TSSK4 (testis specific serine kinase 4) - Rat Genome Database

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Gene: TSSK4 (testis specific serine kinase 4) Homo sapiens
Analyze
Symbol: TSSK4
Name: testis specific serine kinase 4
RGD ID: 1345321
HGNC Page HGNC:19825
Description: Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to be located in acrosomal vesicle and sperm flagellum.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: C14orf20; chromosome 14 open reading frame 20; MGC133264; serine/threonine kinase 22E; serine/threonine-protein kinase 22E; STK22E; testis-specific serine kinase 4; testis-specific serine/threonine-protein kinase 4; TSK-4; TSK4; TSSK5
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,205,696 - 24,208,248 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1424,205,696 - 24,208,362 (+)EnsemblGRCh38hg38GRCh38
GRCh371424,674,902 - 24,677,454 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,744,802 - 23,747,294 (+)NCBINCBI36Build 36hg18NCBI36
Build 341423,744,801 - 23,747,292NCBI
Celera144,539,396 - 4,541,924 (+)NCBICelera
Cytogenetic Map14q12NCBI
HuRef144,789,934 - 4,792,462 (+)NCBIHuRef
CHM1_11424,673,577 - 24,676,105 (+)NCBICHM1_1
T2T-CHM13v2.01418,404,042 - 18,406,594 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14702039   PMID:15489334   PMID:15964553   PMID:18390560   PMID:18452650   PMID:20378615   PMID:21873635   PMID:21988832   PMID:25361759   PMID:25877358   PMID:30683861  
PMID:31753913   PMID:33961781  


Genomics

Comparative Map Data
TSSK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,205,696 - 24,208,248 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1424,205,696 - 24,208,362 (+)EnsemblGRCh38hg38GRCh38
GRCh371424,674,902 - 24,677,454 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,744,802 - 23,747,294 (+)NCBINCBI36Build 36hg18NCBI36
Build 341423,744,801 - 23,747,292NCBI
Celera144,539,396 - 4,541,924 (+)NCBICelera
Cytogenetic Map14q12NCBI
HuRef144,789,934 - 4,792,462 (+)NCBIHuRef
CHM1_11424,673,577 - 24,676,105 (+)NCBICHM1_1
T2T-CHM13v2.01418,404,042 - 18,406,594 (+)NCBIT2T-CHM13v2.0
Tssk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,880,893 - 55,889,996 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,887,641 - 55,889,996 (+)EnsemblGRCm39 Ensembl
GRCm381455,643,651 - 55,652,539 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,650,184 - 55,652,539 (+)EnsemblGRCm38mm10GRCm38
MGSCv371456,269,019 - 56,271,369 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361454,604,253 - 54,606,602 (+)NCBIMGSCv36mm8
Celera1453,455,255 - 53,457,605 (+)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
Tssk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,108,248 - 33,114,083 (+)NCBIGRCr8
mRatBN7.21529,140,803 - 29,144,128 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,141,792 - 29,144,128 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,987,459 - 30,989,820 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,134,680 - 32,137,041 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,377,023 - 30,379,384 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,322,182 - 34,331,187 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,328,851 - 34,331,187 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01538,216,301 - 38,222,217 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,785,676 - 33,788,037 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1528,717,886 - 28,720,247 (+)NCBICelera
Cytogenetic Map15p13NCBI
Tssk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540936,190,182 - 36,191,801 (-)NCBIChiLan1.0ChiLan1.0
TSSK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21525,559,383 - 25,563,656 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,775,409 - 24,780,093 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,980,178 - 4,984,291 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11423,104,197 - 23,108,151 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1423,104,197 - 23,108,037 (+)Ensemblpanpan1.1panPan2
TSSK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,192,060 - 4,195,052 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,192,230 - 4,194,685 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha84,113,823 - 4,116,739 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.084,302,930 - 4,305,815 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,303,024 - 4,305,448 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.183,993,312 - 3,996,226 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.084,055,139 - 4,058,024 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,317,456 - 4,320,341 (+)NCBIUU_Cfam_GSD_1.0
Tssk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864036,035,557 - 36,043,297 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936722346,070 - 348,418 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936722345,698 - 348,531 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TSSK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl775,094,926 - 75,106,331 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1775,094,921 - 75,104,189 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,362,311 - 80,374,993 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TSSK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,181,695 - 1,191,387 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl241,189,063 - 1,191,287 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603612,864,461 - 12,875,672 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tssk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248208,286,307 - 8,289,604 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248208,285,440 - 8,345,918 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TSSK4
9 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q11.2-12(chr14:20151149-27723796)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051484]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051484]|See cases [RCV000051484] Chr14:20151149..27723796 [GRCh38]
Chr14:20619308..28193002 [GRCh37]
Chr14:19689148..27262842 [NCBI36]
Chr14:14q11.2-12		 pathogenic
GRCh38/hg38 14q11.2-21.2(chr14:20196945-45284802)x1 copy number loss See cases [RCV000051485] Chr14:20196945..45284802 [GRCh38]
Chr14:20665104..45754005 [GRCh37]
Chr14:19734944..44823755 [NCBI36]
Chr14:14q11.2-21.2		 pathogenic
GRCh38/hg38 14q11.2-21.1(chr14:23548960-41983402)x1 copy number loss See cases [RCV000051490] Chr14:23548960..41983402 [GRCh38]
Chr14:24018169..42452605 [GRCh37]
Chr14:23088009..41522355 [NCBI36]
Chr14:14q11.2-21.1		 pathogenic
GRCh38/hg38 14q11.2-21.1(chr14:20000611-38984415)x3 copy number gain See cases [RCV000053803] Chr14:20000611..38984415 [GRCh38]
Chr14:20468770..39453619 [GRCh37]
Chr14:19538610..38523370 [NCBI36]
Chr14:14q11.2-21.1		 pathogenic
GRCh38/hg38 14q11.2-21.1(chr14:20150949-39746154)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053806]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053806]|See cases [RCV000053806] Chr14:20150949..39746154 [GRCh38]
Chr14:20619108..40215358 [GRCh37]
Chr14:19688948..39285109 [NCBI36]
Chr14:14q11.2-21.1		 pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q11.2-12(chr14:20412587-25018120)x3 copy number gain See cases [RCV000137725] Chr14:20412587..25018120 [GRCh38]
Chr14:20880746..25487326 [GRCh37]
Chr14:19950586..24557166 [NCBI36]
Chr14:14q11.2-12		 likely pathogenic
GRCh38/hg38 14q11.2-12(chr14:23984065-25374494)x1 copy number loss See cases [RCV000142873] Chr14:23984065..25374494 [GRCh38]
Chr14:24453274..25843700 [GRCh37]
Chr14:23523114..24913540 [NCBI36]
Chr14:14q11.2-12		 pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q11.2-21.2(chr14:20022693-44093672)x3 copy number gain See cases [RCV000143186] Chr14:20022693..44093672 [GRCh38]
Chr14:20490852..44562875 [GRCh37]
Chr14:19560692..43632625 [NCBI36]
Chr14:14q11.2-21.2		 pathogenic
GRCh38/hg38 14q11.2-21.3(chr14:20043513-48642042)x3 copy number gain See cases [RCV000143748] Chr14:20043513..48642042 [GRCh38]
Chr14:20511672..49111245 [GRCh37]
Chr14:19581512..48180995 [NCBI36]
Chr14:14q11.2-21.3		 pathogenic
GRCh37/hg19 14q11.2-12(chr14:19100682-28730087) copy number gain not provided [RCV000767822] Chr14:19100682..28730087 [GRCh37]
Chr14:14q11.2-12		 pathogenic
GRCh37/hg19 14q11.2-12(chr14:19794561-27768254)x3 copy number gain See cases [RCV000240285] Chr14:19794561..27768254 [GRCh37]
Chr14:14q11.2-12		 pathogenic
GRCh37/hg19 14q11.2-22.2(chr14:23164384-54733411)x3 copy number gain See cases [RCV000447658] Chr14:23164384..54733411 [GRCh37]
Chr14:14q11.2-22.2		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19794561-107234280)x3 copy number gain See cases [RCV000446256] Chr14:19794561..107234280 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q11.2-13.1(chr14:19794561-34049214)x3 copy number gain See cases [RCV000448273] Chr14:19794561..34049214 [GRCh37]
Chr14:14q11.2-13.1		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:20511673-107285437) copy number gain See cases [RCV000512041] Chr14:20511673..107285437 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q11.2-12(chr14:24233721-31377083)x1 copy number loss See cases [RCV000510673] Chr14:24233721..31377083 [GRCh37]
Chr14:14q11.2-12		 pathogenic
GRCh37/hg19 14q11.1-32.33(chr14:19000422-107289053)x3 copy number gain not provided [RCV000738412] Chr14:19000422..107289053 [GRCh37]
Chr14:14q11.1-32.33		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19280733-107287663)x3 copy number gain not provided [RCV000738413] Chr14:19280733..107287663 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19327823-107287663)x3 copy number gain not provided [RCV000738414] Chr14:19327823..107287663 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q11.2-21.1(chr14:20511672-42881888)x3 copy number gain not provided [RCV001249358] Chr14:20511672..42881888 [GRCh37]
Chr14:14q11.2-21.1		 not provided
GRCh37/hg19 14q11.2-21.2(chr14:20511672-44829030)x3 copy number gain not provided [RCV001006605] Chr14:20511672..44829030 [GRCh37]
Chr14:14q11.2-21.2		 pathogenic
GRCh37/hg19 14q11.2-12(chr14:24163771-24818728)x3 copy number gain not provided [RCV001259179] Chr14:24163771..24818728 [GRCh37]
Chr14:14q11.2-12		 uncertain significance
GRCh37/hg19 14q11.2-21.3(chr14:20511672-47481203) copy number gain Seizure [RCV002280625] Chr14:20511672..47481203 [GRCh37]
Chr14:14q11.2-21.3		 pathogenic
NC_000014.8:g.(21162263_36986276)_(36987308_50713602)del deletion Brain-lung-thyroid syndrome [RCV002221171] Chr14:36986276..36987308 [GRCh37]
Chr14:14q11.2-21.3		 pathogenic
NC_000014.8:g.(?_23242819)_(25103366_?)dup duplication Lysinuric protein intolerance [RCV003105428]|Specific granule deficiency [RCV003105427] Chr14:23242819..25103366 [GRCh37]
Chr14:14q11.2-12		 uncertain significance
NM_001184739.2(TSSK4):c.56T>G (p.Leu19Arg) single nucleotide variant Inborn genetic diseases [RCV002841300] Chr14:24205979 [GRCh38]
Chr14:24675185 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001184739.2(TSSK4):c.308A>G (p.Glu103Gly) single nucleotide variant Inborn genetic diseases [RCV002950415] Chr14:24206591 [GRCh38]
Chr14:24675797 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001184739.2(TSSK4):c.688T>G (p.Ser230Ala) single nucleotide variant Inborn genetic diseases [RCV002869658] Chr14:24207363 [GRCh38]
Chr14:24676569 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001184739.2(TSSK4):c.439C>T (p.Arg147Cys) single nucleotide variant Inborn genetic diseases [RCV002980964] Chr14:24206722 [GRCh38]
Chr14:24675928 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001184739.2(TSSK4):c.1010C>T (p.Thr337Met) single nucleotide variant Inborn genetic diseases [RCV002703814] Chr14:24208139 [GRCh38]
Chr14:24677345 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001184739.2(TSSK4):c.902C>T (p.Ser301Phe) single nucleotide variant Inborn genetic diseases [RCV002702167] Chr14:24208031 [GRCh38]
Chr14:24677237 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001184739.2(TSSK4):c.250T>A (p.Tyr84Asn) single nucleotide variant Inborn genetic diseases [RCV002762955] Chr14:24206533 [GRCh38]
Chr14:24675739 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001184739.2(TSSK4):c.487A>C (p.Asn163His) single nucleotide variant Inborn genetic diseases [RCV003196932] Chr14:24207162 [GRCh38]
Chr14:24676368 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001184739.2(TSSK4):c.113C>T (p.Ser38Leu) single nucleotide variant Inborn genetic diseases [RCV003179228] Chr14:24206036 [GRCh38]
Chr14:24675242 [GRCh37]
Chr14:14q12		 uncertain significance
GRCh37/hg19 14q11.2-12(chr14:24445622-28262222)x1 copy number loss not provided [RCV003483196] Chr14:24445622..28262222 [GRCh37]
Chr14:14q11.2-12		 likely pathogenic
GRCh37/hg19 14q11.2-23.1(chr14:20511673-61826023)x3 copy number gain not provided [RCV003485022] Chr14:20511673..61826023 [GRCh37]
Chr14:14q11.2-23.1		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1287
Count of miRNA genes:456
Interacting mature miRNAs:495
Transcripts:ENST00000287913, ENST00000339917, ENST00000428351, ENST00000553766, ENST00000554420, ENST00000555092, ENST00000556621
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH98373  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371424,677,157 - 24,677,284UniSTSGRCh37
Build 361423,746,997 - 23,747,124RGDNCBI36
Celera144,541,627 - 4,541,754RGD
Cytogenetic Map14q12UniSTS
HuRef144,792,165 - 4,792,292UniSTS
GeneMap99-GB4 RH Map1419.84UniSTS
SHGC-132422  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371424,674,879 - 24,675,152UniSTSGRCh37
Build 361423,744,719 - 23,744,992RGDNCBI36
Celera144,539,349 - 4,539,622RGD
Cytogenetic Map14q12UniSTS
HuRef144,789,887 - 4,790,160UniSTS
TNG Radiation Hybrid Map142157.0UniSTS
G35868  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371424,673,286 - 24,673,453UniSTSGRCh37
Build 361423,743,126 - 23,743,293RGDNCBI36
Celera144,537,756 - 4,537,923RGD
Cytogenetic Map14q12UniSTS
HuRef144,788,294 - 4,788,461UniSTS
SHGC-31269  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371424,674,863 - 24,675,012UniSTSGRCh37
Build 361423,744,703 - 23,744,852RGDNCBI36
Celera144,539,333 - 4,539,482RGD
Cytogenetic Map14q12UniSTS
HuRef144,789,871 - 4,790,020UniSTS
Stanford-G3 RH Map14446.0UniSTS
GeneMap99-GB4 RH Map1419.84UniSTS
Whitehead-RH Map1421.7UniSTS
NCBI RH Map1443.0UniSTS
GeneMap99-G3 RH Map14446.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 7 1 4 3 86 3 4 2 33 9 376 20 1
Low 2354 2465 1472 402 1529 240 3992 1664 3313 322 1002 1503 170 1190 2469 2
Below cutoff 65 513 222 192 325 196 356 521 360 78 67 67 14 318 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001184739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001308067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_174944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011536663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024449542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024449543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024449544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054332338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054332339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054375885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054375886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF542390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK131042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL136295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY461663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC111088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI825382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HY040551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000287913   ⟹   ENSP00000287913
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1424,205,756 - 24,208,248 (+)Ensembl
RefSeq Acc Id: ENST00000339917   ⟹   ENSP00000339179
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1424,205,696 - 24,208,248 (+)Ensembl
RefSeq Acc Id: ENST00000428351   ⟹   ENSP00000412180
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1424,205,858 - 24,208,248 (+)Ensembl
RefSeq Acc Id: ENST00000553766   ⟹   ENSP00000450752
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1424,207,256 - 24,208,362 (+)Ensembl
RefSeq Acc Id: ENST00000554420
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1424,205,697 - 24,208,248 (+)Ensembl
RefSeq Acc Id: ENST00000555092   ⟹   ENSP00000451121
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1424,205,941 - 24,208,248 (+)Ensembl
RefSeq Acc Id: ENST00000556621   ⟹   ENSP00000452054
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1424,205,728 - 24,208,203 (+)Ensembl
RefSeq Acc Id: NM_001184739   ⟹   NP_001171668
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381424,205,696 - 24,208,248 (+)NCBI
GRCh371424,674,753 - 24,677,568 (+)NCBI
Celera144,539,396 - 4,541,924 (+)RGD
HuRef144,789,934 - 4,792,462 (+)RGD
CHM1_11424,673,577 - 24,676,105 (+)NCBI
T2T-CHM13v2.01418,404,042 - 18,406,594 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001308067   ⟹   NP_001294996
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381424,205,696 - 24,208,248 (+)NCBI
CHM1_11424,673,508 - 24,676,105 (+)NCBI
T2T-CHM13v2.01418,404,042 - 18,406,594 (+)NCBI
Sequence:
RefSeq Acc Id: NM_174944   ⟹   NP_777604
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381424,205,696 - 24,208,248 (+)NCBI
GRCh371424,674,753 - 24,677,568 (+)NCBI
Build 361423,744,802 - 23,747,294 (+)NCBI Archive
Celera144,539,396 - 4,541,924 (+)RGD
HuRef144,789,934 - 4,792,462 (+)RGD
CHM1_11424,673,577 - 24,676,105 (+)NCBI
T2T-CHM13v2.01418,404,042 - 18,406,594 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011536663   ⟹   XP_011534965
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381424,205,696 - 24,208,248 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024449542   ⟹   XP_024305310
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381424,205,696 - 24,208,248 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054375885   ⟹   XP_054231860
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01418,404,042 - 18,406,594 (+)NCBI
RefSeq Acc Id: XM_054375886   ⟹   XP_054231861
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01418,404,042 - 18,406,594 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_777604   ⟸   NM_174944
- Peptide Label: isoform 2
- UniProtKB: Q2TA60 (UniProtKB/Swiss-Prot),   Q6ZNM2 (UniProtKB/Swiss-Prot),   Q6SA08 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001171668   ⟸   NM_001184739
- Peptide Label: isoform 1
- UniProtKB: Q6SA08 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011534965   ⟸   XM_011536663
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001294996   ⟸   NM_001308067
- Peptide Label: isoform 3
- UniProtKB: Q6SA08 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_024305310   ⟸   XM_024449542
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000451121   ⟸   ENST00000555092
RefSeq Acc Id: ENSP00000452054   ⟸   ENST00000556621
RefSeq Acc Id: ENSP00000412180   ⟸   ENST00000428351
RefSeq Acc Id: ENSP00000339179   ⟸   ENST00000339917
RefSeq Acc Id: ENSP00000287913   ⟸   ENST00000287913
RefSeq Acc Id: ENSP00000450752   ⟸   ENST00000553766
RefSeq Acc Id: XP_054231860   ⟸   XM_054375885
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054231861   ⟸   XM_054375886
- Peptide Label: isoform X2
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6SA08-F1-model_v2 AlphaFold Q6SA08 1-328 view protein structure

Promoters
RGD ID:6791984
Promoter ID:HG_KWN:19087
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562,   Lymphoblastoid
Transcripts:OTTHUMT00000073139,   OTTHUMT00000073140,   UC001WNE.1,   UC001WNF.1,   UC001WNH.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361423,743,856 - 23,745,137 (+)MPROMDB
RGD ID:7227265
Promoter ID:EPDNEW_H19378
Type:initiation region
Name:TSSK4_1
Description:testis specific serine kinase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381424,205,696 - 24,205,756EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:19825 AgrOrtholog
COSMIC TSSK4 COSMIC
Ensembl Genes ENSG00000139908 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000285140 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000287913 ENTREZGENE
  ENST00000287913.10 UniProtKB/Swiss-Prot
  ENST00000339917 ENTREZGENE
  ENST00000339917.10 UniProtKB/Swiss-Prot
  ENST00000428351.2 UniProtKB/TrEMBL
  ENST00000553766.1 UniProtKB/TrEMBL
  ENST00000555092.1 UniProtKB/TrEMBL
  ENST00000556621 ENTREZGENE
  ENST00000556621.5 UniProtKB/Swiss-Prot
  ENST00000643387.1 UniProtKB/Swiss-Prot
  ENST00000645264.1 UniProtKB/Swiss-Prot
  ENST00000645272.2 UniProtKB/Swiss-Prot
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000139908 GTEx
  ENSG00000285140 GTEx
HGNC ID HGNC:19825 ENTREZGENE
Human Proteome Map TSSK4 Human Proteome Map
InterPro Aur-like UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  TSSK4_cat UniProtKB/Swiss-Prot
KEGG Report hsa:283629 UniProtKB/Swiss-Prot
NCBI Gene 283629 ENTREZGENE
OMIM 610711 OMIM
PANTHER AURORA KINASE UniProtKB/TrEMBL
  CAMK_CAMKL_KIN4 PROTEIN KINASE PPK1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAP/MICROTUBULE AFFINITY-REGULATING KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE IAL-RELATED UniProtKB/TrEMBL
Pfam PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134908318 PharmGKB
PIRSF Integrin-linked_kinase UniProtKB/Swiss-Prot
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt H0YJ36_HUMAN UniProtKB/TrEMBL
  H0YJB1_HUMAN UniProtKB/TrEMBL
  H7C3J1_HUMAN UniProtKB/TrEMBL
  Q2TA60 ENTREZGENE
  Q6SA08 ENTREZGENE
  Q6ZNM2 ENTREZGENE
  Q8IZN1_HUMAN UniProtKB/TrEMBL
  TSSK4_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary Q2TA60 UniProtKB/Swiss-Prot
  Q6ZNM2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-02 TSSK4  testis specific serine kinase 4    testis-specific serine kinase 4  Symbol and/or name change 5135510 APPROVED