Myo1c (myosin 1C) - Rat Genome Database

Name: Myo1c
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Myo1c (myosin 1C) Rattus norvegicus

Analyze

Symbol:

Myo1c

Name:

myosin 1C

RGD ID:

620443

Description:

Enables actin filament binding activity; calmodulin binding activity; and microfilament motor activity. Involved in positive regulation of actin filament polymerization and positive regulation of cellular response to insulin stimulus. Located in membrane raft; ruffle membrane; and stereocilium bundle. Orthologous to human MYO1C (myosin IC); PARTICIPATES IN auditory mechanotransduction pathway; insulin responsive facilitative sugar transporter mediated glucose transport pathway; INTERACTS WITH 17beta-estradiol; 2,4-dinitrotoluene; 4,4'-diaminodiphenylmethane.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC100365624; LOC686250; MMI-beta; MMIb; myosin heavy chain myr 2; myosin I beta; myosin IC; myosin IC-like; myosin-Ic; Myr2; similar to unconventional myosin Myr2 I heavy chain; unconventional myosin Myr2 I heavy chain; unconventional myosin-Ic

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MYO1C (myosin IC)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther
Mus musculus (house mouse):	Myo1c (myosin IC)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Myo1c (myosin IC)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MYO1C (myosin IC)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MYO1C (myosin IC)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Myo1c (myosin IC)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MYO1C (myosin IC)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MYO1C (myosin IC)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Myo1c (myosin IC)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	UBXN7 (UBX domain protein 7)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Myo1c (myosin IC)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	MYO1C (myosin IC)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	myo1cb (myosin Ic, paralog b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	myo1ca (myosin Ic, paralog a)	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Myo61F	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	myo1c	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	60,996,642 - 61,019,022 (+)	NCBI		GRCr8
mRatBN7.2	10	60,498,372 - 60,520,752 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	60,498,280 - 60,520,752 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	65,150,370 - 65,167,442 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	64,655,787 - 64,672,859 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	60,118,363 - 60,135,435 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	63,803,311 - 63,819,614 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	63,803,309 - 63,819,614 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	64,185,628 - 64,201,931 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	62,990,673 - 63,006,974 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	63,004,293 - 63,020,597 (+)	NCBI
Celera	10	59,530,993 - 59,546,121 (+)	NCBI		Celera
Cytogenetic Map	10	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

atrial fibrillation (ISO)

Experimental Liver Cirrhosis (ISO)

Miller-Dieker lissencephaly syndrome (ISO)

syndromic microphthalmia 5 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-diaminotoluene (ISO)

2,4-dinitrotoluene (EXP)

2-butoxyethanol (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

acetamide (EXP)

acrolein (ISO)

Aflatoxin B2 alpha (ISO)

alpha-pinene (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

benzoates (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

bleomycin A2 (EXP)

cadmium atom (ISO)

caffeine (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

choline (ISO)

cobalt dichloride (EXP,ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (ISO)

dexamethasone (ISO)

dibutyl phthalate (EXP,ISO)

doxorubicin (ISO)

entinostat (ISO)

epoxiconazole (ISO)

fenvalerate (EXP)

folic acid (ISO)

FR900359 (ISO)

fumonisin B1 (ISO)

gentamycin (EXP)

hydrogen cyanide (ISO)

hydrogen peroxide (ISO)

indometacin (ISO)

ivermectin (ISO)

L-methionine (ISO)

methapyrilene (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

pentachlorophenol (ISO)

perfluorooctanoic acid (EXP)

pioglitazone (ISO)

pirinixic acid (EXP,ISO)

potassium cyanide (ISO)

sodium arsenite (ISO)

tamoxifen (ISO)

tetrachloromethane (EXP)

thapsigargin (EXP)

thioacetamide (EXP)

trichloroethene (EXP)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin filament organization (IBA)

actin filament-based movement (IBA)

cellular response to type II interferon (IEA,ISO)

endocytosis (IBA)

positive regulation of actin filament polymerization (IMP)

positive regulation of cell migration (ISO)

positive regulation of cell migration by vascular endothelial growth factor signaling pathway (IEA)

positive regulation of cellular response to insulin stimulus (IEA,IMP,ISO)

positive regulation of protein targeting to membrane (IEA,ISO)

positive regulation of transcription by RNA polymerase III (ISO)

positive regulation of vascular endothelial growth factor signaling pathway (IEA)

protein targeting to membrane (IEA,ISO)

protein transport (IEA)

regulation of bicellular tight junction assembly (IEA,ISO)

vascular endothelial growth factor signaling pathway (ISO)

vesicle transport along actin filament (IEA,ISO)

Cellular Component

actin cytoskeleton (IBA)

B-WICH complex (ISO)

basal plasma membrane (IEA,ISO)

brush border (IEA,ISO)

cell cortex (IEA)

cytoplasm (IBA,IEA,ISO)

cytoplasmic vesicle membrane (IEA,ISO)

filamentous actin (IEA,ISO)

lateral plasma membrane (IEA,ISO)

membrane (ISO)

membrane raft (IDA,IEA,ISO)

microvillus (IBA,IEA,ISO)

myosin complex (IEA)

nuclear body (IEA,ISO)

nucleus (IEA)

phagocytic vesicle (IEA,ISO)

plasma membrane (IBA,ISO)

ruffle membrane (IDA)

stereocilium (ISO)

stereocilium bundle (IDA)

stereocilium membrane (IEA)

stress fiber (ISO)

Molecular Function

actin binding (IEA)

actin filament binding (IBA,IDA)

ATP binding (IEA)

calmodulin binding (IDA)

cytoskeletal motor activity (IEA)

microfilament motor activity (IBA,IDA,ISO)

protein binding (ISO)

signaling receptor binding (IEA,ISO)

small GTPase binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

auditory mechanotransduction pathway (ISO)

insulin responsive facilitative sugar transporter mediated glucose transport pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Modification of loop 1 affects the nucleotide binding properties of Myo1c, the adaptation motor in the inner ear.	Adamek N, etal., Biochemistry. 2010 Feb 9;49(5):958-71. doi: 10.1021/bi901803j.
2.	Motor protein Myo1c is a podocyte protein that facilitates the transport of slit diaphragm protein Neph1 to the podocyte membrane.	Arif E, etal., Mol Cell Biol. 2011 May;31(10):2134-50. doi: 10.1128/MCB.05051-11. Epub 2011 Mar 14.
3.	A model of stereocilia adaptation based on single molecule mechanical studies of myosin I.	Batters C, etal., Philos Trans R Soc Lond B Biol Sci. 2004 Dec 29;359(1452):1895-905.
4.	Myo1c binding to submembrane actin mediates insulin-induced tethering of GLUT4 vesicles.	Boguslavsky S, etal., Mol Biol Cell. 2012 Oct;23(20):4065-78. doi: 10.1091/mbc.E12-04-0263. Epub 2012 Aug 23.
5.	Mechanism and specificity of pentachloropseudilin-mediated inhibition of myosin motor activity.	Chinthalapudi K, etal., J Biol Chem. 2011 Aug 26;286(34):29700-8. doi: 10.1074/jbc.M111.239210. Epub 2011 Jun 16.
6.	Myosin-I isozymes in neonatal rodent auditory and vestibular epithelia.	Dumont RA, etal., J Assoc Res Otolaryngol 2002 Dec;3(4):375-89. Epub 2002 Feb 27.
7.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8.	Mechanotransduction by hair cells: models, molecules, and mechanisms.	Gillespie PG and Muller U, Cell. 2009 Oct 2;139(1):33-44. doi: 10.1016/j.cell.2009.09.010.
9.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
10.	Calcium, nucleotide, and actin affect the interaction of mammalian Myo1c with its light chain calmodulin.	Lieto-Trivedi A and Coluccio LM, Biochemistry. 2008 Sep 23;47(38):10218-26. doi: 10.1021/bi8011059. Epub 2008 Aug 26.
11.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
12.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
13.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
14.	GOA pipeline	RGD automated data pipeline
15.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
16.	Information Derived from GenBank Report	RGD, Sept. 2003
17.	Rho GTPases in insulin-stimulated glucose uptake.	Satoh T Small GTPases. 2014;5:e28102. doi: 10.4161/sgtp.28102. Epub 2014 Mar 10.
18.	Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus.	Shakib K, etal., Proteomics. 2005 Jul;5(11):2819-38.

Additional References at PubMed

PMID:8719884	PMID:9858156	PMID:11208135	PMID:12490950	PMID:15758024	PMID:15976448	PMID:16957816	PMID:17050716	PMID:17994197	PMID:19046570	PMID:19056867	PMID:19144319
PMID:19199708	PMID:19946888	PMID:20089841	PMID:20458337	PMID:21362503	PMID:22114352	PMID:23262137	PMID:23376485	PMID:23533145	PMID:24056301	PMID:24625528	PMID:26940917
PMID:35352799	PMID:36513634

Genomics

Comparative Map Data

Myo1c
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	60,996,642 - 61,019,022 (+)	NCBI		GRCr8
mRatBN7.2	10	60,498,372 - 60,520,752 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	60,498,280 - 60,520,752 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	65,150,370 - 65,167,442 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	64,655,787 - 64,672,859 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	60,118,363 - 60,135,435 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	63,803,311 - 63,819,614 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	63,803,309 - 63,819,614 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	64,185,628 - 64,201,931 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	62,990,673 - 63,006,974 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	63,004,293 - 63,020,597 (+)	NCBI
Celera	10	59,530,993 - 59,546,121 (+)	NCBI		Celera
Cytogenetic Map	10	q24	NCBI

MYO1C
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	1,464,186 - 1,492,686 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	1,464,186 - 1,492,686 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	1,367,480 - 1,395,980 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	1,314,230 - 1,342,751 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	1,314,874 - 1,342,745	NCBI
Celera	17	1,382,666 - 1,411,498 (-)	NCBI		Celera
Cytogenetic Map	17	p13.3	NCBI
HuRef	17	1,267,587 - 1,296,167 (-)	NCBI		HuRef
CHM1_1	17	1,376,234 - 1,404,693 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	1,352,909 - 1,381,443 (-)	NCBI		T2T-CHM13v2.0

Myo1c
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	75,541,345 - 75,565,450 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	75,541,330 - 75,564,736 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	75,650,519 - 75,674,643 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	75,650,504 - 75,673,910 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	75,465,011 - 75,488,145 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	75,467,773 - 75,490,838 (+)	NCBI		MGSCv36	mm8
Celera	11	83,160,567 - 83,183,742 (+)	NCBI		Celera
Cytogenetic Map	11	B5	NCBI
cM Map	11	45.92	NCBI

Myo1c
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955481	1,676,728 - 1,703,488 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955481	1,676,788 - 1,701,421 (+)	NCBI	ChiLan1.0	ChiLan1.0

MYO1C
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	9,034,149 - 9,063,270 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	11,000,420 - 11,029,540 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	1,446,506 - 1,475,634 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	1,345,143 - 1,375,540 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	1,345,143 - 1,375,540 (-)	Ensembl	panpan1.1		panPan2

MYO1C
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	45,635,295 - 45,658,226 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	45,636,208 - 45,658,035 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	44,787,550 - 44,810,320 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	46,463,244 - 46,486,023 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	46,463,244 - 46,485,945 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	45,233,730 - 45,256,432 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	45,528,186 - 45,550,881 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	45,581,598 - 45,604,345 (-)	NCBI		UU_Cfam_GSD_1.0

Myo1c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	44,733,124 - 44,761,658 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936538	7,611,008 - 7,639,581 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936538	7,614,985 - 7,639,603 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MYO1C
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	47,691,256 - 47,718,337 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	47,691,252 - 47,715,670 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	49,785,597 - 49,802,342 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MYO1C
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	1,137,469 - 1,167,497 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666059	20,819,456 - 20,849,629 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Myo1c
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624786	4,188,143 - 4,211,732 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624786	4,188,143 - 4,211,712 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Myo1c
58 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	233
Count of miRNA genes:	149
Interacting mature miRNAs:	167
Transcripts:	ENSRNOT00000036666
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	5801990	62146030	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6154182	73453136	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14487011	89062041	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14487011	104060283	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14487011	107057807	Rat
6893350	Bw99	Body weight QTL 99	0.87	0.16	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
6893352	Bw100	Body weight QTL 100	0.33	0.6	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
1598852	Anxrr19	Anxiety related response QTL 19	5.07		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	10	18167841	63167841	Rat
2313055	Bw96	Body weight QTL 96	3.6	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	10	19606483	64606483	Rat
2313087	Bmd80	Bone mineral density QTL 80	3.2	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	10	19606483	64606483	Rat
1554317	Bmd4	Bone mineral density QTL 4	9.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	19816042	99406971	Rat
1581497	Esta1	Estrogen-induced thymic atrophy QTL 1			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	21329805	61345413	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22427500	90627625	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
70224	Eae3	Experimental allergic encephalomyelitis QTL 3	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	26521957	61345413	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	26521957	98003205	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	26521957	98952741	Rat
2300171	Bmd58	Bone mineral density QTL 58	4.9	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	26944628	71944628	Rat
10402859	Bp381	Blood pressure QTL 381		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
2292441	Bp308	Blood pressure QTL 308			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
724527	Bp148	Blood pressure QTL 148		0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	28453136	73453136	Rat
1331762	Rf40	Renal function QTL 40	3.873		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	10	29299504	64155584	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29299504	107211142	Rat
631557	Bp136	Blood pressure QTL 136		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	30632053	75632053	Rat
1576311	Pia26	Pristane induced arthritis QTL 26			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	31224026	75632053	Rat
1578779	Tcas10	Tongue tumor susceptibility QTL 10	3.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	10	31297439	76297439	Rat
1576319	Cia29	Collagen induced arthritis QTL 29			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	33973921	78973921	Rat
1358897	Stresp6	Stress response QTL 6	4.17	0.022	blood norepinephrine amount (VT:0005663)	plasma norepinephrine level (CMO:0001010)	10	35392267	64155584	Rat
61441	Btemp1	Thermal response to stress QTL 1	4		body temperature trait (VT:0005535)	core body temperature (CMO:0001036)	10	35392457	63642539	Rat
2317042	Aia20	Adjuvant induced arthritis QTL 20	3.38		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	10	37565079	82565079	Rat
2317043	Aia7	Adjuvant induced arthritis QTL 7	3.82		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	10	37565079	82565079	Rat
1576308	Schws1	Schwannoma susceptibility QTL 1		0.0041	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	40035094	102359817	Rat
631269	Cia22	Collagen induced arthritis QTL 22	8.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40035094	104060283	Rat
631270	Cia23	Collagen induced arthritis QTL 23	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40035094	104060283	Rat
631552	Vetf2	Vascular elastic tissue fragility QTL 2	4.5	0.0002	aorta elastic tissue integrity trait (VT:0010556)	artery internal elastic lamina non-tumorous lesion count (CMO:0001913)	10	41142633	86142633	Rat
61463	Bp12	Blood pressure QTL 12	6.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	41333258	86333258	Rat
8552805	Bw145	Body weight QTL 145	2.2		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	10	41944526	78307017	Rat
1298078	Stresp5	Stress response QTL 5	2.99	0.00025	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	42045676	104670812	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	42323132	87323132	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	42323132	87323132	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	42323132	87323132	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	42323132	87323132	Rat
70198	BpQTLcluster9	Blood pressure QTL cluster 9	2.94		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	42323132	87323132	Rat
6893342	Cm78	Cardiac mass QTL 78	0.1	0.88	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	10	42876766	79813922	Rat
9589030	Epfw9	Epididymal fat weight QTL 9	19.24	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	10	44441699	89441699	Rat
7411614	Foco18	Food consumption QTL 18		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	44441699	89441699	Rat
8694173	Bw149	Body weight QTL 149	4.38	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	10	44441699	89441699	Rat
2300218	Hpcl2	Hepatic cholesterol level QTL 2			liver cholesterol amount (VT:0010498)	liver cholesterol level (CMO:0001597)	10	45029650	95600334	Rat
631547	Bp87	Blood pressure QTL 87	4.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	47369470	92369470	Rat
2293705	Bmd25	Bone mineral density QTL 25	7.1	0.0001	femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	10	49444551	81709989	Rat
7207811	Bmd90	Bone mineral density QTL 90	5.2		femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	10	49444551	81709989	Rat
2293652	Bmd22	Bone mineral density QTL 22	4.9	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	10	49444551	81709989	Rat
2293669	Bmd33	Bone mineral density QTL 33	4.5	0.0001	femur strength trait (VT:0010010)	femoral neck polar moment of inertia (CMO:0001670)	10	49444551	81709989	Rat
2293679	Bmd30	Bone mineral density QTL 30	3.5	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	10	49444551	81709989	Rat
1549846	Scl47	Serum cholesterol level QTL 47	3.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	10	50574707	95574707	Rat
70364	Bp72	Blood pressure QTL 72			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	51121100	96121100	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	51770177	107211142	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	51770177	107211142	Rat
1359017	Hrtrt21	Heart rate QTL 21	2.4		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	10	51772940	96772940	Rat
631530	Tls3	T-lymphoma susceptibility QTL 3	0	0.0001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	10	51774612	95600334	Rat
631535	Cm51	Cardiac mass QTL 51	3		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	51786282	91669536	Rat
2306787	Ean3	Experimental allergic neuritis QTL 3	3.1		nervous system integrity trait (VT:0010566)	body weight loss (CMO:0001399)	10	53797385	66979128	Rat
70171	Cari1	Carrageenan-induced inflammation QTL 1	4.9	0.0005	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	10	53797385	107211142	Rat
70164	Bw21	Body weight QTL 21	4.36	0.00005	body mass (VT:0001259)	body weight (CMO:0000012)	10	53797494	98952626	Rat
1354608	Cm33	Cardiac mass QTL 33	2.8		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	10	54809292	99809292	Rat
2298495	Eae23	Experimental allergic encephalomyelitis QTL 23	16.93		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis duration (CMO:0001424)	10	55273696	60677262	Rat
2312662	Slep8	Serum leptin concentration QTL 8		0.05	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	10	57134272	102134272	Rat
2312668	Scl65	Serum cholesterol level QTL 65		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	10	57134272	102134272	Rat
2312672	Insul15	Insulin level QTL 15		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	10	57134272	102134272	Rat
1549831	Bss6	Bone structure and strength QTL 6	4		lumbar vertebra strength trait (VT:0010574)	vertebra ultimate force (CMO:0001678)	10	57576521	102576521	Rat
2293698	Bss43	Bone structure and strength QTL 43	5.33	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	10	59209888	104209888	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	51	35	19	35	8	11	74	35	34	11	8
Low			6	6		6					7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001414168	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_023092	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039086809	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039086811	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063269827	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU139350	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU139351	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU139354	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X74800	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000036666 ⟹ ENSRNOP00000028929

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	60,503,411 - 60,520,752 (+)	Ensembl
Rnor_6.0 Ensembl	10	63,803,309 - 63,819,614 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000101210 ⟹ ENSRNOP00000097261

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	60,498,280 - 60,520,752 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000108756 ⟹ ENSRNOP00000080420

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	60,503,692 - 60,520,752 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000117022 ⟹ ENSRNOP00000096158

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	60,501,879 - 60,520,752 (+)	Ensembl

RefSeq Acc Id:

NM_001414168 ⟹ NP_001401097

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	60,996,642 - 61,019,022 (+)	NCBI
mRatBN7.2	10	60,498,372 - 60,520,752 (+)	NCBI

RefSeq Acc Id:

NM_023092 ⟹ NP_075580

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	61,001,953 - 61,019,022 (+)	NCBI
mRatBN7.2	10	60,503,683 - 60,520,752 (+)	NCBI
Rnor_6.0	10	63,803,311 - 63,819,614 (+)	NCBI
Rnor_5.0	10	64,185,628 - 64,201,931 (-)	NCBI
RGSC_v3.4	10	62,990,673 - 63,006,974 (+)	RGD
Celera	10	59,530,993 - 59,546,121 (+)	NCBI

Sequence:

show sequence

GATAGACTCGAGCGGAATCGACGCCGGAGGTCCCAAGGCCCACTCCCACCCAGCCTGGCCAGGC
CGGCTACAGTGGGATCCAGGGGTCGAGACTCCGATCCCCCTAAGCCAAAGGGCCTGCAAGGGGC
AGTGCGGGGGGGGGGGCTAGCCCCTCCCTCGGTGACCGTGCGCCGGAGCACTGATTAACGCGGG
CACGGAGCAGGGCACCAGGTCGCAGGATGCGCTACCGGGCGTCGGCCCTGGGCAGTGACGGGGT
ACGAGTGACCATGGAGAGCGCCTTGACTGCCCGAGACCGGGTGGGGGTGCAAGACTTTGTTCTG
CTGGAGAACTTCACCAGTGAGGCTGCCTTCATTGAGAACCTCCGGCGTCGATTCCGGGAGAACC
TCATTTATACCTACATTGGCCCTGTCCTGGTCTCTGTCAACCCCTACCGGGACCTACAGATCTA
CACACGGCAACATATGGAACGCTACCGTGGCGTCAGTTTCTATGAAGTGCCGCCTCATCTGTTT
GCAGTGGCTGACACTGTATACCGGGCGCTTCGTACTGAGCGTCGGGACCAAGCAGTGATGATTT
CTGGAGAGAGTGGGGCAGGGAAGACAGAGGCCACCAAGAGATTGCTCCAGTTCTATGCAGAGAC
CTGCCCAGCCCCTGAAAGGGGTGGCGCAGTGCGAGACCGCCTGTTGCAGAGCAACCCTGTGCTG
GAGGCCTTTGGGAATGCCAAGACTCTCCGCAACGACAACTCCAGCCGCTTTGGGAAGTACATGG
ATGTGCAGTTTGACTTCAAGGGTGCCCCTGTGGGAGGCCACATTCTCAGTTACCTCCTGGAGAA
GTCTCGAGTGGTACACCAGAATCACGGAGAACGGAACTTCCACGTCTTTTACCAGCTCCTGGAG
GGGGGGGAGGAGGAGGCTCTTCGTCGTCTGGGCTTGGAACGGAACCCCCAGAGCTACTTGTACC
TGGTGAAGGGCCAGTGTGCCAAGGTCTCCTCCATCAATGACAAGAGTGACTGGAAGGTTGTGAG
GAAGGCGCTGTCAGTCATTGACTTCACTGAGGATGAAGTGGAGGACTTGCTAAGCATCGTGGCC
AGCGTCCTACATCTGGGCAATATCCACTTTGCTGCTGATGAGGACAGCAATGCCCAGGTTACTA
CTGAGAACCAGCTCAAATATCTGACCAGGCTCCTTGGTGTGGAAGGCACAACACTGAGGGAAGC
CCTGACCCACAGGAAGATCATCGCCAAGGGGGAAGAGCTCCTGAGCCCACTGAACCTTGAACAG
GCTGCATATGCAAGGGATGCTCTTGCCAAGGCTGTGTACAGCCGCACTTTCACCTGGTTGGTCA
GAAAGATCAATAGGTCTCTGGCCTCTAAGGACGCTGAGAGCCCCAGCTGGCGAAGCACCACAGT
TCTTGGGCTCCTGGACATTTATGGCTTCGAAGTGTTTCAGCATAACAGCTTCGAGCAGTTCTGC
ATCAACTATTGCAATGAGAAGCTGCAGCAGCTCTTCATTGAGCTGACTCTCAAGTCCGAGCAGG
AGGAATACGAGGCAGAGGGCATCGCGTGGGAACCTGTCCAATACTTCAACAACAAGATCATCTG
TGACCTGGTGGAGGAGAAATTCAAGGGCATCATCTCCATCTTGGATGAAGAGTGCCTGCGTCCT
GGGGAGGCCACAGACCTGACCTTCCTGGAGAAGCTGGAGGACACAATCAAGCACCACCCTCACT
TCCTGACGCACAAGCTTGCTGACCAGAAGACCAGGAAATCCCTCGACCGAGGGGAGTTCCGCCT
TCTTCATTATGCGGGAGAGGTGACCTACAGCGTGACTGGGTTTCTGGATAAAAACAATGACCTC
CTCTTCCGGAACCTGAAGGAGACCATGTGCAGCTCCACGAACCCCATCATGGCCCAGTGCTTTG
ACAAGAGTGAGCTCAGTGACAAGAAGCGGCCAGAGACGGTGGCCACCCAGTTCAAGATGAGCCT
CTTGCAGCTAGTGGAGATCCTGAGGTCTAAGGAACCTGCTTATATCCGGTGCATCAAGCCAAAT
GACGCCAAACAGCCGGGTCGCTTTGATGAGGTGCTCATCCGACACCAAGTGAAGTACCTGGGAC
TTATGGAGAATCTGCGTGTGCGCAGAGCTGGCTTTGCCTACCGTCGAAAATATGAGGCTTTCCT
GCAGAGGTACAAGTCACTGTGCCCAGAGACATGGCCCGTGTGGACAGGACGGCCCCAGGATGGG
GTGGCTGTGTTGGTCAGACACCTTGGCTATAAGCCAGAAGAGTACAAAATGGGCAGGACTAAGA
TCTTCATCCGATTCCCCAAGACCTTGTTTGCCACAGAGGACTCCCTGGAAGTCCGACGGCAGAG
TCTAGCCACCAAGATCCAGGCGGCGTGGAGGGGCTTTCATTGGCGGCAGAAATTTCTCCGGGTG
AAGCGATCAGCCATCTGTATCCAGTCCTGGTGGCGCGGTACACTGGGCCGGAGGAAGGCAGCCA
AAAGGAAGTGGGCAGCCCAGACTATCCGTAGACTCATCCGTGGCTTCATTTTGCGTCATGCACC
CCGGTGCCCTGAGAATGCCTTCTTCCTGGACCACGTGCGCACGTCATTTTTGCTTAACCTGAGG
CGACAACTACCCCGGAATGTTCTGGACACCTCCTGGCCCACACCCCCACCTGCCCTGAGAGAGG
CCTCGGAGCTGCTCCGGGAGCTATGCATGAAGAACATGGTGTGGAAATACTGCCGGAGTATCAG
CCCTGAGTGGAAGCAGCAGCTGCAGCAAAAGGCGGTGGCTAGTGAAATTTTCAAGGGCAAGAAG
GACAATTACCCCCAGAGTGTCCCCAGACTTTTCATCAGCACACGGCTTGGCACAGAGGAGATCA
GCCCCAGAGTGCTTCAGGCCTTGGGCTCTGAACCCATCCAGTATGCAGTGCCTGTGGTAAAATA
CGACCGTAAGGGCTACAAGCCTCGTTCCCGGCAGCTGCTGCTCACACCCAGTGCTGTGGTCATC
GTGGAGGATGCCAAAGTCAAGCAGAGAATTGATTATGCCAACCTAACTGGAATCTCCGTCAGTA
GCCTGAGTGATAGCCTGTTTGTGCTTCACGTGCAGCGTGAAGACAGCAAGCAGAAGGGAGATGT
GGTACTGCAGAGCGATCATGTGATCGAGACACTAACCAAGACGGCCCTCAGTGCTGACCGTGTG
AATAATATCAACATCAACCAGGGCAGCATCACGTTTGCAGGGGGTCCAGGCAGGGATGGCATCA
TCGACTTCACATCTGGCTCAGAGCTTCTCATCACCAAGGCTAAGAATGGCCACCTGGCTGTGGT
GGCCCCACGGCTGAATTCTCGGTGATGAAGGTGCCGGTGGACCCCTCCTGACTCCTGATGCTTT
GCTTAGTCCCCTCCTCCCCTCCCAGTTACCAAAGACTCAAGCTTCCAGACAGGGATCCAGGGAC
ACCCTCAAAGCCCACCTGCAGACTCCTGCCCCCTGCTCATCCTCTCTTGAGGTGATCAGGAACC
AGGGAGCTTCCCCAGGAGTGGGCCAGGCCGGGCCAAGCAATAGAAAAGCAGAGGTCTGAGCAGG
CCAGGCCAGCCCTCTGCTGATGCCAAATATCTAAGAGAAGGGAATTTTAACTGAGGTTTTCTCT
GAGACTTTTTGATGCTTTATAGGAAACTATTTTTTTAAAAAAGTCATTTTCCTATCCTAAACAC
ACTGGATGTGTTTTCCCTGACTCAAACAGGACAAGGAATGTAGCTGAAAGACTGACTGGGCTGG
CTGAGGCCCCCCCTCTCTGCCAAGCCTCTCCTCA

hide sequence

RefSeq Acc Id:

XM_039086809 ⟹ XP_038942737

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	60,997,600 - 61,019,020 (+)	NCBI
mRatBN7.2	10	60,499,330 - 60,520,750 (+)	NCBI

RefSeq Acc Id:

XM_039086811 ⟹ XP_038942739

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	61,003,366 - 61,019,020 (+)	NCBI
mRatBN7.2	10	60,505,094 - 60,520,750 (+)	NCBI

RefSeq Acc Id:

XM_063269827 ⟹ XP_063125897

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	61,000,209 - 61,019,020 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001401097	(Get FASTA)	NCBI Sequence Viewer
	NP_075580	(Get FASTA)	NCBI Sequence Viewer
	XP_038942737	(Get FASTA)	NCBI Sequence Viewer
	XP_038942739	(Get FASTA)	NCBI Sequence Viewer
	XP_063125897	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	CAA52807	(Get FASTA)	NCBI Sequence Viewer
	EDM05235	(Get FASTA)	NCBI Sequence Viewer
	EDM05236	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000028929
	ENSRNOP00000028929.6
	ENSRNOP00000080420.1
	ENSRNOP00000096158
	ENSRNOP00000096158.1
	ENSRNOP00000097261
	ENSRNOP00000097261.1
GenBank Protein	Q63355	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_075580 ⟸ NM_023092
- Peptide Label:	isoform 2
- UniProtKB:	Q63355 (UniProtKB/Swiss-Prot), A0A8I5ZQN4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRYRASALGSDGVRVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPV LVSVNPYRDLQIYTRQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKT EATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGA PVGGHILSYLLEKSRVVHQNHGERNFHVFYQLLEGGEEEALRRLGLERNPQSYLYLVKGQCAKV SSINDKSDWKVVRKALSVIDFTEDEVEDLLSIVASVLHLGNIHFAADEDSNAQVTTENQLKYLT RLLGVEGTTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVRKINRSLAS KDAESPSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIA WEPVQYFNNKIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTIKHHPHFLTHKLADQ KTRKSLDRGEFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSTNPIMAQCFDKSELSDKK RPETVATQFKMSLLQLVEILRSKEPAYIRCIKPNDAKQPGRFDEVLIRHQVKYLGLMENLRVRR AGFAYRRKYEAFLQRYKSLCPETWPVWTGRPQDGVAVLVRHLGYKPEEYKMGRTKIFIRFPKTL FATEDSLEVRRQSLATKIQAAWRGFHWRQKFLRVKRSAICIQSWWRGTLGRRKAAKRKWAAQTI RRLIRGFILRHAPRCPENAFFLDHVRTSFLLNLRRQLPRNVLDTSWPTPPPALREASELLRELC MKNMVWKYCRSISPEWKQQLQQKAVASEIFKGKKDNYPQSVPRLFISTRLGTEEISPRVLQALG SEPIQYAVPVVKYDRKGYKPRSRQLLLTPSAVVIVEDAKVKQRIDYANLTGISVSSLSDSLFVL HVQREDSKQKGDVVLQSDHVIETLTKTALSADRVNNININQGSITFAGGPGRDGIIDFTSGSEL LITKAKNGHLAVVAPRLNSR hide sequence

RefSeq Acc Id:

ENSRNOP00000028929 ⟸ ENSRNOT00000036666

RefSeq Acc Id:	XP_038942737 ⟸ XM_039086809
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I5ZQN4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038942739 ⟸ XM_039086811
- Peptide Label:	isoform X3
- UniProtKB:	A0A8L2QFL2 (UniProtKB/TrEMBL), A0A8I5ZQN4 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000096158 ⟸ ENSRNOT00000117022

RefSeq Acc Id:

ENSRNOP00000080420 ⟸ ENSRNOT00000108756

RefSeq Acc Id:

ENSRNOP00000097261 ⟸ ENSRNOT00000101210

RefSeq Acc Id:	NP_001401097 ⟸ NM_001414168
- Peptide Label:	isoform 1
- UniProtKB:	A0A8I6ASB9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063125897 ⟸ XM_063269827
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6AQB5 (UniProtKB/TrEMBL)

Protein Domains

IQ Myosin motor TH1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q63355-F1-model_v2	AlphaFold	Q63355	1-1044	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13697443

Promoter ID:

EPDNEW_R7967

Type:

initiation region

Name:

Myo1c_1

Description:

myosin 1C

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	63,803,333 - 63,803,393	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620443	AgrOrtholog
BioCyc Gene	G2FUF-24191	BioCyc
Ensembl Genes	ENSRNOG00000004072	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000036666.6	UniProtKB/TrEMBL
	ENSRNOT00000101210	ENTREZGENE
	ENSRNOT00000101210.1	UniProtKB/TrEMBL
	ENSRNOT00000108756.1	UniProtKB/TrEMBL
	ENSRNOT00000117022	ENTREZGENE
	ENSRNOT00000117022.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.820	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	1.20.5.190	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	1.20.58.530	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.850.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	6.20.240.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Myosin VI head, motor domain, U50 subdomain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	IQ_motif_EF-hand-BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kinesin_motor_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Myosin_head_motor_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Myosin_TH1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MYSc_Myo1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:65261	UniProtKB/Swiss-Prot
NCBI Gene	65261	ENTREZGENE
PANTHER	MYOSIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	UNCONVENTIONAL MYOSIN-IC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Myosin_head	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Myosin_TH1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PF00612	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Myo1c	PhenoGen
PRINTS	MYOSINHEAVY	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	MYOSIN_MOTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PS50096	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TH1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000004072	RatGTEx
SMART	MYSc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SM00015	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5ZQN4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AQB5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6ASB9	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2QFL2	ENTREZGENE, UniProtKB/TrEMBL
	A6HGT0_RAT	UniProtKB/TrEMBL
	MYO1C_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-06-15	Myo1c	myosin 1C	Myo1c	myosin IC	Name changed	629549	APPROVED
2013-04-17	Myo1c	myosin IC	LOC686250	similar to unconventional myosin Myr2 I heavy chain	Data merged from RGD:1584314	737654	PROVISIONAL
2013-04-17	Myo1c	myosin IC	LOC100365624	myosin IC-like	Data merged from RGD:2318660	737654	PROVISIONAL
2010-05-05	LOC100365624	myosin IC-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-19	LOC686250	similar to unconventional myosin Myr2 I heavy chain			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-12-02	Myo1c	myosin IC	Myr2	unconventional myosin Myr2 I heavy chain	Symbol and Name updated to reflect Human and Mouse nomenclature	1299863	APPROVED
2002-08-07	Myr2	unconventional myosin Myr2 I heavy chain			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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