Zfp36 (ZFP36 ring finger protein) - Rat Genome Database

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Gene: Zfp36 (ZFP36 ring finger protein) Heterocephalus glaber
Analyze
Symbol: Zfp36
Name: ZFP36 ring finger protein
RGD ID: 18929093
Description: ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); C-C chemokine binding (ortholog); enzyme binding (ortholog); INVOLVED IN 3'-UTR-mediated mRNA stabilization (ortholog); cellular response to epidermal growth factor stimulus (ortholog); cellular response to fibroblast growth factor stimulus (ortholog); ASSOCIATED WITH alopecia (ortholog); arthritis (ortholog); breast cancer (ortholog); FOUND IN CCR4-NOT complex (ortholog); cytoplasmic stress granule (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: mRNA decay activator protein ZFP36
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479412,734,191 - 12,737,971 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479412,732,222 - 12,738,006 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
3'-UTR-mediated mRNA destabilization  (IEA)
3'-UTR-mediated mRNA stabilization  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to glucocorticoid stimulus  (ISO)
cellular response to granulocyte macrophage colony-stimulating factor stimulus  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to tumor necrosis factor  (ISO)
hematopoietic stem cell differentiation  (ISO)
intracellular signal transduction  (ISO)
MAPK cascade  (ISO)
miRNA-mediated gene silencing by inhibition of translation  (ISO)
mRNA catabolic process  (ISO)
mRNA transport  (ISO)
myeloid cell differentiation  (ISO)
negative regulation of erythrocyte differentiation  (ISO)
negative regulation of hematopoietic stem cell differentiation  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of interleukin-2 production  (ISO)
negative regulation of myeloid cell differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of viral transcription  (ISO)
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  (ISO)
nuclear-transcribed mRNA catabolic process, deadenylation-independent decay  (ISO)
nuclear-transcribed mRNA poly(A) tail shortening  (ISO)
p38MAPK cascade  (ISO)
positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA  (ISO)
positive regulation of fat cell differentiation  (ISO)
positive regulation of intracellular mRNA localization  (ISO)
positive regulation of miRNA-mediated gene silencing  (ISO)
positive regulation of mRNA catabolic process  (ISO)
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  (IEA)
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  (ISO)
regulation of keratinocyte apoptotic process  (ISO)
regulation of keratinocyte differentiation  (ISO)
regulation of keratinocyte proliferation  (ISO)
regulation of mRNA stability  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of tumor necrosis factor production  (ISO)
response to starvation  (ISO)
response to wounding  (ISO)
RNA destabilization  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Zfp36
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479412,734,191 - 12,737,971 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479412,732,222 - 12,738,006 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
ZFP36
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381939,406,847 - 39,409,407 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1939,406,847 - 39,409,407 (+)EnsemblGRCh38hg38GRCh38
GRCh371939,897,487 - 39,900,047 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361944,589,327 - 44,591,885 (+)NCBINCBI36Build 36hg18NCBI36
Build 341944,589,326 - 44,591,885NCBI
Celera1936,699,177 - 36,701,735 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1936,344,174 - 36,346,739 (+)NCBIHuRef
CHM1_11939,898,190 - 39,900,755 (+)NCBICHM1_1
T2T-CHM13v2.01942,211,127 - 42,213,687 (+)NCBIT2T-CHM13v2.0
Zfp36
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,076,208 - 28,078,680 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl728,076,209 - 28,079,678 (-)EnsemblGRCm39 Ensembl
GRCm38728,376,784 - 28,379,228 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,376,784 - 28,380,253 (-)EnsemblGRCm38mm10GRCm38
MGSCv37729,161,803 - 29,164,247 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36728,085,544 - 28,087,988 (-)NCBIMGSCv36mm8
Celera722,938,422 - 22,940,866 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map716.72NCBI
Zfp36
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,796,628 - 92,799,108 (-)NCBIGRCr8
mRatBN7.2183,669,084 - 83,671,564 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,669,084 - 83,671,564 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx189,079,138 - 89,081,618 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,537,626 - 97,540,106 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0190,835,008 - 90,837,488 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0185,380,088 - 85,382,565 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl185,380,088 - 85,382,569 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0186,595,418 - 86,597,898 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,486,643 - 83,489,123 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1183,564,759 - 83,567,219 (-)NCBI
Celera178,065,353 - 78,067,833 (-)NCBICelera
Cytogenetic Map1q21NCBI
Zfp36
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955468152,744 - 155,140 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955468152,744 - 155,140 (-)NCBIChiLan1.0ChiLan1.0
ZFP36
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22045,702,255 - 45,704,872 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11947,572,812 - 47,575,456 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01936,505,056 - 36,507,693 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11945,052,797 - 45,055,390 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1945,052,801 - 45,055,390 (+)Ensemblpanpan1.1panPan2
ZFP36
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11113,815,972 - 113,818,093 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1113,816,273 - 113,818,065 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1113,219,568 - 113,221,705 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01114,416,855 - 114,418,992 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1114,417,021 - 114,418,955 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11113,975,583 - 113,977,718 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01113,608,361 - 113,610,498 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01114,603,453 - 114,605,590 (-)NCBIUU_Cfam_GSD_1.0
Zfp36
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,822,651 - 13,825,464 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366612,250,665 - 2,253,787 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366612,251,148 - 2,253,527 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZFP36
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl648,063,677 - 48,066,250 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1648,063,732 - 48,066,235 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214143,677,781 - 143,680,284 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZFP36
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1634,011,073 - 34,013,665 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl634,011,031 - 34,013,870 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607312,032,267 - 12,034,907 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000011212   ⟹   ENSHGLP00000011088
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462479412,734,191 - 12,737,971 (+)Ensembl
RefSeq Acc Id: XM_004859117   ⟹   XP_004859174
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479412,732,355 - 12,738,006 (+)NCBI
RefSeq Acc Id: XM_021239757   ⟹   XP_021095416
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479412,732,222 - 12,738,006 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004859174 (Get FASTA)   NCBI Sequence Viewer  
  XP_021095416 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000011088
Reference Protein Sequences
RefSeq Acc Id: XP_021095416   ⟸   XM_021239757
- UniProtKB: G5BJD9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004859174   ⟸   XM_004859117
- UniProtKB: G5BJD9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000011088   ⟸   ENSHGLT00000011212


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000007955 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000011212 ENTREZGENE
Gene3D-CATH Zinc finger, CCCH-type UniProtKB/TrEMBL
InterPro ZFP36-like UniProtKB/TrEMBL
  Znf_CCCH UniProtKB/TrEMBL
  Znf_CCCH_sf UniProtKB/TrEMBL
NCBI Gene Zfp36 ENTREZGENE
PANTHER CCCH ZINC FINGER/TIS11-RELATED UniProtKB/TrEMBL
  MRNA DECAY ACTIVATOR PROTEIN ZFP36 UniProtKB/TrEMBL
Pfam zf-CCCH UniProtKB/TrEMBL
PROSITE ZF_C3H1 UniProtKB/TrEMBL
SMART ZnF_C3H1 UniProtKB/TrEMBL
Superfamily-SCOP CCCH zinc finger UniProtKB/TrEMBL
UniProt G5BJD9 ENTREZGENE, UniProtKB/TrEMBL