Krt14 (keratin 14) - Rat Genome Database

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Gene: Krt14 (keratin 14) Rattus norvegicus
Analyze
Symbol: Krt14 (Ensembl: Ka11)
Name: keratin 14 (Ensembl:type I keratin KA11)
RGD ID: 1307463
Description: Predicted to enable keratin filament binding activity. Predicted to be a structural constituent of skin epidermis. Involved in epithelial cell differentiation; response to ionizing radiation; and response to zinc ion. Located in keratin filament. Biomarker of esophagus small cell carcinoma. Human ortholog(s) of this gene implicated in Naegeli-Franceschetti-Jadassohn syndrome; dermatopathia pigmentosa reticularis; and epidermolysis bullosa simplex. Orthologous to human KRT14 (keratin 14); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CK-14; cytokeratin-14; K14; Ka14; keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner); keratin 14, type I; keratin complex 1, acidic, gene 14; keratin, type I cytoskeletal 14; keratin-14; Krt1-14; LOC287701; type I keratin Ka14
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81085,638,182 - 85,642,450 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.21085,137,786 - 85,142,054 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,066,802 - 85,171,799 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1090,155,919 - 90,159,989 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01089,654,291 - 89,658,349 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,046,229 - 85,050,287 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,118,029 - 88,122,233 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,055,823 - 88,122,233 (-)Ensemblrn6Rnor6.0
Rnor_5.01087,910,658 - 87,914,716 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41089,144,357 - 89,148,415 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1083,857,265 - 83,861,323 (-)NCBICelera
RGSC_v3.11089,158,726 - 89,162,785 (-)NCBI
Cytogenetic Map10q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dimethoxyphenol  (ISO)
2-acetamidofluorene  (EXP)
2-nitroanisole  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-Amino-2-nitrophenol  (EXP)
9-cis-retinoic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
aristolochic acids  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
calcidiol  (EXP)
chlordecone  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dimethylarsinic acid  (EXP)
Disperse Blue 1  (EXP)
diuron  (EXP)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
fenamic acid  (EXP)
folic acid  (ISO)
furan  (EXP)
furfural  (ISO)
genistein  (ISO)
glycidyl methacrylate  (ISO)
graphite  (ISO)
indole-3-methanol  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
lead nitrate  (ISO)
lead(0)  (ISO)
malathion  (ISO)
melamine  (EXP)
methamphetamine  (ISO)
methimazole  (EXP)
N,N-bis(2-hydroxypropyl)nitrosamine  (EXP)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nickel atom  (ISO)
para-Cresidine  (EXP)
paracetamol  (EXP)
pentane-2,3-dione  (ISO)
perfluorododecanoic acid  (EXP)
phenethyl isothiocyanate  (EXP)
phenobarbital  (EXP)
phenyl isocyanate  (ISO)
phenylbutazone  (EXP)
resveratrol  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
sulindac sulfide  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
triadimefon  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
troglitazone  (ISO)
uracil  (EXP)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Spontaneous metastasis of rat liver epithelial cells transformed with v-raf and v-raf/v-myc: association with different phenotypic properties. Bisgaard HC, etal., Invasion Metastasis. 1997;17(5):240-50.
2. The action of a dietary retinoid on gene expression and cancer induction in electron-irradiated rat skin. Burns FJ, etal., J Radiat Res (Tokyo). 2002 Dec;43 Suppl:S229-32.
3. Point mutations in human keratin 14 genes of epidermolysis bullosa simplex patients: genetic and functional analyses. Coulombe PA, etal., Cell. 1991 Sep 20;66(6):1301-11.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Immunohistochemical expression of keratins 13 and 14 in the lingual epithelium of rats during the morphogenesis of filiform papillae. Iwasaki S, etal., Arch Oral Biol. 2006 May;51(5):416-26. Epub 2005 Nov 4.
7. Transgenic rats overexpressing the human MrgX3 gene show cataracts and an abnormal skin phenotype. Kaisho Y, etal., Biochem Biophys Res Commun. 2005 May 13;330(3):653-7.
8. Modulation of gene expression in precancerous rat esophagus by dietary zinc deficit and replenishment. Liu CG, etal., Cancer Res. 2005 Sep 1;65(17):7790-9.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Immunohistochemistry of myoepithelial cells during development of the rat salivary glands. Ogawa Y, etal., Anat Embryol (Berl). 1999 Aug;200(2):215-28.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Identification of cytokeratin subspecies altered in rat experimental esophageal tumors by subtractive cloning. Wang DY, etal., Cancer Lett 1996 Nov 12;108(1):119-27.
Additional References at PubMed
PMID:7679677   PMID:10852826   PMID:11698679   PMID:11724817   PMID:14673151   PMID:15057822   PMID:15085952   PMID:16489008   PMID:16682203   PMID:17960487   PMID:18262229   PMID:18692037  
PMID:19199708   PMID:19303854   PMID:19487454   PMID:20346438   PMID:21464233   PMID:21630459   PMID:21916889   PMID:23284756   PMID:23599337   PMID:26956522  


Genomics

Comparative Map Data
Krt14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81085,638,182 - 85,642,450 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.21085,137,786 - 85,142,054 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,066,802 - 85,171,799 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1090,155,919 - 90,159,989 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01089,654,291 - 89,658,349 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,046,229 - 85,050,287 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,118,029 - 88,122,233 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,055,823 - 88,122,233 (-)Ensemblrn6Rnor6.0
Rnor_5.01087,910,658 - 87,914,716 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41089,144,357 - 89,148,415 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1083,857,265 - 83,861,323 (-)NCBICelera
RGSC_v3.11089,158,726 - 89,162,785 (-)NCBI
Cytogenetic Map10q31NCBI
KRT14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381741,582,279 - 41,586,895 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1741,582,279 - 41,586,895 (-)Ensemblhg38GRCh38
GRCh371739,738,531 - 39,743,147 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361736,992,059 - 36,996,673 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341736,992,058 - 36,996,673NCBI
Celera1736,391,486 - 36,396,102 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1735,501,649 - 35,506,252 (-)NCBIHuRef
CHM1_11739,973,838 - 39,978,454 (-)NCBICHM1_1
T2T-CHM13v2.01742,437,869 - 42,442,485 (-)NCBIT2T-CHM13v2.0
Krt14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,093,988 - 100,098,336 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11100,093,988 - 100,098,374 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3811100,203,162 - 100,207,510 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,203,162 - 100,207,548 (-)Ensemblmm10GRCm38
MGSCv3711100,064,476 - 100,068,824 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611100,019,252 - 100,023,600 (-)NCBIMGSCv36mm8
Celera11110,819,617 - 110,823,965 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.43NCBI
LOC100975309
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21923,398,101 - 23,402,706 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11725,288,234 - 25,292,839 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01715,730,066 - 15,734,665 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11715,948,570 - 15,953,191 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,948,596 - 15,953,191 (+)EnsemblpanPan2panpan1.1
KRT14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1921,190,672 - 21,195,060 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl921,156,045 - 21,265,564 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha920,652,119 - 20,656,507 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0921,911,274 - 21,915,662 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1920,697,290 - 20,701,678 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,963,294 - 20,967,682 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0921,067,094 - 21,071,483 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC110255312
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1221,074,850 - 21,079,391 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11221,074,965 - 21,079,393 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KRT14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11664,654,988 - 64,660,327 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1664,655,807 - 64,660,319 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607735,500,284 - 35,505,086 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Krt14
19 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:120
Count of miRNA genes:90
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000005285
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108101207791729860Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108306123692869129Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
724516Uae17Urinary albumin excretion QTL 173.6urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)107870758585720738Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108450348796432422Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108450348796432422Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
AI626930  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,137,852 - 85,137,946 (+)MAPPERmRatBN7.2
Rnor_6.01088,118,096 - 88,118,189NCBIRnor6.0
Rnor_5.01087,910,579 - 87,910,672UniSTSRnor5.0
RGSC_v3.41089,144,278 - 89,144,371UniSTSRGSC3.4
Celera1083,857,186 - 83,857,279UniSTS
Cytogenetic Map10q32.1UniSTS
Krt1-14  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,137,787 - 85,138,011 (+)MAPPERmRatBN7.2
Rnor_6.01088,118,031 - 88,118,254NCBIRnor6.0
Rnor_5.01087,910,514 - 87,910,737UniSTSRnor5.0
RGSC_v3.41089,144,213 - 89,144,436UniSTSRGSC3.4
Celera1083,857,121 - 83,857,344UniSTS
Cytogenetic Map10q32.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 4 55 46 71 74 43 24 43 6 224 100 5 25 62 81 31 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000005285   ⟹   ENSRNOP00000005285
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,137,789 - 85,142,164 (-)Ensembl
Rnor_6.0 Ensembl1088,118,175 - 88,122,233 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000019037   ⟹   ENSRNOP00000019037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,066,802 - 85,070,614 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000019133   ⟹   ENSRNOP00000019133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,075,835 - 85,080,552 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000019477   ⟹   ENSRNOP00000019477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1085,669,276 - 85,672,211 (-)Ensembl
mRatBN7.2 Ensembl1085,168,883 - 85,171,799 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080167   ⟹   ENSRNOP00000069752
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,137,789 - 85,141,990 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083895   ⟹   ENSRNOP00000070301
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,075,835 - 85,142,164 (-)Ensembl
Rnor_6.0 Ensembl1088,055,823 - 88,122,233 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084619   ⟹   ENSRNOP00000068964
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,161,424 - 85,164,304 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086209   ⟹   ENSRNOP00000068575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,137,789 - 85,171,799 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100338   ⟹   ENSRNOP00000089695
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,066,802 - 85,080,649 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102784   ⟹   ENSRNOP00000087249
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,075,835 - 85,142,164 (-)Ensembl
RefSeq Acc Id: NM_001008751   ⟹   NP_001008751
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81085,638,182 - 85,642,450 (-)NCBI
mRatBN7.21085,137,786 - 85,142,054 (-)NCBI
Rnor_6.01088,118,175 - 88,122,233 (-)NCBI
Rnor_5.01087,910,658 - 87,914,716 (-)NCBI
RGSC_v3.41089,144,357 - 89,148,415 (-)RGD
Celera1083,857,265 - 83,861,323 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001008751 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein DAA04481 (Get FASTA)   NCBI Sequence Viewer  
  EDM06022 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005285.3
GenBank Protein Q6IFV1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001008751   ⟸   NM_001008751
- UniProtKB: O35813 (UniProtKB/Swiss-Prot),   Q6IFV1 (UniProtKB/Swiss-Prot),   A6HJ17 (UniProtKB/TrEMBL),   A0A0G2JT54 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005285   ⟸   ENSRNOT00000005285
Ensembl Acc Id: ENSRNOP00000070301   ⟸   ENSRNOT00000083895
Ensembl Acc Id: ENSRNOP00000019037   ⟸   ENSRNOT00000019037
Ensembl Acc Id: ENSRNOP00000068575   ⟸   ENSRNOT00000086209
Ensembl Acc Id: ENSRNOP00000019477   ⟸   ENSRNOT00000019477
Ensembl Acc Id: ENSRNOP00000068964   ⟸   ENSRNOT00000084619
Ensembl Acc Id: ENSRNOP00000087249   ⟸   ENSRNOT00000102784
Ensembl Acc Id: ENSRNOP00000069752   ⟸   ENSRNOT00000080167
Ensembl Acc Id: ENSRNOP00000089695   ⟸   ENSRNOT00000100338
Ensembl Acc Id: ENSRNOP00000019133   ⟸   ENSRNOT00000019133
Protein Domains
IF rod

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IFV1-F1-model_v2 AlphaFold Q6IFV1 1-485 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697710
Promoter ID:EPDNEW_R8235
Type:single initiation site
Name:Krt14_1
Description:keratin 14
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01088,122,297 - 88,122,357EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307463 AgrOrtholog
BioCyc Gene G2FUF-23248 BioCyc
Ensembl Genes ENSRNOG00000003899 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005285.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
  Single helix bin UniProtKB/Swiss-Prot
  Vasodilator-stimulated phosphoprotein UniProtKB/Swiss-Prot
InterPro IF_conserved UniProtKB/Swiss-Prot
  IF_rod_dom UniProtKB/Swiss-Prot
  Keratin_I UniProtKB/Swiss-Prot
KEGG Report rno:287701 UniProtKB/Swiss-Prot
NCBI Gene 287701 ENTREZGENE
PANTHER KERATIN, TYPE I CYTOSKELETAL 14 UniProtKB/Swiss-Prot
  PTHR23239 UniProtKB/Swiss-Prot
Pfam Filament UniProtKB/Swiss-Prot
PhenoGen Krt14 PhenoGen
PRINTS TYPE1KERATIN UniProtKB/Swiss-Prot
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot
  IF_ROD_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003899 RatGTEx
SMART Filament UniProtKB/Swiss-Prot
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/Swiss-Prot
  Prefoldin UniProtKB/Swiss-Prot
UniProt A0A0G2JT54 ENTREZGENE
  A6HJ17 ENTREZGENE, UniProtKB/TrEMBL
  K1C14_RAT UniProtKB/Swiss-Prot
  O35813 ENTREZGENE
  Q6IFV1 ENTREZGENE
UniProt Secondary O35813 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Krt14  keratin 14  Krt14  keratin 14, type I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-28 Krt14  keratin 14, type I  Krt14  keratin 14  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-11 Krt14  keratin 14  Krt14  keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Krt14  keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner)  Krt14  keratin 14  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Krt14  keratin 14  Krt1-14  keratin complex 1, acidic, gene 14  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Krt1-14  keratin complex 1, acidic, gene 14  Krt1-14_predicted  keratin complex 1, acidic, gene 14 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Krt1-14_predicted  keratin complex 1, acidic, gene 14 (predicted)      Symbol and Name status set to approved 70820 APPROVED