Nip7 (nucleolar pre-rRNA processing protein NIP7)

Gene: Nip7 (nucleolar pre-rRNA processing protein NIP7) Rattus norvegicus

Analyze

Symbol:

Nip7

Name:

nucleolar pre-rRNA processing protein NIP7

RGD ID:

620069

Description:

Predicted to enable RNA binding activity. Predicted to be involved in ribosomal large subunit biogenesis. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleolus. Orthologous to human NIP7 (nucleolar pre-rRNA processing protein NIP7); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

60S ribosome subunit biogenesis protein NIP7 homolog; CGI-37; comparative gene identification transcript 37; kDa93; NIP7, nucleolar pre-rRNA processing protein; Nip7p; nuclear import 7 homolog; nuclear import 7 homolog (S. cerevisiae); pEachy; Saccharomyces cerevisiae Nip7p homolog

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NIP7 (nucleolar pre-rRNA processing protein NIP7)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Nip7 (NIP7, nucleolar pre-rRNA processing protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Nip7 (nucleolar pre-rRNA processing protein NIP7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NIP7 (nucleolar pre-rRNA processing protein NIP7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NIP7 (nucleolar pre-rRNA processing protein NIP7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Nip7 (nucleolar pre-rRNA processing protein NIP7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NIP7 (nucleolar pre-rRNA processing protein NIP7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NIP7 (nucleolar pre-rRNA processing protein NIP7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nip7 (nucleolar pre-rRNA processing protein NIP7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	TSSK4 (testis specific serine kinase 4)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	NIP7 (nucleolar pre-rRNA processing protein NIP7)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Nip7 (NIP7, nucleolar pre-rRNA processing protein)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	nip7 (NIP7 nucleolar pre-rRNA processing protein)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C43E11.9	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG7006	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	NIP7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	nip7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	51,872,306 - 51,874,448 (+)	NCBI		GRCr8
mRatBN7.2	19	34,962,557 - 34,964,700 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	34,962,557 - 34,964,711 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	41,778,036 - 41,780,178 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	42,431,383 - 42,433,525 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	44,730,401 - 44,732,528 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	39,257,586 - 39,259,728 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	39,257,586 - 39,259,728 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	50,121,494 - 50,123,636 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	36,915,152 - 36,917,294 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	36,920,032 - 36,922,175 (+)	NCBI
Celera	19	34,386,191 - 34,388,333 (+)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant dyskeratosis congenita 6 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

(2,4,5-trichlorophenoxy)acetic acid (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2-methylcholine (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

aldrin (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

Aroclor 1254 (ISO)

arsenite(3-) (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (ISO)

chloroethene (ISO)

choline (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

dicrotophos (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

ethyl methanesulfonate (ISO)

fipronil (EXP)

flavonoids (EXP)

flutamide (EXP)

folic acid (ISO)

glafenine (EXP)

hydrogen peroxide (ISO)

ivermectin (ISO)

L-methionine (ISO)

methimazole (EXP)

methyl methanesulfonate (ISO)

N-methyl-4-phenylpyridinium (ISO)

nickel atom (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (EXP,ISO)

phorone (EXP)

pregnenolone 16alpha-carbonitrile (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

sulfadimethoxine (EXP)

temozolomide (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

trichostatin A (ISO)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

zinc dichloride (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

ribosomal large subunit biogenesis (IBA)

ribosome assembly (IEA)

Cellular Component

cytosol (ISO)

nucleolus (IBA,ISO)

nucleoplasm (ISO)

preribosome, large subunit precursor (IBA)

Molecular Function

protein binding (ISO)

RNA binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:15489334	PMID:22658674	PMID:22681889

Genomics

Comparative Map Data

Nip7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	51,872,306 - 51,874,448 (+)	NCBI		GRCr8
mRatBN7.2	19	34,962,557 - 34,964,700 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	34,962,557 - 34,964,711 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	41,778,036 - 41,780,178 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	42,431,383 - 42,433,525 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	44,730,401 - 44,732,528 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	39,257,586 - 39,259,728 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	39,257,586 - 39,259,728 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	50,121,494 - 50,123,636 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	36,915,152 - 36,917,294 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	36,920,032 - 36,922,175 (+)	NCBI
Celera	19	34,386,191 - 34,388,333 (+)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

NIP7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	69,339,772 - 69,343,106 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	69,337,996 - 69,343,106 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	69,373,675 - 69,377,009 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	67,931,047 - 67,934,510 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	67,931,091 - 67,934,496	NCBI
Celera	16	53,888,086 - 53,891,549 (+)	NCBI		Celera
Cytogenetic Map	16	q22.1	NCBI
HuRef	16	55,251,189 - 55,254,788 (+)	NCBI		HuRef
CHM1_1	16	70,781,431 - 70,785,030 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	75,141,466 - 75,144,800 (+)	NCBI		T2T-CHM13v2.0

Nip7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	107,783,509 - 107,787,563 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	107,783,509 - 107,787,563 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	107,056,877 - 107,060,931 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	107,056,877 - 107,060,931 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	109,580,777 - 109,584,831 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	109,946,006 - 109,948,374 (+)	NCBI		MGSCv36	mm8
Celera	8	111,283,431 - 111,287,692 (+)	NCBI		Celera
Cytogenetic Map	8	D3	NCBI
cM Map	8	53.57	NCBI

Nip7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955484	7,354,897 - 7,356,939 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955484	7,354,897 - 7,356,939 (-)	NCBI	ChiLan1.0	ChiLan1.0

NIP7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	78,884,002 - 78,887,723 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	84,795,837 - 84,799,199 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	49,714,014 - 49,717,432 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	69,099,907 - 69,103,578 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	69,099,907 - 69,103,578 (+)	Ensembl	panpan1.1		panPan2

NIP7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	80,287,699 - 80,316,350 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	80,313,741 - 80,316,275 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	80,304,051 - 80,306,585 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	80,721,620 - 80,750,261 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	80,747,612 - 80,750,218 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	80,574,801 - 80,577,350 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	80,257,644 - 80,260,180 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	80,897,229 - 80,899,763 (-)	NCBI		UU_Cfam_GSD_1.0

Nip7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	40,123,926 - 40,132,822 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936475	19,456,269 - 19,459,805 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936475	19,456,300 - 19,465,139 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NIP7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	17,635,548 - 17,645,422 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	17,642,092 - 17,645,404 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	16,588,814 - 16,592,128 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NIP7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	58,064,294 - 58,067,645 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	58,064,954 - 58,067,340 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	20,794,368 - 20,797,641 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nip7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624746	17,028,639 - 17,034,391 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624746	17,021,139 - 17,034,443 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Nip7
16 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	49
Count of miRNA genes:	43
Interacting mature miRNAs:	45
Transcripts:	ENSRNOT00000027653
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9590298	Uminl5	Urine mineral level QTL 5	3.59	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	19	1	36824771	Rat
8552935	Pigfal10	Plasma insulin-like growth factor 1 level QTL 10	5.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	19	1	36824771	Rat
9590250	Scort11	Serum corticosterone level QTL 11	23.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	19	1	36824771	Rat
9590090	Insglur8	Insulin/glucose ratio QTL 8	10.81	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	19	1	36824771	Rat
9589102	Slep13	Serum leptin concentration QTL 13	4.63	0.001	blood leptin amount (VT:0005667)	plasma leptin level (CMO:0000781)	19	569374	45569374	Rat
8694186	Bw152	Body weight QTL 152	3.34	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	569374	45569374	Rat
7247442	Uae39	Urinary albumin excretion QTL 39			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	2187927	46708701	Rat
724566	Uae12	Urinary albumin excretion QTL 12	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	2187927	56457239	Rat
61447	Tcas1	Tongue tumor susceptibility QTL 1	6.08		tongue integrity trait (VT:0010553)	squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)	19	2316121	47316121	Rat
2317848	Alcrsp21	Alcohol response QTL 21	1.899999976158142	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	19	3204777	48204777	Rat
1331737	Uae29	Urinary albumin excretion QTL 29	5.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	4096155	55283277	Rat
724518	Uae19	Urinary albumin excretion QTL 19	5.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	7457249	42983518	Rat
724565	Tcas5	Tongue tumor susceptibility QTL 5	10.04		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	19	9977753	39654489	Rat
61423	Cia14	Collagen induced arthritis QTL 14	3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	19	10827970	43544039	Rat
7411549	Bw130	Body weight QTL 130	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	15455860	57337602	Rat
1331788	Rf45	Renal function QTL 45	2.818		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	19	15605023	46559041	Rat
1578764	Stresp19	Stress response QTL 19	3.6	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	19	15630201	57337602	Rat
2298478	Eau8	Experimental allergic uveoretinitis QTL 8		0.0163	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	19	17154433	57337602	Rat
61350	Bp32	Blood pressure QTL 32		0.012	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	19	20483575	57337602	Rat
1549835	Tcas7	Tongue tumor susceptibility QTL 7		0.001	tongue integrity trait (VT:0010553)	squamous cell carcinoma of the head and neck tumor number (CMO:0001876)	19	24817978	39654489	Rat
1354600	Salc2	Saline consumption QTL 2	9.91	0.001	drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	19	27530207	37947399	Rat
1354607	Gmadr1	Adrenal mass QTL 1	5.83		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	19	27530207	37947399	Rat
1354633	Bw28	Body weight QTL 28	6.04		body mass (VT:0001259)	body weight (CMO:0000012)	19	27530207	37947399	Rat
724546	Kidm3	Kidney mass QTL 3	3.1		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	19	29322490	57337602	Rat
1358200	Insglur2	Insulin/glucose ratio QTL 2	4.1		blood glucose amount (VT:0000188)	serum insulin level (CMO:0000358)	19	33838214	55283146	Rat
1358200	Insglur2	Insulin/glucose ratio QTL 2	4.1		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	19	33838214	55283146	Rat

Markers in Region

RH133532

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	34,964,473 - 34,964,654 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	39,259,502 - 39,259,682	NCBI	Rnor6.0
Rnor_5.0	19	50,123,410 - 50,123,590	UniSTS	Rnor5.0
RGSC_v3.4	19	36,917,068 - 36,917,248	UniSTS	RGSC3.4
Celera	19	34,388,107 - 34,388,287	UniSTS
Cytogenetic Map	19	q12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	29	57	41	19	41	2	2	74	35	40	11	2
Low		14					6	9			1		6
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_138847	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC116255	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF158186	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC059114	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC086589	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473972	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HH770977	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000027653 ⟹ ENSRNOP00000027653

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	34,962,586 - 34,964,694 (+)	Ensembl
Rnor_6.0 Ensembl	19	39,257,586 - 39,259,728 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000098147 ⟹ ENSRNOP00000082613

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	34,962,557 - 34,964,711 (+)	Ensembl

RefSeq Acc Id:

NM_138847 ⟹ NP_620202

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	51,872,306 - 51,874,448 (+)	NCBI
mRatBN7.2	19	34,962,557 - 34,964,700 (+)	NCBI
Rnor_6.0	19	39,257,586 - 39,259,728 (+)	NCBI
Rnor_5.0	19	50,121,494 - 50,123,636 (+)	NCBI
RGSC_v3.4	19	36,915,152 - 36,917,294 (+)	RGD
Celera	19	34,386,191 - 34,388,333 (+)	RGD

Sequence:

show sequence

CTTTGGTGTACCCAGGAAGTAGAGATAAAGTGACTTCCACTTCCGGCTCTCCAGGGACGAGGAT
CCGGAGAGCCAAGCTAGTGGGTAAAATGAGGCCTTTGACTGAAGAAGAGACCCGCGTAATGTTT
GAGAAGATTGCGAAATACATTGGAGAGAATCTACAACTCCTGGTGGACAGACCGGACGGCACCT
ACTGTTTCCGGCTGCACAACGACCGAGTGTACTATGTGAGTGAGATGATCCTGAAGCTGGCCGC
CAACATCTCCGGAGATAAGCTAGTGTCCCTGGGTACGTGTTTTGGAAAGTTTACCAAGACCCAC
AAGTTCCGGTTGCACGTTACAGCTCTGGATTTCCTTGCACCCTACGCCAAGTATAAAGTGTGGA
TAAAGCCTGGAGCTGAGCAGTCCTTCTTGTATGGAAACCATGTGTTGAAATCCGGTCTGGGTCG
GATCACTGAAAACACGTCTCAGTACCAGGGAGTAGTGGTTTATTCCATGGCAGACGTTCCTTTG
GGTTTTGGGGTGGCAGCAAAGTCTACCCAAGACTGCAGGAAAGTGGACCCCATGGCAATTGTGG
TGTTCCATCAAGCAGACATTGGGGAGTACATACGCCATGAAGAGACGTTAACTTAAGATGGCCA
TCCCAAGAACATTTTGCTGTGTGAGAAGACTTAGCTTTGTTTCCTGTGTGCCGGCCATCATGTT
TAAATCTGGATAACACTGAGATATGCAGCTTGGATTCTTATCAACAGAAATGGCTCAAAAATAG
GTTTCTGGCCTCTACAACCAAATGCAGGTGGATCACAAGGATAAGGCCACTCAGGCTACTTGGC
AATTCCAGGCTAGCCTGGGCTACCTAGTGAGGCTTGTCTCACAAATTAAAACAGACAAATCAGA
ACCTATGAGCATTTGTGTGAGCAAATTGAGTGTTTCTATTTTATGTCTGCATCATCGTTGATTC
AGAAGCCTTGTTCTGAGTGACGGTTTCTAAGTTACTTCACCGAGGACAGGGATAATCTTACTGT
TATCTGTGATAACTCTTTTCCAGGCTTATAACAGCACAGTGGACTTTCTAATGTTTGTTAATAT
TAAAGTTAGAAACAGCTATATAAGGACAGTAGGCCATGCCTATGGTTTTATATATGGAGTTTAA
TAAATTGTAATGGTTTTATTTTC

hide sequence

Protein Sequences


Protein RefSeqs	NP_620202	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAD42887	(Get FASTA)	NCBI Sequence Viewer
	AAH59114	(Get FASTA)	NCBI Sequence Viewer
	AAH86589	(Get FASTA)	NCBI Sequence Viewer
	CBX86195	(Get FASTA)	NCBI Sequence Viewer
	EDL92467	(Get FASTA)	NCBI Sequence Viewer
	EDL92468	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000027653
	ENSRNOP00000027653.3
	ENSRNOP00000082613.1
	ENSRNOP00055026396
	ENSRNOP00060017578
GenBank Protein	Q9WV50	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_620202 ⟸ NM_138847
- UniProtKB:	Q5RJL7 (UniProtKB/Swiss-Prot), Q9WV50 (UniProtKB/Swiss-Prot), A6IYY9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRPLTEEETRVMFEKIAKYIGENLQLLVDRPDGTYCFRLHNDRVYYVSEMILKLAANISGDKLV SLGTCFGKFTKTHKFRLHVTALDFLAPYAKYKVWIKPGAEQSFLYGNHVLKSGLGRITENTSQY QGVVVYSMADVPLGFGVAAKSTQDCRKVDPMAIVVFHQADIGEYIRHEETLT hide sequence

RefSeq Acc Id:

ENSRNOP00000027653 ⟸ ENSRNOT00000027653

RefSeq Acc Id:

ENSRNOP00000082613 ⟸ ENSRNOT00000098147

Protein Domains

PUA

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9WV50-F1-model_v2	AlphaFold	Q9WV50	1-180	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701120

Promoter ID:

EPDNEW_R11644

Type:

initiation region

Name:

Nip7_1

Description:

NIP7, nucleolar pre-rRNA processing protein

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	19	39,257,638 - 39,257,698	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620069	AgrOrtholog
BioCyc Gene	G2FUF-5765	BioCyc
Ensembl Genes	ENSRNOG00000020391	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055019107	UniProtKB/Swiss-Prot
	ENSRNOG00060013017	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000027653	ENTREZGENE
	ENSRNOT00000027653.7	UniProtKB/Swiss-Prot
	ENSRNOT00000098147.1	UniProtKB/TrEMBL
	ENSRNOT00055032593	UniProtKB/Swiss-Prot
	ENSRNOT00060022175	UniProtKB/Swiss-Prot
Gene3D-CATH	2.30.130.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.10.450.220	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:6921568	IMAGE-MGC_LOAD
	IMAGE:7309991	IMAGE-MGC_LOAD
InterPro	PUA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PUA-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PUA_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ribosomal_synth_fac_NIP7	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	UPF0113_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	UPF0113_PUA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:192180	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:105322	IMAGE-MGC_LOAD
	MGC:72689	IMAGE-MGC_LOAD
NCBI Gene	192180	ENTREZGENE
PANTHER	60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7 HOMOLOG	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	UPF0113	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	UPF0113_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Nip7	PhenoGen
PIRSF	Rbsml_synth_fac_NIP7	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	PUA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000020391	RatGTEx
	ENSRNOG00055019107	RatGTEx
	ENSRNOG00060013017	RatGTEx
SMART	PUA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Pre-PUA domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF88697	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5ZXK1_RAT	UniProtKB/TrEMBL
	A6IYY9	ENTREZGENE, UniProtKB/TrEMBL
	A6IYZ0_RAT	UniProtKB/TrEMBL
	NIP7_RAT	UniProtKB/Swiss-Prot
	Q5RJL7	ENTREZGENE
	Q9WV50	ENTREZGENE
UniProt Secondary	Q5RJL7	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-04-04	Nip7	nucleolar pre-rRNA processing protein NIP7	Nip7	NIP7, nucleolar pre-rRNA processing protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-03-20	Nip7	NIP7, nucleolar pre-rRNA processing protein	Nip7	nuclear import 7 homolog (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Nip7	nuclear import 7 homolog (S. cerevisiae)	pEachy	Saccharomyces cerevisiae Nip7p homolog	Symbol and Name updated	1299863	APPROVED
2002-08-07	pEachy	Saccharomyces cerevisiae Nip7p homolog			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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