Mybpc3 (myosin binding protein C3) - Rat Genome Database

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Gene: Mybpc3 (myosin binding protein C3) Chinchilla lanigera
Analyze
Symbol: Mybpc3
Name: myosin binding protein C3 (Ensembl:myosin binding protein C, cardiac)
RGD ID: 8714363
Description: ENCODES a protein that exhibits identical protein binding (ortholog); myosin binding (ortholog); myosin heavy chain binding (ortholog); INVOLVED IN cardiac muscle contraction (ortholog); heart morphogenesis (ortholog); myosin filament assembly (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); arrhythmogenic right ventricular cardiomyopathy (ortholog); arrhythmogenic right ventricular dysplasia 1 (ortholog); FOUND IN A band (ortholog); cardiac myofibril (ortholog); myofibril (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: myosin binding protein C, cardiac; myosin-binding protein C, cardiac-type
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955422888,589 - 901,725 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955422888,529 - 902,074 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Animal Disease Models  (ISO)
arrhythmogenic right ventricular cardiomyopathy  (ISO)
arrhythmogenic right ventricular dysplasia 1  (ISO)
Brugada syndrome  (ISO)
cardiac amyloidosis  (ISO)
cardiac arrest  (ISO)
Cardiac Conduction Defect  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
catecholaminergic polymorphic ventricular tachycardia  (ISO)
catecholaminergic polymorphic ventricular tachycardia 1  (ISO)
congenital disorder of glycosylation type IIc  (ISO)
dilated cardiomyopathy  (ISO)
dilated cardiomyopathy 1A  (ISO)
dilated cardiomyopathy 1B  (ISO)
dilated cardiomyopathy 1H  (ISO)
dilated cardiomyopathy 1I  (ISO)
dilated cardiomyopathy 1MM  (ISO)
Dilated Cardiomyopathy with Left Ventricular Noncompaction  (ISO)
Dyspnea  (ISO)
Familial Amyloid Polyneuropathies  (ISO)
familial hypertrophic cardiomyopathy  (ISO)
fetal akinesia deformation sequence syndrome 1  (ISO)
genetic disease  (ISO)
Heart Block  (ISO)
Hirschsprung's disease  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypertrophic cardiomyopathy 1  (ISO)
hypertrophic cardiomyopathy 4  (ISO)
intellectual disability  (ISO)
Isolated Noncompaction of the Ventricular Myocardium  (ISO)
Left Ventricular Hypertrophy  (ISO)
left ventricular noncompaction  (ISO)
Left Ventricular Noncompaction 1  (ISO)
long QT syndrome  (ISO)
neuropathy  (ISO)
nuclear type mitochondrial complex I deficiency 20  (ISO)
Paroxysmal Atrial Fibrillation  (ISO)
peripheral nervous system disease  (ISO)
Sudden Cardiac Death  (ISO)
Sudden Death  (ISO)
sudden infant death syndrome  (ISO)
Sudden Unexpected Nocturnal Death Syndrome  (ISO)
Tachycardia  (ISO)
transthyretin amyloidosis  (ISO)
Ventricular Premature Complexes  (ISO)
Wolff-Parkinson-White syndrome  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Mybpc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955422888,589 - 901,725 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955422888,529 - 902,074 (+)NCBIChiLan1.0ChiLan1.0
MYBPC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381147,331,406 - 47,352,702 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1147,331,406 - 47,352,702 (-)EnsemblGRCh38hg38GRCh38
GRCh371147,352,957 - 47,374,253 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361147,309,533 - 47,330,829 (-)NCBINCBI36Build 36hg18NCBI36
Build 341147,309,526 - 47,330,798NCBI
Celera1147,492,237 - 47,513,531 (-)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1147,052,045 - 47,073,383 (-)NCBIHuRef
CHM1_11147,352,197 - 47,373,500 (-)NCBICHM1_1
T2T-CHM13v2.01147,488,226 - 47,509,533 (-)NCBIT2T-CHM13v2.0
Mybpc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39290,948,459 - 90,966,862 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl290,948,489 - 90,966,861 (+)EnsemblGRCm39 Ensembl
GRCm38291,118,114 - 91,136,516 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,118,144 - 91,136,516 (+)EnsemblGRCm38mm10GRCm38
MGSCv37290,958,301 - 90,976,673 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36290,919,009 - 90,937,348 (+)NCBIMGSCv36mm8
Celera292,502,890 - 92,521,291 (+)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.44NCBI
Mybpc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8397,550,974 - 97,569,216 (+)NCBIGRCr8
mRatBN7.2377,095,165 - 77,113,406 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,095,252 - 77,113,405 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx380,573,681 - 80,591,786 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,172,692 - 89,190,793 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,023,927 - 87,042,063 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0379,940,509 - 79,958,731 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl379,940,561 - 79,958,730 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0386,649,264 - 86,667,484 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,478,579 - 75,496,750 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1375,375,715 - 75,394,374 (+)NCBI
Celera376,303,526 - 76,321,687 (+)NCBICelera
Cytogenetic Map3q24NCBI
MYBPC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2949,532,715 - 49,553,783 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11149,552,509 - 49,573,577 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01147,277,799 - 47,299,102 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11147,830,605 - 47,851,909 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,831,087 - 47,851,849 (-)Ensemblpanpan1.1panPan2
MYBPC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11842,271,159 - 42,288,782 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1842,271,724 - 42,289,215 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1841,000,886 - 41,017,318 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01842,926,187 - 42,943,245 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1842,926,235 - 43,024,307 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11842,412,622 - 42,429,047 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01841,967,840 - 41,984,282 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01842,697,140 - 42,713,582 (+)NCBIUU_Cfam_GSD_1.0
Mybpc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494719,759,573 - 19,778,450 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365621,871,410 - 1,889,648 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365621,871,194 - 1,890,092 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYBPC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,247,340 - 15,270,104 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1215,247,679 - 15,269,714 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2216,454,543 - 16,476,408 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MYBPC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,964,581 - 17,986,351 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl117,963,706 - 17,985,758 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038115,266,096 - 115,286,419 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mybpc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247671,406,587 - 1,420,436 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247671,406,563 - 1,420,778 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000022680   ⟹   ENSCLAP00000022474
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955422888,589 - 901,725 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000022681   ⟹   ENSCLAP00000022475
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955422888,589 - 901,725 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000022682   ⟹   ENSCLAP00000022476
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955422890,931 - 901,725 (+)Ensembl
RefSeq Acc Id: XM_005383977   ⟹   XP_005384034
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955422888,529 - 902,074 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013514330   ⟹   XP_013369784
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955422888,529 - 902,074 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005384034 (Get FASTA)   NCBI Sequence Viewer  
  XP_013369784 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000022474.1
  ENSCLAP00000022475.1
  ENSCLAP00000022476
  ENSCLAP00000022476.1
Reference Protein Sequences
RefSeq Acc Id: XP_005384034   ⟸   XM_005383977
- Peptide Label: isoform X1
- UniProtKB: A0A8C2W0K0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013369784   ⟸   XM_013514330
- Peptide Label: isoform X2
- UniProtKB: A0A8C2W0K0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000022475   ⟸   ENSCLAT00000022681
RefSeq Acc Id: ENSCLAP00000022474   ⟸   ENSCLAT00000022680
RefSeq Acc Id: ENSCLAP00000022476   ⟸   ENSCLAT00000022682
Protein Domains
Fibronectin type-III   Ig-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000015418 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000022680.1 UniProtKB/TrEMBL
  ENSCLAT00000022681.1 UniProtKB/TrEMBL
  ENSCLAT00000022682 ENTREZGENE
  ENSCLAT00000022682.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  MyBP-C_THB UniProtKB/TrEMBL
NCBI Gene Mybpc3 ENTREZGENE
PANTHER MYOSIN-BINDING PROTEIN C, CARDIAC-TYPE UniProtKB/TrEMBL
  TITIN UniProtKB/TrEMBL
Pfam fn3 UniProtKB/TrEMBL
  I-set UniProtKB/TrEMBL
  THB UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
SMART FN3 UniProtKB/TrEMBL
  IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
  SSF49265 UniProtKB/TrEMBL
UniProt A0A8C2W0K0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2W2Z2_CHILA UniProtKB/TrEMBL
  A0A8C2W5B2_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-10-08 Mybpc3  myosin binding protein C3  Mybpc3  myosin binding protein C, cardiac  Symbol and/or name change 5135510 APPROVED