Tomm40 (translocase of outer mitochondrial membrane 40) - Rat Genome Database

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Gene: Tomm40 (translocase of outer mitochondrial membrane 40) Rattus norvegicus
Analyze
Symbol: Tomm40
Name: translocase of outer mitochondrial membrane 40
RGD ID: 1303022
Description: Enables monoatomic cation channel activity; preprotein binding activity; and protein transmembrane transporter activity. Involved in positive regulation of apoptotic process; protein insertion into mitochondrial membrane; and protein targeting to mitochondrion. Located in mitochondrial outer membrane. Part of mitochondrial outer membrane translocase complex. Human ortholog(s) of this gene implicated in cerebral infarction. Orthologous to human TOMM40 (translocase of outer mitochondrial membrane 40); PARTICIPATES IN beta-barrel pathway of mitochondrial protein import; carrier pathway of mitochondrial protein import; intermembrane space assembly pathway of mitochondrial protein import; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: mitochondrial import receptor subunit TOM40 homolog; mitochondrial outer membrane protein of 38 kDa; OM38; outer membrane protein 38 kDa; TOM40; translocase of outer membrane 40 kDa subunit homolog; translocase of outer mitochondrial membrane 40 homolog; translocase of outer mitochondrial membrane 40 homolog (yeast)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,486,745 - 88,498,833 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl188,486,758 - 88,499,671 (-)EnsemblGRCr8
mRatBN7.2179,358,781 - 79,370,882 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,358,786 - 79,370,915 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx184,754,076 - 84,765,628 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0193,305,430 - 93,316,983 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,509,183 - 86,520,735 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,617,749 - 80,630,253 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,618,154 - 80,630,038 (-)Ensemblrn6Rnor6.0
Rnor_5.0181,883,227 - 81,895,703 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4179,008,895 - 79,020,420 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera173,818,380 - 73,829,904 (-)NCBICelera
RGSC_v3.1179,087,005 - 79,098,531 (-)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
DDE  (ISO)
deoxynivalenol  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furfural  (ISO)
genistein  (ISO)
glafenine  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nimesulide  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
rac-lactic acid  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
streptozocin  (ISO)
sulfadimethoxine  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tolcapone  (EXP)
trimellitic anhydride  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism. Anandatheerthavarada HK, etal., J Biol Chem. 2009 Jun 19;284(25):17352-63. doi: 10.1074/jbc.M109.007492. Epub 2009 Apr 28.
2. Bax inserts into the mitochondrial outer membrane by different mechanisms. Cartron PF, etal., FEBS Lett. 2008 Sep 3;582(20):3045-51. doi: 10.1016/j.febslet.2008.07.047. Epub 2008 Aug 5.
3. Biogenesis of mitochondrial outer membrane proteins, problems and diseases. Ellenrieder L, etal., Biol Chem. 2015 Oct 1;396(11):1199-213. doi: 10.1515/hsz-2015-0170.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Assembly of beta-barrel proteins in the mitochondrial outer membrane. Hohr AI, etal., Biochim Biophys Acta. 2015 Jan;1853(1):74-88. doi: 10.1016/j.bbamcr.2014.10.006. Epub 2014 Oct 8.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Impaired transport of mitochondrial transcription factor A (TFAM) and the metabolic memory phenomenon associated with the progression of diabetic retinopathy. Santos JM and Kowluru RA, Diabetes Metab Res Rev. 2013 Mar;29(3):204-13. doi: 10.1002/dmrr.2384.
12. Unlocking the presequence import pathway. Schulz C, etal., Trends Cell Biol. 2015 May;25(5):265-75. doi: 10.1016/j.tcb.2014.12.001. Epub 2014 Dec 23.
13. Characterization of rat TOM40, a central component of the preprotein translocase of the mitochondrial outer membrane. Suzuki H, etal., J Biol Chem 2000 Dec 1;275(48):37930-6.
14. Membrane-embedded C-terminal segment of rat mitochondrial TOM40 constitutes protein-conducting pore with enriched beta-structure. Suzuki H, etal., J Biol Chem. 2004 Nov 26;279(48):50619-29. Epub 2004 Sep 3.
15. Cooperation of protein machineries in mitochondrial protein sorting. Wenz LS, etal., Biochim Biophys Acta. 2015 May;1853(5):1119-29. doi: 10.1016/j.bbamcr.2015.01.012. Epub 2015 Jan 26.
16. Association of TOMM40 and SLC22A4 polymorphisms with ischemic stroke. Yamase Y, etal., Biomed Rep. 2015 Jul;3(4):491-498. doi: 10.3892/br.2015.457. Epub 2015 Apr 29.
Additional References at PubMed
PMID:11745481   PMID:12198123   PMID:12931191   PMID:14651853   PMID:15136728   PMID:15644312   PMID:17437969   PMID:18614015   PMID:20107041   PMID:23376485   PMID:24746669   PMID:28376086  
PMID:30121780   PMID:30296408  


Genomics

Comparative Map Data
Tomm40
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,486,745 - 88,498,833 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl188,486,758 - 88,499,671 (-)EnsemblGRCr8
mRatBN7.2179,358,781 - 79,370,882 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,358,786 - 79,370,915 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx184,754,076 - 84,765,628 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0193,305,430 - 93,316,983 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,509,183 - 86,520,735 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,617,749 - 80,630,253 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,618,154 - 80,630,038 (-)Ensemblrn6Rnor6.0
Rnor_5.0181,883,227 - 81,895,703 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4179,008,895 - 79,020,420 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera173,818,380 - 73,829,904 (-)NCBICelera
RGSC_v3.1179,087,005 - 79,098,531 (-)NCBI
Cytogenetic Map1q21NCBI
TOMM40
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381944,891,254 - 44,903,689 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1944,890,569 - 44,903,695 (+)Ensemblhg38GRCh38
GRCh371945,394,511 - 45,406,946 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,086,334 - 50,098,783 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341950,086,333 - 50,098,775NCBI
Celera1942,198,820 - 42,211,268 (+)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1941,824,784 - 41,837,732 (+)NCBIHuRef
CHM1_11945,397,251 - 45,409,700 (+)NCBICHM1_1
T2T-CHM13v2.01947,715,975 - 47,728,385 (+)NCBIT2T-CHM13v2.0
Tomm40
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39719,435,238 - 19,449,370 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl719,435,238 - 19,449,363 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38719,701,313 - 19,715,442 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,701,313 - 19,715,438 (-)Ensemblmm10GRCm38
MGSCv37720,286,662 - 20,300,778 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36718,859,840 - 18,873,778 (-)NCBIMGSCv36mm8
Celera717,107,398 - 17,121,516 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.94NCBI
Tomm40
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555551,987,261 - 1,996,886 (+)Ensembl
ChiLan1.0NW_0049555551,987,063 - 1,997,329 (+)NCBIChiLan1.0ChiLan1.0
TOMM40
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22051,050,714 - 51,065,341 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11952,922,618 - 52,935,086 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01941,839,025 - 41,851,491 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11950,445,268 - 50,457,729 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1950,444,475 - 50,457,729 (+)EnsemblpanPan2panpan1.1
TOMM40
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11110,530,233 - 110,541,049 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1110,530,597 - 110,541,042 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1110,011,176 - 110,021,984 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01111,060,001 - 111,070,822 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1111,060,005 - 111,071,097 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11110,734,654 - 110,745,459 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01110,370,126 - 110,380,934 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01111,238,917 - 111,249,729 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tomm40
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,152,860 - 17,162,972 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367061,500,244 - 1,510,308 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367061,500,244 - 1,510,328 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOMM40
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl651,359,595 - 51,369,908 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1651,359,948 - 51,369,932 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2647,257,121 - 47,266,690 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TOMM40
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1638,363,060 - 38,375,098 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl638,363,176 - 38,375,218 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607317,932,848 - 17,945,135 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tomm40
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249071,740,549 - 1,751,276 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249071,740,450 - 1,751,066 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tomm40
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12170,904,102 - 170,915,835 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tomm40
96 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:63
Interacting mature miRNAs:70
Transcripts:ENSRNOT00000025281
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat

Markers in Region
RH141850  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,358,945 - 79,359,138 (+)MAPPERmRatBN7.2
Rnor_6.0180,617,914 - 80,618,106NCBIRnor6.0
Rnor_5.0181,883,392 - 81,883,584UniSTSRnor5.0
RGSC_v3.4179,008,655 - 79,008,847UniSTSRGSC3.4
Celera173,818,140 - 73,818,332UniSTS
RH 3.4 Map1819.8UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000025281   ⟹   ENSRNOP00000025281
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl188,486,758 - 88,498,833 (-)Ensembl
mRatBN7.2 Ensembl179,358,786 - 79,370,915 (-)Ensembl
Rnor_6.0 Ensembl180,618,154 - 80,630,038 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000170635   ⟹   ENSRNOP00000099881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl188,486,758 - 88,499,671 (-)Ensembl
RefSeq Acc Id: NM_212520   ⟹   NP_997685
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,486,745 - 88,498,833 (-)NCBI
mRatBN7.2179,358,781 - 79,370,870 (-)NCBI
Rnor_6.0180,618,154 - 80,630,038 (-)NCBI
Rnor_5.0181,883,227 - 81,895,703 (-)NCBI
RGSC_v3.4179,008,895 - 79,020,420 (-)RGD
Celera173,818,380 - 73,829,904 (-)RGD
Sequence:
RefSeq Acc Id: NP_997685   ⟸   NM_212520
- UniProtKB: Q75Q40 (UniProtKB/Swiss-Prot),   G3V8F5 (UniProtKB/TrEMBL),   A6J8T5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025281   ⟸   ENSRNOT00000025281
Ensembl Acc Id: ENSRNOP00000099881   ⟸   ENSRNOT00000170635

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q75Q40-F1-model_v2 AlphaFold Q75Q40 1-361 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689781
Promoter ID:EPDNEW_R305
Type:single initiation site
Name:Tomm40_1
Description:translocase of outer mitochondrial membrane 40
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0180,629,954 - 80,630,014EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303022 AgrOrtholog
BioCyc Gene G2FUF-60487 BioCyc
Ensembl Genes ENSRNOG00000018556 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000025281 ENTREZGENE
Gene3D-CATH 2.40.160.10 UniProtKB/Swiss-Prot
InterPro Porin_dom_sf UniProtKB/Swiss-Prot
  Porin_Euk/Tom40 UniProtKB/Swiss-Prot
  Tom40 UniProtKB/Swiss-Prot
KEGG Report rno:308416 UniProtKB/Swiss-Prot
NCBI Gene 308416 ENTREZGENE
PANTHER PTHR10802 UniProtKB/Swiss-Prot
Pfam Porin_3 UniProtKB/Swiss-Prot
PhenoGen Tomm40 PhenoGen
RatGTEx ENSRNOG00000018556 RatGTEx
UniProt A0ABK0LG66_RAT UniProtKB/TrEMBL
  A6J8T5 ENTREZGENE, UniProtKB/TrEMBL
  A6J8T8_RAT UniProtKB/TrEMBL
  A6J8T9_RAT UniProtKB/TrEMBL
  A6J8U1_RAT UniProtKB/TrEMBL
  A6J8U3_RAT UniProtKB/TrEMBL
  G3V8F5 ENTREZGENE, UniProtKB/TrEMBL
  Q75Q40 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Tomm40  translocase of outer mitochondrial membrane 40  Tomm40  translocase of outer mitochondrial membrane 40 homolog (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Tomm40  translocase of outer mitochondrial membrane 40 homolog (yeast)    translocase of outer mitochondrial membrane 40  Name updated 1299863 APPROVED
2005-01-04 Tomm40  translocase of outer mitochondrial membrane 40  TOM40  translocase of outer mitochondrial membrane 40  Symbol updated 1299863 PROVISIONAL
2005-01-04   translocase of outer mitochondrial membrane 40  TOM40  TOM40 protein  Name updated 1299863 PROVISIONAL