MYL12B (myosin light chain 12B) - Rat Genome Database

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Gene: MYL12B (myosin light chain 12B) Canis lupus familiaris
Analyze
Symbol: MYL12B
Name: myosin light chain 12B
RGD ID: 12116122
Description: ENCODES a protein that exhibits GTPase binding (ortholog); myosin heavy chain binding (ortholog); INVOLVED IN regulation of cell shape (ortholog); ASSOCIATED WITH chromosome 18p deletion syndrome (ortholog); holoprosencephaly 4 (ortholog); hypertrophic cardiomyopathy (ortholog); FOUND IN apical part of cell (ortholog); cell cortex (ortholog); myosin II complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC480193; myosin regulatory light chain 12B; myosin regulatory light polypeptide 9-like; myosin, light chain 12B, regulatory
RGD Orthologs
Human
Mouse
Rat
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1769,877,727 - 69,895,196 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha769,332,485 - 69,350,491 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0769,938,422 - 69,954,234 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl769,939,041 - 69,957,106 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1769,621,752 - 69,639,768 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0769,640,728 - 69,658,745 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0769,939,371 - 69,957,614 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MYL12B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1769,877,727 - 69,895,196 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha769,332,485 - 69,350,491 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0769,938,422 - 69,954,234 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl769,939,041 - 69,957,106 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1769,621,752 - 69,639,768 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0769,640,728 - 69,658,745 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0769,939,371 - 69,957,614 (+)NCBIUU_Cfam_GSD_1.0
MYL12B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38183,262,133 - 3,278,461 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl183,261,479 - 3,278,461 (+)EnsemblGRCh38hg38GRCh38
GRCh37183,262,131 - 3,278,459 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36183,252,135 - 3,268,179 (+)NCBINCBI36Build 36hg18NCBI36
Celera183,141,594 - 3,157,815 (+)NCBICelera
Cytogenetic Map18p11.31NCBI
HuRef183,226,523 - 3,243,194 (+)NCBIHuRef
CHM1_1183,261,491 - 3,277,645 (+)NCBICHM1_1
T2T-CHM13v2.0183,421,438 - 3,437,816 (+)NCBIT2T-CHM13v2.0
Myl12b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391771,280,958 - 71,297,511 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1771,280,128 - 71,297,885 (-)EnsemblGRCm39 Ensembl
GRCm381770,973,963 - 70,990,516 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1770,973,133 - 70,990,890 (-)EnsemblGRCm38mm10GRCm38
MGSCv371771,323,303 - 71,339,856 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361770,878,820 - 70,895,373 (-)NCBIMGSCv36mm8
Celera1775,244,495 - 75,261,050 (-)NCBICelera
Cytogenetic Map17E1.3NCBI
cM Map1741.87NCBI
Myl12b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89118,320,479 - 118,334,810 (-)NCBIGRCr8
mRatBN7.29110,873,855 - 110,888,187 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx9119,261,365 - 119,275,700 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09124,390,953 - 124,405,288 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09122,727,332 - 122,741,665 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09119,307,168 - 119,321,500 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9119,307,176 - 119,321,500 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09118,761,452 - 118,775,834 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.49110,171,418 - 110,186,248 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.19110,380,900 - 110,384,839 (-)NCBI
Celera9108,004,122 - 108,018,394 (-)NCBICelera
Cytogenetic Map9q38NCBI
MYL12B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21735,162,868 - 35,179,082 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11820,855,526 - 20,871,861 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01810,999,849 - 11,016,059 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11813,308,356 - 13,324,754 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1813,308,356 - 13,324,754 (-)Ensemblpanpan1.1panPan2
Myl12b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494466,219,949 - 66,238,423 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366721,300,341 - 1,322,065 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366721,303,510 - 1,321,969 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC733637
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6103,409,717 - 103,420,286 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16103,413,841 - 103,424,790 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2696,440,639 - 96,451,618 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MYL12B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11862,510,012 - 62,527,027 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1862,521,295 - 62,529,131 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605037,373,059 - 37,390,346 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myl12b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477013,393,106 - 13,409,139 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla_female_1.0 EnsemblNW_00462477013,386,194 - 13,392,928 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477013,378,668 - 13,408,633 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MYL12B
283 total Variants

Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00845005307   ⟹   ENSCAFP00845004222
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl769,939,041 - 69,957,106 (+)Ensembl
RefSeq Acc Id: XM_038482293   ⟹   XP_038338221
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1769,622,312 - 69,639,768 (+)NCBI
RefSeq Acc Id: XM_038482294   ⟹   XP_038338222
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1769,621,752 - 69,639,768 (+)NCBI
RefSeq Acc Id: XM_038543727   ⟹   XP_038399655
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0769,939,931 - 69,957,614 (+)NCBI
RefSeq Acc Id: XM_038543728   ⟹   XP_038399656
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0769,939,371 - 69,957,614 (+)NCBI
RefSeq Acc Id: XM_038576890   ⟹   XP_038432818
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha769,332,485 - 69,350,491 (+)NCBI
RefSeq Acc Id: XM_038607852   ⟹   XP_038463780
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0769,641,291 - 69,658,745 (+)NCBI
RefSeq Acc Id: XM_038607853   ⟹   XP_038463781
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0769,640,728 - 69,658,745 (+)NCBI
RefSeq Acc Id: XM_038672532   ⟹   XP_038528460
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0769,938,968 - 69,954,234 (+)NCBI
RefSeq Acc Id: XM_038672533   ⟹   XP_038528461
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0769,938,422 - 69,954,234 (+)NCBI
RefSeq Acc Id: XM_537316   ⟹   XP_537316
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1769,877,727 - 69,895,196 (+)NCBI
Dog10K_Boxer_Tasha769,333,046 - 69,350,491 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_537316   ⟸   XM_537316
- UniProtKB: A0A8C0Q1A0 (UniProtKB/TrEMBL),   A0A8C0LC02 (UniProtKB/TrEMBL),   A0A8I3RR31 (UniProtKB/TrEMBL),   A0A8C0MTV5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038338222   ⟸   XM_038482294
RefSeq Acc Id: XP_038338221   ⟸   XM_038482293
RefSeq Acc Id: XP_038463781   ⟸   XM_038607853
RefSeq Acc Id: XP_038463780   ⟸   XM_038607852
RefSeq Acc Id: XP_038528461   ⟸   XM_038672533
- UniProtKB: A0A8C0Q1A0 (UniProtKB/TrEMBL),   A0A8C0LC02 (UniProtKB/TrEMBL),   A0A8I3RR31 (UniProtKB/TrEMBL),   A0A8C0MTV5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038528460   ⟸   XM_038672532
- UniProtKB: A0A8C0Q1A0 (UniProtKB/TrEMBL),   A0A8C0LC02 (UniProtKB/TrEMBL),   A0A8I3RR31 (UniProtKB/TrEMBL),   A0A8C0MTV5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038432818   ⟸   XM_038576890
- UniProtKB: A0A8C0Q1A0 (UniProtKB/TrEMBL),   A0A8C0LC02 (UniProtKB/TrEMBL),   A0A8I3RR31 (UniProtKB/TrEMBL),   A0A8C0MTV5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038399656   ⟸   XM_038543728
- UniProtKB: A0A8C0LC02 (UniProtKB/TrEMBL),   A0A8C0MTV5 (UniProtKB/TrEMBL),   A0A8C0Q1A0 (UniProtKB/TrEMBL),   A0A8I3RR31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038399655   ⟸   XM_038543727
- UniProtKB: A0A8C0LC02 (UniProtKB/TrEMBL),   A0A8C0MTV5 (UniProtKB/TrEMBL),   A0A8C0Q1A0 (UniProtKB/TrEMBL),   A0A8I3RR31 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845004222   ⟸   ENSCAFT00845005307
Protein Domains
EF-hand

Promoters
RGD ID:13684099
Promoter ID:EPDNEW_C2167
Type:single initiation site
Name:MYL12B_1
Description:myosin light chain 12B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1769,891,328 - 69,891,388EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000051606 UniProtKB/TrEMBL
  ENSCAFG00030010287 UniProtKB/TrEMBL
  ENSCAFG00040003108 UniProtKB/TrEMBL
  ENSCAFG00845003004 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000107662.1 UniProtKB/TrEMBL
  ENSCAFT00030019000.1 UniProtKB/TrEMBL
  ENSCAFT00030019191.1 UniProtKB/TrEMBL
  ENSCAFT00040005907.1 UniProtKB/TrEMBL
  ENSCAFT00845005307 ENTREZGENE
  ENSCAFT00845005307.1 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_DJBP UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
NCBI Gene LOC480193 ENTREZGENE
PANTHER MYOSIN REGULATORY LIGHT CHAIN 12B UniProtKB/TrEMBL
  MYOSIN REGULATORY LIGHT CHAIN 2 UniProtKB/TrEMBL
Pfam EF-hand_11 UniProtKB/TrEMBL
  EF-hand_7 UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A0A8C0LC02 ENTREZGENE
  A0A8C0MTV5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Q1A0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RR31 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:53622 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-09-12 MYL12B  myosin light chain 12B  LOC480193  myosin regulatory light chain 12B  Symbol and/or name change 5135510 APPROVED