Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Pard6b | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Pard6b (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of PARD6B mRNA | CTD | PMID:22206623 | Pard6b | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | PARD6B (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PARD6B mRNA | CTD | PMID:22298810 | Pard6b | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PARD6B mRNA | CTD | PMID:33387578 | Pard6b | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Pard6b (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PARD6B mRNA | CTD | PMID:21570461 | Pard6b | Rat | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of PARD6B mRNA | CTD | PMID:21346803 | Pard6b | Rat | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 6-dinitrotoluene affects the expression of PARD6B mRNA | CTD | PMID:21346803 | Pard6b | Rat | 2-hydroxypropanoic acid | decreases expression | ISO | PARD6B (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of PARD6B mRNA | CTD | PMID:30851411 | Pard6b | Rat | 3-chloropropane-1,2-diol | increases expression | EXP | | 6480464 | alpha-Chlorohydrin results in increased expression of PARD6B protein | CTD | PMID:34915118 | Pard6b | Rat | 3-methylcholanthrene | decreases expression | ISO | Pard6b (Mus musculus) | 6480464 | Methylcholanthrene results in decreased expression of PARD6B mRNA | CTD | PMID:20713471 | Pard6b | Rat | 3-methylcholanthrene | multiple interactions | ISO | Pard6b (Mus musculus) | 6480464 | [Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PARD6B mRNA | CTD | PMID:23519560 | Pard6b | Rat | 4-hydroxyphenyl retinamide | decreases expression | ISO | Pard6b (Mus musculus) | 6480464 | Fenretinide results in decreased expression of PARD6B mRNA | CTD | PMID:28973697 | Pard6b | Rat | 4-hydroxyphenyl retinamide | increases expression | ISO | Pard6b (Mus musculus) | 6480464 | Fenretinide results in increased expression of PARD6B mRNA | CTD | PMID:28973697 | Pard6b | Rat | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of PARD6B mRNA | CTD | PMID:30047161 | Pard6b | Rat | acrolein | multiple interactions | ISO | PARD6B (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of PARD6B mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of PARD6B mRNA | CTD | PMID:32699268 | Pard6b | Rat | acrylamide | increases expression | ISO | PARD6B (Homo sapiens) | 6480464 | Acrylamide results in increased expression of PARD6B mRNA | CTD | PMID:32763439 | Pard6b | Rat | aflatoxin B1 | increases methylation | ISO | PARD6B (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of PARD6B gene | CTD | PMID:27153756 | Pard6b | Rat | all-trans-retinoic acid | increases expression | ISO | PARD6B (Homo sapiens) | 6480464 | Tretinoin results in increased expression of PARD6B mRNA | CTD | PMID:33167477 | Pard6b | Rat | alpha-pinene | multiple interactions | ISO | PARD6B (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of PARD6B mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of PARD6B mRNA | CTD | PMID:32699268 | Pard6b | Rat | amitrole | increases expression | EXP | | 6480464 | Amitrole results in increased expression of PARD6B mRNA | CTD | PMID:30047161 | Pard6b | Rat | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of PARD6B mRNA | CTD | PMID:30779732 | Pard6b | Rat | amphotericin B | increases expression | ISO | PARD6B (Homo sapiens) | 6480464 | Amphotericin B analog results in increased expression of PARD6B mRNA | CTD | PMID:28534445 | Pard6b | Rat | aristolochic acid A | decreases expression | ISO | PARD6B (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of PARD6B mRNA | CTD | PMID:33212167 | Pard6b | Rat | benzo[a]pyrene | increases expression | ISO | PARD6B (Homo sapiens) | 6480464 | Benzo(a)pyrene metabolite results in increased expression of PARD6B mRNA more ... | CTD | PMID:26238291 more ... | Pard6b | Rat | benzo[a]pyrene | affects methylation | ISO | PARD6B (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of PARD6B promoter | CTD | PMID:27901495 | Pard6b | Rat | benzo[a]pyrene diol epoxide I | increases expression | ISO | PARD6B (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:26238291 | Pard6b | Rat | bisphenol A | decreases expression | ISO | Pard6b (Mus musculus) | 6480464 | bisphenol A results in decreased expression of PARD6B mRNA | CTD | PMID:26063408 | Pard6b | Rat | bisphenol A | increases expression | ISO | PARD6B (Homo sapiens) | 6480464 | bisphenol A results in increased expression of PARD6B mRNA | CTD | PMID:36232920 | Pard6b | Rat | bisphenol A | increases expression | ISO | Pard6b (Mus musculus) | 6480464 | bisphenol A results in increased expression of PARD6B mRNA | CTD | PMID:32156529 and PMID:33221593 | Pard6b | Rat | bisphenol A | decreases methylation | ISO | Pard6b (Mus musculus) | 6480464 | bisphenol A results in decreased methylation of PARD6B promoter | CTD | PMID:27312807 | Pard6b | Rat | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of PARD6B gene | CTD | PMID:28505145 | Pard6b | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of PARD6B mRNA | CTD | PMID:25181051 | Pard6b | Rat | bisphenol F | increases expression | ISO | Pard6b (Mus musculus) | 6480464 | bisphenol F results in increased expression of PARD6B mRNA | CTD | PMID:38685157 | Pard6b | Rat | caffeine | increases phosphorylation | ISO | PARD6B (Homo sapiens) | 6480464 | Caffeine results in increased phosphorylation of PARD6B protein | CTD | PMID:35688186 | Pard6b | Rat | CGP 52608 | multiple interactions | ISO | PARD6B (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to PARD6B gene] | CTD | PMID:28238834 | Pard6b | Rat | chlorpyrifos | increases expression | ISO | Pard6b (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of PARD6B mRNA | CTD | PMID:37019170 | Pard6b | Rat | cobalt dichloride | increases expression | ISO | PARD6B (Homo sapiens) | 6480464 | cobaltous chloride results in increased expression of PARD6B mRNA | CTD | PMID:26314263 | Pard6b | Rat | copper atom | multiple interactions | ISO | PARD6B (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of PARD6B mRNA | CTD | PMID:20971185 | Pard6b | Rat | copper(0) | multiple interactions | ISO | PARD6B (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of PARD6B mRNA | CTD | PMID:20971185 | Pard6b | Rat | copper(II) sulfate | increases expression | ISO | PARD6B (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of PARD6B mRNA | CTD | PMID:19549813 | Pard6b | Rat | Dibutyl phosphate | affects expression | ISO | PARD6B (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of PARD6B mRNA | CTD | PMID:37042841 | Pard6b | Rat | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of PARD6B mRNA | CTD | PMID:21266533 | Pard6b | Rat | diuron | increases expression | EXP | | 6480464 | Diuron results in increased expression of PARD6B mRNA | CTD | PMID:21551480 | Pard6b | Rat | diuron | decreases expression | ISO | PARD6B (Homo sapiens) | 6480464 | Diuron results in decreased expression of PARD6B mRNA | CTD | PMID:35967413 | Pard6b | Rat | dorsomorphin | multiple interactions | ISO | PARD6B (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Pard6b | Rat | formaldehyde | increases expression | ISO | PARD6B (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of PARD6B mRNA | CTD | PMID:23649840 | Pard6b | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of PARD6B mRNA | CTD | PMID:33387578 | Pard6b | Rat | indole-3-methanol | multiple interactions | EXP | | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of PARD6B mRNA | CTD | PMID:22129741 | Pard6b | Rat | ivermectin | decreases expression | ISO | PARD6B (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of PARD6B protein | CTD | PMID:32959892 | Pard6b | Rat | leflunomide | increases expression | ISO | PARD6B (Homo sapiens) | 6480464 | leflunomide results in increased expression of PARD6B mRNA | CTD | PMID:28988120 | Pard6b | Rat | levonorgestrel | multiple interactions | ISO | PARD6B (Homo sapiens) | 6480464 | [testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of PARD6B mRNA | CTD | PMID:19074003 | Pard6b | Rat | methapyrilene | increases expression | EXP | | 6480464 | Methapyrilene results in increased expression of PARD6B mRNA | CTD | PMID:30467583 | Pard6b | Rat | methimazole | increases expression | EXP | | 6480464 | Methimazole results in increased expression of PARD6B mRNA | CTD | PMID:30047161 | Pard6b | Rat | methylisothiazolinone | increases expression | ISO | PARD6B (Homo sapiens) | 6480464 | 2-methyl-4-isothiazolin-3-one results in increased expression of PARD6B mRNA | CTD | PMID:31629900 | Pard6b | Rat | methylmercury chloride | decreases expression | ISO | PARD6B (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of PARD6B mRNA | CTD | PMID:23179753 | Pard6b | Rat | methylmercury(1+) | increases expression | ISO | PARD6B (Homo sapiens) | 6480464 | methylmercury II results in increased expression of PARD6B mRNA | CTD | PMID:26314263 | Pard6b | Rat | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of PARD6B mRNA | CTD | PMID:22129741 | Pard6b | Rat | ochratoxin A | increases expression | ISO | PARD6B (Homo sapiens) | 6480464 | ochratoxin A metabolite results in increased expression of PARD6B mRNA and ochratoxin A results in increased expression of PARD6B mRNA | CTD | PMID:26314263 | Pard6b | Rat | ochratoxin A | decreases expression | ISO | PARD6B (Homo sapiens) | 6480464 | ochratoxin A results in decreased expression of PARD6B mRNA | CTD | PMID:30763683 | Pard6b | Rat | ozone | multiple interactions | ISO | PARD6B (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of PARD6B mRNA more ... | CTD | PMID:32699268 and PMID:35430440 | Pard6b | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of PARD6B mRNA | CTD | PMID:33387578 | Pard6b | Rat | pentachlorophenol | increases expression | ISO | Pard6b (Mus musculus) | 6480464 | Pentachlorophenol results in increased expression of PARD6B mRNA | CTD | PMID:23892564 | Pard6b | Rat | phorbol 13-acetate 12-myristate | multiple interactions | ISO | Pard6b (Mus musculus) | 6480464 | [Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PARD6B mRNA | CTD | PMID:23519560 | Pard6b | Rat | potassium dichromate | decreases expression | ISO | Pard6b (Mus musculus) | 6480464 | Potassium Dichromate results in decreased expression of PARD6B mRNA | CTD | PMID:23608068 | Pard6b | Rat | rac-lactic acid | decreases expression | ISO | PARD6B (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of PARD6B mRNA | CTD | PMID:30851411 | Pard6b | Rat | rotenone | increases expression | ISO | Pard6b (Mus musculus) | 6480464 | Rotenone results in increased expression of PARD6B mRNA | CTD | PMID:32937126 | Pard6b | Rat | SB 431542 | multiple interactions | ISO | PARD6B (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Pard6b | Rat | silicon dioxide | increases expression | ISO | Pard6b (Mus musculus) | 6480464 | Silicon Dioxide results in increased expression of PARD6B mRNA | CTD | PMID:19073995 and PMID:33720480 | Pard6b | Rat | silver atom | increases expression | ISO | PARD6B (Homo sapiens) | 6480464 | Silver results in increased expression of PARD6B mRNA | CTD | PMID:26014281 | Pard6b | Rat | silver(0) | increases expression | ISO | PARD6B (Homo sapiens) | 6480464 | Silver results in increased expression of PARD6B mRNA | CTD | PMID:26014281 | Pard6b | Rat | sodium arsenite | decreases expression | ISO | Pard6b (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of PARD6B mRNA | CTD | PMID:37682722 | Pard6b | Rat | sulfadimethoxine | increases expression | EXP | | 6480464 | Sulfadimethoxine results in increased expression of PARD6B mRNA | CTD | PMID:30047161 | Pard6b | Rat | sunitinib | decreases expression | ISO | PARD6B (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of PARD6B mRNA | CTD | PMID:31533062 | Pard6b | Rat | testosterone undecanoate | multiple interactions | ISO | PARD6B (Homo sapiens) | 6480464 | [testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of PARD6B mRNA | CTD | PMID:19074003 | Pard6b | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of PARD6B mRNA | CTD | PMID:34492290 | Pard6b | Rat | titanium dioxide | decreases methylation | ISO | Pard6b (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of PARD6B gene and titanium dioxide results in decreased methylation of PARD6B promoter | CTD | PMID:35295148 | Pard6b | Rat | titanium dioxide | increases methylation | ISO | Pard6b (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of PARD6B promoter | CTD | PMID:35295148 | Pard6b | Rat | titanium dioxide | increases expression | ISO | Pard6b (Mus musculus) | 6480464 | titanium dioxide results in increased expression of PARD6B mRNA | CTD | PMID:35295148 | Pard6b | Rat | tributylstannane | increases expression | ISO | PARD6B (Homo sapiens) | 6480464 | tributyltin results in increased expression of PARD6B mRNA | CTD | PMID:26314263 | Pard6b | Rat | Tributyltin oxide | increases expression | ISO | PARD6B (Homo sapiens) | 6480464 | bis(tri-n-butyltin)oxide results in increased expression of PARD6B mRNA | CTD | PMID:26314263 | Pard6b | Rat | trichostatin A | decreases expression | ISO | PARD6B (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of PARD6B mRNA | CTD | PMID:24935251 and PMID:26272509 | Pard6b | Rat | trichostatin A | multiple interactions | ISO | PARD6B (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PARD6B mRNA | CTD | PMID:27188386 | Pard6b | Rat | triclosan | increases expression | ISO | PARD6B (Homo sapiens) | 6480464 | Triclosan results in increased expression of PARD6B mRNA | CTD | PMID:30510588 | Pard6b | Rat | valproic acid | affects expression | ISO | Pard6b (Mus musculus) | 6480464 | Valproic Acid affects the expression of PARD6B mRNA | CTD | PMID:17963808 | Pard6b | Rat | valproic acid | multiple interactions | ISO | PARD6B (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PARD6B mRNA | CTD | PMID:27188386 | Pard6b | Rat | valproic acid | decreases expression | ISO | PARD6B (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of PARD6B mRNA | CTD | PMID:26272509 | Pard6b | Rat | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of PARD6B mRNA | CTD | PMID:19015723 | |