RGD Reference Report - Cooperation of protein machineries in mitochondrial protein sorting. - Rat Genome Database

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Cooperation of protein machineries in mitochondrial protein sorting.

Authors: Wenz, LS  Opalinski, L  Wiedemann, N  Becker, T 
Citation: Wenz LS, etal., Biochim Biophys Acta. 2015 May;1853(5):1119-29. doi: 10.1016/j.bbamcr.2015.01.012. Epub 2015 Jan 26.
RGD ID: 10412658
Pubmed: PMID:25633533   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbamcr.2015.01.012   (Journal Full-text)

The function of mitochondria depends on the import of proteins, which are synthesized as precursors on cytosolic ribosomes. The majority of the precursor proteins are sorted into the mitochondrial subcompartments via five distinct routes. Recent studies revealed that molecular cooperation between protein machineries is a central feature of mitochondrial protein biogenesis. First, coupling to various partner proteins affects the substrate specificity of translocases and single translocation steps. Second, there is a substantial cooperation between different protein translocases in the import of specific precursor proteins. Third, protein transport is intimately linked to processing, folding and assembly reactions. Fourth, sorting of precursor proteins is functionally and physically connected to protein machineries, which fulfill central functions for respiration, maintenance of membrane architecture and form contacts to the endoplasmic reticulum. Therefore, we propose that the protein transport systems are part of a complicated protein network for mitochondrial biogenesis.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
alpha-helical insertion pathway of mitochondrial protein import  TAS 10412658 RGD 
alpha-helical insertion pathway of mitochondrial protein import  ISOTOMM70 (Homo sapiens)10412658; 10412658 RGD 
intermembrane space assembly pathway of mitochondrial protein import  TAS 10412658 RGD 
intermembrane space assembly pathway of mitochondrial protein import  ISOTOMM40 (Homo sapiens)10412658; 10412658 RGD 
mitochondrial protein import pathway   TAS 10412658 RGD 
mitochondrial protein import pathway   ISOOXA1L (Homo sapiens)10412658; 10412658 RGD 
presequence pathway of mitochondrial protein import  TAS 10412658; 10412658; 10412658; 10412658; 10412658; 10412658; 10412658; 10412658; 10412658; 10412658; 10412658; 10412658 RGD 
presequence pathway of mitochondrial protein import  ISOROMO1 (Homo sapiens)10412658; 10412658 RGD 
presequence pathway of mitochondrial protein import  ISOTIMM17A (Homo sapiens)10412658; 10412658 RGD 
presequence pathway of mitochondrial protein import  ISOTIMM21 (Homo sapiens)10412658; 10412658 RGD 
presequence pathway of mitochondrial protein import  ISOTIMM23 (Homo sapiens)10412658; 10412658 RGD 
presequence pathway of mitochondrial protein import  ISOTIMM50 (Homo sapiens)10412658; 10412658 RGD 
presequence pathway of mitochondrial protein import  ISOTOMM20 (Homo sapiens)10412658; 10412658 RGD 
presequence pathway of mitochondrial protein import  ISOTOMM22 (Homo sapiens)10412658; 10412658 RGD 
presequence pathway of mitochondrial protein import  ISOTOMM40 (Homo sapiens)10412658; 10412658 RGD 
presequence pathway of mitochondrial protein import  ISOTOMM5 (Homo sapiens)10412658; 10412658 RGD 
presequence pathway of mitochondrial protein import  ISOTOMM6 (Homo sapiens)10412658; 10412658 RGD 
presequence pathway of mitochondrial protein import  ISOTOMM7 (Homo sapiens)10412658; 10412658 RGD 
presequence pathway of mitochondrial protein import  ISOTOMM70 (Homo sapiens)10412658; 10412658 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Oxa1l  (OXA1L, mitochondrial inner membrane protein)
Romo1  (reactive oxygen species modulator 1)
Timm17a  (translocase of inner mitochondrial membrane 17A)
Timm21  (translocase of inner mitochondrial membrane 21)
Timm23  (translocase of inner mitochondrial membrane 23)
Timm50  (translocase of inner mitochondrial membrane 50)
Tomm20  (translocase of outer mitochondrial membrane 20)
Tomm22  (translocase of outer mitochondrial membrane 22)
Tomm40  (translocase of outer mitochondrial membrane 40)
Tomm5  (translocase of outer mitochondrial membrane 5)
Tomm6  (translocase of outer mitochondrial membrane 6)
Tomm7  (translocase of outer mitochondrial membrane 7)
Tomm70  (translocase of outer mitochondrial membrane 70)

Genes (Mus musculus)
Oxa1l  (oxidase assembly 1-like)
Romo1  (reactive oxygen species modulator 1)
Timm17a  (translocase of inner mitochondrial membrane 17a)
Timm21  (translocase of inner mitochondrial membrane 21)
Timm23  (translocase of inner mitochondrial membrane 23)
Timm50  (translocase of inner mitochondrial membrane 50)
Tomm20  (translocase of outer mitochondrial membrane 20)
Tomm22  (translocase of outer mitochondrial membrane 22)
Tomm40  (translocase of outer mitochondrial membrane 40)
Tomm5  (translocase of outer mitochondrial membrane 5)
Tomm6  (translocase of outer mitochondrial membrane 6)
Tomm7  (translocase of outer mitochondrial membrane 7)
Tomm70a  (translocase of outer mitochondrial membrane 70A)

Genes (Homo sapiens)
OXA1L  (OXA1L mitochondrial inner membrane protein)
ROMO1  (reactive oxygen species modulator 1)
TIMM17A  (translocase of inner mitochondrial membrane 17A)
TIMM21  (translocase of inner mitochondrial membrane 21)
TIMM23  (translocase of inner mitochondrial membrane 23)
TIMM50  (translocase of inner mitochondrial membrane 50)
TOMM20  (translocase of outer mitochondrial membrane 20)
TOMM22  (translocase of outer mitochondrial membrane 22)
TOMM40  (translocase of outer mitochondrial membrane 40)
TOMM5  (translocase of outer mitochondrial membrane 5)
TOMM6  (translocase of outer mitochondrial membrane 6)
TOMM7  (translocase of outer mitochondrial membrane 7)
TOMM70  (translocase of outer mitochondrial membrane 70)


Additional Information