Uba3 (ubiquitin-like modifier activating enzyme 3) - Rat Genome Database

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Gene: Uba3 (ubiquitin-like modifier activating enzyme 3) Rattus norvegicus
Analyze
Symbol: Uba3
Name: ubiquitin-like modifier activating enzyme 3
RGD ID: 621084
Description: Enables NEDD8 activating enzyme activity and nuclear receptor binding activity. Involved in negative regulation of DNA-templated transcription. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human UBA3 (ubiquitin like modifier activating enzyme 3); PARTICIPATES IN neddylation pathway; proteasome degradation pathway involving cullin-dependent ubiquitin ligases; ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: NEDD8-activating enzyme E1 catalytic subunit; NEDD8-activating enzyme E1C; Ube1c; ubiquitin-activating enzyme 3; ubiquitin-activating enzyme E1C; ubiquitin-activating enzyme E1C (UBA3 homolog, yeast); ubiquitin-like modifier-activating enzyme 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84131,346,219 - 131,367,378 (-)NCBIGRCr8
mRatBN7.24129,789,526 - 129,810,707 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4129,789,204 - 129,810,606 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4135,214,153 - 135,235,250 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04130,995,195 - 131,016,292 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04129,613,140 - 129,634,237 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04129,548,411 - 129,569,550 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4129,548,416 - 129,569,470 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04194,051,838 - 194,072,937 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44131,902,438 - 131,924,610 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14132,147,288 - 132,169,460 (-)NCBI
Celera4118,665,559 - 118,686,969 (-)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
nucleus  (IBA,IEA,ISO)
protein-containing complex  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The activating enzyme of NEDD8 inhibits steroid receptor function. Fan M, etal., Mol Endocrinol 2002 Feb;16(2):315-30.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:10207026   PMID:11696557   PMID:12740388   PMID:15489334   PMID:19245792   PMID:22871113   PMID:25416956  


Genomics

Comparative Map Data
Uba3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84131,346,219 - 131,367,378 (-)NCBIGRCr8
mRatBN7.24129,789,526 - 129,810,707 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4129,789,204 - 129,810,606 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4135,214,153 - 135,235,250 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04130,995,195 - 131,016,292 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04129,613,140 - 129,634,237 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04129,548,411 - 129,569,550 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4129,548,416 - 129,569,470 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04194,051,838 - 194,072,937 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44131,902,438 - 131,924,610 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14132,147,288 - 132,169,460 (-)NCBI
Celera4118,665,559 - 118,686,969 (-)NCBICelera
Cytogenetic Map4q34NCBI
UBA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38369,054,730 - 69,080,373 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl369,054,730 - 69,080,408 (-)EnsemblGRCh38hg38GRCh38
GRCh37369,103,881 - 69,129,524 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36369,186,571 - 69,212,214 (-)NCBINCBI36Build 36hg18NCBI36
Build 34369,186,571 - 69,212,214NCBI
Celera369,031,987 - 69,057,632 (-)NCBICelera
Cytogenetic Map3p14.1NCBI
HuRef369,104,953 - 69,130,599 (-)NCBIHuRef
CHM1_1369,055,090 - 69,080,736 (-)NCBICHM1_1
T2T-CHM13v2.0369,091,517 - 69,117,165 (-)NCBIT2T-CHM13v2.0
Uba3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39697,160,593 - 97,182,608 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl697,160,631 - 97,182,608 (-)EnsemblGRCm39 Ensembl
GRCm38697,183,632 - 97,205,647 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl697,183,670 - 97,205,647 (-)EnsemblGRCm38mm10GRCm38
MGSCv37697,133,810 - 97,155,636 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36697,149,491 - 97,170,806 (-)NCBIMGSCv36mm8
Celera699,042,865 - 99,064,781 (-)NCBICelera
Cytogenetic Map6D3NCBI
cM Map644.9NCBI
Uba3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542118,780,730 - 18,801,266 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542118,781,015 - 18,801,266 (+)NCBIChiLan1.0ChiLan1.0
UBA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2269,010,165 - 69,035,897 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1369,014,952 - 69,043,481 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0368,990,760 - 69,016,377 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1370,357,665 - 70,383,166 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl370,358,371 - 70,383,117 (-)Ensemblpanpan1.1panPan2
UBA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12022,657,758 - 22,682,134 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2022,657,817 - 22,681,447 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2022,632,410 - 22,656,797 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02022,683,590 - 22,708,036 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2022,683,646 - 22,708,036 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12022,377,507 - 22,401,872 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02022,720,892 - 22,745,308 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02022,790,714 - 22,815,179 (+)NCBIUU_Cfam_GSD_1.0
Uba3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049421,555,314 - 1,574,521 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366031,555,548 - 1,577,438 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366031,555,274 - 1,574,521 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UBA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1350,477,458 - 50,504,882 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11350,479,264 - 50,504,901 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21355,560,074 - 55,585,710 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UBA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12230,080,972 - 30,106,450 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2230,080,863 - 30,106,419 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041136,686,030 - 136,711,534 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Uba3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247733,622,362 - 3,646,980 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247733,623,295 - 3,646,974 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Uba3
43 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:346
Count of miRNA genes:218
Interacting mature miRNAs:252
Transcripts:ENSRNOT00000008893
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)484728680129854654Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486730991131730991Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487327165132327165Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487327165132327165Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4119463257147278687Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4120260281147278687Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4120926564148090731Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 10 74 35 41 11 8
Low 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008893   ⟹   ENSRNOP00000008893
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4129,789,535 - 129,810,606 (-)Ensembl
Rnor_6.0 Ensembl4129,548,416 - 129,569,470 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103429   ⟹   ENSRNOP00000076686
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4129,789,204 - 129,810,600 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117124   ⟹   ENSRNOP00000086883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4129,789,204 - 129,808,825 (-)Ensembl
RefSeq Acc Id: NM_057205   ⟹   NP_476553
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,346,219 - 131,367,268 (-)NCBI
mRatBN7.24129,789,535 - 129,810,584 (-)NCBI
Rnor_6.04129,548,411 - 129,569,470 (-)NCBI
Rnor_5.04194,051,838 - 194,072,937 (-)NCBI
RGSC_v3.44131,902,438 - 131,924,610 (-)RGD
Celera4118,665,559 - 118,686,969 (-)RGD
Sequence:
RefSeq Acc Id: XM_006236936   ⟹   XP_006236998
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,346,219 - 131,367,378 (-)NCBI
mRatBN7.24129,789,526 - 129,810,707 (-)NCBI
Rnor_6.04129,548,411 - 129,569,550 (-)NCBI
Rnor_5.04194,051,838 - 194,072,937 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063285431   ⟹   XP_063141501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,346,219 - 131,367,341 (-)NCBI
RefSeq Acc Id: XM_063285432   ⟹   XP_063141502
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,346,219 - 131,365,321 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_476553   ⟸   NM_057205
- UniProtKB: Q99MI7 (UniProtKB/Swiss-Prot),   A6IBF6 (UniProtKB/TrEMBL),   A0A8L2Q4P8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236998   ⟸   XM_006236936
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q4P8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008893   ⟸   ENSRNOT00000008893
RefSeq Acc Id: ENSRNOP00000086883   ⟸   ENSRNOT00000117124
RefSeq Acc Id: ENSRNOP00000076686   ⟸   ENSRNOT00000103429
RefSeq Acc Id: XP_063141501   ⟸   XM_063285431
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063141502   ⟸   XM_063285432
- Peptide Label: isoform X3
Protein Domains
E2 binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99MI7-F1-model_v2 AlphaFold Q99MI7 1-462 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693267
Promoter ID:EPDNEW_R3792
Type:multiple initiation site
Name:Uba3_1
Description:ubiquitin-like modifier activating enzyme 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04129,569,472 - 129,569,532EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621084 AgrOrtholog
BioCyc Gene G2FUF-43604 BioCyc
BioCyc Pathway PWY-7511 [protein ubiquitination] BioCyc
BioCyc Pathway Image PWY-7511 BioCyc
Ensembl Genes ENSRNOG00000006221 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008893.8 UniProtKB/TrEMBL
  ENSRNOT00000103429 ENTREZGENE
  ENSRNOT00000103429.1 UniProtKB/TrEMBL
  ENSRNOT00000117124.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.520 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7124631 IMAGE-MGC_LOAD
InterPro E2-binding UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  ThiF/MoeB/HesA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ThiF_NAD_FAD-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ub_act_enz_dom_a_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Uba3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-activating_enz UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBQ-activ_enz_E1_Cys_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117553 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93250 IMAGE-MGC_LOAD
NCBI Gene 117553 ENTREZGENE
PANTHER PTHR10953 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10953:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam E2_bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ThiF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Uba3 PhenoGen
PROSITE UBIQUITIN_ACTIVAT_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006221 RatGTEx
SMART E2_bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF69572 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5Y925_RAT UniProtKB/TrEMBL
  A0A8I6A673_RAT UniProtKB/TrEMBL
  A0A8L2Q4P8 ENTREZGENE, UniProtKB/TrEMBL
  A6IBF6 ENTREZGENE, UniProtKB/TrEMBL
  Q99MI7 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-02 Uba3  ubiquitin-like modifier activating enzyme 3  Ube1c  ubiquitin-activating enzyme E1C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-19 Ube1c  ubiquitin-activating enzyme E1C  Ube1c  ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Ube1c  ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)  Ube1c  ubiquitin-activating enzyme E1C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Ube1c  ubiquitin-activating enzyme E1C      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Ube1c  ubiquitin-activating enzyme E1C      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction directly binds to ligand-occupied ERalpha and ERbeta 634396