RGD Reference Report - Biogenesis of mitochondrial outer membrane proteins, problems and diseases. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Biogenesis of mitochondrial outer membrane proteins, problems and diseases.

Authors: Ellenrieder, L  Martensson, CU  Becker, T 
Citation: Ellenrieder L, etal., Biol Chem. 2015 Oct 1;396(11):1199-213. doi: 10.1515/hsz-2015-0170.
RGD ID: 10412661
Pubmed: PMID:25980382   (View Abstract at PubMed)
DOI: DOI:10.1515/hsz-2015-0170   (Journal Full-text)

Proteins of the mitochondrial outer membrane are synthesized as precursors on cytosolic ribosomes and sorted via internal targeting sequences to mitochondria. Two different types of integral outer membrane proteins exist: proteins with a transmembrane beta-barrel and proteins embedded by a single or multiple alpha-helices. The import pathways of these two types of membrane proteins differ fundamentally. Precursors of beta-barrel proteins are first imported across the outer membrane via the translocase of the outer membrane (TOM complex). The TOM complex is coupled to the sorting and assembly machinery (SAM complex), which catalyzes folding and membrane insertion of these precursors. The mitochondrial import machinery (MIM complex) promotes import of proteins with multiple alpha-helical membrane spans. Depending on the topology precursors of proteins with a single alpha-helical membrane anchor are imported via several distinct routes. We summarize current models and open questions of biogenesis of mitochondrial outer membrane proteins and discuss the impact of malfunctions of protein sorting on the development of diseases.

Objects Annotated

Genes (Rattus norvegicus)
Tomm20  (translocase of outer mitochondrial membrane 20)
Tomm22  (translocase of outer mitochondrial membrane 22)
Tomm40  (translocase of outer mitochondrial membrane 40)
Tomm5  (translocase of outer mitochondrial membrane 5)
Tomm6  (translocase of outer mitochondrial membrane 6)
Tomm7  (translocase of outer mitochondrial membrane 7)
Tomm70  (translocase of outer mitochondrial membrane 70)

Genes (Mus musculus)
Tomm20  (translocase of outer mitochondrial membrane 20)
Tomm22  (translocase of outer mitochondrial membrane 22)
Tomm40  (translocase of outer mitochondrial membrane 40)
Tomm5  (translocase of outer mitochondrial membrane 5)
Tomm6  (translocase of outer mitochondrial membrane 6)
Tomm7  (translocase of outer mitochondrial membrane 7)
Tomm70a  (translocase of outer mitochondrial membrane 70A)

Genes (Homo sapiens)
TOMM20  (translocase of outer mitochondrial membrane 20)
TOMM22  (translocase of outer mitochondrial membrane 22)
TOMM40  (translocase of outer mitochondrial membrane 40)
TOMM5  (translocase of outer mitochondrial membrane 5)
TOMM6  (translocase of outer mitochondrial membrane 6)
TOMM7  (translocase of outer mitochondrial membrane 7)
TOMM70  (translocase of outer mitochondrial membrane 70)


Additional Information