Zfp36 (zinc finger protein 36) - Rat Genome Database

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Gene: Zfp36 (zinc finger protein 36) Rattus norvegicus
Analyze
Symbol: Zfp36
Name: zinc finger protein 36
RGD ID: 620722
Description: Enables mRNA 3'-UTR binding activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and regulation of gene expression. Predicted to act upstream of or within several processes, including negative regulation of cell differentiation; negative regulation of inflammatory response; and regulation of RNA metabolic process. Predicted to be located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleus. Predicted to be part of CCR4-NOT complex and ribonucleoprotein complex. Orthologous to human ZFP36 (ZFP36 ring finger protein); INTERACTS WITH 1,2,4-trimethylbenzene; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: mRNA decay activator protein ZFP36; Tis11; TPA-induced sequence 11; tristetraprolin; tristetraproline; TTP; zfp-36
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,796,628 - 92,799,108 (-)NCBIGRCr8
mRatBN7.2183,669,084 - 83,671,564 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,669,084 - 83,671,564 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx189,079,138 - 89,081,618 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,537,626 - 97,540,106 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0190,835,008 - 90,837,488 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0185,380,088 - 85,382,565 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl185,380,088 - 85,382,569 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0186,595,418 - 86,597,898 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,486,643 - 83,489,123 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1183,564,759 - 83,567,219 (-)NCBI
Celera178,065,353 - 78,067,833 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-palmitoylglycerol  (ISO)
3-hydroxybutyric acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
belinostat  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
C.I. Natural Red 20  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
chlorohydrocarbon  (EXP)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
cortisol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diethyl maleate  (ISO)
dimethyl sulfoxide  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ferric oxide  (ISO)
ferrostatin-1  (ISO)
fluoranthene  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gentamycin  (EXP,ISO)
hemin  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
iron dichloride  (ISO)
isoeugenol  (ISO)
ketamine  (EXP)
KT 5720  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
medroxyprogesterone acetate  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metformin  (EXP)
methamphetamine  (EXP,ISO)
methyllycaconitine  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
naphthalenes  (EXP)
nickel atom  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
okadaic acid  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
paraoxon  (ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
SB 203580  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
Shikonin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
succimer  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
tobramycin  (ISO)
topotecan  (EXP)
toxaphene  (EXP)
trans-isoeugenol  (ISO)
tributylstannane  (EXP)
Tributyltin oxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zinc atom  (EXP,ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
3'-UTR-mediated mRNA destabilization  (IEA,ISO,ISS)
3'-UTR-mediated mRNA stabilization  (ISO,ISS)
cellular response to epidermal growth factor stimulus  (ISO,ISS)
cellular response to fibroblast growth factor stimulus  (IEA,ISO,ISS)
cellular response to glucocorticoid stimulus  (ISO,ISS)
cellular response to granulocyte macrophage colony-stimulating factor stimulus  (ISO,ISS)
cellular response to lipopolysaccharide  (IEA,ISO,ISS)
cellular response to tumor necrosis factor  (IEA,ISO,ISS)
hematopoietic stem cell differentiation  (IEA,ISO)
intracellular signal transduction  (ISO)
MAPK cascade  (ISO,ISS)
miRNA-mediated gene silencing by inhibition of translation  (IEA,ISO,ISS)
mRNA catabolic process  (ISO,ISS)
mRNA transport  (ISO,ISS)
myeloid cell differentiation  (IEA,ISO)
negative regulation of erythrocyte differentiation  (ISO,ISS)
negative regulation of hematopoietic stem cell differentiation  (IEA,ISO)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of interleukin-2 production  (IEA,ISO,ISS)
negative regulation of myeloid cell differentiation  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of viral transcription  (ISO,ISS)
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  (ISO)
nuclear-transcribed mRNA catabolic process, deadenylation-independent decay  (ISO,ISS)
nuclear-transcribed mRNA poly(A) tail shortening  (IEA,ISO)
p38MAPK cascade  (IEA,ISO,ISS)
positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA  (ISO,ISS)
positive regulation of fat cell differentiation  (IEA,ISO,ISS)
positive regulation of intracellular mRNA localization  (ISO,ISS)
positive regulation of miRNA-mediated gene silencing  (ISO,ISS)
positive regulation of mRNA catabolic process  (ISO,ISS)
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  (IEA,ISO,ISS)
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  (IEA,ISO,ISS)
regulation of keratinocyte apoptotic process  (ISO,ISS)
regulation of keratinocyte differentiation  (ISO,ISS)
regulation of keratinocyte proliferation  (ISO,ISS)
regulation of mRNA stability  (ISO,ISS)
regulation of transcription by RNA polymerase II  (ISO)
regulation of tumor necrosis factor production  (ISO,ISS)
response to starvation  (ISO,ISS)
response to wounding  (IEA,ISO,ISS)
RNA destabilization  (ISO)

Cellular Component
CCR4-NOT complex  (IEA,ISO,ISS)
cytoplasm  (ISO,ISS)
cytoplasmic stress granule  (ISO,ISS)
cytosol  (IEA,ISO)
exosome (RNase complex)  (IEA,ISO,ISS)
nucleus  (IEA,ISO,ISS)
P-body  (ISO,ISS)
ribonucleoprotein complex  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of an AP1-ZFP36 Regulatory Network Associated with Breast Cancer Prognosis. Canzoneri R, etal., J Mammary Gland Biol Neoplasia. 2020 Jun;25(2):163-172. doi: 10.1007/s10911-020-09448-1. Epub 2020 Apr 4.
2. ZFP36 protects lungs from intestinal I/R-induced injury and fibrosis through the CREBBP/p53/p21/Bax pathway. Cao Y, etal., Cell Death Dis. 2021 Jul 8;12(7):685. doi: 10.1038/s41419-021-03950-y.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Sequence of a rat TIS11 cDNA, an immediate early gene induced by growth factors and phorbol esters. Kaneda N, etal., Gene 1992 Sep 10;118(2):289-91.
6. Cloning and characterization of the rat TIS11 gene. Kaneda N, etal., Mol Cell Biochem 2000 Oct;213(1-2):119-26.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Identification of nuclear import and export signals within the structure of the zinc finger protein TIS11. Murata T, etal., Biochem Biophys Res Commun 2002 May 17;293(4):1242-7.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Destabilization of the ornithine decarboxylase mRNA transcript by the RNA-binding protein tristetraprolin. Nowotarski SL, etal., Amino Acids. 2016 May 19.
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:7768935   PMID:8630730   PMID:9703499   PMID:10330172   PMID:10751406   PMID:11279239   PMID:11533235   PMID:11588035   PMID:11719186   PMID:11782475   PMID:11796723   PMID:12198173  
PMID:12748283   PMID:14679154   PMID:14766228   PMID:15014438   PMID:15187101   PMID:15467755   PMID:15489334   PMID:15634918   PMID:15652343   PMID:15687258   PMID:15766526   PMID:15814898  
PMID:16364915   PMID:17288565   PMID:17369404   PMID:17971298   PMID:20166898   PMID:20221403   PMID:20410487   PMID:20595389   PMID:20702587   PMID:21278420   PMID:21784977   PMID:21964062  
PMID:22405826   PMID:22658674   PMID:22701344   PMID:22844456   PMID:23644599   PMID:24190969   PMID:24733888   PMID:25038453   PMID:27182009  


Genomics

Comparative Map Data
Zfp36
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,796,628 - 92,799,108 (-)NCBIGRCr8
mRatBN7.2183,669,084 - 83,671,564 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,669,084 - 83,671,564 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx189,079,138 - 89,081,618 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,537,626 - 97,540,106 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0190,835,008 - 90,837,488 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0185,380,088 - 85,382,565 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl185,380,088 - 85,382,569 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0186,595,418 - 86,597,898 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,486,643 - 83,489,123 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1183,564,759 - 83,567,219 (-)NCBI
Celera178,065,353 - 78,067,833 (-)NCBICelera
Cytogenetic Map1q21NCBI
ZFP36
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381939,406,847 - 39,409,407 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1939,406,847 - 39,409,412 (+)EnsemblGRCh38hg38GRCh38
GRCh371939,897,487 - 39,900,047 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361944,589,327 - 44,591,885 (+)NCBINCBI36Build 36hg18NCBI36
Build 341944,589,326 - 44,591,885NCBI
Celera1936,699,177 - 36,701,735 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1936,344,174 - 36,346,739 (+)NCBIHuRef
CHM1_11939,898,190 - 39,900,755 (+)NCBICHM1_1
T2T-CHM13v2.01942,211,127 - 42,213,687 (+)NCBIT2T-CHM13v2.0
Zfp36
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,076,208 - 28,078,680 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl728,076,209 - 28,079,678 (-)EnsemblGRCm39 Ensembl
GRCm38728,376,784 - 28,379,228 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,376,784 - 28,380,253 (-)EnsemblGRCm38mm10GRCm38
MGSCv37729,161,803 - 29,164,247 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36728,085,544 - 28,087,988 (-)NCBIMGSCv36mm8
Celera722,938,422 - 22,940,866 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map716.72NCBI
Zfp36
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955468152,744 - 155,140 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955468152,744 - 155,140 (-)NCBIChiLan1.0ChiLan1.0
ZFP36
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22045,702,255 - 45,704,872 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11947,572,812 - 47,575,456 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01936,505,056 - 36,507,693 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11945,052,797 - 45,055,390 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1945,052,801 - 45,055,390 (+)Ensemblpanpan1.1panPan2
ZFP36
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11113,815,972 - 113,818,093 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1113,816,273 - 113,818,065 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1113,219,568 - 113,221,705 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01114,416,855 - 114,418,992 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1114,417,021 - 114,418,955 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11113,975,583 - 113,977,718 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01113,608,361 - 113,610,498 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01114,603,453 - 114,605,590 (-)NCBIUU_Cfam_GSD_1.0
Zfp36
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,822,651 - 13,825,464 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366612,250,665 - 2,253,787 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366612,251,148 - 2,253,527 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZFP36
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl648,063,677 - 48,066,250 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1648,063,732 - 48,066,235 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214143,677,781 - 143,680,284 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZFP36
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1634,011,073 - 34,013,665 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl634,011,031 - 34,013,870 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607312,032,267 - 12,034,907 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zfp36
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479412,734,191 - 12,737,971 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479412,732,222 - 12,738,006 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zfp36
2 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:132
Count of miRNA genes:95
Interacting mature miRNAs:119
Transcripts:ENSRNOT00000026661
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat

Markers in Region
D1Bda11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2183,669,498 - 83,669,873 (-)MAPPERmRatBN7.2
Rnor_6.0185,381,779 - 85,382,153NCBIRnor6.0
Rnor_5.0186,597,109 - 86,597,483UniSTSRnor5.0
RGSC_v3.4183,487,058 - 83,487,432UniSTSRGSC3.4
Celera178,065,768 - 78,066,142UniSTS
Cytogenetic Map1q21UniSTS
Zfp36  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0186,597,131 - 86,597,295NCBIRnor5.0
RGSC_v3.4183,487,246 - 83,487,409UniSTSRGSC3.4
Celera178,065,956 - 78,066,119UniSTS
Cytogenetic Map1q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 41 33 19 33 3 27 28 11
Low 8 16 8 8 8 8 74 8 13 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000090129   ⟹   ENSRNOP00000073413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl183,669,084 - 83,671,564 (-)Ensembl
Rnor_6.0 Ensembl185,380,088 - 85,382,569 (+)Ensembl
RefSeq Acc Id: NM_133290   ⟹   NP_579824
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8192,796,628 - 92,799,108 (-)NCBI
mRatBN7.2183,669,084 - 83,671,564 (-)NCBI
Rnor_6.0185,380,088 - 85,382,565 (+)NCBI
Rnor_5.0186,595,418 - 86,597,898 (+)NCBI
RGSC_v3.4183,486,643 - 83,489,123 (-)RGD
Celera178,065,353 - 78,067,833 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_579824 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH60308 (Get FASTA)   NCBI Sequence Viewer  
  BAB12432 (Get FASTA)   NCBI Sequence Viewer  
  EDM07897 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073413
  ENSRNOP00000073413.1
GenBank Protein P47973 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_579824   ⟸   NM_133290
- UniProtKB: Q54AH1 (UniProtKB/Swiss-Prot),   P47973 (UniProtKB/Swiss-Prot),   G3V8K6 (UniProtKB/TrEMBL),   A6J9I7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073413   ⟸   ENSRNOT00000090129
Protein Domains
C3H1-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P47973-F1-model_v2 AlphaFold P47973 1-320 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689871
Promoter ID:EPDNEW_R396
Type:single initiation site
Name:Zfp36_1
Description:zinc finger protein 36
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0185,380,088 - 85,380,148EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620722 AgrOrtholog
BioCyc Gene G2FUF-60245 BioCyc
Ensembl Genes ENSRNOG00000058388 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000090129 ENTREZGENE
  ENSRNOT00000090129.3 UniProtKB/TrEMBL
Gene3D-CATH Zinc finger, CCCH-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6922188 IMAGE-MGC_LOAD
InterPro ZFP36-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_CCCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_CCCH_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79426 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72649 IMAGE-MGC_LOAD
NCBI Gene 79426 ENTREZGENE
PANTHER MRNA DECAY ACTIVATOR PROTEIN ZFP36 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12547 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam zf-CCCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Zfp36 PhenoGen
PROSITE ZF_C3H1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000058388 RatGTEx
SMART ZnF_C3H1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF90229 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6J9I7 ENTREZGENE, UniProtKB/TrEMBL
  G3V8K6 ENTREZGENE, UniProtKB/TrEMBL
  P47973 ENTREZGENE
  Q54AH1 ENTREZGENE
  TTP_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q54AH1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Zfp36  zinc finger protein 36      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Zfp36        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization may shuttle between the nucleus and cytoplasm 727988
gene_product member of the CCCH zinc finger protein family 727988