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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305950
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mybpc3
Name: myosin binding protein C3
Acc ID: CHEBI:64317
Term: isoprenaline
Definition: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Chemical ID: MESH:D007545
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mybpc3affects response to substanceISOMybpc3 (Mus musculus)6480464CTDMYBPC3 protein affects the susceptibility to IsoproterenolPMID:23896226
Mybpc3multiple interactionsISOMYBPC3 (Homo sapiens)6480464CTDMYBPC3 mutant form results in increased susceptibility to [Isoproterenol co-treated with Phenylephrine]PMID:22076249
Mybpc3multiple interactionsISOMybpc3 (Mus musculus)6480464CTDMYBPC3 gene mutant form results in increased susceptibility to [Isoproterenol co-treated with Phenylephrine]PMID:22076249
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