Myl12b (myosin light chain 12B) - Rat Genome Database

Name: Myl12b
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Myl12b (myosin light chain 12B) Rattus norvegicus

Analyze

Symbol:

Myl12b

Name:

myosin light chain 12B

RGD ID:

628855

Description:

Predicted to enable GTPase binding activity; calcium ion binding activity; and myosin heavy chain binding activity. Predicted to act upstream of or within regulation of cell shape. Part of protein-containing complex. Orthologous to several human genes including MYL12B (myosin light chain 12B); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

MGC114341; MLC-2; MLC20; Mrlc2; Mrlcb; Mylc2b; myosin light chain, regulatory B; myosin regulatory light chain; myosin regulatory light chain 12B; myosin regulatory light chain 2-B, smooth muscle isoform; myosin regulatory light chain 20 kDa; myosin regulatory light chain MRLC2; myosin regulatory light chain-B; myosin RLC-B; myosin, light chain 12B, regulatory

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MYL12B (myosin light chain 12B)	HGNC	Ensembl, Inparanoid, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Myl12b (myosin, light chain 12B, regulatory)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MYL12B (myosin light chain 12B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MYL12B (myosin light chain 12B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Myl12b (myosin light chain 12B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LOC733637 (myosin regulatory light chain 2 protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MYL12B (myosin light chain 12B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Myl12b (myosin light chain 12B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	MYL12A (myosin light chain 12A)	HGNC	HomoloGene
Alliance orthologs ³
Mus musculus (house mouse):	Myl12b (myosin, light chain 12B, regulatory)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	MYL12B (myosin light chain 12B)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	MYL12A (myosin light chain 12A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	myl12.2 (myosin, light chain 12, genome duplicate 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mlc-4	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	sqh	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	myl12b	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)

Candidate Gene For:

Vetf6

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	118,320,479 - 118,334,810 (-)	NCBI		GRCr8
mRatBN7.2	9	110,873,855 - 110,888,187 (-)	NCBI	mRatBN7.2	mRatBN7.2
UTH_Rnor_SHR_Utx	9	119,261,365 - 119,275,700 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	124,390,953 - 124,405,288 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	122,727,332 - 122,741,665 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	119,307,168 - 119,321,500 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	119,307,176 - 119,321,500 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	118,761,452 - 118,775,834 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	110,171,418 - 110,186,248 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	110,380,900 - 110,384,839 (-)	NCBI
Celera	9	108,004,122 - 108,018,394 (-)	NCBI		Celera
Cytogenetic Map	9	q38	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

chromosome 18p deletion syndrome (ISO)

holoprosencephaly 4 (ISO)

hypertrophic cardiomyopathy (ISO)

intellectual disability (ISO)

Majeed Syndrome (ISO)

Neurodevelopmental Disorders (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3H-1,2-dithiole-3-thione (EXP)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amiloride (ISO)

amitrole (EXP)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bleomycin A2 (EXP)

bucladesine (ISO)

cadmium dichloride (EXP)

cannabidiol (ISO)

carbon nanotube (ISO)

chloropicrin (ISO)

clofibrate (EXP)

copper atom (ISO)

copper(0) (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (ISO)

dicrotophos (ISO)

disodium selenite (ISO)

diuron (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

ethanol (ISO)

fluoranthene (ISO)

flutamide (EXP)

folic acid (ISO)

genistein (ISO)

gentamycin (EXP)

hyaluronic acid (EXP)

hydrogen peroxide (EXP)

medroxyprogesterone acetate (ISO)

methimazole (EXP)

methotrexate (ISO)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

paracetamol (ISO)

phenylmercury acetate (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenate (ISO)

Soman (EXP)

sulfadimethoxine (EXP)

tetrachloromethane (ISO)

thapsigargin (EXP,ISO)

titanium dioxide (ISO)

tremolite asbestos (ISO)

triadimefon (EXP)

trichloroethene (EXP)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

regulation of cell shape (ISO)

Cellular Component

apical part of cell (ISO)

cell cortex (ISO,ISS)

cytoplasm (IBA)

myofibril (IBA)

myosin II complex (ISO)

protein-containing complex (IDA)

stress fiber (IBA,ISO)

Z disc (ISO)

Molecular Function

calcium ion binding (IBA)

GTPase binding (ISO)

myosin heavy chain binding (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Mammalian nonsarcomeric myosin regulatory light chains are encoded by two differentially regulated and linked genes.	Grant JW, etal., J Cell Biol 1990 Sep;111(3):1127-35.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Identification of a multiprotein "motor" complex binding to water channel aquaporin-2.	Noda Y, etal., Biochem Biophys Res Commun. 2005 May 20;330(4):1041-7.
5.	Molecular cloning of a unique complementary DNA of rat myosin regulatory light chain and its elevated expression in v-src-transformed rat culture cell lines.	Ozaki T, etal., Cell Growth Differ 1993 Nov;4(11):939-45.
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
9.	Cloning and characterization of mammalian myosin regulatory light chain (RLC) cDNA: the RLC gene is expressed in smooth, sarcomeric, and nonmuscle tissues.	Taubman MB, etal., J Cell Biol 1987 Jun;104(6):1505-13.

Additional References at PubMed

PMID:1649372	PMID:8034049	PMID:12970723	PMID:15037549	PMID:15277470	PMID:15489334	PMID:17543276	PMID:20458337	PMID:21126233	PMID:22114352	PMID:22661704	PMID:23870127
PMID:24625528	PMID:24825904	PMID:25002582	PMID:27233767	PMID:35352799

Genomics

Comparative Map Data

Myl12b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	118,320,479 - 118,334,810 (-)	NCBI		GRCr8
mRatBN7.2	9	110,873,855 - 110,888,187 (-)	NCBI	mRatBN7.2	mRatBN7.2
UTH_Rnor_SHR_Utx	9	119,261,365 - 119,275,700 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	124,390,953 - 124,405,288 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	122,727,332 - 122,741,665 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	119,307,168 - 119,321,500 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	119,307,176 - 119,321,500 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	118,761,452 - 118,775,834 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	110,171,418 - 110,186,248 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	110,380,900 - 110,384,839 (-)	NCBI
Celera	9	108,004,122 - 108,018,394 (-)	NCBI		Celera
Cytogenetic Map	9	q38	NCBI

MYL12B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	3,262,133 - 3,278,461 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	3,261,479 - 3,278,461 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	18	3,262,131 - 3,278,459 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	3,252,135 - 3,268,179 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	18	3,141,594 - 3,157,815 (+)	NCBI		Celera
Cytogenetic Map	18	p11.31	NCBI
HuRef	18	3,226,523 - 3,243,194 (+)	NCBI		HuRef
CHM1_1	18	3,261,491 - 3,277,645 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	18	3,421,438 - 3,437,816 (+)	NCBI		T2T-CHM13v2.0

Myl12b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	71,280,958 - 71,297,511 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	71,280,128 - 71,297,885 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	70,973,963 - 70,990,516 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	70,973,133 - 70,990,890 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	71,323,303 - 71,339,856 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	70,878,820 - 70,895,373 (-)	NCBI		MGSCv36	mm8
Celera	17	75,244,495 - 75,261,050 (-)	NCBI		Celera
Cytogenetic Map	17	E1.3	NCBI
cM Map	17	41.87	NCBI

MYL12B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	17	35,162,868 - 35,179,082 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	18	20,855,526 - 20,871,861 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	10,999,849 - 11,016,059 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	13,308,356 - 13,324,754 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	13,308,356 - 13,324,754 (-)	Ensembl	panpan1.1		panPan2

MYL12B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	69,877,727 - 69,895,196 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	69,332,485 - 69,350,491 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	69,938,422 - 69,954,234 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	69,939,041 - 69,957,106 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	69,621,752 - 69,639,768 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	69,640,728 - 69,658,745 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	69,939,371 - 69,957,614 (+)	NCBI		UU_Cfam_GSD_1.0

Myl12b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	66,219,949 - 66,238,423 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936672	1,300,341 - 1,322,065 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936672	1,303,510 - 1,321,969 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LOC733637
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	103,409,717 - 103,420,286 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	103,413,841 - 103,424,790 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	96,440,639 - 96,451,618 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MYL12B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	62,510,012 - 62,527,027 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	62,521,295 - 62,529,131 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	37,373,059 - 37,390,346 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Myl12b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624770	13,393,106 - 13,409,139 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla_female_1.0 Ensembl	NW_004624770	13,386,194 - 13,392,928 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624770	13,378,668 - 13,408,633 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Myl12b
103 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	336
Count of miRNA genes:	166
Interacting mature miRNAs:	179
Transcripts:	ENSRNOT00000048125
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724544	Uae9	Urinary albumin excretion QTL 9	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	9	25268044	114175309	Rat
1354626	Bvd1	Brain ventricular dilatation QTL 1	3.73	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	9	75712843	111552878	Rat
7794784	Mcs31	Mammary carcinoma susceptibility QTL 31	2.98		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	9	77813894	111552878	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	3	6	74	35	41	11	3
Low							5	5					5
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_017343	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039084137	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC060577	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CF977112	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474043	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CO405920	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D14688	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EV769828	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ215510	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220506	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ229195	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X52840	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X53594	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000048125 ⟹ ENSRNOP00000045992

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	9	119,307,176 - 119,321,500 (-)	Ensembl

RefSeq Acc Id:

NM_017343 ⟹ NP_059039

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	118,320,479 - 118,334,810 (-)	NCBI
mRatBN7.2	9	110,873,855 - 110,888,187 (-)	NCBI
Rnor_6.0	9	119,307,168 - 119,321,500 (-)	NCBI
Rnor_5.0	9	118,761,452 - 118,775,834 (-)	NCBI
RGSC_v3.4	9	110,171,418 - 110,186,248 (-)	RGD
Celera	9	108,004,122 - 108,018,394 (-)	RGD

Sequence:

show sequence

AGTGCGGCGCCTCCACTGTCCCGCCGCAGCCTCCGCTGGTTGCAGTCGCCGGTCTGGTCCTCTT
GTGCGTGCAGCTTCAGGTCAGATTTGAACCGCCACCATGTCGAGCAAAAAAGCAAAGACCAAGA
CCACCAAAAAGCGCCCTCAGCGCGCAACGTCCAACGTGTTCGCCATGTTTGACCAGTCCCAGAT
CCAGGAGTTCAAAGAGGCCTTCAACATGATCGACCAGAACCGGGACGGCTTCATTGACAAGGAG
GACCTGCACGACATGCTCGCGTCTCTGGGGAAGAACCCCACCGACGCCTACCTGGACGCCATGA
TGAACGAGGCCCCGGGCCCCATCAATTTCACCATGTTCCTCACCATGTTTGGAGAGAAGCTGAA
CGGCACCGACCCAGAGGACGTCATCAGAAACGCCTTCGCTTGCTTCGATGAGGAAGCCACAGGC
ACCATCCAGGAGGATTACCTGAGGGAGCTGCTGACCACCATGGGTGACCGCTTCACAGATGAGG
AAGTGGATGAGCTGTACAGGGAGGCCCCCATCGACAAAAAGGGCAATTTCAACTACATCGAGTT
CACGCGCATCCTCAAGCACGGAGCGAAAGACAAAGATGACTGAAGAGCTGCAGCTGACATTCCT
GTTGAGTTTCCTTATTCACTTCATGTCTCAGACACGCACCCCATAGGACCTACTGTGTGCCACT
TTGTCCCTCAGACACCCCCTCCCATAGGGCCTACTGTGTGCCGCTTAGTCCCTCAGACACCCCC
TCCCATAGGGCCTACTGTGTGCCACTTAGTCCCTCAGACACCCCCTCCCATAGGGCCTACTGTG
TGCCACTTTGTCCCTCAGACACCCCCTCCCATAGGACCTACTGTGTACCACTTGGTTTCTCAGA
CAGCCCCACCCCCAAACCCCCTAAGGACCTACTGCGGGCCACTTAGTTTCACAGCCTTTCCTCT
TTTTTAATGTATTTATTCCAGACCCTTTCTGCCACTTAGCATGTGTATAATCAGACTGGAATGG
GGACAATGTTGTAAATTGTACTGAAAATGAGATGCAAATAAAAAAATCAACCAATGTGAAAGCC
CAGGAAAATATATCGGCATTTCTGGTTTTGCTGGATTTTTTTACATTTTTATATAATAAAAATG
TTATTTTGAAATAAAGATTATGCTGACTCAAGTGGAGTATAAAACAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039084137 ⟹ XP_038940065

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	118,320,581 - 118,334,486 (-)	NCBI
mRatBN7.2	9	110,873,872 - 110,887,861 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_059039	(Get FASTA)	NCBI Sequence Viewer
	XP_038940065	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH60577	(Get FASTA)	NCBI Sequence Viewer
	BAA03514	(Get FASTA)	NCBI Sequence Viewer
	CAA37024	(Get FASTA)	NCBI Sequence Viewer
	CAA37663	(Get FASTA)	NCBI Sequence Viewer
	EDL90944	(Get FASTA)	NCBI Sequence Viewer
	EDL90945	(Get FASTA)	NCBI Sequence Viewer
	P18666	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_059039 ⟸ NM_017343
- UniProtKB:	Q6P9V4 (UniProtKB/Swiss-Prot), P18666 (UniProtKB/Swiss-Prot), A6KF93 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSSKKAKTKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLASLGKN PTDAYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQEDYLRELLT TMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD hide sequence

RefSeq Acc Id:

ENSRNOP00000045992 ⟸ ENSRNOT00000048125

RefSeq Acc Id:	XP_038940065 ⟸ XM_039084137
- Peptide Label:	isoform X1
- UniProtKB:	Q6P9V4 (UniProtKB/Swiss-Prot), P18666 (UniProtKB/Swiss-Prot), A6KF93 (UniProtKB/TrEMBL)

Protein Domains

EF-hand

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P18666-F1-model_v2	AlphaFold	P18666	1-172	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696910

Promoter ID:

EPDNEW_R7435

Type:

initiation region

Name:

Myl12b_1

Description:

myosin light chain 12B

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	9	119,321,483 - 119,321,543	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628855	AgrOrtholog
BioCyc Gene	G2FUF-26345	BioCyc
Ensembl Genes	ENSRNOG00000015733	Ensembl
Gene3D-CATH	EF-hand	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:6889406	IMAGE-MGC_LOAD
	IMAGE:7378266	IMAGE-MGC_LOAD
InterPro	EF-hand-dom_pair	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EF_Hand_1_Ca_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EF_hand_DJBP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EF_hand_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:50685	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:114341	IMAGE-MGC_LOAD
	MGC:72883	IMAGE-MGC_LOAD
NCBI Gene	50685	ENTREZGENE
PANTHER	MYOSIN REGULATORY LIGHT CHAIN 12B	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MYOSIN REGULATORY LIGHT CHAIN 2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	EF-hand_11	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EF-hand_7	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Myl12b	PhenoGen
PROSITE	EF_HAND_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EF_HAND_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000015733	RatGTEx
SMART	EFh	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF47473	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A6KF93	ENTREZGENE, UniProtKB/TrEMBL
	ML12B_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q6P9V4	ENTREZGENE
UniProt Secondary	Q6P9V4	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-10	Myl12b	myosin light chain 12B	Myl12b	myosin, light chain 12B, regulatory	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-05-07	Myl12b	myosin, light chain 12B, regulatory	Mrlc2	myosin regulatory light chain MRLC2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-11-14	Mrlc2	myosin regulatory light chain MRLC2	Mylc2b	myosin light chain, regulatory B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-25	Mylc2b	myosin light chain, regulatory B	Mrlcb	myosin light chain, regulatory B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Mrlcb	myosin light chain, regulatory B		myosin regulatory light chain	Name updated	1299863	APPROVED
2003-02-27	Mrlcb	myosin regulatory light chain			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - ClinVar