Smurf1 (SMAD specific E3 ubiquitin protein ligase 1) - Rat Genome Database

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Gene: Smurf1 (SMAD specific E3 ubiquitin protein ligase 1) Rattus norvegicus
Analyze
Symbol: Smurf1
Name: SMAD specific E3 ubiquitin protein ligase 1
RGD ID: 1594738
Description: Predicted to enable SMAD binding activity; signaling receptor binding activity; and ubiquitin protein ligase activity. Involved in positive regulation of axon extension. Located in axon and neuronal cell body. Orthologous to human SMURF1 (SMAD specific E3 ubiquitin protein ligase 1); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: E3 ubiquitin-protein ligase SMURF1; LOC690516; RGD1309707; similar to Smad ubiquitination regulatory factor 1 isoform 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81214,748,717 - 14,840,273 (+)NCBIGRCr8
mRatBN7.2129,635,009 - 9,726,520 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,635,025 - 9,726,519 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1210,438,588 - 10,530,424 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01211,061,801 - 11,153,638 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01210,086,150 - 10,176,124 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01211,433,815 - 11,526,465 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1211,407,213 - 11,526,465 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01213,499,018 - 13,591,105 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4129,950,304 - 10,042,391 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1211,439,779 - 11,530,606 (+)NCBICelera
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The Nedd4-like family of E3 ubiquitin ligases and cancer. Chen C and Matesic LE, Cancer Metastasis Rev. 2007 Dec;26(3-4):587-604.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. p250GAP is a novel player in the Cdh1-APC/Smurf1 pathway of axon growth regulation. Kannan M, etal., PLoS One. 2012;7(11):e50735. doi: 10.1371/journal.pone.0050735. Epub 2012 Nov 30.
4. Up-regulation of Smurf1 after spinal cord injury in adult rats. Li D, etal., J Mol Histol. 2013 Aug;44(4):381-90. doi: 10.1007/s10735-013-9499-2. Epub 2013 Apr 18.
5. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Shi Y and Massague J, Cell. 2003 Jun 13;113(6):685-700.
10. Protein kinase Czeta and glycogen synthase kinase-3beta control neuronal polarity in developing rodent enteric neurons, whereas SMAD specific E3 ubiquitin protein ligase 1 promotes neurite growth but does not influence polarity. Vohra BP, etal., J Neurosci. 2007 Aug 29;27(35):9458-68.
Additional References at PubMed
PMID:10458166   PMID:11278251   PMID:12151385   PMID:15820682   PMID:19056867   PMID:19937093   PMID:21454619   PMID:21572392   PMID:22020285   PMID:23999003   PMID:25901863   PMID:27214554  
PMID:28341855   PMID:28940129   PMID:29016730   PMID:30158054   PMID:31778769   PMID:32871042   PMID:33000773   PMID:35034538   PMID:35126820   PMID:36579844  


Genomics

Comparative Map Data
Smurf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81214,748,717 - 14,840,273 (+)NCBIGRCr8
mRatBN7.2129,635,009 - 9,726,520 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,635,025 - 9,726,519 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1210,438,588 - 10,530,424 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01211,061,801 - 11,153,638 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01210,086,150 - 10,176,124 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01211,433,815 - 11,526,465 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1211,407,213 - 11,526,465 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01213,499,018 - 13,591,105 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4129,950,304 - 10,042,391 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1211,439,779 - 11,530,606 (+)NCBICelera
Cytogenetic Map12p11NCBI
SMURF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38799,027,440 - 99,144,108 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl799,027,440 - 99,144,108 (-)EnsemblGRCh38hg38GRCh38
GRCh37798,625,063 - 98,741,731 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36798,463,000 - 98,579,659 (-)NCBINCBI36Build 36hg18NCBI36
Celera793,353,908 - 93,471,364 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef793,257,804 - 93,374,432 (-)NCBIHuRef
CHM1_1798,555,482 - 98,672,053 (-)NCBICHM1_1
T2T-CHM13v2.07100,260,765 - 100,377,379 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2797,981,091 - 98,097,765 (-)NCBI
Smurf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395144,813,305 - 144,902,657 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5144,813,305 - 144,902,657 (-)EnsemblGRCm39 Ensembl
GRCm385144,876,495 - 144,965,899 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5144,876,495 - 144,965,847 (-)EnsemblGRCm38mm10GRCm38
MGSCv375145,637,364 - 145,726,699 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365145,130,022 - 145,219,357 (-)NCBIMGSCv36mm8
MGSCv365143,961,853 - 144,051,632 (-)NCBIMGSCv36mm8
Celera5141,867,627 - 141,904,898 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map584.83NCBI
Smurf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546014,774,545 - 14,802,879 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546014,774,545 - 14,860,783 (-)NCBIChiLan1.0ChiLan1.0
SMURF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26116,882,049 - 116,998,395 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17165,146,684 - 165,263,030 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0790,995,923 - 91,112,240 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17104,500,965 - 104,568,046 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7104,500,965 - 104,568,046 (-)Ensemblpanpan1.1panPan2
SMURF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1610,385,781 - 10,498,071 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl610,385,779 - 10,494,922 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha612,010,745 - 12,124,123 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0610,384,720 - 10,498,106 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl610,384,957 - 10,497,052 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1610,254,596 - 10,367,952 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0610,233,259 - 10,346,407 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0610,466,893 - 10,580,346 (+)NCBIUU_Cfam_GSD_1.0
Smurf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344138,531,835 - 138,563,396 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367501,381,851 - 1,407,323 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367501,381,864 - 1,406,736 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMURF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl36,037,741 - 6,142,575 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.136,037,732 - 6,142,569 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.236,098,677 - 6,149,341 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SMURF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12814,019,733 - 14,141,588 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2814,019,968 - 14,141,795 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660702,154,820 - 2,276,911 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Smurf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474032,483,092 - 32,615,260 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474032,480,138 - 32,615,436 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Smurf1
697 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:891
Count of miRNA genes:300
Interacting mature miRNAs:403
Transcripts:ENSRNOT00000031901
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12390696910373166Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12683319017870186Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12931821612829686Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat

Markers in Region
RH142403  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,726,080 - 9,726,238 (+)MAPPERmRatBN7.2
Rnor_6.01211,526,027 - 11,526,184NCBIRnor6.0
Rnor_5.01213,590,667 - 13,590,824UniSTSRnor5.0
RGSC_v3.41210,041,953 - 10,042,110UniSTSRGSC3.4
Celera1211,530,168 - 11,530,325UniSTS
RH 3.4 Map12144.41UniSTS
Cytogenetic Map12p11UniSTS
BE096092  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,653,529 - 9,653,679 (+)MAPPERmRatBN7.2
Rnor_6.01211,453,456 - 11,453,605NCBIRnor6.0
Rnor_6.01211,425,771 - 11,425,920NCBIRnor6.0
Rnor_5.01213,518,096 - 13,518,245UniSTSRnor5.0
Rnor_5.01213,490,974 - 13,491,123UniSTSRnor5.0
RGSC_v3.4129,969,383 - 9,969,532UniSTSRGSC3.4
Celera1211,457,969 - 11,458,118UniSTS
RH 3.4 Map12119.7UniSTS
Cytogenetic Map12p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 32 14 6 14 6 72 28 41 11
Low 11 43 35 5 35 8 11 2 7 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000031901   ⟹   ENSRNOP00000031927
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,635,025 - 9,726,519 (+)Ensembl
Rnor_6.0 Ensembl1211,433,813 - 11,523,820 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000082989   ⟹   ENSRNOP00000071653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,635,309 - 9,726,519 (+)Ensembl
Rnor_6.0 Ensembl1211,407,213 - 11,526,465 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084577   ⟹   ENSRNOP00000073635
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,635,309 - 9,726,519 (+)Ensembl
Rnor_6.0 Ensembl1211,433,819 - 11,523,771 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112221   ⟹   ENSRNOP00000076358
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,700,949 - 9,726,519 (+)Ensembl
RefSeq Acc Id: NM_001109598   ⟹   NP_001103068
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81214,749,043 - 14,840,273 (+)NCBI
mRatBN7.2129,635,309 - 9,726,519 (+)NCBI
Rnor_6.01211,433,815 - 11,526,465 (+)NCBI
Rnor_5.01213,499,018 - 13,591,105 (+)NCBI
RGSC_v3.4129,950,304 - 10,042,391 (+)ENTREZGENE
Celera1211,439,779 - 11,530,606 (+)ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006248882   ⟹   XP_006248944
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81214,748,717 - 14,840,273 (+)NCBI
mRatBN7.2129,635,009 - 9,726,520 (+)NCBI
Rnor_6.01211,433,819 - 11,526,465 (+)NCBI
Rnor_5.01213,499,018 - 13,591,105 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769002   ⟹   XP_008767224
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81214,748,751 - 14,840,273 (+)NCBI
mRatBN7.2129,635,009 - 9,726,520 (+)NCBI
Rnor_6.01211,433,819 - 11,526,465 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598462   ⟹   XP_017453951
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81214,748,748 - 14,840,273 (+)NCBI
mRatBN7.2129,635,009 - 9,726,520 (+)NCBI
Rnor_6.01211,433,819 - 11,526,465 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039089789   ⟹   XP_038945717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81214,748,749 - 14,840,273 (+)NCBI
mRatBN7.2129,635,009 - 9,726,520 (+)NCBI
RefSeq Acc Id: XR_010056420
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81214,750,769 - 14,815,647 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001103068   ⟸   NM_001109598
- UniProtKB: D3ZCF5 (UniProtKB/TrEMBL),   A6K1G6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248944   ⟸   XM_006248882
- Peptide Label: isoform X4
- UniProtKB: A0A0G2K612 (UniProtKB/TrEMBL),   D3ZCF5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767224   ⟸   XM_008769002
- Peptide Label: isoform X2
- UniProtKB: D3ZCF5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453951   ⟸   XM_017598462
- Peptide Label: isoform X1
- UniProtKB: D3ZCF5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071653   ⟸   ENSRNOT00000082989
RefSeq Acc Id: ENSRNOP00000073635   ⟸   ENSRNOT00000084577
RefSeq Acc Id: ENSRNOP00000031927   ⟸   ENSRNOT00000031901
RefSeq Acc Id: XP_038945717   ⟸   XM_039089789
- Peptide Label: isoform X3
- UniProtKB: D3ZCF5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000076358   ⟸   ENSRNOT00000112221
Protein Domains
C2   HECT   WW

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K612-F1-model_v2 AlphaFold A0A0G2K612 1-731 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1594738 AgrOrtholog
BioCyc Gene G2FUF-20049 BioCyc
Ensembl Genes ENSRNOG00000000999 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031901.7 UniProtKB/TrEMBL
  ENSRNOT00000082989.2 UniProtKB/TrEMBL
  ENSRNOT00000084577.2 UniProtKB/TrEMBL
  ENSRNOT00000112221.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.70.10 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/TrEMBL
InterPro C2_Ca-dep UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  E3_ub_ligase_SMURF1 UniProtKB/TrEMBL
  HECT UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/TrEMBL
  WW_Rsp5_WWP UniProtKB/TrEMBL
KEGG Report rno:690516 UniProtKB/TrEMBL
NCBI Gene 690516 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE SMURF1 UniProtKB/TrEMBL
  HECT DOMAIN UBIQUITIN-PROTEIN LIGASE UniProtKB/TrEMBL
Pfam HECT UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
  PF00397 UniProtKB/TrEMBL
PhenoGen Smurf1 PhenoGen
PIRSF E3_ub_ligase_SMURF1 UniProtKB/TrEMBL
PROSITE HECT UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000999 RatGTEx
SMART HECTc UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
  SM00456 UniProtKB/TrEMBL
Superfamily-SCOP HECT UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
  WW_Rsp5_WWP UniProtKB/TrEMBL
UniProt A0A0G2K105_RAT UniProtKB/TrEMBL
  A0A0G2K612 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZK23_RAT UniProtKB/TrEMBL
  A6K1G6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZCF5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-23 Smurf1  SMAD specific E3 ubiquitin protein ligase 1  LOC690516  similar to Smad ubiquitination regulatory factor 1 isoform 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-08 LOC690516  similar to Smad ubiquitination regulatory factor 1 isoform 2  RGD1309707  similar to RIKEN cDNA 4930431E10   Data merged from RGD:1309707 1643240 APPROVED
2008-04-30 RGD1309707  similar to RIKEN cDNA 4930431E10   RGD1309707_predicted  similar to RIKEN cDNA 4930431E10 (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-20 LOC690516  similar to Smad ubiquitination regulatory factor 1 isoform 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 RGD1309707_predicted  similar to RIKEN cDNA 4930431E10 (predicted)  LOC288469_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC288469_predicted  similar to RIKEN cDNA 4930431E10 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL