Mybpc3 (myosin binding protein C3) - Rat Genome Database

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Gene: Mybpc3 (myosin binding protein C3) Rattus norvegicus
Analyze
Symbol: Mybpc3
Name: myosin binding protein C3
RGD ID: 1305950
Description: Predicted to enable identical protein binding activity and myosin heavy chain binding activity. Predicted to be a structural constituent of muscle. Involved in cardiac muscle contraction and regulation of striated muscle contraction. Located in striated muscle myosin thick filament. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1MM; familial hypertrophic cardiomyopathy; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 4. Orthologous to human MYBPC3 (myosin binding protein C3); PARTICIPATES IN dilated cardiomyopathy pathway; hypertrophic cardiomyopathy pathway; INTERACTS WITH acetamide; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C-protein, cardiac muscle isoform; cardiac MyBP-C; LOC295929; myosin binding protein C, cardiac; myosin-binding protein C, cardiac-type
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8397,550,974 - 97,569,216 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl397,551,061 - 97,569,216 (+)EnsemblGRCr8
mRatBN7.2377,095,165 - 77,113,406 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,095,252 - 77,113,405 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx380,573,681 - 80,591,786 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,172,692 - 89,190,793 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,023,927 - 87,042,063 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0379,940,509 - 79,958,731 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl379,940,561 - 79,958,730 (+)Ensemblrn6Rnor6.0
Rnor_5.0386,649,264 - 86,667,484 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4375,478,579 - 75,496,750 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera376,303,526 - 76,321,687 (+)NCBICelera
RGSC_v3.1375,375,715 - 75,394,374 (+)NCBI
Cytogenetic Map3q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Animal Disease Models  (ISO)
arrhythmogenic right ventricular cardiomyopathy  (ISO)
arrhythmogenic right ventricular dysplasia 1  (ISO)
Brugada syndrome  (ISO)
cardiac amyloidosis  (ISO)
cardiac arrest  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
cardiovascular system disease  (ISO)
catecholaminergic polymorphic ventricular tachycardia  (ISO)
catecholaminergic polymorphic ventricular tachycardia 1  (ISO)
dilated cardiomyopathy  (ISO)
dilated cardiomyopathy 1A  (ISO)
dilated cardiomyopathy 1B  (ISO)
dilated cardiomyopathy 1I  (ISO)
dilated cardiomyopathy 1MM  (ISO)
Dilated Cardiomyopathy with Left Ventricular Noncompaction  (ISO)
Dyspnea  (ISO)
Familial Amyloid Polyneuropathies  (ISO)
familial hypertrophic cardiomyopathy  (ISO)
genetic disease  (ISO)
Heart Block  (ISO)
hereditary systemic amyloidosis 1  (ISO)
Hirschsprung's disease  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypertrophic cardiomyopathy 1  (ISO)
hypertrophic cardiomyopathy 4  (ISO,ISS)
intellectual disability  (ISO)
Isolated Noncompaction of the Ventricular Myocardium  (ISO)
Left Ventricular Hypertrophy  (ISO)
left ventricular noncompaction  (ISO)
Left Ventricular Noncompaction 1  (ISO)
long QT syndrome  (ISO)
neuropathy  (ISO)
nuclear type mitochondrial complex I deficiency 20  (ISO)
Paroxysmal Atrial Fibrillation  (ISO)
Sudden Cardiac Death  (ISO)
Sudden Death  (ISO)
sudden infant death syndrome  (ISO)
Sudden Unexpected Nocturnal Death Syndrome  (ISO)
Tachycardia  (ISO)
Ventricular Premature Complexes  (ISO)
Wolff-Parkinson-White syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional and spectroscopic studies of a familial hypertrophic cardiomyopathy mutation in Motif X of cardiac myosin binding protein-C. Brown LJ, etal., Eur Biophys J. 2002 Sep;31(5):400-8. Epub 2002 Jun 25.
2. Organization and sequence of human cardiac myosin binding protein C gene (MYBPC3) and identification of mutations predicted to produce truncated proteins in familial hypertrophic cardiomyopathy. Carrier L, etal., Circ Res. 1997 Mar;80(3):427-34.
3. Hypertrophic cardiomyopathy linked to homozygosity for a new mutation in the myosin-binding protein C gene (A627V) suggests a dosage effect. Garcia-Castro M, etal., Int J Cardiol. 2005 Jul 20;102(3):501-7. Epub 2004 Sep 23.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Mutations in the cardiac myosin-binding protein C gene are the predominant cause of familial hypertrophic cardiomyopathy in eastern Finland. Jaaskelainen P, etal., J Mol Med. 2002 Jul;80(7):412-22. Epub 2002 Apr 11.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Mutations in the gene for cardiac myosin-binding protein C and late-onset familial hypertrophic cardiomyopathy. Niimura H, etal., N Engl J Med. 1998 Apr 30;338(18):1248-57.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Infantile restrictive cardiomyopathy resulting from a mutation in the cardiac troponin T gene. Peddy SB, etal., Pediatrics. 2006 May;117(5):1830-3.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Myosin binding protein C mutations and compound heterozygosity in hypertrophic cardiomyopathy. Van Driest SL, etal., J Am Coll Cardiol. 2004 Nov 2;44(9):1903-10.
17. MYBPC3 polymorphism is a modifier for expression of cardiac hypertrophy in patients with hypertrophic cardiomyopathy. Wang P, etal., Biochem Biophys Res Commun. 2005 Apr 8;329(2):796-9.
18. Alteration of myosin cross bridges by phosphorylation of myosin-binding protein C in cardiac muscle. Weisberg A and Winegrad S, Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):8999-9003.
Additional References at PubMed
PMID:7493025   PMID:8618961   PMID:9784245   PMID:10024460   PMID:10532952   PMID:10545522   PMID:11815426   PMID:14500336   PMID:15059932   PMID:15472117   PMID:16224063   PMID:16380103  
PMID:16754800   PMID:17075052   PMID:17192269   PMID:17254601   PMID:18201573   PMID:19850579   PMID:21971072   PMID:22527638   PMID:22982234   PMID:25512492   PMID:25583989   PMID:25771144  
PMID:26316108   PMID:27233767   PMID:28315668   PMID:29470978   PMID:30082313   PMID:31308242   PMID:35352799  


Genomics

Comparative Map Data
Mybpc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8397,550,974 - 97,569,216 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl397,551,061 - 97,569,216 (+)EnsemblGRCr8
mRatBN7.2377,095,165 - 77,113,406 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,095,252 - 77,113,405 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx380,573,681 - 80,591,786 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,172,692 - 89,190,793 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,023,927 - 87,042,063 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0379,940,509 - 79,958,731 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl379,940,561 - 79,958,730 (+)Ensemblrn6Rnor6.0
Rnor_5.0386,649,264 - 86,667,484 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4375,478,579 - 75,496,750 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera376,303,526 - 76,321,687 (+)NCBICelera
RGSC_v3.1375,375,715 - 75,394,374 (+)NCBI
Cytogenetic Map3q24NCBI
MYBPC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381147,331,406 - 47,352,702 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1147,331,406 - 47,352,702 (-)Ensemblhg38GRCh38
GRCh371147,352,957 - 47,374,253 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361147,309,533 - 47,330,829 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341147,309,526 - 47,330,798NCBI
Celera1147,492,237 - 47,513,531 (-)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1147,052,045 - 47,073,383 (-)NCBIHuRef
CHM1_11147,352,197 - 47,373,500 (-)NCBICHM1_1
T2T-CHM13v2.01147,488,226 - 47,509,533 (-)NCBIT2T-CHM13v2.0
Mybpc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39290,948,459 - 90,966,862 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl290,948,489 - 90,966,861 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38291,118,114 - 91,136,516 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,118,144 - 91,136,516 (+)Ensemblmm10GRCm38
MGSCv37290,958,301 - 90,976,673 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36290,919,009 - 90,937,348 (+)NCBIMGSCv36mm8
Celera292,502,890 - 92,521,291 (+)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.44NCBI
Mybpc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955422888,589 - 901,725 (+)Ensembl
ChiLan1.0NW_004955422888,529 - 902,074 (+)NCBIChiLan1.0ChiLan1.0
MYBPC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2949,532,715 - 49,553,783 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11149,552,509 - 49,573,577 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01147,277,799 - 47,299,102 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11147,830,605 - 47,851,909 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,831,087 - 47,851,849 (-)EnsemblpanPan2panpan1.1
MYBPC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11842,271,159 - 42,288,782 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1842,271,724 - 42,289,215 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1841,000,886 - 41,017,318 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01842,926,187 - 42,943,245 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1842,926,235 - 43,024,307 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11842,412,622 - 42,429,047 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01841,967,840 - 41,984,282 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01842,697,140 - 42,713,582 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mybpc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494719,759,573 - 19,778,450 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365621,871,410 - 1,889,648 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365621,871,194 - 1,890,092 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYBPC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,247,340 - 15,270,104 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1215,247,679 - 15,269,714 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2216,454,543 - 16,476,408 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MYBPC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,964,581 - 17,986,351 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl117,963,706 - 17,985,758 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038115,266,096 - 115,286,419 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mybpc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247671,406,587 - 1,420,436 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247671,406,563 - 1,420,778 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Mybpc3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1565,286,303 - 65,304,238 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mybpc3
108 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:174
Count of miRNA genes:139
Interacting mature miRNAs:153
Transcripts:ENSRNOT00000016652
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat

Markers in Region
PMC181559P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8397,567,494 - 97,567,855 (+)Marker Load Pipeline
mRatBN7.2377,111,683 - 77,112,044 (+)MAPPERmRatBN7.2
Rnor_6.0379,957,009 - 79,957,369NCBIRnor6.0
Rnor_5.0386,665,762 - 86,666,122UniSTSRnor5.0
RGSC_v3.4375,495,029 - 75,495,389UniSTSRGSC3.4
Celera376,319,966 - 76,320,326UniSTS
Cytogenetic Map3q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 10 62 98 65 66 36 74 36 6 276 164 10 71 59 68 30 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000016652   ⟹   ENSRNOP00000016652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl397,551,061 - 97,569,216 (+)Ensembl
mRatBN7.2 Ensembl377,095,252 - 77,113,405 (+)Ensembl
Rnor_6.0 Ensembl379,940,561 - 79,958,730 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104096   ⟹   ENSRNOP00000081300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl397,551,550 - 97,569,216 (+)Ensembl
mRatBN7.2 Ensembl377,095,741 - 77,113,405 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000159695   ⟹   ENSRNOP00000099748
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl397,551,061 - 97,569,216 (+)Ensembl
RefSeq Acc Id: NM_001106490   ⟹   NP_001099960
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,551,061 - 97,569,216 (+)NCBI
mRatBN7.2377,095,252 - 77,113,405 (+)NCBI
Rnor_6.0379,940,561 - 79,958,730 (+)NCBI
Rnor_5.0386,649,264 - 86,667,484 (+)NCBI
RGSC_v3.4375,478,579 - 75,496,750 (+)RGD
Celera376,303,526 - 76,321,687 (+)RGD
Sequence:
RefSeq Acc Id: XM_063283293   ⟹   XP_063139363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,550,974 - 97,569,213 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001099960 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139363 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL79508 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016652
  ENSRNOP00000099748
GenBank Protein P56741 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001099960   ⟸   NM_001106490
- UniProtKB: P56741 (UniProtKB/Swiss-Prot),   A0A8I5ZRN0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016652   ⟸   ENSRNOT00000016652
Ensembl Acc Id: ENSRNOP00000081300   ⟸   ENSRNOT00000104096
RefSeq Acc Id: XP_063139363   ⟸   XM_063283293
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZRN0 (UniProtKB/TrEMBL),   A0A8L2Q868 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000099748   ⟸   ENSRNOT00000159695
Protein Domains
Fibronectin type-III   Ig-like   Ig-like C2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P56741-F1-model_v2 AlphaFold P56741 1-1274 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692207
Promoter ID:EPDNEW_R2732
Type:single initiation site
Name:Mybpc3_1
Description:myosin binding protein C, cardiac
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0379,940,542 - 79,940,602EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305950 AgrOrtholog
BioCyc Gene G2FUF-48748 BioCyc
Ensembl Genes ENSRNOG00000012307 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000016652 ENTREZGENE
  ENSRNOT00000159695 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
InterPro FN3_dom UniProtKB/Swiss-Prot
  FN3_sf UniProtKB/Swiss-Prot
  Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_I-set UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_sub2 UniProtKB/Swiss-Prot
  MyBP-C_THB UniProtKB/Swiss-Prot
  Striated_Muscle_Regulatory UniProtKB/Swiss-Prot
KEGG Report rno:295929 UniProtKB/Swiss-Prot
NCBI Gene 295929 ENTREZGENE
PANTHER PTHR13817:SF168 UniProtKB/Swiss-Prot
  TITIN UniProtKB/Swiss-Prot
Pfam fn3 UniProtKB/Swiss-Prot
  I-set UniProtKB/Swiss-Prot
  THB UniProtKB/Swiss-Prot
PhenoGen Mybpc3 PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot
  IG_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012307 RatGTEx
SMART FN3 UniProtKB/Swiss-Prot
  IGc2 UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
  SSF49265 UniProtKB/Swiss-Prot
UniProt A0A8I5ZRN0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q868 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LFV1_RAT UniProtKB/TrEMBL
  MYPC_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-11-11 Mybpc3  myosin binding protein C3  Mybpc3  myosin binding protein C, cardiac  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Mybpc3  myosin binding protein C, cardiac   Mybpc3_predicted  myosin binding protein C, cardiac (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Mybpc3_predicted  myosin binding protein C, cardiac (predicted)      Symbol and Name status set to approved 70820 APPROVED