UBA3 (ubiquitin like modifier activating enzyme 3) - Rat Genome Database

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Gene: UBA3 (ubiquitin like modifier activating enzyme 3) Homo sapiens
Analyze
Symbol: UBA3
Name: ubiquitin like modifier activating enzyme 3
RGD ID: 737348
HGNC Page HGNC:12470
Description: Enables identical protein binding activity and protein heterodimerization activity. Contributes to NEDD8 activating enzyme activity. Involved in protein neddylation. Located in nucleus. Part of protein-containing complex.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: DKFZp566J164; hUBA3; MGC22384; NAE2; NEDD8-activating enzyme E1 catalytic subunit; NEDD8-activating enzyme E1 subunit 2; NEDD8-activating enzyme E1C; Nedd8-activating enzyme hUba3; UBA3, ubiquitin-activating enzyme E1 homolog; UBE1C; ubiquitin-activating enzyme 3; ubiquitin-activating enzyme E1C (homologous to yeast UBA3); ubiquitin-activating enzyme E1C (UBA3 homolog, yeast); ubiquitin-like modifier activating enzyme 3; ubiquitin-like modifier-activating enzyme 3
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38369,054,730 - 69,080,373 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl369,054,730 - 69,080,408 (-)EnsemblGRCh38hg38GRCh38
GRCh37369,103,881 - 69,129,524 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36369,186,571 - 69,212,214 (-)NCBINCBI36Build 36hg18NCBI36
Build 34369,186,571 - 69,212,214NCBI
Celera369,031,987 - 69,057,632 (-)NCBICelera
Cytogenetic Map3p14.1NCBI
HuRef369,104,953 - 69,130,599 (-)NCBIHuRef
CHM1_1369,055,090 - 69,080,736 (-)NCBICHM1_1
T2T-CHM13v2.0369,091,517 - 69,117,165 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)
cytosol  (TAS)
nucleus  (IBA,IDA,IEA)
protein-containing complex  (IDA)

References

References - curated
# Reference Title Reference Citation
1. The activating enzyme of NEDD8 inhibits steroid receptor function. Fan M, etal., Mol Endocrinol 2002 Feb;16(2):315-30.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9694792   PMID:10207026   PMID:10409428   PMID:10722740   PMID:11076863   PMID:11230166   PMID:11256614   PMID:12477932   PMID:12646924   PMID:12740388   PMID:14690597   PMID:14702039  
PMID:15361859   PMID:15489334   PMID:15489336   PMID:15694336   PMID:16169070   PMID:16381901   PMID:16400609   PMID:16503656   PMID:16620772   PMID:16712842   PMID:17220875   PMID:17353931  
PMID:18264111   PMID:18652489   PMID:19250909   PMID:19549727   PMID:19615732   PMID:21145461   PMID:21873635   PMID:22404213   PMID:22821745   PMID:22863883   PMID:22939629   PMID:23455924  
PMID:24525735   PMID:24691136   PMID:25229838   PMID:25416956   PMID:26186194   PMID:26344197   PMID:26549023   PMID:27182664   PMID:27348078   PMID:27371349   PMID:28475037   PMID:28514442  
PMID:28581483   PMID:29547696   PMID:29643511   PMID:29791485   PMID:29973603   PMID:30033366   PMID:30097011   PMID:31267705   PMID:31391242   PMID:31540324   PMID:32145688   PMID:32296183  
PMID:32344865   PMID:32694731   PMID:32814053   PMID:32994395   PMID:33226137   PMID:33961781   PMID:34373451   PMID:34518685   PMID:35256949   PMID:35271311   PMID:35509820   PMID:35544948  
PMID:35671810   PMID:35831314   PMID:35914814   PMID:36215168   PMID:36253371   PMID:36629882   PMID:37656220   PMID:37668436   PMID:37827155   PMID:38496616  


Genomics

Comparative Map Data
UBA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38369,054,730 - 69,080,373 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl369,054,730 - 69,080,408 (-)EnsemblGRCh38hg38GRCh38
GRCh37369,103,881 - 69,129,524 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36369,186,571 - 69,212,214 (-)NCBINCBI36Build 36hg18NCBI36
Build 34369,186,571 - 69,212,214NCBI
Celera369,031,987 - 69,057,632 (-)NCBICelera
Cytogenetic Map3p14.1NCBI
HuRef369,104,953 - 69,130,599 (-)NCBIHuRef
CHM1_1369,055,090 - 69,080,736 (-)NCBICHM1_1
T2T-CHM13v2.0369,091,517 - 69,117,165 (-)NCBIT2T-CHM13v2.0
Uba3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39697,160,593 - 97,182,608 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl697,160,631 - 97,182,608 (-)EnsemblGRCm39 Ensembl
GRCm38697,183,632 - 97,205,647 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl697,183,670 - 97,205,647 (-)EnsemblGRCm38mm10GRCm38
MGSCv37697,133,810 - 97,155,636 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36697,149,491 - 97,170,806 (-)NCBIMGSCv36mm8
Celera699,042,865 - 99,064,781 (-)NCBICelera
Cytogenetic Map6D3NCBI
cM Map644.9NCBI
Uba3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84131,346,219 - 131,367,378 (-)NCBIGRCr8
mRatBN7.24129,789,526 - 129,810,707 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4129,789,204 - 129,810,606 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4135,214,153 - 135,235,250 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04130,995,195 - 131,016,292 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04129,613,140 - 129,634,237 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04129,548,411 - 129,569,550 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4129,548,416 - 129,569,470 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04194,051,838 - 194,072,937 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44131,902,438 - 131,924,610 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14132,147,288 - 132,169,460 (-)NCBI
Celera4118,665,559 - 118,686,969 (-)NCBICelera
Cytogenetic Map4q34NCBI
Uba3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542118,780,730 - 18,801,266 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542118,781,015 - 18,801,266 (+)NCBIChiLan1.0ChiLan1.0
UBA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2269,010,165 - 69,035,897 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1369,014,952 - 69,043,481 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0368,990,760 - 69,016,377 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1370,357,665 - 70,383,166 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl370,358,371 - 70,383,117 (-)Ensemblpanpan1.1panPan2
UBA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12022,657,758 - 22,682,134 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2022,657,817 - 22,681,447 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2022,632,410 - 22,656,797 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02022,683,590 - 22,708,036 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2022,683,646 - 22,708,036 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12022,377,507 - 22,401,872 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02022,720,892 - 22,745,308 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02022,790,714 - 22,815,179 (+)NCBIUU_Cfam_GSD_1.0
Uba3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049421,555,314 - 1,574,521 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366031,555,548 - 1,577,438 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366031,555,274 - 1,574,521 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UBA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1350,477,458 - 50,504,882 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11350,479,264 - 50,504,901 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21355,560,074 - 55,585,710 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UBA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12230,080,972 - 30,106,450 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2230,080,863 - 30,106,419 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041136,686,030 - 136,711,534 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Uba3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247733,622,362 - 3,646,980 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247733,623,295 - 3,646,974 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in UBA3
8 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3p14.1-12.3(chr3:64761248-78410098)x1 copy number loss See cases [RCV000051512] Chr3:64761248..78410098 [GRCh38]
Chr3:64746924..78459248 [GRCh37]
Chr3:64721964..78541938 [NCBI36]
Chr3:3p14.1-12.3		 pathogenic
GRCh38/hg38 3p14.1-13(chr3:67391006-73414001)x1 copy number loss See cases [RCV000133821] Chr3:67391006..73414001 [GRCh38]
Chr3:67441430..73463152 [GRCh37]
Chr3:67524120..73545842 [NCBI36]
Chr3:3p14.1-13		 pathogenic
GRCh38/hg38 3p14.1-12.3(chr3:68328980-76764319)x3 copy number gain See cases [RCV000140215] Chr3:68328980..76764319 [GRCh38]
Chr3:68378130..76813470 [GRCh37]
Chr3:68460820..76896160 [NCBI36]
Chr3:3p14.1-12.3		 likely pathogenic|uncertain significance
GRCh38/hg38 3p14.3-11.1(chr3:57140424-90259960)x1 copy number loss See cases [RCV000139626] Chr3:57140424..90259960 [GRCh38]
Chr3:57174452..90309110 [GRCh37]
Chr3:57149492..90391800 [NCBI36]
Chr3:3p14.3-11.1		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p14.1-12.3(chr3:66133719-75076440)x1 copy number loss not provided [RCV000682270] Chr3:66133719..75076440 [GRCh37]
Chr3:3p14.1-12.3		 pathogenic
GRCh37/hg19 3p14.1(chr3:68461188-69158250)x1 copy number loss not provided [RCV000709799] Chr3:68461188..69158250 [GRCh37]
Chr3:3p14.1		 not provided
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p14.1(chr3:69038217-69139300)x3 copy number gain not provided [RCV000742491] Chr3:69038217..69139300 [GRCh37]
Chr3:3p14.1		 benign
GRCh37/hg19 3p14.1(chr3:68831471-69535890)x3 copy number gain not provided [RCV000846320] Chr3:68831471..69535890 [GRCh37]
Chr3:3p14.1		 uncertain significance
Single allele deletion See cases [RCV001374461] Chr3:68965654..72679568 [GRCh37]
Chr3:3p14.1-13		 pathogenic
GRCh37/hg19 3p14.1-13(chr3:68968872-70829637)x3 copy number gain not provided [RCV001829083] Chr3:68968872..70829637 [GRCh37]
Chr3:3p14.1-13		 uncertain significance
GRCh37/hg19 3p14.2-13(chr3:59332508-70686155)x1 copy number loss not provided [RCV001829252] Chr3:59332508..70686155 [GRCh37]
Chr3:3p14.2-13		 pathogenic
NM_003968.4(UBA3):c.467A>G (p.Tyr156Cys) single nucleotide variant not specified [RCV004234949] Chr3:69064073 [GRCh38]
Chr3:69113224 [GRCh37]
Chr3:3p14.1		 uncertain significance
NM_003968.4(UBA3):c.1334C>T (p.Ala445Val) single nucleotide variant not specified [RCV004154229] Chr3:69055495 [GRCh38]
Chr3:69104646 [GRCh37]
Chr3:3p14.1		 uncertain significance
NM_003968.4(UBA3):c.1387T>G (p.Ser463Ala) single nucleotide variant not specified [RCV004179123] Chr3:69055442 [GRCh38]
Chr3:69104593 [GRCh37]
Chr3:3p14.1		 uncertain significance
NM_003968.4(UBA3):c.916G>C (p.Val306Leu) single nucleotide variant not specified [RCV004101504] Chr3:69057304 [GRCh38]
Chr3:69106455 [GRCh37]
Chr3:3p14.1		 uncertain significance
NM_003968.4(UBA3):c.650T>A (p.Met217Lys) single nucleotide variant not specified [RCV004347317] Chr3:69063025 [GRCh38]
Chr3:69112176 [GRCh37]
Chr3:3p14.1		 uncertain significance
NM_003968.4(UBA3):c.734T>G (p.Leu245Arg) single nucleotide variant not specified [RCV004349960] Chr3:69062139 [GRCh38]
Chr3:69111290 [GRCh37]
Chr3:3p14.1		 uncertain significance
NM_003968.4(UBA3):c.505A>G (p.Ile169Val) single nucleotide variant not specified [RCV004352243] Chr3:69063471 [GRCh38]
Chr3:69112622 [GRCh37]
Chr3:3p14.1		 uncertain significance
GRCh37/hg19 3p14.2-13(chr3:62188399-71663248)x1 copy number loss not specified [RCV003986442] Chr3:62188399..71663248 [GRCh37]
Chr3:3p14.2-13		 pathogenic
NM_003968.4(UBA3):c.20+7A>G single nucleotide variant not provided [RCV003887679] Chr3:69080327 [GRCh38]
Chr3:69129478 [GRCh37]
Chr3:3p14.1		 uncertain significance
NM_003968.4(UBA3):c.281G>C (p.Arg94Thr) single nucleotide variant not specified [RCV004484226] Chr3:69071601 [GRCh38]
Chr3:69120752 [GRCh37]
Chr3:3p14.1		 uncertain significance
NM_003968.4(UBA3):c.415T>G (p.Cys139Gly) single nucleotide variant not specified [RCV004484227] Chr3:69067941 [GRCh38]
Chr3:69117092 [GRCh37]
Chr3:3p14.1		 uncertain significance
NM_003968.4(UBA3):c.793G>A (p.Gly265Arg) single nucleotide variant not specified [RCV004484228] Chr3:69062080 [GRCh38]
Chr3:69111231 [GRCh37]
Chr3:3p14.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2512
Count of miRNA genes:742
Interacting mature miRNAs:861
Transcripts:ENST00000349511, ENST00000361055, ENST00000415609, ENST00000461522, ENST00000461934, ENST00000464605, ENST00000465108, ENST00000465627, ENST00000466763, ENST00000485424, ENST00000493957, ENST00000540295
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
WI-12011  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37369,103,902 - 69,104,039UniSTSGRCh37
Build 36369,186,592 - 69,186,729RGDNCBI36
Celera369,032,008 - 69,032,145RGD
Cytogenetic Map3p24.3-p13UniSTS
HuRef369,104,974 - 69,105,111UniSTS
GeneMap99-GB4 RH Map3209.13UniSTS
Whitehead-RH Map3259.7UniSTS
NCBI RH Map3577.4UniSTS
A005V36  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37369,104,051 - 69,104,154UniSTSGRCh37
Build 36369,186,741 - 69,186,844RGDNCBI36
Celera369,032,157 - 69,032,260RGD
Cytogenetic Map3p24.3-p13UniSTS
HuRef369,105,123 - 69,105,226UniSTS
GeneMap99-GB4 RH Map3208.4UniSTS
NCBI RH Map3583.6UniSTS
UBE1C_8886  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37369,103,823 - 69,104,588UniSTSGRCh37
Build 36369,186,513 - 69,187,278RGDNCBI36
Celera369,031,929 - 69,032,694RGD
HuRef369,104,895 - 69,105,660UniSTS
SHGC-77074  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37369,103,907 - 69,104,046UniSTSGRCh37
Build 36369,186,597 - 69,186,736RGDNCBI36
Celera369,032,013 - 69,032,152RGD
Cytogenetic Map3p24.3-p13UniSTS
HuRef369,104,979 - 69,105,118UniSTS
TNG Radiation Hybrid Map340973.0UniSTS
GeneMap99-GB4 RH Map3209.13UniSTS
NCBI RH Map3581.6UniSTS
G32297  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37369,104,051 - 69,104,154UniSTSGRCh37
Celera369,032,157 - 69,032,260UniSTS
Cytogenetic Map3p24.3-p13UniSTS
HuRef369,105,123 - 69,105,226UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2430 2698 1654 557 1762 398 4353 2099 3606 388 1450 1610 175 1 1203 2785 5 2
Low 9 293 72 67 189 67 4 98 128 31 10 3 1 3 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001363861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_198195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011534210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054348326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB012190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC092060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC109587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF046024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK289392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK316540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL117566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG940987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD700642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR533537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JC212133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000349511   ⟹   ENSP00000340041
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl369,054,730 - 69,080,408 (-)Ensembl
RefSeq Acc Id: ENST00000361055   ⟹   ENSP00000354340
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl369,054,730 - 69,080,365 (-)Ensembl
RefSeq Acc Id: ENST00000415609   ⟹   ENSP00000400294
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl369,054,730 - 69,080,381 (-)Ensembl
RefSeq Acc Id: ENST00000461522
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl369,061,583 - 69,064,091 (-)Ensembl
RefSeq Acc Id: ENST00000461934   ⟹   ENSP00000417547
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl369,055,298 - 69,080,377 (-)Ensembl
RefSeq Acc Id: ENST00000464605
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl369,079,744 - 69,080,354 (-)Ensembl
RefSeq Acc Id: ENST00000465108
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl369,071,093 - 69,080,368 (-)Ensembl
RefSeq Acc Id: ENST00000465627   ⟹   ENSP00000419077
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl369,055,298 - 69,080,377 (-)Ensembl
RefSeq Acc Id: ENST00000466763
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl369,075,084 - 69,080,365 (-)Ensembl
RefSeq Acc Id: ENST00000485424
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl369,077,339 - 69,080,363 (-)Ensembl
RefSeq Acc Id: ENST00000493957
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl369,075,083 - 69,080,365 (-)Ensembl
RefSeq Acc Id: ENST00000630585   ⟹   ENSP00000486985
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl369,063,118 - 69,080,353 (-)Ensembl
RefSeq Acc Id: ENST00000631029   ⟹   ENSP00000486366
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl369,076,406 - 69,077,356 (-)Ensembl
RefSeq Acc Id: NM_001363861   ⟹   NP_001350790
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38369,054,730 - 69,080,373 (-)NCBI
T2T-CHM13v2.0369,091,517 - 69,117,165 (-)NCBI
Sequence:
RefSeq Acc Id: NM_003968   ⟹   NP_003959
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38369,054,730 - 69,080,365 (-)NCBI
GRCh37369,103,881 - 69,129,524 (-)ENTREZGENE
GRCh37369,103,881 - 69,129,524 (-)NCBI
Build 36369,186,571 - 69,212,214 (-)NCBI Archive
HuRef369,104,953 - 69,130,599 (-)ENTREZGENE
CHM1_1369,055,090 - 69,080,736 (-)NCBI
T2T-CHM13v2.0369,091,517 - 69,117,157 (-)NCBI
Sequence:
RefSeq Acc Id: NM_198195   ⟹   NP_937838
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38369,054,730 - 69,080,365 (-)NCBI
GRCh37369,103,881 - 69,129,524 (-)ENTREZGENE
GRCh37369,103,881 - 69,129,524 (-)NCBI
Build 36369,186,571 - 69,212,214 (-)NCBI Archive
HuRef369,104,953 - 69,130,599 (-)ENTREZGENE
CHM1_1369,055,090 - 69,080,736 (-)NCBI
T2T-CHM13v2.0369,091,517 - 69,117,157 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011534210   ⟹   XP_011532512
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38369,054,730 - 69,080,373 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054348326   ⟹   XP_054204301
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0369,091,517 - 69,117,165 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_937838   ⟸   NM_198195
- Peptide Label: isoform 2
- UniProtKB: B2RBP3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_003959   ⟸   NM_003968
- Peptide Label: isoform 1
- UniProtKB: O76088 (UniProtKB/Swiss-Prot),   A8K027 (UniProtKB/Swiss-Prot),   A6NLB5 (UniProtKB/Swiss-Prot),   Q9NTU3 (UniProtKB/Swiss-Prot),   Q8TBC4 (UniProtKB/Swiss-Prot),   B2RBP3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011532512   ⟸   XM_011534210
- Peptide Label: isoform X1
- UniProtKB: B2RBP3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001350790   ⟸   NM_001363861
- Peptide Label: isoform 3
- UniProtKB: F8W8D4 (UniProtKB/TrEMBL),   B2RBP3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSP00000419077   ⟸   ENST00000465627
RefSeq Acc Id: ENSP00000340041   ⟸   ENST00000349511
RefSeq Acc Id: ENSP00000354340   ⟸   ENST00000361055
RefSeq Acc Id: ENSP00000400294   ⟸   ENST00000415609
RefSeq Acc Id: ENSP00000486985   ⟸   ENST00000630585
RefSeq Acc Id: ENSP00000486366   ⟸   ENST00000631029
RefSeq Acc Id: ENSP00000417547   ⟸   ENST00000461934
RefSeq Acc Id: XP_054204301   ⟸   XM_054348326
- Peptide Label: isoform X1
Protein Domains
E2 binding   THIF-type NAD/FAD binding fold

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8TBC4-F1-model_v2 AlphaFold Q8TBC4 1-463 view protein structure

Promoters
RGD ID:6864956
Promoter ID:EPDNEW_H5642
Type:initiation region
Name:UBA3_1
Description:ubiquitin like modifier activating enzyme 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38369,080,363 - 69,080,423EPDNEW
RGD ID:6801849
Promoter ID:HG_KWN:45481
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000334839,   OTTHUMT00000334840,   OTTHUMT00000334841,   OTTHUMT00000334842,   OTTHUMT00000334843,   OTTHUMT00000334844,   OTTHUMT00000334845,   OTTHUMT00000334846
Position:
Human AssemblyChrPosition (strand)Source
Build 36369,211,929 - 69,212,429 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:12470 AgrOrtholog
COSMIC UBA3 COSMIC
Ensembl Genes ENSG00000144744 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000349511 ENTREZGENE
  ENST00000349511.8 UniProtKB/Swiss-Prot
  ENST00000361055 ENTREZGENE
  ENST00000361055.9 UniProtKB/Swiss-Prot
  ENST00000415609 ENTREZGENE
  ENST00000415609.6 UniProtKB/TrEMBL
  ENST00000461934.5 UniProtKB/TrEMBL
  ENST00000465627.5 UniProtKB/TrEMBL
  ENST00000630585.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.520 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000144744 GTEx
HGNC ID HGNC:12470 ENTREZGENE
Human Proteome Map UBA3 Human Proteome Map
InterPro E2-binding UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  ThiF/MoeB/HesA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ThiF_NAD_FAD-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ub_act_enz_dom_a_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Uba3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-activating_enz UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBQ-activ_enz_E1_Cys_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:9039 UniProtKB/Swiss-Prot
NCBI Gene 9039 ENTREZGENE
OMIM 603172 OMIM
PANTHER PTHR10953 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10953:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam E2_bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ThiF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA162407622 PharmGKB
PROSITE UBIQUITIN_ACTIVAT_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART E2_bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF69572 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6NLB5 ENTREZGENE
  A8K027 ENTREZGENE
  B2RBP3 ENTREZGENE, UniProtKB/TrEMBL
  F8W8D4 ENTREZGENE, UniProtKB/TrEMBL
  F8WAT6_HUMAN UniProtKB/TrEMBL
  F8WF86_HUMAN UniProtKB/TrEMBL
  O76088 ENTREZGENE
  Q8TBC4 ENTREZGENE
  Q9NTU3 ENTREZGENE
  UBA3_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary A6NLB5 UniProtKB/Swiss-Prot
  A8K027 UniProtKB/Swiss-Prot
  O76088 UniProtKB/Swiss-Prot
  Q9NTU3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-02 UBA3  ubiquitin like modifier activating enzyme 3  UBA3  ubiquitin-like modifier activating enzyme 3  Symbol and/or name change 5135510 APPROVED