Stat6 (signal transducer and activator of transcription 6) - Rat Genome Database

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Gene: Stat6 (signal transducer and activator of transcription 6) Rattus norvegicus
Analyze
Symbol: Stat6
Name: signal transducer and activator of transcription 6
RGD ID: 1309063
Description: Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to reactive nitrogen species; and positive regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in cytoplasm and nucleus. Used to study asthma and renal fibrosis. Biomarker of asthma and myocarditis. Human ortholog(s) of this gene implicated in colon adenocarcinoma; lipoid nephrosis; prostate carcinoma; rectum adenocarcinoma; and urinary schistosomiasis. Orthologous to human STAT6 (signal transducer and activator of transcription 6); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-4 signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 17beta-estradiol; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC362896; signal transducer and activator of transcription 6, interleukin-4 induced; signal transducer and transcription activator 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8765,365,505 - 65,382,825 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl765,365,306 - 65,383,795 (+)EnsemblGRCr8
mRatBN7.2763,480,229 - 63,497,551 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl763,479,642 - 63,498,495 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx765,369,479 - 65,386,799 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0767,571,769 - 67,589,089 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0767,373,031 - 67,390,379 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0770,946,228 - 70,963,542 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,946,228 - 70,964,484 (+)Ensemblrn6Rnor6.0
Rnor_5.0771,118,725 - 71,135,848 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4767,623,534 - 67,642,283 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera760,619,697 - 60,637,001 (+)NCBICelera
RGSC_v3.1767,622,590 - 67,662,987 (+)NCBI
Cytogenetic Map7q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-tert-Octylphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpinumisoflavone  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
calcium dichloride  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carboplatin  (ISO)
carveol  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyfluthrin  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
donepezil hydrochloride  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
Fidarestat  (ISO)
flavonoids  (ISO)
fluorescein 5-isothiocyanate  (ISO)
flutamide  (EXP,ISO)
geraniol  (ISO)
glycidol  (EXP)
histamine  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
ketorolac  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mechlorethamine  (ISO)
melatonin  (ISO)
mercury dichloride  (EXP)
methamphetamine  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
mitomycin C  (ISO)
MitoTEMPO  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nicotine  (ISO)
okadaic acid  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
serpentine asbestos  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium benzoate  (ISO)
sodium dodecyl sulfate  (ISO)
Sodium salicylate  (ISO)
sunitinib  (ISO)
synephrine  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
thioacetamide  (EXP)
thymoquinone  (ISO)
tofacitinib  (ISO)
trichostatin A  (EXP,ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Polymorphism of the interleukin-4, interleukin-13, and signal transducer and activator of transcription 6 genes in Indonesian children with minimal change nephrotic syndrome. Acharya B, etal., Am J Nephrol. 2005 Jan-Feb;25(1):30-5. Epub 2005 Feb 1.
2. STAT6 transcription factor binding sites with mismatches within the canonical 5'-TTC...GAA-3' motif involved in regulation of delta- and mu-opioid receptors. Borner C, etal., J Neurochem. 2004 Dec;91(6):1493-500.
3. Expression of the IKr components KCNH2 (rERG) and KCNE2 (rMiRP1) during late rat heart development. Chun KR, etal., Exp Mol Med. 2004 Aug 31;36(4):367-71.
4. Signal transducer and activator of transcription-6 (STAT6) is a constitutively expressed survival factor in human prostate cancer. Das S, etal., Prostate. 2007 Oct 1;67(14):1550-64.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Identification of immune checkpoint inhibitors and biomarkers among STAT family in stomach adenocarcinoma. Guo L, etal., Am J Transl Res. 2020 Sep 15;12(9):4977-4997. eCollection 2020.
8. A STAT6 gene polymorphism is associated with high infection levels in urinary schistosomiasis. He H, etal., Genes Immun. 2008 Apr;9(3):195-206. doi: 10.1038/gene.2008.2. Epub 2008 Feb 14.
9. Polymorphisms in interleukin-4-related genes in patients with minimal change nephrotic syndrome. Ikeuchi Y, etal., Pediatr Nephrol. 2009 Mar;24(3):489-95. doi: 10.1007/s00467-008-1003-y. Epub 2008 Nov 15.
10. Pivotal role of Stat4 and Stat6 in the pathogenesis of the lupus-like disease in the New Zealand mixed 2328 mice. Jacob CO, etal., J Immunol. 2003 Aug 1;171(3):1564-71.
11. Signaling through the JAK/STAT pathway, recent advances and future challenges. Kisseleva T, etal., Gene 2002 Feb 20;285(1-2):1-24.
12. Polymorphisms of interleukin-4--related genes in Japanese children with minimal change nephrotic syndrome. Kobayashi Y, etal., Am J Kidney Dis. 2003 Aug;42(2):271-6.
13. Signal transducer and activator of transcription (Stat)-6-dependent, but not Stat4-dependent, immunity is required for the development of autoimmunity in Graves' hyperthyroidism. Land KJ, etal., Endocrinology. 2004 Aug;145(8):3724-30. Epub 2004 Apr 29.
14. Loss of STAT6 promotes autoimmune disease and atopy on a susceptible genetic background. Lau M, etal., J Autoimmun. 2012 Dec;39(4):388-97. doi: 10.1016/j.jaut.2012.06.003. Epub 2012 Aug 4.
15. [Expression of signal transducer and activator of transcription 6 in rat asthma model and the modulatory effect of dexamethasone]. Li CC, etal., Zhonghua Er Ke Za Zhi. 2005 Jul;43(7):521-5.
16. [Effects of interleukin 1 receptor antagonist on allergy asthma in rat model and its mechanism]. Liu ZC, etal., Zhonghua Yi Xue Za Zhi. 2008 Sep 9;88(34):2432-6.
17. Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease. Low SH, etal., Dev Cell. 2006 Jan;10(1):57-69.
18. Pivotal role of signal transducer and activator of transcription (Stat)4 and Stat6 in the innate immune response during sepsis. Matsukawa A, etal., J Exp Med. 2001 Mar 19;193(6):679-88.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. The JAK-STAT signaling pathway: input and output integration. Murray PJ J Immunol. 2007 Mar 1;178(5):2623-9.
21. Selective activation of members of the signal transducers and activators of transcription family in prostate carcinoma. Ni Z, etal., J Urol. 2002 Apr;167(4):1859-62.
22. Mechanical stretch and angiotensin II increase interleukin-13 production and interleukin-13 receptor alpha2 expression in rat neonatal cardiomyocytes. Nishimura Y, etal., Circ J. 2008 Apr;72(4):647-53.
23. Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney disease. Olsan EE, etal., Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18067-72. doi: 10.1073/pnas.1111966108. Epub 2011 Oct 24.
24. A role for T helper 2 cells in mediating skin fibrosis in tight-skin mice. Ong CJ, etal., Cell Immunol. 1999 Aug 25;196(1):60-8.
25. Cutting edge: STAT6-deficient mice have enhanced tumor immunity to primary and metastatic mammary carcinoma. Ostrand-Rosenberg S, etal., J Immunol. 2000 Dec 1;165(11):6015-9.
26. Astrocytes, but not microglia, rapidly sense H(2)O(2)via STAT6 phosphorylation, resulting in cyclooxygenase-2 expression and prostaglandin release. Park SJ, etal., J Immunol. 2012 May 15;188(10):5132-41. doi: 10.4049/jimmunol.1101600. Epub 2012 Apr 13.
27. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
28. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
29. Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Qiu Y, etal., Cell. 2014 Jun 5;157(6):1292-308. doi: 10.1016/j.cell.2014.03.066.
30. GOA pipeline RGD automated data pipeline
31. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. Peptide YY attenuates STAT1 and STAT3 activation induced by TNF-alpha in acinar cell line AR42J. Robinson K, etal., J Am Coll Surg. 2006 May;202(5):788-96.
34. JAK/STAT/SOCS-signaling pathway and colon and rectal cancer. Slattery ML, etal., Mol Carcinog. 2013 Feb;52(2):155-66. doi: 10.1002/mc.21841. Epub 2011 Nov 28.
35. Signal transducer and activation of transcription 6 (STAT6) regulates T helper type 1 (Th1) and Th17 nephritogenic immunity in experimental crescentic glomerulonephritis. Summers SA, etal., Clin Exp Immunol. 2011 Nov;166(2):227-34. doi: 10.1111/j.1365-2249.2011.04437.x.
36. Modulation of signal transducers and activators of transcription (STAT) factor pathways during focal cerebral ischaemia: a gene expression array study in rat hippocampus after middle cerebral artery occlusion. Sun SL, etal., Clin Exp Pharmacol Physiol. 2007 Nov;34(11):1097-101.
37. Contrasting roles for STAT4 and STAT6 signal transduction pathways in murine renal ischemia-reperfusion injury. Yokota N, etal., Am J Physiol Renal Physiol. 2003 Aug;285(2):F319-25. Epub 2003 Apr 22.
38. STAT6 deficiency inhibits tubulointerstitial fibrosis in obstructive nephropathy. Yukawa K, etal., Int J Mol Med. 2005 Feb;15(2):225-30.
39. Imbalance of Th1 and Th2 cells in cardiac injury induced by ambient fine particles. Zhao J, etal., Toxicol Lett. 2012 Feb 5;208(3):225-31. doi: 10.1016/j.toxlet.2011.11.012. Epub 2011 Nov 23.
Additional References at PubMed
PMID:8810328   PMID:9110977   PMID:10438949   PMID:10490661   PMID:12093868   PMID:12634107   PMID:15187136   PMID:15659391   PMID:16728393   PMID:17210636   PMID:17658279   PMID:18997793  
PMID:19531027   PMID:20706986   PMID:20956546   PMID:21162243   PMID:21217760   PMID:21269961   PMID:22000020   PMID:22588720   PMID:24280217   PMID:24296793   PMID:24321062   PMID:29115389  
PMID:35240467   PMID:38509602  


Genomics

Comparative Map Data
Stat6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8765,365,505 - 65,382,825 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl765,365,306 - 65,383,795 (+)EnsemblGRCr8
mRatBN7.2763,480,229 - 63,497,551 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl763,479,642 - 63,498,495 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx765,369,479 - 65,386,799 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0767,571,769 - 67,589,089 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0767,373,031 - 67,390,379 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0770,946,228 - 70,963,542 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,946,228 - 70,964,484 (+)Ensemblrn6Rnor6.0
Rnor_5.0771,118,725 - 71,135,848 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4767,623,534 - 67,642,283 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera760,619,697 - 60,637,001 (+)NCBICelera
RGSC_v3.1767,622,590 - 67,662,987 (+)NCBI
Cytogenetic Map7q22NCBI
STAT6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381257,095,408 - 57,111,362 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1257,095,404 - 57,132,139 (-)Ensemblhg38GRCh38
GRCh371257,489,191 - 57,505,145 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,775,458 - 55,791,428 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341255,775,461 - 55,791,428NCBI
Celera1257,143,115 - 57,159,124 (-)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1254,527,593 - 54,543,593 (-)NCBIHuRef
CHM1_11257,456,871 - 57,472,880 (-)NCBICHM1_1
T2T-CHM13v2.01257,063,280 - 57,079,195 (-)NCBIT2T-CHM13v2.0
Stat6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,478,855 - 127,496,856 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10127,478,855 - 127,496,826 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3810127,642,955 - 127,660,987 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,642,986 - 127,660,957 (+)Ensemblmm10GRCm38
MGSCv3710127,080,042 - 127,098,043 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610127,046,120 - 127,063,352 (+)NCBIMGSCv36mm8
Celera10130,035,284 - 130,053,348 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1074.59NCBI
Stat6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554584,833,515 - 4,843,273 (-)Ensembl
ChiLan1.0NW_0049554584,833,417 - 4,847,956 (-)NCBIChiLan1.0ChiLan1.0
STAT6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21037,230,007 - 37,246,616 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11237,227,037 - 37,243,631 (+)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl1232,068,679 - 32,085,099 (+)EnsemblpanPan2panpan1.1
STAT6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1101,232,515 - 1,247,011 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,233,691 - 1,247,075 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha101,297,560 - 1,307,021 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0101,243,003 - 1,257,485 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl101,242,995 - 1,256,854 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1101,220,880 - 1,230,352 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0101,462,887 - 1,472,341 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0101,587,736 - 1,597,208 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Stat6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494557,557,740 - 57,572,832 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366461,296,290 - 1,312,157 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366461,297,530 - 1,312,508 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STAT6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl522,406,368 - 22,421,989 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1522,406,356 - 22,422,412 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2524,206,059 - 24,221,697 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STAT6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11153,005,378 - 53,020,899 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1153,006,145 - 53,021,203 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037192,951,160 - 192,967,461 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stat6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480210,809,252 - 10,846,693 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462480210,809,234 - 10,847,762 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Stat6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11206,088,546 - 206,108,072 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Stat6
113 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:103
Count of miRNA genes:77
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000039306
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72380760668807606Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74913799967614020Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)756625161101625161Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73984590284845902Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73299870277998702Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)763889858108889858Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73617876481178764Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73617876481178764Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72862457565788017Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)762963207107963207Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)763889858108889858Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat

Markers in Region
AI451907  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,498,755 - 63,498,869 (+)MAPPERmRatBN7.2
Rnor_6.0770,964,747 - 70,964,860NCBIRnor6.0
Rnor_5.0771,137,053 - 71,137,166UniSTSRnor5.0
RGSC_v3.4767,643,488 - 67,643,601UniSTSRGSC3.4
Celera760,638,214 - 60,638,327UniSTS
Cytogenetic Map7q22UniSTS
UniSTS:224451  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8765,382,937 - 65,383,107 (+)Marker Load Pipeline
mRatBN7.2763,497,663 - 63,497,833 (+)MAPPERmRatBN7.2
Rnor_6.0770,963,655 - 70,963,824NCBIRnor6.0
Rnor_5.0771,135,961 - 71,136,130UniSTSRnor5.0
RGSC_v3.4767,642,396 - 67,642,565UniSTSRGSC3.4
Celera760,637,114 - 60,637,291UniSTS
Cytogenetic Map7q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000039306   ⟹   ENSRNOP00000034983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl765,365,377 - 65,383,758 (+)Ensembl
Rnor_6.0 Ensembl770,946,228 - 70,963,542 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085350   ⟹   ENSRNOP00000072301
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl765,365,306 - 65,383,795 (+)Ensembl
mRatBN7.2 Ensembl763,479,642 - 63,498,495 (+)Ensembl
Rnor_6.0 Ensembl770,950,231 - 70,964,484 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000159178   ⟹   ENSRNOP00000109216
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl765,368,115 - 65,383,795 (+)Ensembl
RefSeq Acc Id: NM_001044250   ⟹   NP_001037715
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8765,365,505 - 65,382,825 (+)NCBI
mRatBN7.2763,480,229 - 63,497,551 (+)NCBI
Rnor_6.0770,946,228 - 70,963,542 (+)NCBI
Rnor_5.0771,118,725 - 71,135,848 (+)NCBI
RGSC_v3.4767,623,534 - 67,642,283 (+)RGD
Celera760,619,697 - 60,637,001 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001037715 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC12759 (Get FASTA)   NCBI Sequence Viewer  
  ABE73454 (Get FASTA)   NCBI Sequence Viewer  
  EDM16459 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072301
  ENSRNOP00000072301.2
  ENSRNOP00000109216.1
RefSeq Acc Id: NP_001037715   ⟸   NM_001044250
- UniProtKB: Q1KQ07 (UniProtKB/TrEMBL),   A0A0G2K2M3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072301   ⟸   ENSRNOT00000085350
Ensembl Acc Id: ENSRNOP00000034983   ⟸   ENSRNOT00000039306
Ensembl Acc Id: ENSRNOP00000109216   ⟸   ENSRNOT00000159178
Protein Domains
SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q1KQ07-F1-model_v2 AlphaFold Q1KQ07 1-841 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695266
Promoter ID:EPDNEW_R5790
Type:initiation region
Name:Stat6_1
Description:signal transducer and activator of transcription 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0770,946,220 - 70,946,280EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309063 AgrOrtholog
BioCyc Gene G2FUF-33729 BioCyc
Ensembl Genes ENSRNOG00000025023 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000085350 ENTREZGENE
  ENSRNOT00000085350.3 UniProtKB/TrEMBL
  ENSRNOT00000159178.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.630 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
  STAT transcription factor, all-alpha domain UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  STAT6_C UniProtKB/TrEMBL
  STAT6_SH2 UniProtKB/TrEMBL
  STAT_linker UniProtKB/TrEMBL
  STAT_N_sf UniProtKB/TrEMBL
  STAT_TF_alpha UniProtKB/TrEMBL
  STAT_TF_coiled-coil UniProtKB/TrEMBL
  STAT_TF_core UniProtKB/TrEMBL
  STAT_TF_DNA-bd UniProtKB/TrEMBL
  STAT_TF_DNA-bd_sub UniProtKB/TrEMBL
  STAT_TF_prot_interaction UniProtKB/TrEMBL
KEGG Report rno:362896 UniProtKB/TrEMBL
NCBI Gene 362896 ENTREZGENE
PANTHER STAT UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
  STAT6_C UniProtKB/TrEMBL
  STAT_alpha UniProtKB/TrEMBL
  STAT_bind UniProtKB/TrEMBL
  STAT_int UniProtKB/TrEMBL
  STAT_linker UniProtKB/TrEMBL
PhenoGen Stat6 PhenoGen
PROSITE SH2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025023 RatGTEx
SMART SH2 UniProtKB/TrEMBL
  STAT_int UniProtKB/TrEMBL
Superfamily-SCOP P53_like_DNA_bnd UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
  STAT UniProtKB/TrEMBL
  STAT UniProtKB/TrEMBL
UniProt A0A0G2K2M3 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M257_RAT UniProtKB/TrEMBL
  O70429_RAT UniProtKB/TrEMBL
  Q1KQ07 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Stat6  signal transducer and activator of transcription 6  Stat6  signal transducer and activator of transcription 6, interleukin-4 induced  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-03-01 Stat6  signal transducer and activator of transcription 6, interleukin-4 induced  Stat6  signal transducer and activator of transcription 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Stat6  signal transducer and activator of transcription 6   Stat6_predicted  signal transducer and activator of transcription 6 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Stat6_predicted  signal transducer and activator of transcription 6 (predicted)      Symbol and Name status set to approved 70820 APPROVED