Stk11 (serine/threonine kinase 11) - Rat Genome Database

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Pathways
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Gene: Stk11 (serine/threonine kinase 11) Ictidomys tridecemlineatus
Analyze
Symbol: Stk11
Name: serine/threonine kinase 11
RGD ID: 12488060
Description: ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN axonogenesis (ortholog); dendrite extension (ortholog); epithelial cell proliferation involved in prostate gland development (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); B-lymphoblastic leukemia/lymphoma (ortholog); bile duct cancer (ortholog); FOUND IN protein-containing complex (ortholog); serine/threonine protein kinase complex (ortholog); Z disc (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serine/threonine kinase 11, transcript variant X1; serine/threonine kinase 11, transcript variant X2; serine/threonine kinase 11, transcript variant X3; serine/threonine kinase 11, transcript variant X4; serine/threonine-protein kinase STK11
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,234,125 - 217,254,944 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588579,816 - 603,654 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588579,816 - 601,033 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adenocarcinoma  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
bile duct cancer  (ISO)
brain cancer  (ISO)
Brain Neoplasms  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Cardiomegaly  (ISO)
cerebral creatine deficiency syndrome  (ISO)
cervical mucinous adenocarcinoma  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
Cronkhite-Canada syndrome  (ISO)
cyclic hematopoiesis  (ISO)
disease of cellular proliferation  (ISO)
Distal Arthrogryposis, with Impaired Proprioception and Touch  (ISO)
dysplastic nevus syndrome  (ISO)
embryonal rhabdomyosarcoma  (ISO)
endometrial cancer  (ISO)
endometrial carcinoma  (ISO)
familial adenomatous polyposis  (ISO)
familial adenomatous polyposis 1  (ISO)
familial adenomatous polyposis 2  (ISO)
familial melanoma  (ISO)
genetic disease  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatoblastoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hypertension  (ISO)
hyperthyroidism  (ISO)
Insulin Resistance  (ISO)
juvenile polyposis syndrome  (ISO)
Left Ventricular Hypertrophy  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
Marfanoid Mental Retardation Syndrome, Autosomal  (ISO)
melanoma  (ISO)
multiple endocrine neoplasia type 1  (ISO)
obesity  (ISO)
ovarian cancer  (ISO)
ovarian carcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISO)
pancreatic ductal carcinoma  (ISO)
Pancreatic Neoplasms  (ISO)
Peutz-Jeghers syndrome  (ISO)
prostate carcinoma in situ  (ISO)
skin melanoma  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
testicular cancer  (ISO)
testicular germ cell cancer  (ISO)
Testicular Germ Cell Tumor  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anoikis  (IEA)
axonogenesis  (IEA,ISO)
cellular response to UV-B  (IEA)
dendrite extension  (IEA,ISO)
DNA damage response  (IEA)
epithelial cell proliferation involved in prostate gland development  (IEA,ISO)
establishment of cell polarity  (IEA)
G1 to G0 transition  (IEA,ISO)
glucose homeostasis  (IEA)
Golgi localization  (IEA,ISO)
intrinsic apoptotic signaling pathway by p53 class mediator  (IEA)
negative regulation of canonical Wnt signaling pathway  (IEA)
negative regulation of cell growth  (IEA)
negative regulation of cell population proliferation  (IEA)
negative regulation of cold-induced thermogenesis  (IEA)
negative regulation of epithelial cell proliferation involved in prostate gland development  (IEA,ISO)
negative regulation of TORC1 signaling  (IEA)
positive regulation of autophagy  (IEA)
positive regulation of axonogenesis  (IEA,ISO)
positive regulation of cellular senescence  (ISO)
positive regulation of gluconeogenesis  (ISO)
positive regulation of protein localization to nucleus  (IEA,ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (IEA)
positive regulation of vesicle transport along microtubule  (IEA)
positive thymic T cell selection  (IEA,ISO)
protein localization to nucleus  (IEA,ISO)
regulation of cell growth  (IEA)
regulation of dendrite morphogenesis  (IEA,ISO)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
regulation of Wnt signaling pathway  (IEA,ISO)
response to activity  (ISO)
response to glucagon  (ISO)
response to ionizing radiation  (IEA)
response to lipid  (ISO)
response to peptide hormone  (ISO)
response to thyroid hormone  (ISO)
signal transduction  (IEA)
spermatid development  (ISO)
T cell receptor signaling pathway  (IEA,ISO)
tissue homeostasis  (IEA,ISO)
vasculature development  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Stk11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,234,125 - 217,254,944 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588579,816 - 603,654 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588579,816 - 601,033 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STK11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38191,205,778 - 1,228,431 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl191,177,558 - 1,228,431 (+)EnsemblGRCh38hg38GRCh38
GRCh37191,205,777 - 1,228,430 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,156,798 - 1,179,434 (+)NCBINCBI36Build 36hg18NCBI36
Build 34191,156,797 - 1,179,434NCBI
Celera191,140,029 - 1,162,667 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19981,572 - 1,004,116 (+)NCBIHuRef
CHM1_1191,205,350 - 1,228,397 (+)NCBICHM1_1
T2T-CHM13v2.0191,174,325 - 1,196,989 (+)NCBIT2T-CHM13v2.0
Stk11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,951,602 - 79,966,513 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,951,637 - 79,966,516 (+)EnsemblGRCm39 Ensembl
GRCm381080,115,767 - 80,130,679 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,115,803 - 80,130,682 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,579,281 - 79,593,215 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,519,331 - 79,533,808 (+)NCBIMGSCv36mm8
Celera1081,131,368 - 81,145,302 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Stk11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,225,204 - 10,241,965 (-)NCBIGRCr8
mRatBN7.279,574,553 - 9,591,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,575,269 - 9,591,315 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,457,505 - 12,474,280 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,332,844 - 14,349,619 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,193,941 - 12,210,702 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,440,751 - 12,457,513 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,440,751 - 12,457,513 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,610,856 - 12,627,616 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,086,760 - 11,103,522 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,089,427 - 11,103,113 (-)NCBI
Celera77,750,545 - 7,767,310 (-)NCBICelera
Cytogenetic Map7q11NCBI
Stk11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,678,195 - 6,699,058 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554956,678,195 - 6,699,408 (-)NCBIChiLan1.0ChiLan1.0
STK11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,548,808 - 5,570,145 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,784,506 - 4,806,946 (+)NCBINHGRI_mPanPan1
PanPan1.1191,188,537 - 1,210,677 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl191,188,537 - 1,210,677 (+)Ensemblpanpan1.1panPan2
STK11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,558,966 - 57,579,163 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,559,424 - 57,579,118 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,361,634 - 57,381,897 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,301,527 - 58,321,790 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,301,538 - 58,321,845 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,357,343 - 57,377,554 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,836,582 - 57,856,814 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,039,595 - 58,059,787 (-)NCBIUU_Cfam_GSD_1.0
STK11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,230,372 - 77,249,327 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,229,888 - 77,249,322 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,814,541 - 77,823,643 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STK11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16973,033 - 996,857 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl6974,144 - 995,136 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660817,866,551 - 7,890,682 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stk11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,445,069 - 7,467,298 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248287,444,339 - 7,466,926 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000002615   ⟹   ENSSTOP00000002339
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936588579,816 - 603,654 (+)Ensembl
RefSeq Acc Id: XM_005331960   ⟹   XP_005332017
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118217,234,481 - 217,254,940 (-)NCBI
SpeTri2.0NW_004936588579,816 - 600,581 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013361472   ⟹   XP_013216926
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118217,234,125 - 217,254,944 (-)NCBI
SpeTri2.0NW_004936588579,816 - 601,033 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021730819   ⟹   XP_021586494
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118217,234,481 - 217,254,942 (-)NCBI
SpeTri2.0NW_004936588579,816 - 600,581 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040290768   ⟹   XP_040146702
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118217,234,125 - 217,254,944 (-)NCBI
RefSeq Acc Id: XM_040290769   ⟹   XP_040146703
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118217,234,478 - 217,254,944 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_013216926   ⟸   XM_013361472
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005332017   ⟸   XM_005331960
- Peptide Label: isoform X5
- UniProtKB: I3M0R8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021586494   ⟸   XM_021730819
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_040146702   ⟸   XM_040290768
- Peptide Label: isoform X1
RefSeq Acc Id: XP_040146703   ⟸   XM_040290769
- Peptide Label: isoform X3
RefSeq Acc Id: ENSSTOP00000002339   ⟸   ENSSTOT00000002615
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000002617 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000002615.3 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  LKB1_c UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Stk11 ENTREZGENE
PANTHER CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE STK11 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt I3M0R8 ENTREZGENE, UniProtKB/TrEMBL