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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308653
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stk11
Name: serine/threonine kinase 11
Acc ID: CHEBI:32585
Term: 4-hydroxynon-2-enal
Definition: An enal consisting of non-2-ene having an oxo group at the 1-position and a hydroxy group at the 4-position.
Chemical ID: MESH:C027576
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stk11affects bindingEXP 6480464CTD4-hydroxy-2-nonenal binds to STK11 proteinPMID:19289642
Stk11decreases activityEXP 6480464CTD4-hydroxy-2-nonenal results in decreased activity of STK11 proteinPMID:19289642
Stk11decreases expressionEXP 6480464CTD4-hydroxy-2-nonenal results in decreased expression of STK11 protein; 4-hydroxy-2-nonenal results in decreased expression of STK11 protein modified formPMID:19289642
Stk11multiple interactionsEXP 6480464CTDresveratrol inhibits the reaction [4-hydroxy-2-nonenal binds to STK11 protein]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased activity of STK11 protein]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of STK11 protein modified form]PMID:19289642
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