Agl (amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Agl (amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase) Rattus norvegicus
Analyze
Symbol: Agl
Name: amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
RGD ID: 1306376
Description: Enables 4-alpha-glucanotransferase activity; amylo-alpha-1,6-glucosidase activity; and carbohydrate binding activity. Involved in glycogen catabolic process; response to glucocorticoid; and response to nutrient. Located in sarcoplasmic reticulum. Used to study uremia. Human ortholog(s) of this gene implicated in glycogen storage disease III. Orthologous to human AGL (amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase); PARTICIPATES IN glycogen degradation pathway; congenital sucrase-isomaltase deficiency pathway; glycogen storage disease type III pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: amylo-1, 6-glucosidase, 4-alpha-glucanotransferase (glycogen debranching enzyme, glycogen storage disease type III); amylo-1,6-glucosidase, 4-alpha-glucanotransferase; glycogen debranching enzyme; LOC362029
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82207,389,949 - 207,445,959 (-)NCBIGRCr8
mRatBN7.22204,705,053 - 204,760,966 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2204,705,053 - 204,760,828 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2212,360,352 - 212,416,298 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02210,276,718 - 210,333,402 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02205,093,802 - 205,150,486 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02219,788,234 - 219,843,189 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2219,788,234 - 219,842,986 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02237,375,913 - 237,430,811 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42212,985,676 - 213,041,451 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12212,950,852 - 213,004,133 (-)NCBI
Celera2197,196,717 - 197,252,494 (-)NCBICelera
Cytogenetic Map2q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
chlorpyrifos  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
glucose  (ISO)
glycogen  (ISO)
ivermectin  (ISO)
Licochalcone B  (ISO)
methimazole  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
motexafin gadolinium  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
zinc acetate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
2. Inhibition of glycogenolysis by a glucose analogue in the working rat heart. Depre C and Hue L, J Mol Cell Cardiol. 1997 Aug;29(8):2253-9.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Glycogen debranching enzyme is associated with rat skeletal muscle sarcoplasmic reticulum. Lees SJ, etal., Acta Physiol Scand. 2004 Jun;181(2):239-45.
5. Hepatic and neuromuscular forms of glycogenosis type III: nine mutations in AGL. Lucchiari S, etal., Hum Mutat. 2006 Jun;27(6):600-1.
6. Carbohydrate metabolism in the chronically uremic rat. Mannan A, etal., Clin Biochem. 1975 Jun;8(3):194-8.
7. N-methyl-1-deoxynojirimycin (MOR-14), an alpha-glucosidase inhibitor, markedly improves postischemic left ventricular dysfunction. Nishida Y, etal., Heart Vessels. 2000;15(6):268-73.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. [Effect of biogenic amines on glycogen degradation in isolated rat hepatocytes]. Popova IA, etal., Vopr Med Khim. 1992 Mar-Apr;38(2):30-3.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Glycogen-binding protein components of rat tissues. Satoh K and Sato K, Biochem Biophys Res Commun. 1980 Sep 16;96(1):28-33.
17. Mutations in exon 3 of the glycogen debranching enzyme gene are associated with glycogen storage disease type III that is differentially expressed in liver and muscle. Shen J, etal., J Clin Invest. 1996 Jul 15;98(2):352-7.
18. [Development and control of liver amylo-1,6-glucosidase activity in the fetal rat] Vaillant R, etal., Can J Biochem. 1979 Oct;57(10):1245-9.
Additional References at PubMed
PMID:2961257   PMID:11785984   PMID:17908927  


Genomics

Comparative Map Data
Agl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82207,389,949 - 207,445,959 (-)NCBIGRCr8
mRatBN7.22204,705,053 - 204,760,966 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2204,705,053 - 204,760,828 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2212,360,352 - 212,416,298 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02210,276,718 - 210,333,402 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02205,093,802 - 205,150,486 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02219,788,234 - 219,843,189 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2219,788,234 - 219,842,986 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02237,375,913 - 237,430,811 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42212,985,676 - 213,041,451 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12212,950,852 - 213,004,133 (-)NCBI
Celera2197,196,717 - 197,252,494 (-)NCBICelera
Cytogenetic Map2q42NCBI
AGL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38199,849,258 - 99,924,023 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl199,850,361 - 99,924,023 (+)EnsemblGRCh38hg38GRCh38
GRCh371100,315,917 - 100,389,579 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361100,088,228 - 100,162,167 (+)NCBINCBI36Build 36hg18NCBI36
Celera198,570,515 - 98,644,447 (+)NCBICelera
Cytogenetic Map1p21.2NCBI
HuRef198,438,182 - 98,512,138 (+)NCBIHuRef
CHM1_11100,431,893 - 100,506,067 (+)NCBICHM1_1
T2T-CHM13v2.0199,697,491 - 99,772,284 (+)NCBIT2T-CHM13v2.0
Agl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393116,533,648 - 116,601,815 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3116,533,648 - 116,601,815 (-)EnsemblGRCm39 Ensembl
GRCm383116,739,999 - 116,808,166 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3116,739,999 - 116,808,166 (-)EnsemblGRCm38mm10GRCm38
MGSCv373116,442,917 - 116,511,084 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363116,732,003 - 116,800,170 (-)NCBIMGSCv36mm8
Celera3123,163,575 - 123,226,478 (-)NCBICelera
Cytogenetic Map3G1NCBI
cM Map350.47NCBI
Agl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554354,621,991 - 4,688,139 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554354,622,142 - 4,684,439 (+)NCBIChiLan1.0ChiLan1.0
AGL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21127,105,703 - 127,181,631 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11126,260,783 - 126,336,647 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01102,506,234 - 102,580,183 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11101,225,646 - 101,299,511 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1101,226,120 - 101,299,511 (+)Ensemblpanpan1.1panPan2
AGL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1650,039,661 - 50,112,543 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl650,041,947 - 50,112,279 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha652,720,444 - 52,790,584 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0650,395,404 - 50,468,323 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl650,397,314 - 50,468,172 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1650,089,271 - 50,159,524 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0650,068,211 - 50,138,107 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0650,499,977 - 50,570,258 (-)NCBIUU_Cfam_GSD_1.0
Agl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058109,668,098 - 109,703,925 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493722423,225 - 32,639 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4118,177,377 - 118,269,101 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14118,186,031 - 118,269,106 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24129,759,895 - 129,831,601 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AGL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12033,422,807 - 33,491,335 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2033,422,790 - 33,490,016 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603824,565,816 - 24,633,799 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Agl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248572,629,313 - 2,728,196 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248572,629,158 - 2,730,764 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Agl
291 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:493
Count of miRNA genes:259
Interacting mature miRNAs:318
Transcripts:ENSRNOT00000055735
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 43 41 38 4 38 8 11 66 31 33 11 8
Low 2 16 3 15 3 8 4 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000055735   ⟹   ENSRNOP00000052593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2204,705,053 - 204,760,828 (-)Ensembl
Rnor_6.0 Ensembl2219,788,234 - 219,842,986 (-)Ensembl
RefSeq Acc Id: NM_001108564   ⟹   NP_001102034
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82207,389,949 - 207,445,724 (-)NCBI
mRatBN7.22204,705,053 - 204,760,828 (-)NCBI
Rnor_6.02219,788,234 - 219,842,986 (-)NCBI
Rnor_5.02237,375,913 - 237,430,811 (+)NCBI
RGSC_v3.42212,985,676 - 213,041,451 (-)RGD
Celera2197,196,717 - 197,252,494 (-)RGD
Sequence:
RefSeq Acc Id: XM_006233229   ⟹   XP_006233291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82207,390,821 - 207,445,959 (-)NCBI
mRatBN7.22204,705,925 - 204,760,966 (-)NCBI
Rnor_6.02219,789,105 - 219,843,189 (-)NCBI
Rnor_5.02237,375,913 - 237,430,811 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001102034 (Get FASTA)   NCBI Sequence Viewer  
  XP_006233291 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL82045 (Get FASTA)   NCBI Sequence Viewer  
  EDL82046 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000052593
  ENSRNOP00000052593.2
Reference Protein Sequences
RefSeq Acc Id: NP_001102034   ⟸   NM_001108564
- UniProtKB: D4AEH9 (UniProtKB/TrEMBL),   A6HVA9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233291   ⟸   XM_006233229
- Peptide Label: isoform X1
- UniProtKB: D4AEH9 (UniProtKB/TrEMBL),   A6HVA9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000052593   ⟸   ENSRNOT00000055735
Protein Domains
Eukaryotic glycogen debranching enzyme N-terminal   Glycogen debranching enzyme C-terminal   Glycogen debranching enzyme central   Glycogen debranching enzyme glucanotransferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AEH9-F1-model_v2 AlphaFold D4AEH9 1-1532 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691711
Promoter ID:EPDNEW_R2236
Type:initiation region
Name:Agl_1
Description:amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02219,843,027 - 219,843,087EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306376 AgrOrtholog
BioCyc Gene G2FUF-51488 BioCyc
Ensembl Genes ENSRNOG00000016214 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000055735 ENTREZGENE
  ENSRNOT00000055735.3 UniProtKB/TrEMBL
Gene3D-CATH Glycosidases UniProtKB/TrEMBL
InterPro 6-hairpin_glycosidase-like UniProtKB/TrEMBL
  AGL_central UniProtKB/TrEMBL
  AGL_euk_N UniProtKB/TrEMBL
  AGL_glucanoTrfase UniProtKB/TrEMBL
  GDE_C UniProtKB/TrEMBL
  GDE_C UniProtKB/TrEMBL
  Glyc_debranch UniProtKB/TrEMBL
  Glyco_hydro_catalytic_core UniProtKB/TrEMBL
KEGG Report rno:362029 UniProtKB/TrEMBL
NCBI Gene 362029 ENTREZGENE
PANTHER GDE_C UniProtKB/TrEMBL
  GLYCOGEN DEBRANCHING ENZYME UniProtKB/TrEMBL
Pfam GDE_C UniProtKB/TrEMBL
  hDGE_amylase UniProtKB/TrEMBL
  hGDE_central UniProtKB/TrEMBL
  hGDE_N UniProtKB/TrEMBL
PhenoGen Agl PhenoGen
RatGTEx ENSRNOG00000016214 RatGTEx
Superfamily-SCOP Glyco_hydro_cat UniProtKB/TrEMBL
  Glyco_trans_6hp UniProtKB/TrEMBL
UniProt A6HVA9 ENTREZGENE, UniProtKB/TrEMBL
  D4AEH9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-28 Agl  amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase  Agl  amylo-1,6-glucosidase, 4-alpha-glucanotransferase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-03 Agl  amylo-1,6-glucosidase, 4-alpha-glucanotransferase  Agl_predicted  amylo-1, 6-glucosidase, 4-alpha-glucanotransferase (glycogen debranching enzyme, glycogen storage disease type III) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Agl_predicted  amylo-1, 6-glucosidase, 4-alpha-glucanotransferase (glycogen debranching enzyme, glycogen storage disease type III) (predicted)      Symbol and Name status set to approved 70820 APPROVED