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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308653
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stk11
Name: serine/threonine kinase 11
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stk11decreases expressionISOStk11 (Mus musculus)6480464CTDEthanol results in decreased expression of STK11 protein; Ethanol results in decreased expression of STK11 protein modified formPMID:27688165
Stk11decreases phosphorylationISOStk11 (Mus musculus)6480464CTDEthanol results in decreased phosphorylation of STK11 proteinPMID:28964808
Stk11multiple interactionsISOStk11 (Mus musculus)6480464CTDacanthoic acid inhibits the reaction [Ethanol results in decreased phosphorylation of STK11 protein]; thymoquinone inhibits the reaction [Ethanol results in decreased expression of STK11 protein modified form]; thymoquinone inhibits the reaction [Ethanol results in decreased expression of STK11 protein]PMID:27688165 PMID:28964808
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