Uba3 (ubiquitin like modifier activating enzyme 3)

Gene: Uba3 (ubiquitin like modifier activating enzyme 3) Chinchilla lanigera

Analyze

Symbol:

Uba3

Name:

ubiquitin like modifier activating enzyme 3

RGD ID:

8759089

Description:

ENCODES a protein that exhibits identical protein binding (ortholog); NEDD8 activating enzyme activity (ortholog); nuclear receptor binding (ortholog); INVOLVED IN endomitotic cell cycle (ortholog); mitotic cell cycle (ortholog); negative regulation of DNA-templated transcription (ortholog); PARTICIPATES IN neddylation pathway; proteasome degradation pathway involving cullin-dependent ubiquitin ligases; FOUND IN nucleus (ortholog); protein-containing complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

NEDD8-activating enzyme E1 catalytic subunit; ubiquitin-like modifier activating enzyme 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955421	18,780,730 - 18,801,266 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955421	18,781,015 - 18,801,266 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

endomitotic cell cycle (ISO)

mitotic cell cycle (ISO)

negative regulation of DNA-templated transcription (ISO)

protein neddylation (ISO)

regulation of cell cycle (ISO)

Cellular Component

nucleus (ISO)

protein-containing complex (ISO)

Molecular Function

identical protein binding (ISO)

NEDD8 activating enzyme activity (ISO)

nuclear receptor binding (ISO)

protein binding (ISO)

protein heterodimerization activity (ISO)

protein-containing complex binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

neddylation pathway (ISO)

proteasome degradation pathway involving cullin-dependent ubiquitin ligases (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Uba3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955421	18,780,730 - 18,801,266 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955421	18,781,015 - 18,801,266 (+)	NCBI	ChiLan1.0	ChiLan1.0

UBA3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	69,054,730 - 69,080,373 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	69,054,730 - 69,080,408 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	69,103,881 - 69,129,524 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	69,186,571 - 69,212,214 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	69,186,571 - 69,212,214	NCBI
Celera	3	69,031,987 - 69,057,632 (-)	NCBI		Celera
Cytogenetic Map	3	p14.1	NCBI
HuRef	3	69,104,953 - 69,130,599 (-)	NCBI		HuRef
CHM1_1	3	69,055,090 - 69,080,736 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	69,091,517 - 69,117,165 (-)	NCBI		T2T-CHM13v2.0

Uba3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	97,160,593 - 97,182,608 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	97,160,631 - 97,182,608 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	97,183,632 - 97,205,647 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	97,183,670 - 97,205,647 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	97,133,810 - 97,155,636 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	97,149,491 - 97,170,806 (-)	NCBI		MGSCv36	mm8
Celera	6	99,042,865 - 99,064,781 (-)	NCBI		Celera
Cytogenetic Map	6	D3	NCBI
cM Map	6	44.9	NCBI

Uba3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	131,346,219 - 131,367,378 (-)	NCBI		GRCr8
mRatBN7.2	4	129,789,526 - 129,810,707 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	129,789,204 - 129,810,606 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	135,214,153 - 135,235,250 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	130,995,195 - 131,016,292 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	129,613,140 - 129,634,237 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	129,548,411 - 129,569,550 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	129,548,416 - 129,569,470 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	194,051,838 - 194,072,937 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	131,902,438 - 131,924,610 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	132,147,288 - 132,169,460 (-)	NCBI
Celera	4	118,665,559 - 118,686,969 (-)	NCBI		Celera
Cytogenetic Map	4	q34	NCBI

UBA3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	69,010,165 - 69,035,897 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	69,014,952 - 69,043,481 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	68,990,760 - 69,016,377 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	70,357,665 - 70,383,166 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	70,358,371 - 70,383,117 (-)	Ensembl	panpan1.1		panPan2

UBA3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	22,657,758 - 22,682,134 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	22,657,817 - 22,681,447 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	22,632,410 - 22,656,797 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	22,683,590 - 22,708,036 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	22,683,646 - 22,708,036 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	22,377,507 - 22,401,872 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	22,720,892 - 22,745,308 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	22,790,714 - 22,815,179 (+)	NCBI		UU_Cfam_GSD_1.0

Uba3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404942	1,555,314 - 1,574,521 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936603	1,555,548 - 1,577,438 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936603	1,555,274 - 1,574,521 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

UBA3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	50,477,458 - 50,504,882 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	50,479,264 - 50,504,901 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	55,560,074 - 55,585,710 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

UBA3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	30,080,972 - 30,106,450 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	30,080,863 - 30,106,419 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	136,686,030 - 136,711,534 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Uba3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624773	3,622,362 - 3,646,980 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624773	3,623,295 - 3,646,974 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013513797	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01022056	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCB01042753	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCQ01070793	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000005237 ⟹ ENSCLAP00000005143

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955421	18,780,730 - 18,800,561 (+)	Ensembl

RefSeq Acc Id:

ENSCLAT00000005238 ⟹ ENSCLAP00000005144

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955421	18,781,007 - 18,801,266 (+)	Ensembl

RefSeq Acc Id:

XM_013513797 ⟹ XP_013369251

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955421	18,781,015 - 18,801,266 (+)	NCBI

Sequence:

show sequence

CCGCCCCTCCCCTCACGCCAGCCCCGCCCCGCCCCGCCGCAAGGACCCCTGGGAAGAGGCGGAG
AACAATATGGCGGATGGCGAGGAGCCGGAGAAGAAAAGAAGGAGAGTAGAGGAGCTGCTGGCTG
AGAAAATGGCTGTTGATGGTGGGTGTGGGGACACTGGAGACTGGGAAGGTCGCTGGAACCATGT
AAAGAAGTTCCTCGAGCGATCTGGACCCTTCACACACCCTGATTTCGAACCGAGCACTGAATCT
CTCCAGTTTTTGTTAGATACATGTAAAGTTCTAGTCATTGGAGCTGGCGGCTTAGGATGTGAGC
TCCTGAAAAATCTGGCGTTGTCTGGTTTTAGACAGATCCATGTCATAGACATGGACACTATAGA
TGTTTCCAATCTAAATAGGCAGTTTTTATTTAGGCCTAAAGATGTTGGAAGACCTAAGGCTGAA
GTTGCTGCAGAATTTCTAAATGACAGAATTCCTAATTGTAATGTAGTTCCACATTTCAGCAAGA
TCCAAGATTTTAATGACACTTTCTACCGACAATTTCATATTATTGTTTGTGGACTGGACTCTAT
TATAGCCAGAAGATGGATAAATGGAATGCTGATATCTCTTCTAAATTATGAAGATGGTGTGTTA
GATCCAAGCTCCATTGTCCCTATGATAGATGGGGGTACAGAAGGTTTTAAAGGAAATGCTCGGG
TGATTCTTCCTGGAATGACTGCTTGTATCGAATGTACACTGGAACTTTATCCACCACAGGTTAA
TTTTCCCATGTGCACCATTGCATCTATGCCCAGGCTACCAGAGCACTGTATTGAGTATGTAAGG
ATGTTGCAGTGGCCTAAAGAGCAACCTTTTGGAGAAGGGGTTCCATTAGATGGAGATGATCCTG
AACATATTCAGTGGATATTTCAAAAATCTGTAGAGAGAGCATCACAATATAATATTAGAGGTGT
TACATATAGACTCACTCAAGGGGTAGTAAAACGAATCATTCCTGCAGTAGCTTCCACAAATGCA
GTCATTGCAGCTGTGTGTGCCACTGAGGTTTTTAAAATAGCCACAAGTGCATACATTCCCCTTA
ATAATTACTTGGTATTCAATGATGTAGATGGGCTGTACACTTACACATTTGAAGCAGAGAGAAA
GGAGAACTGCCCAGCTTGTAGCCAACTTCCTCAAAATATTCAGTTTTCTCCATCAGCTAAACTG
CAGGAAGTTTTGGACTATCTAACCAATAGTGCTTCTCTGCAGATGAAATCTCCAGCAATCACAG
CCACATTAGAAGGGAAAAATAGAACCCTTTACTTACAGTCGGTAACCTCTATTGAAGAACGAAC
AAGGCCGAATCTTTCCAAAACTTTGAAAGAATTAGGACTTGTTGATGGACAAGAACTGGCAGTT
GCTGATGTCACCACACCGCAGACTGTACTATTCAAACTTCATTTTACTTCTTAAAGAAAATAAA
TTTGCACATAATAGACAACTTACGGAAATAATACACTTCATGGATGCTAAGAAATTGAATTTAT
GTCACTTTTAGCTAGCGTTGCTGAAATTTGACTTTTAATATAAGAACTACTCTTTTCTAACTTT
GTAACTTTCCCTTGAAGATAAGAGTTTTGGGGTCAGTGCTTGTCAACGTGTCCATTAGAAATAC
AGGAAATGATGCCTGGAGAGAGAGATTCTGAGTAAATGTAAAACTTTTAGAGGAGGAGGCAAAC
TCCCTCTTGTGTGTGAATTTTGTTATTATGGTCAAAATGCATTCCTCAGCTTTCATTTGGGTAC
CACAAGTACAGAAGATGTCCCTTTAGAGTAAACAAGGAATTAAGTTTTAAGTAACTTTAAATAT
TACAATCTGACATCCAGAGTATAACAAACATAGGCTATCACTGGACATAATATTCCTTTAATTG
TTCCAGTCCGAATCAATAATGGTTGTTACAGTTTATCTTGTCCATAATAATTTGTAAGCAGTGT
TATAGCTGAATACTTGTGCATGGAAATAGGGAATATTTTCATGTGTGTATTTGTAGTGCCGTAC
AGGCCGTTATGCACAAATTTAAGCCAACTTGGCTGTTTCAAAAAATTTAATGTTTAAACAGTTA
TCACAGATGCTTTTGCATTATTTATTAATAAAATCATACATTGCTACTTCTTTCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_013369251	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000005143.1
	ENSCLAP00000005144
	ENSCLAP00000005144.1

RefSeq Acc Id:

XP_013369251 ⟸ XM_013513797

- UniProtKB:

A0A8C2USF8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MADGEEPEKKRRRVEELLAEKMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPSTESLQ
FLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDVGRPKAEVA
AEFLNDRIPNCNVVPHFSKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLISLLNYEDGVLDP
SSIVPMIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIASMPRLPEHCIEYVRML
QWPKEQPFGEGVPLDGDDPEHIQWIFQKSVERASQYNIRGVTYRLTQGVVKRIIPAVASTNAVI
AAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAERKENCPACSQLPQNIQFSPSAKLQE
VLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTSIEERTRPNLSKTLKELGLVDGQELAVAD
VTTPQTVLFKLHFTS

hide sequence

RefSeq Acc Id:

ENSCLAP00000005144 ⟸ ENSCLAT00000005238

RefSeq Acc Id:

ENSCLAP00000005143 ⟸ ENSCLAT00000005237

Protein Domains

E2 binding

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000003651	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000005237.1	UniProtKB/TrEMBL
	ENSCLAT00000005238	ENTREZGENE
	ENSCLAT00000005238.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.520	UniProtKB/TrEMBL
	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
	Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3	UniProtKB/TrEMBL
InterPro	E2-binding	UniProtKB/TrEMBL
	ThiF/MoeB/HesA	UniProtKB/TrEMBL
	ThiF_NAD_FAD-bd	UniProtKB/TrEMBL
	Ub_act_enz_dom_a_sf	UniProtKB/TrEMBL
	Uba3	UniProtKB/TrEMBL
	Ubiquitin-activating_enz	UniProtKB/TrEMBL
	UBQ-activ_enz_E1_Cys_AS	UniProtKB/TrEMBL
NCBI Gene	Uba3	ENTREZGENE
PANTHER	PTHR10953	UniProtKB/TrEMBL
	PTHR10953:SF6	UniProtKB/TrEMBL
Pfam	E2_bind	UniProtKB/TrEMBL
	ThiF	UniProtKB/TrEMBL
PROSITE	UBIQUITIN_ACTIVAT_2	UniProtKB/TrEMBL
SMART	E2_bind	UniProtKB/TrEMBL
Superfamily-SCOP	SSF69572	UniProtKB/TrEMBL
UniProt	A0A8C2USF8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C2USI9_CHILA	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Uba3	ubiquitin like modifier activating enzyme 3		ubiquitin-like modifier activating enzyme 3	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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