SMURF1 (SMAD specific E3 ubiquitin protein ligase 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: SMURF1 (SMAD specific E3 ubiquitin protein ligase 1) Sus scrofa
Analyze
Symbol: SMURF1
Name: SMAD specific E3 ubiquitin protein ligase 1
RGD ID: 13883498
Description: ENCODES a protein that exhibits activin receptor binding (inferred); I-SMAD binding (inferred); R-SMAD binding (inferred); INVOLVED IN negative regulation of ossification (ortholog); parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization (ortholog); positive regulation of axon extension (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH Cocaine-Related Disorders (ortholog); pleomorphic xanthoastrocytoma (ortholog); Spinal Cord Injuries (ortholog); FOUND IN axon (ortholog); neuronal cell body (ortholog); plasma membrane (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 ubiquitin-protein ligase SMURF1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl36,037,741 - 6,142,575 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.136,037,732 - 6,142,569 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.236,098,677 - 6,149,341 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (ISO)
cytoplasm  (IBA,IEA)
mitochondrion  (IEA)
neuronal cell body  (ISO)
plasma membrane  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SMURF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl36,037,741 - 6,142,575 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.136,037,732 - 6,142,569 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.236,098,677 - 6,149,341 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SMURF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38799,027,440 - 99,144,108 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl799,027,440 - 99,144,108 (-)EnsemblGRCh38hg38GRCh38
GRCh37798,625,063 - 98,741,731 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36798,463,000 - 98,579,659 (-)NCBINCBI36Build 36hg18NCBI36
Celera793,353,908 - 93,471,364 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef793,257,804 - 93,374,432 (-)NCBIHuRef
CHM1_1798,555,482 - 98,672,053 (-)NCBICHM1_1
T2T-CHM13v2.07100,260,765 - 100,377,379 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2797,981,091 - 98,097,765 (-)NCBI
Smurf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395144,813,305 - 144,902,657 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5144,813,305 - 144,902,657 (-)EnsemblGRCm39 Ensembl
GRCm385144,876,495 - 144,965,899 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5144,876,495 - 144,965,847 (-)EnsemblGRCm38mm10GRCm38
MGSCv375145,637,364 - 145,726,699 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365145,130,022 - 145,219,357 (-)NCBIMGSCv36mm8
MGSCv365143,961,853 - 144,051,632 (-)NCBIMGSCv36mm8
Celera5141,867,627 - 141,904,898 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map584.83NCBI
Smurf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81214,748,717 - 14,840,273 (+)NCBIGRCr8
mRatBN7.2129,635,009 - 9,726,520 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,635,025 - 9,726,519 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1210,438,588 - 10,530,424 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01211,061,801 - 11,153,638 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01210,086,150 - 10,176,124 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01211,433,815 - 11,526,465 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1211,407,213 - 11,526,465 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01213,499,018 - 13,591,105 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4129,950,304 - 10,042,391 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1211,439,779 - 11,530,606 (+)NCBICelera
Cytogenetic Map12p11NCBI
Smurf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546014,774,545 - 14,802,879 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546014,774,545 - 14,860,783 (-)NCBIChiLan1.0ChiLan1.0
SMURF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26116,882,049 - 116,998,395 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17165,146,684 - 165,263,030 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0790,995,923 - 91,112,240 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17104,500,965 - 104,568,046 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7104,500,965 - 104,568,046 (-)Ensemblpanpan1.1panPan2
SMURF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1610,385,781 - 10,498,071 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl610,385,779 - 10,494,922 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha612,010,745 - 12,124,123 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0610,384,720 - 10,498,106 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl610,384,957 - 10,497,052 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1610,254,596 - 10,367,952 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0610,233,259 - 10,346,407 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0610,466,893 - 10,580,346 (+)NCBIUU_Cfam_GSD_1.0
Smurf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344138,531,835 - 138,563,396 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367501,381,851 - 1,407,323 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367501,381,864 - 1,406,736 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMURF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12814,019,733 - 14,141,588 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2814,019,968 - 14,141,795 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660702,154,820 - 2,276,911 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Smurf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474032,483,092 - 32,615,260 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474032,480,138 - 32,615,436 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SMURF1
3907 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1
Low 10 4 3 4 2 23 2 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000028241   ⟹   ENSSSCP00000027381
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl36,037,741 - 6,142,575 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000068341   ⟹   ENSSSCP00000064332
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl36,040,301 - 6,142,501 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000088272   ⟹   ENSSSCP00000069876
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl36,037,741 - 6,142,575 (-)Ensembl
RefSeq Acc Id: XM_021086114   ⟹   XP_020941773
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.136,037,732 - 6,141,378 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021086115   ⟹   XP_020941774
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.136,037,732 - 6,141,378 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021086116   ⟹   XP_020941775
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.136,037,732 - 6,142,569 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021086117   ⟹   XP_020941776
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.136,037,732 - 6,142,569 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020941776   ⟸   XM_021086117
- Peptide Label: isoform X4
- UniProtKB: A0A8D2CB16 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020941775   ⟸   XM_021086116
- Peptide Label: isoform X3
- UniProtKB: A0A4X1U770 (UniProtKB/TrEMBL),   A0A5G2QY82 (UniProtKB/TrEMBL),   A0A8D2CB16 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020941774   ⟸   XM_021086115
- Peptide Label: isoform X2
- UniProtKB: A0A8D2CB16 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020941773   ⟸   XM_021086114
- Peptide Label: isoform X1
- UniProtKB: A0A8D2CB16 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000069876   ⟸   ENSSSCT00000088272
RefSeq Acc Id: ENSSSCP00000064332   ⟸   ENSSSCT00000068341
RefSeq Acc Id: ENSSSCP00000027381   ⟸   ENSSSCT00000028241
Protein Domains
C2   HECT   WW


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000030153 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025045994 UniProtKB/TrEMBL
  ENSSSCG00030054418 UniProtKB/TrEMBL
  ENSSSCG00035046977 UniProtKB/TrEMBL
  ENSSSCG00040062061 UniProtKB/TrEMBL
  ENSSSCG00045009004 UniProtKB/TrEMBL
  ENSSSCG00050001017 UniProtKB/TrEMBL
  ENSSSCG00055023493 UniProtKB/TrEMBL
  ENSSSCG00060040688 UniProtKB/TrEMBL
  ENSSSCG00065051744 UniProtKB/TrEMBL
  ENSSSCG00070014633 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000028241.4 UniProtKB/TrEMBL
  ENSSSCT00000088272 ENTREZGENE
  ENSSSCT00000088272.2 UniProtKB/TrEMBL
  ENSSSCT00025062525.1 UniProtKB/TrEMBL
  ENSSSCT00025062756.1 UniProtKB/TrEMBL
  ENSSSCT00025063034.1 UniProtKB/TrEMBL
  ENSSSCT00030075855.1 UniProtKB/TrEMBL
  ENSSSCT00030075867.1 UniProtKB/TrEMBL
  ENSSSCT00030075894.1 UniProtKB/TrEMBL
  ENSSSCT00035062504.1 UniProtKB/TrEMBL
  ENSSSCT00035062511.1 UniProtKB/TrEMBL
  ENSSSCT00035062521.1 UniProtKB/TrEMBL
  ENSSSCT00040085063.1 UniProtKB/TrEMBL
  ENSSSCT00040085245.1 UniProtKB/TrEMBL
  ENSSSCT00040085443.1 UniProtKB/TrEMBL
  ENSSSCT00040085678.1 UniProtKB/TrEMBL
  ENSSSCT00045015275.1 UniProtKB/TrEMBL
  ENSSSCT00045015341.1 UniProtKB/TrEMBL
  ENSSSCT00045015438.1 UniProtKB/TrEMBL
  ENSSSCT00050001179.1 UniProtKB/TrEMBL
  ENSSSCT00050001184.1 UniProtKB/TrEMBL
  ENSSSCT00050001191.1 UniProtKB/TrEMBL
  ENSSSCT00050001220.1 UniProtKB/TrEMBL
  ENSSSCT00055046564.1 UniProtKB/TrEMBL
  ENSSSCT00055046695.1 UniProtKB/TrEMBL
  ENSSSCT00055046864.1 UniProtKB/TrEMBL
  ENSSSCT00060055132.1 UniProtKB/TrEMBL
  ENSSSCT00060055139.1 UniProtKB/TrEMBL
  ENSSSCT00060055168.1 UniProtKB/TrEMBL
  ENSSSCT00060055207.1 UniProtKB/TrEMBL
  ENSSSCT00065070867.1 UniProtKB/TrEMBL
  ENSSSCT00070028749.1 UniProtKB/TrEMBL
  ENSSSCT00070028755.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.70.10 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  E3_ub_ligase_SMURF1 UniProtKB/TrEMBL
  HECT_dom UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/TrEMBL
  WW_dom UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/TrEMBL
NCBI Gene SMURF1 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE SMURF1 UniProtKB/TrEMBL
  HECT DOMAIN UBIQUITIN-PROTEIN LIGASE UniProtKB/TrEMBL
Pfam HECT UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
  PF00397 UniProtKB/TrEMBL
PIRSF E3_ub_ligase_SMURF1 UniProtKB/TrEMBL
PROSITE HECT UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
SMART HECTc UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
  SM00456 UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/TrEMBL
  SSF51045 UniProtKB/TrEMBL
  SSF56204 UniProtKB/TrEMBL
UniProt A0A4X1U553_PIG UniProtKB/TrEMBL
  A0A4X1U770 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QY82 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0XET4_PIG UniProtKB/TrEMBL
  A0A8D1A1H4_PIG UniProtKB/TrEMBL
  A0A8D1GZJ8_PIG UniProtKB/TrEMBL
  A0A8D2CB16 ENTREZGENE, UniProtKB/TrEMBL
  I3LTD6_PIG UniProtKB/TrEMBL
VGNC ID VGNC:93270 ENTREZGENE