursor
- UniProtKB: P26644 (UniProtKB/Swiss-Prot),   Q5I0M1 (UniProtKB/TrEMBL),   A6HK92 (UniProtKB/TrEMBL),   F7FC04 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004756   ⟸   ENSRNOT00000004756
Ensembl Acc Id: ENSRNOP00000107954   ⟸   ENSRNOT00000151332
Protein Domains
Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P26644-F1-model_v2 AlphaFold P26644 1-297 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697854
Promoter ID:EPDNEW_R8379
Type:initiation region
Name:Apoh_1
Description:apolipoprotein H
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01096,639,990 - 96,640,050EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310625 AgrOrtholog
BioCyc Gene G2FUF-22879 BioCyc
Ensembl Genes ENSRNOG00000003566 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000151332 ENTREZGENE
Gene3D-CATH Complement Module, domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7364928 IMAGE-MGC_LOAD
InterPro Compl-Cell_Adhes-Reg UniProtKB/Swiss-Prot
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot
  Sushi_2 UniProtKB/Swiss-Prot
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot
MGC_CLONE MGC:108825 IMAGE-MGC_LOAD
NCBI Gene 287774 ENTREZGENE
PANTHER BETA-2-GLYCOPROTEIN 1 UniProtKB/Swiss-Prot
  COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING UniProtKB/Swiss-Prot
Pfam Sushi UniProtKB/Swiss-Prot
  Sushi_2 UniProtKB/Swiss-Prot
PhenoGen Apoh PhenoGen
PROSITE SUSHI UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003566 RatGTEx
SMART CCP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57535 UniProtKB/Swiss-Prot
UniProt A0ABZ3NNC0_RAT UniProtKB/TrEMBL
  A6HK92 ENTREZGENE, UniProtKB/TrEMBL
  APOH_RAT UniProtKB/Swiss-Prot
  F7FC04 ENTREZGENE, UniProtKB/TrEMBL
  P26644 ENTREZGENE
  Q3T940_RAT UniProtKB/TrEMBL
  Q5I0M1 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Apoh  apolipoprotein H  Apoh  apolipoprotein H (beta-2-glycoprotein I)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Apoh  apolipoprotein H (beta-2-glycoprotein I)  Apoh  apolipoprotein H  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Apoh  apolipoprotein H  Apoh_predicted  apolipoprotein H (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Apoh_predicted  apolipoprotein H (predicted)      Symbol and Name status set to approved 70820 APPROVED