AGL (amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase) - Rat Genome Database

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Gene: AGL (amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase) Canis lupus familiaris
Analyze
Symbol: AGL
Name: amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
RGD ID: 12413071
Description: ENCODES a protein that exhibits 4-alpha-glucanotransferase activity (ortholog); amylo-alpha-1,6-glucosidase activity (ortholog); carbohydrate binding (ortholog); INVOLVED IN glycogen catabolic process (ortholog); glycogen metabolic process (ortholog); response to glucocorticoid (ortholog); PARTICIPATES IN congenital sucrase-isomaltase deficiency pathway; glycogen degradation pathway; glycogen storage disease type III pathway; ASSOCIATED WITH Glycogen Storage Disease IIIA; Arthrogryposis, Impaired Intellectual Development, and Seizures (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); sarcoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: amylo-1, 6-glucosidase, 4-alpha-glucanotransferase; glycogen debrancher; glycogen debranching enzyme
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1650,039,661 - 50,112,543 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl650,041,947 - 50,112,279 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha652,720,444 - 52,790,584 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0650,395,404 - 50,468,323 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl650,397,314 - 50,468,172 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1650,089,271 - 50,159,524 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0650,068,211 - 50,138,107 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0650,499,977 - 50,570,258 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISS)
cytosol  (IEA,ISO)
inclusion body  (IEA)
nucleus  (IEA)
sarcoplasmic reticulum  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
AGL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1650,039,661 - 50,112,543 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl650,041,947 - 50,112,279 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha652,720,444 - 52,790,584 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0650,395,404 - 50,468,323 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl650,397,314 - 50,468,172 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1650,089,271 - 50,159,524 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0650,068,211 - 50,138,107 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0650,499,977 - 50,570,258 (-)NCBIUU_Cfam_GSD_1.0
AGL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38199,849,258 - 99,924,023 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl199,850,361 - 99,924,023 (+)EnsemblGRCh38hg38GRCh38
GRCh371100,315,917 - 100,389,579 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361100,088,228 - 100,162,167 (+)NCBINCBI36Build 36hg18NCBI36
Celera198,570,515 - 98,644,447 (+)NCBICelera
Cytogenetic Map1p21.2NCBI
HuRef198,438,182 - 98,512,138 (+)NCBIHuRef
CHM1_11100,431,893 - 100,506,067 (+)NCBICHM1_1
T2T-CHM13v2.0199,697,491 - 99,772,284 (+)NCBIT2T-CHM13v2.0
Agl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393116,533,648 - 116,601,815 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3116,533,648 - 116,601,815 (-)EnsemblGRCm39 Ensembl
GRCm383116,739,999 - 116,808,166 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3116,739,999 - 116,808,166 (-)EnsemblGRCm38mm10GRCm38
MGSCv373116,442,917 - 116,511,084 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363116,732,003 - 116,800,170 (-)NCBIMGSCv36mm8
Celera3123,163,575 - 123,226,478 (-)NCBICelera
Cytogenetic Map3G1NCBI
cM Map350.47NCBI
Agl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82207,389,949 - 207,445,959 (-)NCBIGRCr8
mRatBN7.22204,705,053 - 204,760,966 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2204,705,053 - 204,760,828 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2212,360,352 - 212,416,298 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02210,276,718 - 210,333,402 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02205,093,802 - 205,150,486 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02219,788,234 - 219,843,189 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2219,788,234 - 219,842,986 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02237,375,913 - 237,430,811 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42212,985,676 - 213,041,451 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12212,950,852 - 213,004,133 (-)NCBI
Celera2197,196,717 - 197,252,494 (-)NCBICelera
Cytogenetic Map2q42NCBI
Agl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554354,621,991 - 4,688,139 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554354,622,142 - 4,684,439 (+)NCBIChiLan1.0ChiLan1.0
AGL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21127,105,703 - 127,181,631 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11126,260,783 - 126,336,647 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01102,506,234 - 102,580,183 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11101,225,646 - 101,299,511 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1101,226,120 - 101,299,511 (+)Ensemblpanpan1.1panPan2
Agl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058109,668,098 - 109,703,925 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493722423,225 - 32,639 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4118,177,377 - 118,269,101 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14118,186,031 - 118,269,106 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24129,759,895 - 129,831,601 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AGL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12033,422,807 - 33,491,335 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2033,422,790 - 33,490,016 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603824,565,816 - 24,633,799 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Agl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248572,629,313 - 2,728,196 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248572,629,158 - 2,730,764 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in AGL
819 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 20 6 6 6 6 6 12 10 6
Low 2 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000031896   ⟹   ENSCAFP00000029699
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl650,041,947 - 50,112,279 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000047455   ⟹   ENSCAFP00000039212
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl650,041,947 - 50,110,430 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000063103   ⟹   ENSCAFP00000064993
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl650,047,703 - 50,112,279 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000078100   ⟹   ENSCAFP00000046698
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl650,047,703 - 50,112,279 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000085859   ⟹   ENSCAFP00000047427
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl650,047,703 - 50,112,279 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000090431   ⟹   ENSCAFP00000054885
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl650,097,596 - 50,112,097 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845024274   ⟹   ENSCAFP00845019069
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl650,397,314 - 50,468,172 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845024393   ⟹   ENSCAFP00845019174
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl650,453,683 - 50,467,950 (-)Ensembl
RefSeq Acc Id: NM_001048096   ⟹   NP_001041561
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1650,041,947 - 50,112,279 (-)NCBI
Dog10K_Boxer_Tasha652,720,444 - 52,790,584 (-)NCBI
ROS_Cfam_1.0650,397,691 - 50,468,065 (-)NCBI
UMICH_Zoey_3.1650,089,271 - 50,159,524 (-)NCBI
UNSW_CanFamBas_1.0650,068,211 - 50,138,107 (-)NCBI
UU_Cfam_GSD_1.0650,499,977 - 50,570,258 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038667584   ⟹   XP_038523512
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0650,395,404 - 50,468,253 (-)NCBI
RefSeq Acc Id: XM_038667585   ⟹   XP_038523513
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0650,395,404 - 50,467,949 (-)NCBI
RefSeq Acc Id: XM_038667586   ⟹   XP_038523514
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0650,395,404 - 50,468,323 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001041561   ⟸   NM_001048096
- UniProtKB: Q2PQH8 (UniProtKB/Swiss-Prot),   A0A8C0NRI8 (UniProtKB/TrEMBL),   A0A8P0STI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000064993   ⟸   ENSCAFT00000063103
RefSeq Acc Id: ENSCAFP00000046698   ⟸   ENSCAFT00000078100
RefSeq Acc Id: ENSCAFP00000039212   ⟸   ENSCAFT00000047455
RefSeq Acc Id: ENSCAFP00000029699   ⟸   ENSCAFT00000031896
RefSeq Acc Id: ENSCAFP00000054885   ⟸   ENSCAFT00000090431
RefSeq Acc Id: ENSCAFP00000047427   ⟸   ENSCAFT00000085859
RefSeq Acc Id: XP_038523514   ⟸   XM_038667586
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NVS9 (UniProtKB/TrEMBL),   A0A8I3P0C9 (UniProtKB/TrEMBL),   A0A8C0NRI8 (UniProtKB/TrEMBL),   A0A8P0STI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038523512   ⟸   XM_038667584
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NVS9 (UniProtKB/TrEMBL),   A0A8I3P0C9 (UniProtKB/TrEMBL),   A0A8C0NRI8 (UniProtKB/TrEMBL),   A0A8P0STI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038523513   ⟸   XM_038667585
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NVS9 (UniProtKB/TrEMBL),   A0A8I3P0C9 (UniProtKB/TrEMBL),   A0A8C0NRI8 (UniProtKB/TrEMBL),   A0A8P0STI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845019069   ⟸   ENSCAFT00845024274
RefSeq Acc Id: ENSCAFP00845019174   ⟸   ENSCAFT00845024393
Protein Domains
Eukaryotic glycogen debranching enzyme N-terminal   Glycogen debranching enzyme C-terminal   Glycogen debranching enzyme central   Glycogen debranching enzyme glucanotransferase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000020040 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030016245 UniProtKB/TrEMBL
  ENSCAFG00040002387 UniProtKB/TrEMBL
  ENSCAFG00845013603 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000031896.4 UniProtKB/TrEMBL
  ENSCAFT00000047455.4 UniProtKB/TrEMBL
  ENSCAFT00000090431.2 UniProtKB/TrEMBL
  ENSCAFT00030029977.1 UniProtKB/TrEMBL
  ENSCAFT00030030067.1 UniProtKB/TrEMBL
  ENSCAFT00030030256.1 UniProtKB/TrEMBL
  ENSCAFT00040004543.1 UniProtKB/TrEMBL
  ENSCAFT00845024274 ENTREZGENE
  ENSCAFT00845024274.1 UniProtKB/TrEMBL
  ENSCAFT00845024393.1 UniProtKB/TrEMBL
Gene3D-CATH Glycosidases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 6-hairpin_glycosidase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AGL/Gdb1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AGL_central UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AGL_euk_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AGL_glucanoTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GDE_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycogen_debranch_met UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:479931 UniProtKB/Swiss-Prot
NCBI Gene AGL ENTREZGENE
PANTHER GLYCOGEN DEBRANCHING ENZYME UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10569 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GDE_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  hDGE_amylase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  hGDE_central UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  hGDE_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48208 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51445 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0NRI8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0NS10_CANLF UniProtKB/TrEMBL
  A0A8C0NVS9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NKZ3_CANLF UniProtKB/TrEMBL
  A0A8I3P0C9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0STI5 ENTREZGENE, UniProtKB/TrEMBL
  GDE_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:37704 ENTREZGENE