RGD Reference Report - Pathogenesis of cBFL in common with IPF? Correlation of IP-10/TARC ratio with histological patterns. - Rat Genome Database

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Pathogenesis of cBFL in common with IPF? Correlation of IP-10/TARC ratio with histological patterns.

Authors: Kishi, M  Miyazaki, Y  Jinta, T  Furusawa, H  Ohtani, Y  Inase, N  Yoshizawa, Y 
Citation: Kishi M, etal., Thorax. 2008 Sep;63(9):810-6. Epub 2008 Feb 14.
RGD ID: 4145606
Pubmed: PMID:18276722   (View Abstract at PubMed)
DOI: DOI:10.1136/thx.2007.086074   (Journal Full-text)

BACKGROUND: A Th1 predominant immune response has been shown in acute hypersensitivity pneumonitis. Predominance of Th2 appears to favour the development of pulmonary fibrosis through the profibrotic process and has been described as crucial in the progression of idiopathic pulmonary fibrosis. Chronic bird fancier's lung (cBFL) can present with a histological pattern of usual interstitial pneumonia (UIP)-like lesions. Little is known about the Th1/Th2 balance in the pathogenesis of cBFL. METHODS: To evaluate the relevance of Th1-type chemokines (interferon-inducible protein, IP-10) and Th2-type chemokines (thymus- and activation-regulated chemokine, TARC) and their receptors (CXCR3 and CCR4) to the histological patterns of cBFL, 40 patients with cBFL who underwent surgical lung biopsies, 12 with acute BFL (aBFL) and 10 healthy volunteers were analysed. IP-10 and TARC levels in serum and bronchoalveolar lavage (BAL) fluid were measured by ELISA. Immunohistochemistry for CXCR3 and CCR4 was performed on surgical lung specimens. RESULTS: The ratio of TARC to IP-10 in the serum of patients with UIP-like lesions was significantly higher than in patients with cNSIP/OP-like lesions, aBFL and healthy volunteers. The ratio of CCR4 to CXCR3 in patients with UIP-like lesions was significantly higher than in those with cNSIP/OP-like lesions and fNSIP-like lesions. The ratio of CCR4-positive to CXCR3-positive cells correlated with the ratio of TARC to IP-10 in serum. CONCLUSIONS: A Th2 predominant immune response may play an important role in the development of UIP-like lesions, as already observed in idiopathic pulmonary fibrosis. A Th1 predominance may play a role in the development of cNSIP/OP-like lesions in cBFL.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
interstitial lung disease  IEP 4145606protein:increased expression:serumRGD 
interstitial lung disease  ISOCCL17 (Homo sapiens)4145606; 4145606protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl17  (C-C motif chemokine ligand 17)

Genes (Mus musculus)
Ccl17  (C-C motif chemokine ligand 17)

Genes (Homo sapiens)
CCL17  (C-C motif chemokine ligand 17)


Additional Information