Stk11 (serine/threonine kinase 11) - Rat Genome Database

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Gene: Stk11 (serine/threonine kinase 11) Rattus norvegicus
Analyze
Symbol: Stk11
Name: serine/threonine kinase 11
RGD ID: 1308653
Description: Enables protein serine/threonine kinase activity. Involved in several processes, including positive regulation of gluconeogenesis; response to glucagon; and response to thyroid hormone. Located in Z disc. Part of protein-containing complex. Biomarker of hyperthyroidism and obesity. Human ortholog(s) of this gene implicated in Peutz-Jeghers syndrome; familial melanoma; female reproductive organ cancer (multiple); and pancreatic cancer. Orthologous to human STK11 (serine/threonine kinase 11); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; mTOR signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: liver kinase B1 homolog; Lkb1; LOC314621; serine/threonine-protein kinase 11; serine/threonine-protein kinase LKB1; serine/threonine-protein kinase STK11
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,225,204 - 10,241,965 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl710,225,204 - 10,241,965 (-)EnsemblGRCr8
mRatBN7.279,574,553 - 9,591,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,575,269 - 9,591,315 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx712,457,505 - 12,474,280 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,332,844 - 14,349,619 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,193,941 - 12,210,702 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,440,751 - 12,457,513 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,440,751 - 12,457,513 (-)Ensemblrn6Rnor6.0
Rnor_5.0712,610,856 - 12,627,616 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4711,086,760 - 11,103,522 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera77,750,545 - 7,767,310 (-)NCBICelera
RGSC_v3.1711,089,427 - 11,103,113 (-)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
adenocarcinoma  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
bile duct cancer  (ISO)
brain cancer  (ISO)
Brain Neoplasms  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Cardiomegaly  (ISO)
cervical mucinous adenocarcinoma  (ISO)
colon carcinoma  (ISO)
Cronkhite-Canada syndrome  (ISO)
Distal Arthrogryposis, with Impaired Proprioception and Touch  (ISO)
dysplastic nevus syndrome  (ISO)
embryonal rhabdomyosarcoma  (ISO)
endometrial cancer  (ISO,ISS)
endometrial carcinoma  (ISO)
familial adenomatous polyposis  (ISO)
familial adenomatous polyposis 1  (ISO)
familial adenomatous polyposis 2  (ISO)
familial melanoma  (ISO)
Familial Pancreatic Carcinoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatoblastoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hypertension  (ISO)
hyperthyroidism  (IEP)
Insulin Resistance  (IEP)
juvenile polyposis syndrome  (ISO)
Left Ventricular Hypertrophy  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
Marfanoid Mental Retardation Syndrome, Autosomal  (ISO)
melanoma  (ISO)
multiple endocrine neoplasia type 1  (ISO)
obesity  (IEP)
ovarian cancer  (ISO)
ovarian carcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISO)
pancreatic ductal carcinoma  (ISO)
Peutz-Jeghers syndrome  (ISO,ISS)
prostate carcinoma in situ  (ISO)
skin melanoma  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
testicular cancer  (ISO)
testicular germ cell cancer  (ISO)
Testicular Germ Cell Tumor  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-acanthoic acid  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-deoxy-D-glucose  (ISO)
3',5'-cyclic GMP  (ISO)
3-aminobenzamide  (ISO)
3-bromopyruvic acid  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (EXP)
5-methyltetrahydrofolic acid  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (ISO)
amitrole  (EXP)
Ammothamnine  (EXP)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
ATP  (ISO)
bafilomycin A1  (ISO)
benzo[a]pyrene  (ISO)
berberine  (EXP)
beta-ionone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
chenodeoxycholic acid  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
corosolic acid  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
deoxycholic acid  (EXP)
deoxypodophyllotoxin  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (ISO)
diosgenin  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
fenofibrate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formononetin  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
Gastrodin  (ISO)
geldanamycin  (ISO)
ginsenoside Re  (ISO)
ginsenoside Rg2  (ISO)
glucose  (ISO)
hexadecanoic acid  (ISO)
histamine  (ISO)
ionomycin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoprenaline  (EXP)
L-methionine  (ISO)
lactacystin  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
lonidamine  (ISO)
maslinic acid  (ISO)
mechlorethamine  (ISO)
metformin  (EXP,ISO)
methimazole  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
oleanolic acid  (ISO)
oleic acid  (EXP)
orotic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
Picroside ii  (ISO)
pioglitazone  (ISO)
pterostilbene  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
rubimaillin  (ISO)
selenium atom  (ISO)
sertraline  (ISO)
silicon atom  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sucrose  (EXP)
tamoxifen  (ISO)
thymoquinone  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
U-73122  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (ISO,ISS)
anoikis  (ISO)
apoptotic process  (IEA)
autophagy  (IEA)
axonogenesis  (IMP,ISO)
cell differentiation  (IEA)
cellular response to UV-B  (ISO)
dendrite extension  (ISO)
DNA damage response  (IBA,IEA,ISO)
establishment of cell polarity  (IBA,IEA,IMP,ISO,ISS)
G1 to G0 transition  (ISO)
glucose homeostasis  (IEA,ISO,ISS)
Golgi localization  (ISO)
intrinsic apoptotic signaling pathway by p53 class mediator  (ISO,ISS)
negative regulation of canonical Wnt signaling pathway  (ISO,ISS)
negative regulation of cell growth  (ISO,ISS)
negative regulation of cell population proliferation  (ISO)
negative regulation of cold-induced thermogenesis  (ISO,ISS)
negative regulation of epithelial cell proliferation involved in prostate gland development  (ISO)
negative regulation of TORC1 signaling  (ISO)
peptidyl-threonine phosphorylation  (ISO)
positive regulation of autophagy  (ISO)
positive regulation of axonogenesis  (ISO)
positive regulation of cellular senescence  (ISO)
positive regulation of gluconeogenesis  (IMP)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (ISO)
positive regulation of vesicle transport along microtubule  (IBA,IEA,IMP,ISO)
positive thymic T cell selection  (ISO)
protein autophosphorylation  (ISO,ISS)
protein dephosphorylation  (ISO,ISS)
protein phosphorylation  (ISO)
regulation of cell growth  (IEA,ISO,ISS)
regulation of dendrite morphogenesis  (ISO)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
regulation of Wnt signaling pathway  (IBA,ISO)
response to activity  (IEP)
response to glucagon  (IEP)
response to ionizing radiation  (ISO,ISS)
response to lipid  (IDA)
response to peptide hormone  (IEP)
response to thyroid hormone  (IEP)
signal transduction  (IBA)
spermatid development  (ISO)
spermatogenesis  (IEA)
T cell receptor signaling pathway  (ISO)
tissue homeostasis  (ISO)
vasculature development  (ISO,ISS)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Liver Kinase B1 complex acts as a novel modifier of myofilament function and localizes to the Z-disk in cardiac myocytes. Behunin SM, etal., Arch Biochem Biophys. 2016 Jul 1;601:32-41. doi: 10.1016/j.abb.2016.03.012. Epub 2016 Mar 10.
2. Thyroid hormone effects on LKB1, MO25, phospho-AMPK, phospho-CREB, and PGC-1alpha in rat muscle. Branvold DJ, etal., J Appl Physiol (1985). 2008 Oct;105(4):1218-27. doi: 10.1152/japplphysiol.00997.2007. Epub 2008 Jul 31.
3. Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas. Contreras CM, etal., Cancer Res. 2008 Feb 1;68(3):759-66.
4. Identification of transmembrane proteins as potential prognostic markers and therapeutic targets in breast cancer by a screen for signal sequence encoding transcripts. Esseghir S, etal., J Pathol. 2006 Dec;210(4):420-30.
5. LKB1 protein expression in human breast cancer. Fenton H, etal., Appl Immunohistochem Mol Morphol. 2006 Jun;14(2):146-53.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. The AMP-activated protein kinase pathway--new players upstream and downstream. Hardie DG J Cell Sci. 2004 Nov 1;117(Pt 23):5479-87.
9. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. Hawley SA, etal., J Biol. 2003;2(4):28. Epub 2003 Sep 24.
10. LKB1/AMPK and PKA control ABCB11 trafficking and polarization in hepatocytes. Homolya L, etal., PLoS One. 2014 Mar 18;9(3):e91921. doi: 10.1371/journal.pone.0091921. eCollection 2014.
11. LKB1, an upstream AMPK kinase, regulates glucose and lipid metabolism in cultured liver and muscle cells. Imai K, etal., Biochem Biophys Res Commun. 2006 Dec 22;351(3):595-601. Epub 2006 Oct 18.
12. Glucagon represses signaling through the mammalian target of rapamycin in rat liver by activating AMP-activated protein kinase. Kimball SR, etal., J Biol Chem. 2004 Dec 24;279(52):54103-9. Epub 2004 Oct 19.
13. Mutations in the STK11 gene characterize minimal deviation adenocarcinoma of the uterine cervix. Kuragaki C, etal., Lab Invest. 2003 Jan;83(1):35-45.
14. Peutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling. Lin-Marq N, etal., Mol Genet Genomics. 2005 Apr;273(2):184-96. doi: 10.1007/s00438-005-1124-y. Epub 2005 Feb 25.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Mutational analysis of STK11 gene in ovarian carcinomas. Nishioka Y, etal., Jpn J Cancer Res. 1999 Jun;90(6):629-32.
17. Expression of an active LKB1 complex in cardiac myocytes results in decreased protein synthesis associated with phenylephrine-induced hypertrophy. Noga AA, etal., Am J Physiol Heart Circ Physiol. 2007 Mar;292(3):H1460-9. Epub 2006 Nov 10.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. Lkb1 deficiency causes prostate neoplasia in the mouse. Pearson HB, etal., Cancer Res. 2008 Apr 1;68(7):2223-32.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3. Shan T, etal., Nat Commun. 2016 Jul 27;7:12205. doi: 10.1038/ncomms12205.
24. The tumor suppressor gene LKB1 is associated with prognosis in human breast carcinoma. Shen Z, etal., Clin Cancer Res. 2002 Jul;8(7):2085-90.
25. LKB1-AMPK signaling in muscle from obese insulin-resistant Zucker rats and effects of training. Sriwijitkamol A, etal., Am J Physiol Endocrinol Metab. 2006 May;290(5):E925-32. Epub 2005 Dec 13.
26. Endurance training increases LKB1 and MO25 protein but not AMP-activated protein kinase kinase activity in skeletal muscle. Taylor EB, etal., Am J Physiol Endocrinol Metab. 2004 Dec;287(6):E1082-9. doi: 10.1152/ajpendo.00179.2004. Epub 2004 Aug 3.
27. Fatty acids stimulate AMP-activated protein kinase and enhance fatty acid oxidation in L6 myotubes. Watt MJ, etal., J Physiol. 2006 Jul 1;574(Pt 1):139-47. Epub 2006 Apr 27.
Additional References at PubMed
PMID:8910387   PMID:10400995   PMID:11297520   PMID:11430832   PMID:11509733   PMID:11741830   PMID:11853558   PMID:12234250   PMID:12489981   PMID:12805220   PMID:15068958   PMID:16014350  
PMID:16308421   PMID:16428351   PMID:17216128   PMID:17244606   PMID:17482548   PMID:17482549   PMID:18063812   PMID:18311138   PMID:18562309   PMID:18687677   PMID:18774945   PMID:18854309  
PMID:19056867   PMID:19622832   PMID:19892943   PMID:19937189   PMID:20142099   PMID:20203304   PMID:20826460   PMID:21111240   PMID:21378336   PMID:21487392   PMID:21872575   PMID:21994947  
PMID:22124463   PMID:22172813   PMID:23653212   PMID:23831466   PMID:23878245   PMID:24295069   PMID:24367100   PMID:24768298   PMID:25329316   PMID:26167077   PMID:26924458   PMID:27235551  
PMID:29740932   PMID:30198433   PMID:31181335   PMID:31939452   PMID:32900241   PMID:35311465   PMID:38105470  


Genomics

Comparative Map Data
Stk11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,225,204 - 10,241,965 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl710,225,204 - 10,241,965 (-)EnsemblGRCr8
mRatBN7.279,574,553 - 9,591,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,575,269 - 9,591,315 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx712,457,505 - 12,474,280 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,332,844 - 14,349,619 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,193,941 - 12,210,702 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,440,751 - 12,457,513 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,440,751 - 12,457,513 (-)Ensemblrn6Rnor6.0
Rnor_5.0712,610,856 - 12,627,616 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4711,086,760 - 11,103,522 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera77,750,545 - 7,767,310 (-)NCBICelera
RGSC_v3.1711,089,427 - 11,103,113 (-)NCBI
Cytogenetic Map7q11NCBI
STK11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38191,205,778 - 1,228,431 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl191,177,558 - 1,228,431 (+)Ensemblhg38GRCh38
GRCh37191,205,777 - 1,228,430 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,156,798 - 1,179,434 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34191,156,797 - 1,179,434NCBI
Celera191,140,029 - 1,162,667 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19981,572 - 1,004,116 (+)NCBIHuRef
CHM1_1191,205,350 - 1,228,397 (+)NCBICHM1_1
T2T-CHM13v2.0191,174,325 - 1,196,989 (+)NCBIT2T-CHM13v2.0
Stk11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,951,602 - 79,966,513 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,951,637 - 79,966,516 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381080,115,767 - 80,130,679 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,115,803 - 80,130,682 (+)Ensemblmm10GRCm38
MGSCv371079,579,281 - 79,593,215 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361079,519,331 - 79,533,808 (+)NCBIMGSCv36mm8
Celera1081,131,368 - 81,145,302 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Stk11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,678,195 - 6,699,058 (-)Ensembl
ChiLan1.0NW_0049554956,678,195 - 6,699,408 (-)NCBIChiLan1.0ChiLan1.0
STK11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,548,808 - 5,570,145 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,784,506 - 4,806,946 (+)NCBINHGRI_mPanPan1
PanPan1.1191,188,537 - 1,210,677 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl191,188,537 - 1,210,677 (+)EnsemblpanPan2panpan1.1
STK11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,558,966 - 57,579,163 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,559,424 - 57,579,118 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2057,361,634 - 57,381,897 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02058,301,527 - 58,321,790 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,301,538 - 58,321,845 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,357,343 - 57,377,554 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,836,582 - 57,856,814 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,039,595 - 58,059,787 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Stk11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,234,125 - 217,254,944 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588579,816 - 603,654 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936588579,816 - 601,033 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STK11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,230,372 - 77,249,327 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1277,229,888 - 77,249,322 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,814,541 - 77,823,643 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STK11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16973,033 - 996,857 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl6974,144 - 995,136 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660817,866,551 - 7,890,682 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stk11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,445,069 - 7,467,298 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248287,444,339 - 7,466,926 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Stk11
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11154,744,704 - 154,760,762 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Stk11
231 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:154
Count of miRNA genes:113
Interacting mature miRNAs:136
Transcripts:ENSRNOT00000060683
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000060683   ⟹   ENSRNOP00000057414
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl710,226,919 - 10,241,965 (-)Ensembl
mRatBN7.2 Ensembl79,575,269 - 9,591,315 (-)Ensembl
Rnor_6.0 Ensembl712,440,751 - 12,457,513 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000138015   ⟹   ENSRNOP00000109626
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl710,225,204 - 10,241,965 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000155773   ⟹   ENSRNOP00000102804
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl710,225,275 - 10,241,965 (-)Ensembl
RefSeq Acc Id: NM_001108069   ⟹   NP_001101539
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,225,204 - 10,241,965 (-)NCBI
mRatBN7.279,574,553 - 9,591,315 (-)NCBI
Rnor_6.0712,440,751 - 12,457,513 (-)NCBI
Rnor_5.0712,610,856 - 12,627,616 (-)NCBI
RGSC_v3.4711,086,760 - 11,103,522 (-)RGD
Celera77,750,545 - 7,767,310 (-)RGD
Sequence:
RefSeq Acc Id: XM_008765096   ⟹   XP_008763318
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,225,964 - 10,241,965 (-)NCBI
mRatBN7.279,575,315 - 9,591,310 (-)NCBI
Rnor_6.0712,441,513 - 12,457,508 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005486597
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,226,441 - 10,241,965 (-)NCBI
mRatBN7.279,575,315 - 9,591,310 (-)NCBI
RefSeq Acc Id: XR_010052966
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,225,964 - 10,241,965 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001101539 (Get FASTA)   NCBI Sequence Viewer  
  XP_008763318 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D4AE59 (Get FASTA)   NCBI Sequence Viewer  
  EDL89333 (Get FASTA)   NCBI Sequence Viewer  
  EDL89334 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000057414.4
  ENSRNOP00000109626
RefSeq Acc Id: NP_001101539   ⟸   NM_001108069
- UniProtKB: D4AE59 (UniProtKB/Swiss-Prot),   D4A179 (UniProtKB/Swiss-Prot),   A0A0H2UI02 (UniProtKB/TrEMBL),   A6K8R3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763318   ⟸   XM_008765096
- Peptide Label: isoform X1
- UniProtKB: D4AE59 (UniProtKB/Swiss-Prot),   D4A179 (UniProtKB/Swiss-Prot),   A0A0H2UI02 (UniProtKB/TrEMBL),   A6K8R3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000057414   ⟸   ENSRNOT00000060683
Ensembl Acc Id: ENSRNOP00000102804   ⟸   ENSRNOT00000155773
Ensembl Acc Id: ENSRNOP00000109626   ⟸   ENSRNOT00000138015
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AE59-F1-model_v2 AlphaFold D4AE59 1-436 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695034
Promoter ID:EPDNEW_R5558
Type:multiple initiation site
Name:Stk11_2
Description:serine/threonine kinase 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5559  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0712,456,921 - 12,456,981EPDNEW
RGD ID:13695035
Promoter ID:EPDNEW_R5559
Type:multiple initiation site
Name:Stk11_1
Description:serine/threonine kinase 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5558  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0712,457,512 - 12,457,572EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308653 AgrOrtholog
BioCyc Gene G2FUF-34916 BioCyc
Ensembl Genes ENSRNOG00000014287 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000060683 ENTREZGENE
  ENSRNOT00000060683.4 UniProtKB/Swiss-Prot
  ENSRNOT00000138015 ENTREZGENE
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  LKB1_c UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:314621 UniProtKB/Swiss-Prot
NCBI Gene 314621 ENTREZGENE
PANTHER MAP/MICROTUBULE AFFINITY-REGULATING KINASE UniProtKB/Swiss-Prot
  NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Stk11 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014287 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A0H2UI02 ENTREZGENE
  A0ABK0LLK9_RAT UniProtKB/TrEMBL
  A6K8R3 ENTREZGENE, UniProtKB/TrEMBL
  D4A179 ENTREZGENE
  D4AE59 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A0A0H2UI02 UniProtKB/Swiss-Prot
  D4A179 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Stk11  serine/threonine kinase 11   Stk11_predicted  serine/threonine kinase 11 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Stk11_predicted  serine/threonine kinase 11 (predicted)      Symbol and Name status set to approved 70820 APPROVED