MYL12B (myosin light chain 12B) - Rat Genome Database

Name: MYL12B
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: MYL12B (myosin light chain 12B) Chlorocebus sabaeus

Analyze

Symbol:

MYL12B

Name:

myosin light chain 12B

RGD ID:

18768868

Description:

ENCODES a protein that exhibits GTPase binding (ortholog); myosin heavy chain binding (ortholog); INVOLVED IN regulation of cell shape (ortholog); ASSOCIATED WITH chromosome 18p deletion syndrome (ortholog); holoprosencephaly 4 (ortholog); hypertrophic cardiomyopathy (ortholog); FOUND IN apical part of cell (ortholog); cell cortex (ortholog); myosin II complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

myosin regulatory light chain 12B

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	62,510,012 - 62,527,027 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	62,521,295 - 62,529,131 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	37,373,059 - 37,390,346 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

chromosome 18p deletion syndrome (ISO)

holoprosencephaly 4 (ISO)

hypertrophic cardiomyopathy (ISO)

intellectual disability (ISO)

Majeed Syndrome (ISO)

Neurodevelopmental Disorders (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

platelet aggregation (IEA)

regulation of cell shape (ISO)

Cellular Component

apical part of cell (ISO)

cell cortex (ISO)

cytoplasm (IEA)

myosin complex (IEA)

myosin II complex (ISO)

protein-containing complex (ISO)

stress fiber (ISO)

Z disc (ISO)

Molecular Function

calcium ion binding (IEA)

GTPase binding (ISO)

metal ion binding (IEA)

myosin heavy chain binding (ISO)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

MYL12B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	62,510,012 - 62,527,027 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	62,521,295 - 62,529,131 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	37,373,059 - 37,390,346 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

MYL12B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	3,262,133 - 3,278,461 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	3,261,479 - 3,278,461 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	18	3,262,131 - 3,278,459 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	3,252,135 - 3,268,179 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	18	3,141,594 - 3,157,815 (+)	NCBI		Celera
Cytogenetic Map	18	p11.31	NCBI
HuRef	18	3,226,523 - 3,243,194 (+)	NCBI		HuRef
CHM1_1	18	3,261,491 - 3,277,645 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	18	3,421,438 - 3,437,816 (+)	NCBI		T2T-CHM13v2.0

Myl12b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	71,280,958 - 71,297,511 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	71,280,128 - 71,297,885 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	70,973,963 - 70,990,516 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	70,973,133 - 70,990,890 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	71,323,303 - 71,339,856 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	70,878,820 - 70,895,373 (-)	NCBI		MGSCv36	mm8
Celera	17	75,244,495 - 75,261,050 (-)	NCBI		Celera
Cytogenetic Map	17	E1.3	NCBI
cM Map	17	41.87	NCBI

Myl12b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	118,320,479 - 118,334,810 (-)	NCBI		GRCr8
mRatBN7.2	9	110,873,855 - 110,888,187 (-)	NCBI	mRatBN7.2	mRatBN7.2
UTH_Rnor_SHR_Utx	9	119,261,365 - 119,275,700 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	124,390,953 - 124,405,288 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	122,727,332 - 122,741,665 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	119,307,168 - 119,321,500 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	119,307,176 - 119,321,500 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	118,761,452 - 118,775,834 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	110,171,418 - 110,186,248 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	110,380,900 - 110,384,839 (-)	NCBI
Celera	9	108,004,122 - 108,018,394 (-)	NCBI		Celera
Cytogenetic Map	9	q38	NCBI

MYL12B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	17	35,162,868 - 35,179,082 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	18	20,855,526 - 20,871,861 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	10,999,849 - 11,016,059 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	13,308,356 - 13,324,754 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	13,308,356 - 13,324,754 (-)	Ensembl	panpan1.1		panPan2

MYL12B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	69,877,727 - 69,895,196 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	69,332,485 - 69,350,491 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	69,938,422 - 69,954,234 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	69,939,041 - 69,957,106 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	69,621,752 - 69,639,768 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	69,640,728 - 69,658,745 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	69,939,371 - 69,957,614 (+)	NCBI		UU_Cfam_GSD_1.0

Myl12b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	66,219,949 - 66,238,423 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936672	1,300,341 - 1,322,065 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936672	1,303,510 - 1,321,969 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LOC733637
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	103,409,717 - 103,420,286 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	103,413,841 - 103,424,790 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	96,440,639 - 96,451,618 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Myl12b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624770	13,393,106 - 13,409,139 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla_female_1.0 Ensembl	NW_004624770	13,386,194 - 13,392,928 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624770	13,378,668 - 13,408,633 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	36	19	60
Low		1
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007974531	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000015694 ⟹ ENSCSAP00000013626

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	18	62,521,295 - 62,529,131 (+)	Ensembl

RefSeq Acc Id:

XM_007974531 ⟹ XP_007972722

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	18	62,510,012 - 62,527,027 (+)	NCBI
Vero_WHO_p1.0	NW_023666050	37,373,059 - 37,390,346 (+)	NCBI

Sequence:

show sequence

CCGCTCCGCCCCTTCAGGCAGGAAGTGTCGGCGCCGCCACTGTCCGGCCACAGCCTAACGCTCT
TCGCTGTCGCTCGTCGTCTCGCGCAGGGCGACCCCGGTTCTGGTGTTTGGCGCCGGAATTAAAC
AACCACCATGTCGAGCAAAAAGGCAAAGACCAAGACCACCAAGAAGCGCCCTCAGCGCGCAACA
TCCAATGTGTTTGCCATGTTTGACCAGTCACAGATTCAGGAGTTCAAAGAGGCCTTCAACATGA
TTGATCAGAACAGAGATGGCTTCATCGACAAGGAAGATTTGCATGATATGCTTGCTTCTCTAGG
GAAGAATCCCACGGATGCATACCTTGATGCCATGATGAATGAGGCACCAGGGCCCATCAATTTC
ACCATGTTCCTCACCATGTTTGGTGAGAAGTTAAATGGCACAGATCCTGAAGATGTCATCAGAA
ATGCTTTTGCTTGCTTTGATGAAGAAGCAACAGGCACCATTCAGGAAGATTACCTGAGAGAGCT
GCTGACAACCATGGGGGATCGGTTTACGGATGAGGAAGTGGATGAGCTGTACAGAGAAGCACCT
ATTGACAAAAAGGGGAATTTCAATTACATCGAGTTCACGCGCATCCTGAAACACGGAGCAAAAG
ACAAAGATGACTGAAAGAACTTTAGCTAAAACCTTCCAATTACATTGTCTTACTCTGTTTTATT
TCTCAGACACTTCCCCCACCCTCATAGAACCTGTTGCATGCAACTTAGTTTCACAGCTTTGCCT
CTTTTTGATGTATTTATTCCAGACCTTTCTGCCACTTAGCACTTGTATAATCAGACTGGAAATG
GGGATGAGGGTGTAAATTGTATTGAAAAAGAGATCGCGAATAAAAATCAAGAAATGTGAAAGCC
CAGAAAAATATATTCGTATTTCTGGTTTTGCTGGATTTTTACATTTTTATATAATAAAAATGTT
ATTTTGAAATAAAGATTATGCTGACTCAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007972722	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000013626
	ENSCSAP00000013626.1

RefSeq Acc Id:	XP_007972722 ⟸ XM_007974531
- UniProtKB:	A0A0D9RYD7 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000013626 ⟸ ENSCSAT00000015694

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000017599	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000015694.1	UniProtKB/TrEMBL
Gene3D-CATH	EF-hand	UniProtKB/TrEMBL
InterPro	EF-hand-dom_pair	UniProtKB/TrEMBL
	EF_Hand_1_Ca_BS	UniProtKB/TrEMBL
	EF_hand_DJBP	UniProtKB/TrEMBL
	EF_hand_dom	UniProtKB/TrEMBL
KEGG Report	csab:103222701	UniProtKB/TrEMBL
NCBI Gene	MYL12B	ENTREZGENE
PANTHER	MYOSIN REGULATORY LIGHT CHAIN 12B	UniProtKB/TrEMBL
	MYOSIN REGULATORY LIGHT CHAIN 2	UniProtKB/TrEMBL
Pfam	EF-hand_11	UniProtKB/TrEMBL
	EF-hand_7	UniProtKB/TrEMBL
PROSITE	EF_HAND_1	UniProtKB/TrEMBL
	EF_HAND_2	UniProtKB/TrEMBL
SMART	EFh	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47473	UniProtKB/TrEMBL
UniProt	A0A0D9RYD7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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