MYBPC3 (myosin binding protein C3)

Gene: MYBPC3 (myosin binding protein C3) Canis lupus familiaris

Analyze

Symbol:

MYBPC3

Name:

myosin binding protein C3

RGD ID:

12326648

Description:

ENCODES a protein that exhibits actin binding (inferred); identical protein binding (inferred); myosin binding (inferred); INVOLVED IN cardiac muscle contraction (ortholog); heart morphogenesis (ortholog); myosin filament assembly (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); arrhythmogenic right ventricular cardiomyopathy (ortholog); arrhythmogenic right ventricular dysplasia 1 (ortholog); FOUND IN myofibril (ortholog)

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

cardiac myosin binding protein C; myosin binding protein C, cardiac; myosin-binding protein C, cardiac-type

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MYBPC3 (myosin binding protein C3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Mybpc3 (myosin binding protein C, cardiac)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Mybpc3 (myosin binding protein C3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mybpc3 (myosin binding protein C3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MYBPC3 (myosin binding protein C3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mybpc3 (myosin binding protein C3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MYBPC3 (myosin binding protein C3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MYBPC3 (myosin binding protein C3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mybpc3 (myosin binding protein C3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	42,271,159 - 42,288,782 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	42,271,724 - 42,289,215 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	41,000,886 - 41,017,318 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	42,926,187 - 42,943,245 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	42,926,235 - 43,024,307 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	42,412,622 - 42,429,047 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	41,967,840 - 41,984,282 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	42,697,140 - 42,713,582 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Animal Disease Models (ISO)

arrhythmogenic right ventricular cardiomyopathy (ISO)

arrhythmogenic right ventricular dysplasia 1 (ISO)

Brugada syndrome (ISO)

cardiac amyloidosis (ISO)

cardiac arrest (ISO)

Cardiac Conduction Defect (ISO)

Cardiomegaly (ISO)

cardiomyopathy (ISO)

catecholaminergic polymorphic ventricular tachycardia (ISO)

catecholaminergic polymorphic ventricular tachycardia 1 (ISO)

congenital disorder of glycosylation type IIc (ISO)

dilated cardiomyopathy (ISO)

dilated cardiomyopathy 1A (ISO)

dilated cardiomyopathy 1B (ISO)

dilated cardiomyopathy 1H (ISO)

dilated cardiomyopathy 1I (ISO)

dilated cardiomyopathy 1MM (ISO)

Dilated Cardiomyopathy with Left Ventricular Noncompaction (ISO)

Dyspnea (ISO)

Familial Amyloid Polyneuropathies (ISO)

familial hypertrophic cardiomyopathy (ISO)

fetal akinesia deformation sequence syndrome 1 (ISO)

genetic disease (ISO)

Heart Block (ISO)

Hirschsprung's disease (ISO)

hypertrophic cardiomyopathy (ISO)

hypertrophic cardiomyopathy 1 (ISO)

hypertrophic cardiomyopathy 4 (ISO)

intellectual disability (ISO)

Isolated Noncompaction of the Ventricular Myocardium (ISO)

Left Ventricular Hypertrophy (ISO)

left ventricular noncompaction (ISO)

Left Ventricular Noncompaction 1 (ISO)

long QT syndrome (ISO)

neuropathy (ISO)

nuclear type mitochondrial complex I deficiency 20 (ISO)

Paroxysmal Atrial Fibrillation (ISO)

peripheral nervous system disease (ISO)

Sudden Cardiac Death (ISO)

Sudden Death (ISO)

sudden infant death syndrome (ISO)

Sudden Unexpected Nocturnal Death Syndrome (ISO)

Tachycardia (ISO)

transthyretin amyloidosis (ISO)

Ventricular Premature Complexes (ISO)

Wolff-Parkinson-White syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cardiac muscle contraction (ISO)

heart morphogenesis (IEA,ISO)

myosin filament assembly (ISO)

regulation of heart contraction (ISO)

regulation of heart rate (ISO)

regulation of striated muscle contraction (ISO)

sarcomere organization (ISO)

ventricular cardiac muscle tissue morphogenesis (IEA)

Cellular Component

A band (IEA)

cardiac myofibril (IEA)

myofibril (ISO)

myosin filament (IEA)

sarcomere (IEA)

striated muscle myosin thick filament (IEA)

Molecular Function

actin binding (IEA)

identical protein binding (IEA)

myosin binding (IEA)

myosin heavy chain binding (IEA)

protein binding (ISO)

structural constituent of muscle (IEA)

References

Additional References at PubMed

PMID:17560599	PMID:22281395	PMID:22301074

Genomics

Comparative Map Data

MYBPC3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	42,271,159 - 42,288,782 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	42,271,724 - 42,289,215 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	41,000,886 - 41,017,318 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	42,926,187 - 42,943,245 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	42,926,235 - 43,024,307 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	42,412,622 - 42,429,047 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	41,967,840 - 41,984,282 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	42,697,140 - 42,713,582 (+)	NCBI		UU_Cfam_GSD_1.0

MYBPC3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	47,331,406 - 47,352,702 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	47,331,406 - 47,352,702 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	47,352,957 - 47,374,253 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	47,309,533 - 47,330,829 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	47,309,526 - 47,330,798	NCBI
Celera	11	47,492,237 - 47,513,531 (-)	NCBI		Celera
Cytogenetic Map	11	p11.2	NCBI
HuRef	11	47,052,045 - 47,073,383 (-)	NCBI		HuRef
CHM1_1	11	47,352,197 - 47,373,500 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	47,488,226 - 47,509,533 (-)	NCBI		T2T-CHM13v2.0

Mybpc3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	90,948,459 - 90,966,862 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	90,948,489 - 90,966,861 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	91,118,114 - 91,136,516 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	91,118,144 - 91,136,516 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	90,958,301 - 90,976,673 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	90,919,009 - 90,937,348 (+)	NCBI		MGSCv36	mm8
Celera	2	92,502,890 - 92,521,291 (+)	NCBI		Celera
Cytogenetic Map	2	E1	NCBI
cM Map	2	50.44	NCBI

Mybpc3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	97,550,974 - 97,569,216 (+)	NCBI		GRCr8
mRatBN7.2	3	77,095,165 - 77,113,406 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	77,095,252 - 77,113,405 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	80,573,681 - 80,591,786 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	89,172,692 - 89,190,793 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	87,023,927 - 87,042,063 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	79,940,509 - 79,958,731 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	79,940,561 - 79,958,730 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	86,649,264 - 86,667,484 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	75,478,579 - 75,496,750 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	75,375,715 - 75,394,374 (+)	NCBI
Celera	3	76,303,526 - 76,321,687 (+)	NCBI		Celera
Cytogenetic Map	3	q24	NCBI

Mybpc3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	888,589 - 901,725 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	888,529 - 902,074 (+)	NCBI	ChiLan1.0	ChiLan1.0

MYBPC3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	49,532,715 - 49,553,783 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	49,552,509 - 49,573,577 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	47,277,799 - 47,299,102 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	47,830,605 - 47,851,909 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	47,831,087 - 47,851,849 (-)	Ensembl	panpan1.1		panPan2

Mybpc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	19,759,573 - 19,778,450 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936562	1,871,410 - 1,889,648 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936562	1,871,194 - 1,890,092 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MYBPC3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	15,247,340 - 15,270,104 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	15,247,679 - 15,269,714 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	16,454,543 - 16,476,408 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MYBPC3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	17,964,581 - 17,986,351 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	17,963,706 - 17,985,758 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	115,266,096 - 115,286,419 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mybpc3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624767	1,406,587 - 1,420,436 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624767	1,406,563 - 1,420,778 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in MYBPC3
311 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High		5
Medium
Low			3							5	1
Below cutoff	5		19	6	6	6	6	6	12	3	9	6

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001048106	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_014120866	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038423433	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038423434	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038423435	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038423436	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ238072	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000213	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000037	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000176	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000013989 ⟹ ENSCAFP00000012944

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	18	42,271,724 - 42,289,215 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845038944 ⟹ ENSCAFP00845030499

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	18	42,926,235 - 43,024,307 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845039171 ⟹ ENSCAFP00845030679

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	18	42,926,235 - 43,024,307 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845039442 ⟹ ENSCAFP00845030909

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	18	42,926,235 - 43,024,307 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845039756 ⟹ ENSCAFP00845031140

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	18	42,926,768 - 42,943,678 (+)	Ensembl

RefSeq Acc Id:

NM_001048106 ⟹ NP_001041571

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	18	42,271,249 - 42,288,287 (+)	NCBI
Dog10K_Boxer_Tasha	18	41,000,886 - 41,017,318 (+)	NCBI
ROS_Cfam_1.0	18	42,926,281 - 42,942,746 (+)	NCBI
UMICH_Zoey_3.1	18	42,412,622 - 42,429,047 (+)	NCBI
UNSW_CanFamBas_1.0	18	41,967,840 - 41,984,282 (+)	NCBI
UU_Cfam_GSD_1.0	18	42,697,140 - 42,713,582 (+)	NCBI

Sequence:

show sequence

GATGCCTGAGCCGGGGAAGAAGCCAGTCTCAGCCTTCAGCAAGAAGCCGAGGTCGGCGGAGGTG
GCCGCCGGCAGCCCTGCTGTGTTTGAGGCCGAGACCGAGCGATCAGGAGTAAAGGTGCGCTGGC
AGCGGGGGGGCAGTGACATCAGCGCCAGTGACAAGTATGGCCTGGCAGCCGAGGGCACAAGGCA
CACTCTGACAGTGCGGGACGTGGGCCCTGCCGACCAGGGGTCCTACGCAGTCATCGCTGGCTCC
TCCAAGGTCAAGTTTGACCTCAAGGTCATAGAAGCGGAGAAGGCAGAGACTGTGCCGGGCCCTG
CTTCTGTCCCTGCCCCTGCCCCTGCTCCTGCTGAGGCTCCCGGAGCCCCCGGAGAAGCCCTAGC
CTCAGCCACTGAGGAGAAAGGAGGCTCCTCAAGTCCCGAAGGGTCGAGCTCGGCAGCCCCTGAT
GGCTCCGGTGCCCCTGATGACCCCATCGGCCTCTTTGTGATGCGGCCACAGGACGGTGAAGTGA
CAGCAGGTGGCAGTATCACCTTCTCAGCACGTGTGGCCGGAGCCAGCCTCCTGAAGCCACCCAC
GGTCAAGTGGTTCAAGGGCAAGTGGGTGGATCTGAGCAGCAAAGCCGGCCAGCACCTGCAGCTG
CACAGCAGCTATGACAGGACCAGCAAGGTCTACCTGTTTGAGTTGCACATTACAGATGCCCAGC
CTACCTCTGCGGGCGGCTACCGCTGTGAGGTGTCCACCAAGGACAAGTTTGACAGCTGCAACTT
CAATCTCACTGTCCACGAGGCCGTTGGCCCGGGAGACCTGGACCTCAGATCAGCTTTCCGCCGC
ACGAGCCTGGCTGGCAGTGGTCGGCGTATCAGTGACAGCCACGAGGACGCAGGAACTCTGGACT
TCAGCTCGCTGCTGAAGAAGAGAGACAGTTTCCGGAGGGACTCCAGGCTGGAGGCACCAGCCGA
GGAGGACGTGTGGGAGATCCTGCGGCAGGCGTCGCCGTCCGAGTACGAGCGCATCGCCTTCCAG
CACGGCGTCACCGACCTGCGTGGCATGCTCAAGAGGCTCAAGGGCATGAAGCGGGATGAGAAGA
AGAGCACAGCCTTTCAGAAGAAGCTGGAGCCGGCCTACCAGGTGAGCAAGGGCCACAAGATCCG
GCTGACTGTGGAGCTGGCCGACCCCGACGCTGACGTCAAGTGGCTTAAGAATGGACAGGAGATC
CAGATGAGCGGCAGCAAGTACATCTTTGAGTCCGTCGGGGCCAAGCGCACGCTGACCATCAGCC
AGTGCTCGCTGGCGGACGACGCAGCCTACCAGTGCGTGGTGGGCGGGGAGAAGTGCAGCACCGA
GCTCTTCGTCAAAGAGCCCCCCGTGCTGATCACTCGGCCCCTGGAAGACCAGCTGGTGATGGTG
GGACAGCGGGTGGAGTTTGAGTGTGAGGTGTCCGAGGAGGGGGCCCAGGTCAAATGGCTGAAGG
ATGGGGTGGAGCTGACCAGGGAGGAGACCTTCAAATACCGGTTCAAGAAGGATGGCCAGAGACA
CCACTTGATCATCAACGAGGCGACGCTGGAGGACGCCGGGCACTACGCGCTGCGCACCAGTGGC
GGCCAGGCGCTGGCCGAGCTCATCGTGCAGGAGAAGAAGCTAGAGGTGTACCAGAGCATTGCGG
ACCTGACGGTGGGCGCGAAGGACCAGGCGGTGTTCAAGTGTGAGGTGTCCGACGAGAATGTGCG
GGGCGTGTGGCTGAAGAACGGGAAGGAGCTGGTGCCTGATAGCCGCATAAAGGTGTCCCACATA
GGGCGAGTCCACAAACTGACCATTGACGACGTCACGCCTGCGGACGAGGCTGACTACAGCTTTG
TGCCTGAAGGCTTTGCCTGCAACCTGTCGGCCAAGCTACACTTCATGGAGGTCAAGATCGACTT
CGTGCCCAGGCAGGAACCTCCCAAGATCCACCTGGACTGCCCGGGCCGCAAGCCAGACACTATC
GTGGTTGTGGCTGGGAACAAGCTACGCCTGGATGTCCCTATCTCTGGGGACCCTGCTCCCACTG
TAATTTGGCAGAAGACCATCACACAGAAGAACAAGGTCCCAGCAGGGCCAGCGCCTGATGCCTC
GGGGGATGCCGCTGCCAGTGACGAGTGGGTGTTTGACAAGAAGCTGCTGTGTGAGACCGAGGGC
CGGGTCCGTGTGGAGACCACCAAGGACCGCAGCATCTTCACTGTGGAGGGGGCCGAGAAGGAAG
ACGAGGGTGTCTATGTCGTCACGGTGAAGAACCCCGTGGGCGAGGACCAGGTCAACCTCACAGT
CAAGGTCATCGATGTGCCGGATGCTCCTGCGGCCCCCAAGATCAGCAACGTGGGCGAGGACTCC
TGCACCGTGCAGTGGGAGCCCCCAGCCTACGACGGTGGCCAGCCGGTCCTGGGCTACATCCTGG
AGCGCAAGAAGAAGAAGAGCTACCGGTGGATGCGGCTCAACTTCGACCTGCTGCGGGAGCTGAG
CCATGAGGCCCGGCGCATGATTGAGGGTGTGGTGTACGAGATGCGAGTCTACGCGGTCAACGCC
ATCGGCATGTCCAGGCCTAGCCCTGCCTCCCAGCCCTTCATGCCAATCGGCCCCCCGAGCGAGC
CCACCCACCTGGCGGTGGAGGACGTGACGGACACCACCGTGTCCCTCAAGTGGAGGCCCCCGGA
GCGCGCGGGCGCGGGCGGCCTGGACGGCTACAGCGTGGAGTACTGCCGGGAGGACTGCTCCGAG
TGGGTGACGGCCCTGCAGGGGCTGACGGAGCACACGGCGGTGCTGGTGAAGGACCTGCCCACGG
GGGCCCGGCTGCAGTTCCGGGTGCGCGCCCACAACATGGCAGGGCCCGGAGCCCCCGTCACCAC
CCAGGAGCCCGTGACGGTGCAGGAGATACTGCAGCGGCCCCGGCTCCAGTTGCCCAGGCACCTG
CGCCAGACCATCCAGAGAAAGGTTGGGGAGCCCGTGAACCTCCTCATTCCTTTCCAGGGCAAGC
CCCGGCCTCAGGTGACCTGGACCAAAGAGGGGCAGCCCCTGGCAGGCGAGGAGGTGAGCATCCG
CAACAGCCCCACGGACACCATCCTGTTCATCCGGGCTGCCCACCGTGCCCACTCTGGCACCTAC
CAGGTGATGTTGCGGATCGAGAACATGGAGGACAAGGCCACGCTGGTCCTGCAGATCGTTGACA
AGCCAAGCCCTCCCCAGGATATTCGGGTCGCCGAAGCCTGGGGTTTCAATGTGGCTCTGGAGTG
GAAGCCACCCCAGGATTATGGCAACACAGAAATCTGGGGTTACACAGTACAGAAAGCCGACACG
AAGACCATGGAGTGGTTCACTGTCCTAGAGCATTACCGCCGCACTCACTGCGTGGTGTCAGAGC
TCATCATTGGCAACGGCTACTACTTCCGGGTCTTCAGCCACAACATGGTGGGGCCCAGTGACAA
AGCCGCCACCACCAAGGAGCCTGTCTTTATCCCCAGACCAGGCATCACGTACGAGCCACCCAGC
TATAAGGCCCTGGACTTCTCGGAGGCCCCGAGCTTCACCCGCCCCCTGGTGAACCGCTCAGTCA
TCGCTGGCTACAATGCTACCCTCTGCTGTGCTGTGCGGGGTAGCCCCAAGCCCAAGATTTCCTG
GTTCAAGAATGGCCTGGATCTGGGGAAGGATGCCCGCTTCCGCATGTTCAGCAAGCAGGGAGTG
TTGACCCTGGAGATTAGAAAGCCCTGTCCCTTTGACGGGGGCATCTATGTCTGTAGGGCTATCA
ACTTACAAGGCGAGGCACAGTGTGAGTGCCGCCTGGAAGTACGAGTGCCTCAGTGAC

hide sequence

RefSeq Acc Id:

XM_038423433 ⟹ XP_038279361

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	18	42,926,187 - 42,943,245 (+)	NCBI

RefSeq Acc Id:

XM_038423434 ⟹ XP_038279362

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	18	42,926,187 - 42,943,245 (+)	NCBI

RefSeq Acc Id:

XM_038423435 ⟹ XP_038279363

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	18	42,926,187 - 42,943,245 (+)	NCBI

RefSeq Acc Id:

XM_038423436 ⟹ XP_038279364

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	18	42,926,187 - 42,941,779 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001041571	(Get FASTA)	NCBI Sequence Viewer
	XP_038279361	(Get FASTA)	NCBI Sequence Viewer
	XP_038279362	(Get FASTA)	NCBI Sequence Viewer
	XP_038279363	(Get FASTA)	NCBI Sequence Viewer
	XP_038279364	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ABB72024	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000012944.4
	ENSCAFP00000070363.1
	ENSCAFP00000073499.1
	ENSCAFP00000074124.1
	ENSCAFP00030006424.1
	ENSCAFP00845030499.1
	ENSCAFP00845030679
	ENSCAFP00845030679.1
	ENSCAFP00845030909.1
	ENSCAFP00845031140
	ENSCAFP00845031140.1

RefSeq Acc Id:

NP_001041571 ⟸ NM_001048106

- UniProtKB:

Q2Q1P6 (UniProtKB/TrEMBL), A0A8I3PNF5 (UniProtKB/TrEMBL), A0A8P0TSX0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPEPGKKPVSAFSKKPRSAEVAAGSPAVFEAETERSGVKVRWQRGGSDISASDKYGLAAEGTRH
TLTVRDVGPADQGSYAVIAGSSKVKFDLKVIEAEKAETVPGPASVPAPAPAPAEAPGAPGEALA
SATEEKGGSSSPEGSSSAAPDGSGAPDDPIGLFVMRPQDGEVTAGGSITFSARVAGASLLKPPT
VKWFKGKWVDLSSKAGQHLQLHSSYDRTSKVYLFELHITDAQPTSAGGYRCEVSTKDKFDSCNF
NLTVHEAVGPGDLDLRSAFRRTSLAGSGRRISDSHEDAGTLDFSSLLKKRDSFRRDSRLEAPAE
EDVWEILRQASPSEYERIAFQHGVTDLRGMLKRLKGMKRDEKKSTAFQKKLEPAYQVSKGHKIR
LTVELADPDADVKWLKNGQEIQMSGSKYIFESVGAKRTLTISQCSLADDAAYQCVVGGEKCSTE
LFVKEPPVLITRPLEDQLVMVGQRVEFECEVSEEGAQVKWLKDGVELTREETFKYRFKKDGQRH
HLIINEATLEDAGHYALRTSGGQALAELIVQEKKLEVYQSIADLTVGAKDQAVFKCEVSDENVR
GVWLKNGKELVPDSRIKVSHIGRVHKLTIDDVTPADEADYSFVPEGFACNLSAKLHFMEVKIDF
VPRQEPPKIHLDCPGRKPDTIVVVAGNKLRLDVPISGDPAPTVIWQKTITQKNKVPAGPAPDAS
GDAAASDEWVFDKKLLCETEGRVRVETTKDRSIFTVEGAEKEDEGVYVVTVKNPVGEDQVNLTV
KVIDVPDAPAAPKISNVGEDSCTVQWEPPAYDGGQPVLGYILERKKKKSYRWMRLNFDLLRELS
HEARRMIEGVVYEMRVYAVNAIGMSRPSPASQPFMPIGPPSEPTHLAVEDVTDTTVSLKWRPPE
RAGAGGLDGYSVEYCREDCSEWVTALQGLTEHTAVLVKDLPTGARLQFRVRAHNMAGPGAPVTT
QEPVTVQEILQRPRLQLPRHLRQTIQRKVGEPVNLLIPFQGKPRPQVTWTKEGQPLAGEEVSIR
NSPTDTILFIRAAHRAHSGTYQVMLRIENMEDKATLVLQIVDKPSPPQDIRVAEAWGFNVALEW
KPPQDYGNTEIWGYTVQKADTKTMEWFTVLEHYRRTHCVVSELIIGNGYYFRVFSHNMVGPSDK
AATTKEPVFIPRPGITYEPPSYKALDFSEAPSFTRPLVNRSVIAGYNATLCCAVRGSPKPKISW
FKNGLDLGKDARFRMFSKQGVLTLEIRKPCPFDGGIYVCRAINLQGEAQCECRLEVRVPQ

hide sequence

RefSeq Acc Id:

ENSCAFP00000012944 ⟸ ENSCAFT00000013989

RefSeq Acc Id:	XP_038279361 ⟸ XM_038423433
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I3PNF5 (UniProtKB/TrEMBL), A0A8P0TSX0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038279363 ⟸ XM_038423435
- Peptide Label:	isoform X3
- UniProtKB:	Q2Q1P6 (UniProtKB/TrEMBL), A0A8I3PNF5 (UniProtKB/TrEMBL), A0A8P0TSX0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038279362 ⟸ XM_038423434
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I3PNF5 (UniProtKB/TrEMBL), A0A8P0TSX0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038279364 ⟸ XM_038423436
- Peptide Label:	isoform X4
- UniProtKB:	A0A8I3PNF5 (UniProtKB/TrEMBL), A0A8P0TSX0 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCAFP00845031140 ⟸ ENSCAFT00845039756

RefSeq Acc Id:

ENSCAFP00845030909 ⟸ ENSCAFT00845039442

RefSeq Acc Id:

ENSCAFP00845030499 ⟸ ENSCAFT00845038944

RefSeq Acc Id:

ENSCAFP00845030679 ⟸ ENSCAFT00845039171

Protein Domains

Fibronectin type-III Ig-like

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000008769	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030003874	UniProtKB/TrEMBL
	ENSCAFG00845021902	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000013989.5	UniProtKB/TrEMBL
	ENSCAFT00000097384.1	UniProtKB/TrEMBL
	ENSCAFT00000101607.1	UniProtKB/TrEMBL
	ENSCAFT00000109022.1	UniProtKB/TrEMBL
	ENSCAFT00030007329.1	UniProtKB/TrEMBL
	ENSCAFT00845038944.1	UniProtKB/TrEMBL
	ENSCAFT00845039171	ENTREZGENE
	ENSCAFT00845039171.1	UniProtKB/TrEMBL
	ENSCAFT00845039442.1	UniProtKB/TrEMBL
	ENSCAFT00845039756	ENTREZGENE
	ENSCAFT00845039756.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/TrEMBL
InterPro	FN3_dom	UniProtKB/TrEMBL
	FN3_sf	UniProtKB/TrEMBL
	Ig-like_dom	UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
	Ig_I-set	UniProtKB/TrEMBL
	Ig_sub	UniProtKB/TrEMBL
	Ig_sub2	UniProtKB/TrEMBL
	MyBP-C_THB	UniProtKB/TrEMBL
KEGG Report	cfa:483624	UniProtKB/TrEMBL
NCBI Gene	MYBPC3	ENTREZGENE
PANTHER	MYOSIN-BINDING PROTEIN C, CARDIAC-TYPE	UniProtKB/TrEMBL
	TITIN	UniProtKB/TrEMBL
Pfam	fn3	UniProtKB/TrEMBL
	I-set	UniProtKB/TrEMBL
	THB	UniProtKB/TrEMBL
PROSITE	FN3	UniProtKB/TrEMBL
	IG_LIKE	UniProtKB/TrEMBL
SMART	FN3	UniProtKB/TrEMBL
	IGc2	UniProtKB/TrEMBL
	SM00409	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48726	UniProtKB/TrEMBL
	SSF49265	UniProtKB/TrEMBL
UniProt	A0A8B0SYX4_CANLF	UniProtKB/TrEMBL
	A0A8C0M8P8_CANLF	UniProtKB/TrEMBL
	A0A8I3PA75_CANLF	UniProtKB/TrEMBL
	A0A8I3PNF5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3PP06_CANLF	UniProtKB/TrEMBL
	A0A8I3PPF9_CANLF	UniProtKB/TrEMBL
	A0A8P0TMR3_CANLF	UniProtKB/TrEMBL
	A0A8P0TSX0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0TUX9_CANLF	UniProtKB/TrEMBL
	Q2Q1P6	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:43524	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-10-08	MYBPC3	myosin binding protein C3	MYBPC3	myosin binding protein C, cardiac	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

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