Ccl17 (C-C motif chemokine ligand 17) - Rat Genome Database

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Gene: Ccl17 (C-C motif chemokine ligand 17) Rattus norvegicus
Analyze
Symbol: Ccl17
Name: C-C motif chemokine ligand 17
RGD ID: 619924
Description: Enables CCR4 chemokine receptor binding activity. Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; cell chemotaxis; and chemokine-mediated signaling pathway. Predicted to act upstream of or within negative regulation of myoblast differentiation. Predicted to be active in extracellular space. Biomarker of anti-basement membrane glomerulonephritis; asthma; pneumonia; and pulmonary fibrosis. Orthologous to human CCL17 (C-C motif chemokine ligand 17); PARTICIPATES IN interleukin-4 signaling pathway; chemokine mediated signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; alpha-Zearalanol; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-C motif chemokine 17; CC chemokine TARC; chemokine (C-C motif) ligand 17; Scya17; small inducible cytokine subfamily A (Cys-Cys), member 17; small-inducible cytokine A17; Tarc; thymus and activation-regulated chemokine
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81910,208,120 - 10,218,340 (-)NCBIGRCr8
mRatBN7.21910,202,128 - 10,203,903 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,202,128 - 10,203,819 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1910,166,373 - 10,167,824 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01910,933,217 - 10,934,668 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,220,166 - 10,221,617 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01910,619,220 - 10,620,671 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1910,619,220 - 10,620,671 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01910,614,027 - 10,615,478 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41910,641,376 - 10,642,827 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11910,646,201 - 10,647,653 (-)NCBI
Celera1910,088,700 - 10,090,151 (-)NCBICelera
Cytogenetic Map19p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
alloxanthine  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Bandrowski's base  (ISO)
benomyl  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
Botulinum toxin type A  (ISO)
budesonide  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (EXP,ISO)
cefaloridine  (EXP)
ceric oxide  (EXP,ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt atom  (ISO)
cordycepin  (ISO)
crocidolite asbestos  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diflorasone  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
enzacamene  (ISO)
Fexofenadine hydrochloride  (ISO)
fragrance  (ISO)
furan  (EXP)
graphene oxide  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoprenaline  (ISO)
linuron  (ISO)
manganese(II) chloride  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
naphthalene  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nifuroxazide  (ISO)
ozone  (ISO)
pevonedistat  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
prostaglandin E2  (ISO)
quartz  (EXP)
resveratrol  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
tacrolimus hydrate  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
TMC-120A  (ISO)
toluene 2,4-diisocyanate  (ISO)
tremolite asbestos  (ISO)
trimellitic anhydride  (ISO)
undecane  (EXP)
valproic acid  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Neutrophils in cystic fibrosis display a distinct gene expression pattern. Adib-Conquy M, etal., Mol Med. 2008 Jan-Feb;14(1-2):36-44.
2. ANG II receptor blockade enhances anti-inflammatory macrophages in anti-glomerular basement membrane glomerulonephritis. Aki K, etal., Am J Physiol Renal Physiol. 2010 Apr;298(4):F870-82. Epub 2010 Jan 13.
3. TARC and RANTES, but not CTACK, are induced in two models of allergic contact dermatitis. Effects of cilomilast and diflorasone diacetate on T-cell-attracting chemokines. Baumer W, etal., Br J Dermatol. 2004 Oct;151(4):823-30.
4. [Cloning of rat TARC cDNA and analysis of tissue-specific mRNA expression] Chae JI, etal., Mol Biol (Mosk). 2008 Jul-Aug;42(4):639-44.
5. GGTI-2133, an inhibitor of geranylgeranyltransferase, inhibits infiltration of inflammatory cells into airways in mouse experimental asthma. Chiba Y, etal., Int J Immunopathol Pharmacol. 2009 Oct-Dec;22(4):929-35.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Pulmonary T(H)2 response in Pseudomonas aeruginosa-infected patients with cystic fibrosis. Hartl D, etal., J Allergy Clin Immunol. 2006 Jan;117(1):204-11. Epub 2005 Nov 28.
9. CCL22 and CCL17 in rat radiation pneumonitis and in human idiopathic pulmonary fibrosis. Inoue T, etal., Eur Respir J. 2004 Jul;24(1):49-56.
10. Role of CCR4 ligands, CCL17 and CCL22, during Schistosoma mansoni egg-induced pulmonary granuloma formation in mice. Jakubzick C, etal., Am J Pathol. 2004 Oct;165(4):1211-21.
11. Intervention of thymus and activation-regulated chemokine attenuates the development of allergic airway inflammation and hyperresponsiveness in mice. Kawasaki S, etal., J Immunol. 2001 Feb 1;166(3):2055-62.
12. Pathogenesis of cBFL in common with IPF? Correlation of IP-10/TARC ratio with histological patterns. Kishi M, etal., Thorax. 2008 Sep;63(9):810-6. Epub 2008 Feb 14.
13. Effects of corticosteroid on the expression of thymus and activation-regulated chemokine in a murine model of allergic asthma. Kurokawa M, etal., Int Arch Allergy Immunol. 2005;137 Suppl 1:60-8. Epub 2005 Jun 2.
14. Comparison of serum markers for allergic bronchopulmonary aspergillosis in cystic fibrosis. Latzin P, etal., Eur Respir J. 2008 Jan;31(1):36-42. Epub 2007 Sep 26.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Elevated levels of thymus- and activation-regulated chemokine in bronchoalveolar lavage fluid from patients with eosinophilic pneumonia. Miyazaki E, etal., Am J Respir Crit Care Med. 2002 Apr 15;165(8):1125-31.
17. Respiratory syncytial virus synergizes with Th2 cytokines to induce optimal levels of TARC/CCL17. Monick MM, etal., J Immunol. 2007 Aug 1;179(3):1648-58.
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. Circulating levels of both Th1 and Th2 chemokines are elevated in patients with sarcoidosis. Nureki S, etal., Respir Med. 2008 Feb;102(2):239-47. Epub 2007 Oct 18.
20. Serum thymus and activation regulated chemokine levels post-lung transplantation as a predictor for the bronchiolitis obliterans syndrome. Paantjens AW, etal., Clin Exp Immunol. 2008 Nov;154(2):202-8. Epub 2008 Sep 8.
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
23. GOA pipeline RGD automated data pipeline
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Comprehensive gene review and curation RGD comprehensive gene curation
26. Information Derived from GenBank Report RGD, Sept. 2003
27. Elevated expression of TARC (CCL17) and MDC (CCL22) in models of cigarette smoke-induced pulmonary inflammation. Ritter M, etal., Biochem Biophys Res Commun. 2005 Aug 19;334(1):254-62.
28. Immunoreactivity profile of peripheral blood mononuclear cells from patients with ragweed-induced allergic rhinitis. Sun J, etal., Clin Exp Allergy. 2007 Jun;37(6):901-8.
29. TARC and IL-5 expression correlates with tissue eosinophilia in peripheral T-cell lymphomas. Thielen C, etal., Leuk Res. 2008 Sep;32(9):1431-8. doi: 10.1016/j.leukres.2008.02.016. Epub 2008 Apr 18.
30. Chemokine receptor 4 plays a key role in T cell recruitment into the airways of asthmatic patients. Vijayanand P, etal., J Immunol. 2010 Apr 15;184(8):4568-74. Epub 2010 Mar 17.
31. Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary disease. Ying S, etal., J Immunol. 2008 Aug 15;181(4):2790-8.
32. Macrophage derived chemokine (CCL22), thymus and activation-regulated chemokine (CCL17), and CCR4 in idiopathic pulmonary fibrosis. Yogo Y, etal., Respir Res. 2009 Aug 29;10:80.
Additional References at PubMed
PMID:12949249   PMID:23844157  


Genomics

Comparative Map Data
Ccl17
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81910,208,120 - 10,218,340 (-)NCBIGRCr8
mRatBN7.21910,202,128 - 10,203,903 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,202,128 - 10,203,819 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1910,166,373 - 10,167,824 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01910,933,217 - 10,934,668 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,220,166 - 10,221,617 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01910,619,220 - 10,620,671 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1910,619,220 - 10,620,671 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01910,614,027 - 10,615,478 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41910,641,376 - 10,642,827 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11910,646,201 - 10,647,653 (-)NCBI
Celera1910,088,700 - 10,090,151 (-)NCBICelera
Cytogenetic Map19p13NCBI
CCL17
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381657,396,093 - 57,416,063 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1657,404,767 - 57,416,063 (+)EnsemblGRCh38hg38GRCh38
GRCh371657,438,679 - 57,449,975 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,996,180 - 56,007,475 (+)NCBINCBI36Build 36hg18NCBI36
Build 341655,996,179 - 56,007,475NCBI
Celera1641,938,673 - 41,949,969 (+)NCBICelera
Cytogenetic Map16q21NCBI
HuRef1643,306,559 - 43,317,854 (+)NCBIHuRef
CHM1_11658,846,760 - 58,858,057 (+)NCBICHM1_1
T2T-CHM13v2.01663,191,214 - 63,211,239 (+)NCBIT2T-CHM13v2.0
Ccl17
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39895,535,996 - 95,538,666 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl895,537,081 - 95,538,664 (+)EnsemblGRCm39 Ensembl
GRCm38894,809,380 - 94,812,038 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl894,810,453 - 94,812,036 (+)EnsemblGRCm38mm10GRCm38
MGSCv37897,334,353 - 97,335,936 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36897,699,598 - 97,701,165 (+)NCBIMGSCv36mm8
Celera899,134,583 - 99,136,166 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map846.85NCBI
Ccl17
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543315,053,061 - 15,054,572 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543315,052,616 - 15,054,732 (+)NCBIChiLan1.0ChiLan1.0
CCL17
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21866,880,374 - 66,883,558 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11672,801,377 - 72,804,561 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01637,678,518 - 37,689,350 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11656,810,923 - 56,822,131 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1656,819,949 - 56,822,131 (+)Ensemblpanpan1.1panPan2
CCL17
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,001,463 - 59,014,347 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,001,464 - 59,005,230 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha255,630,918 - 55,633,430 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0259,539,866 - 59,550,154 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl259,539,866 - 59,551,785 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1256,371,394 - 56,373,906 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0257,379,129 - 57,381,635 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0258,272,358 - 58,274,870 (-)NCBIUU_Cfam_GSD_1.0
Ccl17
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934950,112,663 - 50,114,927 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364759,474,961 - 9,476,398 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364759,475,013 - 9,476,326 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCL17
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl619,345,941 - 19,348,926 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1619,345,929 - 19,372,972 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2617,342,591 - 17,345,444 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CCL17
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1543,343,525 - 43,350,096 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl543,346,329 - 43,348,599 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604732,869,286 - 32,872,957 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccl17
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474628,655,801 - 28,657,470 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474628,655,288 - 28,657,563 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ccl17
7 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:117
Count of miRNA genes:93
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000021842
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 6 9 1
Low 1 3 3 10 1 30 15 20 9
Below cutoff 9 16 12 12 3 3 16 8 9 1 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000021842   ⟹   ENSRNOP00000021842
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1910,202,128 - 10,203,819 (-)Ensembl
Rnor_6.0 Ensembl1910,619,220 - 10,620,671 (-)Ensembl
RefSeq Acc Id: NM_057151   ⟹   NP_476492
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81910,208,120 - 10,209,895 (-)NCBI
mRatBN7.21910,202,128 - 10,203,903 (-)NCBI
Rnor_6.01910,619,220 - 10,620,671 (-)NCBI
Rnor_5.01910,614,027 - 10,615,478 (-)NCBI
RGSC_v3.41910,641,376 - 10,642,827 (-)RGD
Celera1910,088,700 - 10,090,151 (-)RGD
Sequence:
RefSeq Acc Id: XM_063277743   ⟹   XP_063133813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81910,208,120 - 10,218,340 (-)NCBI
Protein Sequences
Protein RefSeqs NP_476492 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133813 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG31159 (Get FASTA)   NCBI Sequence Viewer  
  EDL87324 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021842
  ENSRNOP00000021842.2
GenBank Protein Q9ERE0 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_476492   ⟸   NM_057151
- Peptide Label: precursor
- UniProtKB: E9PTY9 (UniProtKB/TrEMBL),   A6JY46 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021842   ⟸   ENSRNOT00000021842
RefSeq Acc Id: XP_063133813   ⟸   XM_063277743
- Peptide Label: isoform X1
- UniProtKB: A6JY46 (UniProtKB/TrEMBL),   E9PTY9 (UniProtKB/TrEMBL)
Protein Domains
Chemokine interleukin-8-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PTY9-F1-model_v2 AlphaFold E9PTY9 1-93 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700941
Promoter ID:EPDNEW_R11465
Type:single initiation site
Name:Ccl17_1
Description:C-C motif chemokine ligand 17
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01910,620,720 - 10,620,780EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619924 AgrOrtholog
BioCyc Gene G2FUF-6514 BioCyc
Ensembl Genes ENSRNOG00000016278 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021842 ENTREZGENE
  ENSRNOT00000021842.3 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_CC_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117518 UniProtKB/Swiss-Prot
NCBI Gene 117518 ENTREZGENE
PANTHER C-C MOTIF CHEMOKINE 17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12015 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam IL8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ccl17 PhenoGen
PRINTS INTERLEUKIN8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SMALL_CYTOKINES_CC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016278 RatGTEx
SMART SCY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Chemokine_IL8 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6JY46 ENTREZGENE, UniProtKB/TrEMBL
  CCL17_RAT UniProtKB/Swiss-Prot
  E9PTY9 ENTREZGENE, UniProtKB/TrEMBL
  Q9ERE0 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-08 Ccl17  C-C motif chemokine ligand 17  Ccl17  chemokine (C-C motif) ligand 17  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Ccl17  chemokine (C-C motif) ligand 17    small inducible cytokine subfamily A (Cys-Cys), member 17  Name updated 1299863 APPROVED
2004-09-10 Ccl17  small inducible cytokine subfamily A (Cys-Cys), member 17  Scya17    Symbol and Name updated 1299863 APPROVED
2002-08-07 Scya17  small inducible cytokine subfamily A (Cys-Cys), member 17      Symbol and Name status set to provisional 70820 PROVISIONAL