Itgav (integrin subunit alpha V) - Rat Genome Database

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Gene: Itgav (integrin subunit alpha V) Rattus norvegicus
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Symbol: Itgav
Name: integrin subunit alpha V
RGD ID: 1310613
Description: Enables signaling receptor binding activity. Involved in several processes, including blood vessel morphogenesis; positive regulation of cell population proliferation; and positive regulation of cytosolic calcium ion concentration. Predicted to be located in several cellular components, including cell projection membrane; cell surface; and focal adhesion. Predicted to be part of alphav-beta3 integrin-HMGB1 complex; alphav-beta3 integrin-IGF-1-IGF1R complex; and integrin complex. Predicted to be active in external side of plasma membrane. Used to study corneal neovascularization; coronary stenosis; and ischemia. Biomarker of hypertension. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and acute myeloid leukemia. Orthologous to human ITGAV (integrin subunit alpha V); PARTICIPATES IN integrin mediated signaling pathway; platelet-derived growth factor signaling pathway; sphingosine 1-phosphate signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cd51; Dnmt3l-ps1 pseudogene; integrin alpha V ; integrin alpha-V; integrin, alpha V; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8389,245,382 - 89,333,512 (+)NCBIGRCr8
mRatBN7.2368,838,514 - 68,926,653 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl368,838,189 - 68,926,639 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx372,233,903 - 72,315,469 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0380,832,555 - 80,914,128 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0378,567,077 - 78,655,183 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0371,113,269 - 71,205,958 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl371,114,100 - 71,202,411 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0377,643,270 - 77,731,358 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4366,953,403 - 67,029,774 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1366,848,789 - 66,926,146 (+)NCBI
Celera368,209,136 - 68,297,332 (+)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
ItgavRatabdominal aortic aneurysm  ISOITGAV (Homo sapiens)1582446 RGD 
ItgavRatacute myeloid leukemia treatmentISOITGAV (Homo sapiens)10755448 RGD 
ItgavRatAlveolar Bone Loss treatmentIEP 329956421associated with periodontal diseaseRGD 
ItgavRatCarotid Artery Injuries  IEP 329845558mRNA:increased expression:carotic artery (rat)RGD 
ItgavRatCerebral Hemorrhage  ISOITGAV (Homo sapiens)1582447 RGD 
ItgavRatChoroidal Neovascularization  IMP 1582458 RGD 
ItgavRatcorneal neovascularization  IDA 1582461 RGD 
ItgavRatcoronary stenosis  IDA 1582454 RGD 
ItgavRatExperimental Neoplasms treatmentISOITGAV (Homo sapiens)152998949human cells in rat modelRGD 
ItgavRathyperglycemia  ISOITGAV (Homo sapiens)1627644mRNA:increased expression:blood vessel endothelial cellRGD 
ItgavRathypertension  IEP 1627642protein:increased expression:arteryRGD 
ItgavRatischemia  IDA 1582457 RGD 
ItgavRatlimb ischemia  ISOItgav (Mus musculus)1582449 RGD 
ItgavRatlung metastasis treatmentISOITGAV (Homo sapiens)152998949human cells in rat modelRGD 
ItgavRatMetabolic Syndrome  ISOITGAV (Homo sapiens)1627640 RGD 
ItgavRatMyocardial Ischemia  ISOITGAV (Homo sapiens)1582453 RGD 
ItgavRatRetinal Neovascularization  ISOItgav (Mus musculus)1582452 RGD 
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Original Reference(s)
ItgavRatNeurodevelopmental Disorders  ISOITGAV (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
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ItgavRatCerebral Hemorrhage  ISOITGAV (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9445356
ItgavRatStroke  ISOITGAV (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9445356

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ItgavRat(-)-epigallocatechin 3-gallate decreases expressionISOITGAV (Homo sapiens)6480464epigallocatechin gallate results in decreased expression of ITGAV mRNACTDPMID:16084531
ItgavRat(R)-adrenaline increases expressionISOITGAV (Homo sapiens)6480464Epinephrine results in increased expression of ITGAV mRNACTDPMID:12729923
ItgavRat(S)-nicotine increases expressionISOItgav (Mus musculus)6480464Nicotine results in increased expression of ITGAV mRNACTDPMID:17997037
ItgavRat1-chloro-2,4-dinitrobenzene affects expressionISOItgav (Mus musculus)6480464Dinitrochlorobenzene affects the expression of ITGAV mRNACTDPMID:22302311
ItgavRat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of ITGAV mRNACTDPMID:30723492
ItgavRat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of ITGAV mRNACTDPMID:29097150
ItgavRat17beta-estradiol increases expressionISOItgav (Mus musculus)6480464Estradiol results in increased expression of ITGAV mRNACTDPMID:19484750
ItgavRat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of ITGAV mRNACTDPMID:32145629
ItgavRat17beta-estradiol multiple interactionsISOITGAV (Homo sapiens)6480464[Estradiol co-treated with TGFB1 protein] results in increased expression of ITGAV mRNACTDPMID:30165855
ItgavRat17beta-hydroxy-5alpha-androstan-3-one increases expressionISOITGAV (Homo sapiens)6480464Dihydrotestosterone results in increased expression of ITGAV mRNACTDPMID:29581250
ItgavRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of ITGAV mRNACTDPMID:33387578
ItgavRat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520
ItgavRat2,6-dimethoxyphenol multiple interactionsISOITGAV (Homo sapiens)6480464[Sodium Chloride co-treated with pyrogallol 1 and 3-dimethyl ether] results in increased expression of and affects the localization of ITGAV proteinCTDPMID:38598786
ItgavRat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of ITGAV mRNACTDPMID:21346803
ItgavRat2-bromohexadecanoic acid multiple interactionsISOITGAV (Homo sapiens)64804642-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased palmitoylation of ITGAV protein]CTDPMID:38195004
ItgavRat3,4-methylenedioxymethamphetamine decreases expressionISOItgav (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of ITGAV mRNACTDPMID:26251327
ItgavRat4-hydroxyphenyl retinamide increases expressionISOItgav (Mus musculus)6480464Fenretinide results in increased expression of ITGAV mRNACTDPMID:28973697
ItgavRat4-vinylcyclohexene dioxide affects expressionISOItgav (Mus musculus)64804644-vinyl-1-cyclohexene dioxide affects the expression of ITGAV mRNACTDPMID:20829426
ItgavRat5-fluorouracil affects response to substanceISOITGAV (Homo sapiens)6480464ITGAV protein affects the susceptibility to FluorouracilCTDPMID:16217747
ItgavRatacrolein multiple interactionsISOITGAV (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of and results in increased oxidation of ITGAV mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of and results in increased oxidation of ITGAV mRNACTDPMID:32699268

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Biological Process
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Original Reference(s)
ItgavRatangiogenesis  IEP 1582460 RGD 
ItgavRatangiogenesis involved_inIBAPANTHER:PTN002755382 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
ItgavRatangiogenesis involved_inISOITGAV (Homo sapiens)1624291 PMID:11866539RGDPMID:11866539
ItgavRatapolipoprotein A-I-mediated signaling pathway involved_inISOITGAV (Homo sapiens)1624291 PMID:23726972RGDPMID:23726972
ItgavRatapoptotic cell clearance involved_inISOItgav (Mus musculus)1624291UniProtKB:P06756 and PMID:20826760RGDPMID:20826760
ItgavRatapoptotic cell clearance acts_upstream_of_or_withinISOItgav (Mus musculus)1624291 PMID:15647754RGDPMID:15647754
ItgavRatapoptotic cell clearance involved_inISOITGAV (Homo sapiens)1624291UniProtKB:P43406 and PMID:20826760RGDPMID:20826760
ItgavRatblood vessel development acts_upstream_of_or_withinISOItgav (Mus musculus)1624291MGI:1857889 PMID:12370313RGDPMID:12370313
ItgavRatcalcium ion transmembrane transport involved_inISOITGAV (Homo sapiens)1624291 PMID:18395422RGDPMID:18395422
ItgavRatcell adhesion involved_inISOITGAV (Homo sapiens)1624291 PMID:10218736RGDPMID:10218736
ItgavRatcell adhesion mediated by integrin involved_inISOITGAV (Homo sapiens)1624291 PMID:12807887 and PMID:17158881RGDPMID:12807887 and PMID:17158881
ItgavRatcell adhesion mediated by integrin involved_inISOItgav (Mus musculus)1624291 PMID:24681597RGDPMID:24681597
ItgavRatcell adhesion mediated by integrin involved_inIBAFB:FBgn0001250 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
ItgavRatcell migration  IMP 1582456 RGD 
ItgavRatcell migration involved_inISOITGAV (Homo sapiens)1624291 PMID:26934001RGDPMID:26934001
ItgavRatcell-cell adhesion involved_inIBAMGI:96602 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
ItgavRatcell-matrix adhesion involved_inISOITGAV (Homo sapiens)1624291 PMID:24658351 and PMID:7525578RGDPMID:24658351 and PMID:7525578
ItgavRatcell-substrate adhesion involved_inISOITGAV (Homo sapiens)1624291 PMID:19933311RGDPMID:19933311
ItgavRatendodermal cell differentiation involved_inISOITGAV (Homo sapiens)1624291 PMID:23154389RGDPMID:23154389
ItgavRatERK1 and ERK2 cascade involved_inISOItgav (Mus musculus)1624291 PMID:16014375RGDPMID:16014375
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Cellular Component
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Original Reference(s)
ItgavRatalphav-beta3 integrin-HMGB1 complex part_ofISOITGAV (Homo sapiens)1624291 PMID:20826760RGDPMID:20826760
ItgavRatalphav-beta3 integrin-IGF-1-IGF1R complex part_ofISOITGAV (Homo sapiens)1624291 PMID:19578119RGDPMID:19578119
ItgavRatcell surface located_inISOITGAV (Homo sapiens)1624291 PMID:1918072 more ...RGDPMID:1918072 more ...
ItgavRatcell surface located_inISOITGAV (Sus scrofa)1624291 PMID:19920116RGDPMID:19920116
ItgavRatcytosol located_inISOITGAV (Homo sapiens) more ...1624291 RGDGO_REF:0000052
ItgavRatcytosol located_inIEAUniProtKB:P06756 and ensembl:ENSP000002610231600115GO_REF:0000107EnsemblGO_REF:0000107
ItgavRatcytosol located_inIEAUniProtKB:L7RXH0 and ensembl:ENSP000002610231600115GO_REF:0000107EnsemblGO_REF:0000107
ItgavRatexternal side of plasma membrane located_inISOItgav (Mus musculus)1624291 PMID:8557754 and PMID:9553049RGDPMID:8557754 and PMID:9553049
ItgavRatexternal side of plasma membrane is_active_inIBAMGI:1298377 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
ItgavRatfilopodium membrane located_inISOITGAV (Homo sapiens)1624291 PMID:25063885RGDPMID:25063885
ItgavRatfocal adhesion located_inISOITGAV (Homo sapiens) more ...1624291 RGDGO_REF:0000052
ItgavRatfocal adhesion located_inISOITGAV (Homo sapiens)1624291 PMID:17158881 more ...RGDPMID:17158881 more ...
ItgavRatintegrin alphav-beta1 complex part_ofISOITGAV (Homo sapiens)1624291 PMID:25398877RGDPMID:25398877
ItgavRatintegrin alphav-beta3 complex part_ofISOITGAV (Homo sapiens)1624291 PMID:11546839 more ...RGDPMID:11546839 more ...
ItgavRatintegrin alphav-beta5 complex part_ofISOITGAV (Homo sapiens)1624291 PMID:1694173 and PMID:25063885RGDPMID:1694173 and PMID:25063885
ItgavRatintegrin alphav-beta5 complex part_ofISOItgav (Mus musculus)1624291 PMID:20826760RGDPMID:20826760
ItgavRatintegrin alphav-beta6 complex part_ofISOITGAV (Homo sapiens)1624291 PMID:22278742 and PMID:25383667RGDPMID:22278742 and PMID:25383667
ItgavRatintegrin alphav-beta6 complex part_ofISOItgav (Mus musculus)1624291 PMID:24681597RGDPMID:24681597
ItgavRatintegrin alphav-beta8 complex part_ofISOITGAV (Homo sapiens)1624291 PMID:1918072 more ...RGDPMID:1918072 more ...
ItgavRatintegrin complex part_ofISOITGAV (Homo sapiens)1624291 PMID:15215180RGDPMID:15215180
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Molecular Function
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Original Reference(s)
ItgavRatC-X3-C chemokine binding contributes_toISOITGAV (Homo sapiens)1624291 PMID:23125415RGDPMID:23125415
ItgavRatcollagen binding enablesISOITGAV (Sus scrofa)1624291 PMID:21307347RGDPMID:21307347
ItgavRatextracellular matrix binding enablesISOITGAV (Homo sapiens)1624291 PMID:22505472RGDPMID:22505472
ItgavRatextracellular matrix protein binding enablesISOITGAV (Homo sapiens)1624291 PMID:7525578RGDPMID:7525578
ItgavRatfibroblast growth factor binding contributes_toISOITGAV (Homo sapiens)1624291 PMID:18441324RGDPMID:18441324
ItgavRatfibronectin binding enablesISOITGAV (Homo sapiens)1624291 PMID:24658351RGDPMID:24658351
ItgavRatinsulin-like growth factor I binding contributes_toISOITGAV (Homo sapiens)1624291 PMID:19578119RGDPMID:19578119
ItgavRatintegrin binding enablesISOITGAV (Homo sapiens)1624291UniProtKB:P05106 and PMID:20826760RGDPMID:20826760
ItgavRatintegrin binding enablesIBAMGI:104756 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
ItgavRatintegrin binding enablesISOItgav (Mus musculus)1624291UniProtKB:O70309 and PMID:20826760RGDPMID:20826760
ItgavRatneuregulin binding contributes_toISOITGAV (Homo sapiens)1624291 PMID:20682778RGDPMID:20682778
ItgavRatopsonin binding contributes_toISOItgav (Mus musculus)1624291 PMID:20826760RGDPMID:20826760
ItgavRatprotease binding enablesISOITGAV (Homo sapiens)1624291 PMID:22505472RGDPMID:22505472
ItgavRatprotein binding  IPIItgb3 (Rattus norvegicus)8693379 RGD 
ItgavRatprotein binding  IPIItgb5 (Rattus norvegicus)2302243 RGD 
ItgavRatprotein binding enablesISOItgav (Mus musculus)1624291UniProtKB:E9Q9H8 and PMID:38016540RGDPMID:38016540
ItgavRatprotein binding enablesISOITGAV (Homo sapiens)1624291UniProtKB:P05106 more ...RGDPMID:11546839 more ...
ItgavRatprotein kinase C binding contributes_toISOItgav (Mus musculus)1624291 PMID:16014375RGDPMID:16014375
ItgavRatsignaling receptor binding  IPICasr (Rattus norvegicus)7205691 RGD 
ItgavRattransforming growth factor beta binding enablesISOITGAV (Sus scrofa)1624291UniProtKB:P07200 and PMID:19920116RGDPMID:19920116
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RGD Manual Annotations


  
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Original Reference(s)
ItgavRatintegrin mediated signaling pathway   ISOITGAV (Homo sapiens)1358329 RGD 
ItgavRatintegrin mediated signaling pathway   ISOITGAV (Homo sapiens)5135538 RGD 
ItgavRatintegrin mediated signaling pathway   IDA 1625134 RGD 

Imported Annotations - PID (archival)


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#
Reference Title
Reference Citation
1. Endothelial microparticles and platelet and leukocyte activation in patients with the metabolic syndrome. Arteaga RB, etal., Am J Cardiol. 2006 Jul 1;98(1):70-4. Epub 2006 May 4.
2. The oligodendrocyte precursor mitogen PDGF stimulates proliferation by activation of alpha(v)beta3 integrins. Baron W, etal., EMBO J. 2002 Apr 15;21(8):1957-66.
3. The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted. Bonnet S, etal., Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11418-23. Epub 2007 Jun 27.
4. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
5. Connection between integrins and cell activation in rat adrenal glomerulosa cells: a role for Arg-Gly-Asp peptide in the activation of the p42/p44(mapk) pathway and intracellular calcium. Campbell S, etal., Endocrinology. 2003 Apr;144(4):1486-95.
6. Tetraspanin CD81 is required for the alpha v beta5-integrin-dependent particle-binding step of RPE phagocytosis. Chang Y and Finnemann SC, J Cell Sci. 2007 Sep 1;120(Pt 17):3053-63. Epub 2007 Aug 7.
7. Acute hyperglycaemia induces changes in the transcription levels of 4 major genes in human endothelial cells: macroarrays-based expression analysis. Chettab K, etal., Thromb Haemost. 2002 Jan;87(1):141-8.
8. Beta3-integrin mediates smooth muscle cell accumulation in neointima after carotid ligation in mice. Choi ET, etal., Circulation. 2004 Mar 30;109(12):1564-9. Epub 2004 Mar 8.
9. Abdominal aortic aneurysm rupture is associated with increased medial neovascularization and overexpression of proangiogenic cytokines. Choke E, etal., Arterioscler Thromb Vasc Biol. 2006 Sep;26(9):2077-82. Epub 2006 Jun 29.
10. Vitronectin is up-regulated after vascular injury and vitronectin blockade prevents neointima formation. Dufourcq P, etal., Cardiovasc Res. 2002 Mar;53(4):952-62.
11. New vessel formation after surgical brain injury in the rat's cerebral cortex I. Formation of the blood vessels proximally to the surgical injury. Frontczak-Baniewicz M and Walski M, Acta Neurobiol Exp (Wars). 2003;63(2):65-75.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. alphaV integrins are necessary for eutrophic inward remodeling of small arteries in hypertension. Heerkens EH, etal., Hypertension. 2006 Feb;47(2):281-7. Epub 2005 Dec 27.
15. Integrins on rat osteoclasts: characterization of two monoclonal antibodies (F4 and F11) to rat beta 3. Helfrich MH, etal., J Bone Miner Res. 1992 Mar;7(3):345-51.
16. Integrins: bidirectional, allosteric signaling machines. Hynes RO Cell 2002 Sep 20;110(6):673-87.
17. Inhibition of corneal neovascularization by alpha(v)-integrin antagonists in the rat. Klotz O, etal., Graefes Arch Clin Exp Ophthalmol. 2000 Jan;238(1):88-93.
18. Radiolabeled RGD uptake and alphav integrin expression is enhanced in ischemic murine hindlimbs. Lee KH, etal., J Nucl Med. 2005 Mar;46(3):472-8.
19. Assessment of endogenous and therapeutic arteriogenesis by contrast ultrasound molecular imaging of integrin expression. Leong-Poi H, etal., Circulation. 2005 Jun 21;111(24):3248-54. Epub 2005 Jun 13.
20. In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling. Miller PG, etal., Cancer Cell. 2013 Jul 8;24(1):45-58. doi: 10.1016/j.ccr.2013.05.004. Epub 2013 Jun 13.
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PMID:1918072   PMID:7525578   PMID:8557754   PMID:9553049   PMID:10218736   PMID:10570297   PMID:10708943   PMID:11866539   PMID:12370313   PMID:12807887   PMID:14566019   PMID:15044441  
PMID:15203217   PMID:15215180   PMID:15591537   PMID:15647754   PMID:15695822   PMID:16014375   PMID:16135088   PMID:16489109   PMID:17158881   PMID:17442458   PMID:18221819   PMID:18256073  
PMID:18395422   PMID:18441324   PMID:18538673   PMID:19056867   PMID:19122172   PMID:19359426   PMID:19578119   PMID:19581412   PMID:19723805   PMID:19734584   PMID:19739252   PMID:19920116  
PMID:19933311   PMID:20151413   PMID:20458337   PMID:20463011   PMID:20563599   PMID:20580365   PMID:20645409   PMID:20675382   PMID:20682778   PMID:20826760   PMID:21307347   PMID:21310825  
PMID:21423176   PMID:21502139   PMID:21792920   PMID:22262456   PMID:22278742   PMID:22505472   PMID:22885106   PMID:22915765   PMID:23125415   PMID:23154389   PMID:23161541   PMID:23376485  
PMID:23422496   PMID:23533145   PMID:23658023   PMID:23726972   PMID:23747317   PMID:23755149   PMID:24019890   PMID:24556923   PMID:24644077   PMID:24658351   PMID:24681597   PMID:24959065  
PMID:25063885   PMID:25389530   PMID:26010756   PMID:26279426   PMID:27235833   PMID:27535240   PMID:29162887   PMID:29210651   PMID:30541573   PMID:31010681   PMID:31331973  



Itgav
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8389,245,382 - 89,333,512 (+)NCBIGRCr8
mRatBN7.2368,838,514 - 68,926,653 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl368,838,189 - 68,926,639 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx372,233,903 - 72,315,469 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0380,832,555 - 80,914,128 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0378,567,077 - 78,655,183 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0371,113,269 - 71,205,958 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl371,114,100 - 71,202,411 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0377,643,270 - 77,731,358 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4366,953,403 - 67,029,774 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1366,848,789 - 66,926,146 (+)NCBI
Celera368,209,136 - 68,297,332 (+)NCBICelera
Cytogenetic Map3q24NCBI
ITGAV
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382186,590,056 - 186,680,901 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2186,590,010 - 186,680,901 (+)EnsemblGRCh38hg38GRCh38
GRCh372187,454,783 - 187,545,628 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362187,163,045 - 187,253,873 (+)NCBINCBI36Build 36hg18NCBI36
Build 342187,280,305 - 187,371,133NCBI
Celera2181,050,405 - 181,141,257 (+)NCBICelera
Cytogenetic Map2q32.1NCBI
HuRef2179,314,524 - 179,405,486 (+)NCBIHuRef
CHM1_12187,460,842 - 187,551,625 (+)NCBICHM1_1
T2T-CHM13v2.02187,079,132 - 187,170,024 (+)NCBIT2T-CHM13v2.0
Itgav
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39283,554,796 - 83,637,261 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl283,554,741 - 83,637,260 (+)EnsemblGRCm39 Ensembl
GRCm38283,722,303 - 83,806,917 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl283,724,397 - 83,806,916 (+)EnsemblGRCm38mm10GRCm38
MGSCv37283,564,554 - 83,647,073 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36283,525,354 - 83,604,646 (+)NCBIMGSCv36mm8
Celera285,367,604 - 85,456,006 (+)NCBICelera
Cytogenetic Map2DNCBI
cM Map249.33NCBI
Itgav
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540311,592,339 - 11,659,297 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540311,588,536 - 11,669,809 (-)NCBIChiLan1.0ChiLan1.0
ITGAV
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21389,252,238 - 89,359,439 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B89,280,655 - 89,374,419 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B73,880,962 - 73,972,486 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B191,680,655 - 191,773,028 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B191,680,655 - 191,773,028 (+)Ensemblpanpan1.1panPan2
ITGAV
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13628,815,215 - 28,890,569 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3628,804,013 - 28,887,430 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3628,702,231 - 28,789,503 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03629,028,662 - 29,116,151 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3629,031,003 - 29,116,148 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13629,087,085 - 29,173,016 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03629,020,979 - 29,108,231 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03629,188,373 - 29,276,043 (+)NCBIUU_Cfam_GSD_1.0
Itgav
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303145,999,260 - 146,087,955 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650610,750,101 - 10,839,303 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650610,750,116 - 10,839,018 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGAV
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1591,604,676 - 91,711,851 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11591,604,666 - 91,711,843 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215101,654,958 - 101,717,935 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITGAV
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11072,125,710 - 72,216,757 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1072,125,962 - 72,216,809 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040127,289,910 - 127,381,992 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itgav
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248993,239,112 - 3,291,586 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248993,235,434 - 3,292,584 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Itgav
578 total Variants

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:43
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000006961
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 52 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat

1 to 10 of 52 rows
D3Got143  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8389,288,529 - 89,288,731 (+)Marker Load Pipeline
mRatBN7.2368,881,666 - 68,881,868 (+)MAPPERmRatBN7.2
Rnor_6.0371,156,983 - 71,157,184NCBIRnor6.0
Rnor_5.0377,686,821 - 77,687,022UniSTSRnor5.0
RGSC_v3.4366,985,224 - 66,985,426RGDRGSC3.4
RGSC_v3.4366,985,225 - 66,985,426UniSTSRGSC3.4
RGSC_v3.1366,881,596 - 66,881,798RGD
Celera368,252,850 - 68,253,051UniSTS
RH 2.0 Map31034.3RGD
Cytogenetic Map3q24UniSTS
RH140315  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2368,923,665 - 68,923,861 (+)MAPPERmRatBN7.2
Rnor_6.0371,202,971 - 71,203,166NCBIRnor6.0
Rnor_5.0377,728,371 - 77,728,566UniSTSRnor5.0
RGSC_v3.4367,029,877 - 67,030,072UniSTSRGSC3.4
Celera368,294,341 - 68,294,536UniSTS
Cytogenetic Map3q24UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000006961   ⟹   ENSRNOP00000006961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl368,838,189 - 68,926,639 (+)Ensembl
Rnor_6.0 Ensembl371,114,100 - 71,202,411 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088549   ⟹   ENSRNOP00000069681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl368,838,599 - 68,926,639 (+)Ensembl
Rnor_6.0 Ensembl371,114,100 - 71,202,411 (+)Ensembl
RefSeq Acc Id: NM_001398692   ⟹   NP_001385621
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,245,382 - 89,333,512 (+)NCBI
mRatBN7.2368,838,514 - 68,926,653 (+)NCBI
RefSeq Acc Id: NM_001398693   ⟹   NP_001385622
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,245,382 - 89,333,512 (+)NCBI
mRatBN7.2368,838,514 - 68,926,653 (+)NCBI
RefSeq Acc Id: XM_039106447   ⟹   XP_038962375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,266,090 - 89,333,512 (+)NCBI
mRatBN7.2368,859,226 - 68,926,653 (+)NCBI
RefSeq Acc Id: XM_063283421   ⟹   XP_063139491
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,248,393 - 89,333,512 (+)NCBI
RefSeq Acc Id: XR_010064598
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,245,526 - 89,333,512 (+)NCBI
RefSeq Acc Id: XR_010064599
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,245,504 - 89,333,512 (+)NCBI
Protein RefSeqs NP_001385621 (Get FASTA)   NCBI Sequence Viewer  
  NP_001385622 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962375 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139491 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL79295 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006961.8
  ENSRNOP00000069681.2
Ensembl Acc Id: ENSRNOP00000006961   ⟸   ENSRNOT00000006961
Ensembl Acc Id: ENSRNOP00000069681   ⟸   ENSRNOT00000088549
RefSeq Acc Id: XP_038962375   ⟸   XM_039106447
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001385621   ⟸   NM_001398692
- Peptide Label: isoform 1 precursor
- UniProtKB: A0A0G2JVZ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001385622   ⟸   NM_001398693
- Peptide Label: isoform 2 precursor
- UniProtKB: F1LZX9 (UniProtKB/TrEMBL),   A0A0G2JVZ6 (UniProtKB/TrEMBL)
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JVZ6-F1-model_v2 AlphaFold A0A0G2JVZ6 1-1052 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 36 of 36 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-49196 BioCyc
Ensembl Genes ENSRNOG00000004912 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006961.8 UniProtKB/TrEMBL
  ENSRNOT00000088549.2 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.130 UniProtKB/TrEMBL
  Bicelle-embedded integrin alpha(iib) transmembrane segment UniProtKB/TrEMBL
  Integrin domains. Chain A, domain 2 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 4 UniProtKB/TrEMBL
InterPro FG-GAP UniProtKB/TrEMBL
  Int_alpha_beta-p UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  Integrin_alpha-2 UniProtKB/TrEMBL
  Integrin_alpha_C_CS UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_2 UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_3 UniProtKB/TrEMBL
  Integrin_alpha_N UniProtKB/TrEMBL
  Integrin_dom UniProtKB/TrEMBL
NCBI Gene 296456 ENTREZGENE
PANTHER INTEGRIN ALPHA UniProtKB/TrEMBL
  INTEGRIN ALPHA-V UniProtKB/TrEMBL
Pfam FG-GAP UniProtKB/TrEMBL
  Integrin_A_Ig_2 UniProtKB/TrEMBL
  Integrin_A_Ig_3 UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  Integrin_alpha2 UniProtKB/TrEMBL
PhenoGen Itgav PhenoGen
PRINTS INTEGRINA UniProtKB/TrEMBL
PROSITE FG_GAP UniProtKB/TrEMBL
  INTEGRIN_ALPHA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004912 RatGTEx
SMART Int_alpha UniProtKB/TrEMBL
Superfamily-SCOP SSF69179 UniProtKB/TrEMBL
  SSF69318 UniProtKB/TrEMBL
UniProt A0A0G2JVZ6 ENTREZGENE, UniProtKB/TrEMBL
  F1LZX9 ENTREZGENE, UniProtKB/TrEMBL
1 to 36 of 36 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Itgav  integrin subunit alpha V  Itgav  integrin, alpha V  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-15 Itgav  integrin, alpha V  Itgav  integrin alpha V   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Itgav  integrin alpha V   Itgav_predicted  integrin alpha V (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Itgav_predicted  integrin alpha V (predicted)    integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) (predicted)  Name updated 1299863 APPROVED
2005-01-12 Itgav_predicted  integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) (predicted)      Symbol and Name status set to approved 70820 APPROVED