Morc1 (MORC family CW-type zinc finger 1) - Rat Genome Database

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Gene: Morc1 (MORC family CW-type zinc finger 1) Rattus norvegicus
Analyze
Symbol: Morc1
Name: MORC family CW-type zinc finger 1
RGD ID: 1565610
Description: Predicted to enable zinc ion binding activity. Predicted to be involved in negative regulation of gene expression. Predicted to act upstream of or within several processes, including behavioral fear response; regulation of gene expression; and retrotransposon silencing by heterochromatin formation. Predicted to be active in male germ cell nucleus. Orthologous to human MORC1 (MORC family CW-type zinc finger 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; atrazine.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: LOC360712; microrchidia 1; Morc; MORC family CW-type zinc finger protein 1; RGD1565610; similar to microrchidia
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81165,641,786 - 65,847,257 (-)NCBIGRCr8
mRatBN7.21152,178,769 - 52,384,255 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1152,178,769 - 52,384,255 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1160,941,928 - 61,147,394 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01153,603,718 - 53,809,200 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01152,716,585 - 52,938,563 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01154,762,654 - 55,044,581 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1154,762,654 - 55,044,581 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01157,921,428 - 58,071,702 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01158,179,362 - 58,208,671 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41153,424,929 - 53,653,313 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1151,776,017 - 51,985,152 (-)NCBICelera
Cytogenetic Map11q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9826705   PMID:10369865   PMID:25503965   PMID:26275923   PMID:34331083  


Genomics

Comparative Map Data
Morc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81165,641,786 - 65,847,257 (-)NCBIGRCr8
mRatBN7.21152,178,769 - 52,384,255 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1152,178,769 - 52,384,255 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1160,941,928 - 61,147,394 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01153,603,718 - 53,809,200 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01152,716,585 - 52,938,563 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01154,762,654 - 55,044,581 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1154,762,654 - 55,044,581 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01157,921,428 - 58,071,702 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01158,179,362 - 58,208,671 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41153,424,929 - 53,653,313 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1151,776,017 - 51,985,152 (-)NCBICelera
Cytogenetic Map11q21NCBI
MORC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383108,958,248 - 109,118,134 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3108,958,248 - 109,118,134 (-)EnsemblGRCh38hg38GRCh38
GRCh373108,677,095 - 108,836,981 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363110,159,776 - 110,319,658 (-)NCBINCBI36Build 36hg18NCBI36
Build 343110,159,780 - 110,319,658NCBI
Celera3107,074,840 - 107,234,730 (-)NCBICelera
Cytogenetic Map3q13.13NCBI
HuRef3106,050,639 - 106,210,559 (-)NCBIHuRef
CHM1_13108,640,979 - 108,801,142 (-)NCBICHM1_1
T2T-CHM13v2.03111,678,481 - 111,838,414 (-)NCBIT2T-CHM13v2.0
Morc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391648,251,600 - 48,451,268 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1648,251,600 - 48,451,263 (+)EnsemblGRCm39 Ensembl
GRCm381648,431,237 - 48,630,905 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1648,431,237 - 48,630,900 (+)EnsemblGRCm38mm10GRCm38
MGSCv371648,431,350 - 48,631,018 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361648,350,863 - 48,550,531 (+)NCBIMGSCv36mm8
Celera1648,791,593 - 48,991,779 (+)NCBICelera
Cytogenetic Map16B5NCBI
cM Map1630.75NCBI
Morc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554279,789,971 - 9,968,613 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554279,790,069 - 9,974,140 (-)NCBIChiLan1.0ChiLan1.0
MORC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22106,943,518 - 107,103,368 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13106,948,297 - 107,108,147 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03106,091,990 - 106,251,790 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13113,021,874 - 113,180,165 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3113,021,874 - 113,180,331 (-)Ensemblpanpan1.1panPan2
MORC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13314,120,370 - 14,302,995 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3314,147,504 - 14,291,024 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3314,225,798 - 14,407,372 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03314,286,395 - 14,470,720 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3314,309,957 - 14,454,632 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13314,155,473 - 14,339,454 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03314,222,690 - 14,406,239 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03314,634,171 - 14,816,395 (-)NCBIUU_Cfam_GSD_1.0
Morc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602140,135,935 - 140,285,971 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366452,560,397 - 2,707,661 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366452,570,071 - 2,725,796 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MORC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13150,268,234 - 150,560,867 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113150,387,942 - 150,561,808 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213159,468,092 - 159,609,868 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MORC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12271,664,183 - 71,828,879 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604194,631,843 - 94,793,589 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Morc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473139,984,649 - 40,191,042 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473140,014,713 - 40,191,395 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Morc1
1046 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:12
Count of miRNA genes:12
Interacting mature miRNAs:12
Transcripts:ENSRNOT00000046330
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat

Markers in Region
RH130734  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23155,928,598 - 155,928,784 (-)MAPPERmRatBN7.2
mRatBN7.23155,928,598 - 155,928,784 (+)MAPPERmRatBN7.2
mRatBN7.21152,245,400 - 52,245,586 (-)MAPPERmRatBN7.2
mRatBN7.21152,245,400 - 52,245,586 (+)MAPPERmRatBN7.2
Rnor_6.01154,830,061 - 54,830,246NCBIRnor6.0
Rnor_6.03163,950,781 - 163,950,966NCBIRnor6.0
Rnor_5.03170,109,352 - 170,109,537UniSTSRnor5.0
Rnor_5.01157,988,636 - 57,988,821UniSTSRnor5.0
RGSC_v3.43158,356,913 - 158,357,098UniSTSRGSC3.4
RGSC_v3.41153,492,284 - 53,492,469UniSTSRGSC3.4
Celera1151,841,764 - 51,841,949UniSTS
Celera3154,508,808 - 154,508,993UniSTS
RH 3.4 Map2755.19UniSTS
Cytogenetic Map11q21UniSTS
Cytogenetic Map3q42UniSTS
AU048273  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21152,328,430 - 52,328,568 (+)MAPPERmRatBN7.2
Rnor_6.01154,912,257 - 54,912,394NCBIRnor6.0
Rnor_5.01158,070,800 - 58,070,937UniSTSRnor5.0
RGSC_v3.41153,575,318 - 53,575,455UniSTSRGSC3.4
Celera1151,924,974 - 51,925,111UniSTS
Cytogenetic Map11q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7 7 3
Low 2 6 4 12 4 6 11 3
Below cutoff 1 17 34 27 27 6 6 27 17 23 8 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000046330   ⟹   ENSRNOP00000046114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1152,178,769 - 52,384,255 (-)Ensembl
Rnor_6.0 Ensembl1154,762,654 - 55,044,581 (-)Ensembl
RefSeq Acc Id: NM_001172090   ⟹   NP_001165561
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,641,786 - 65,847,257 (-)NCBI
mRatBN7.21152,178,769 - 52,384,255 (-)NCBI
Rnor_6.01154,762,654 - 55,044,581 (-)NCBI
Rnor_5.01157,921,428 - 58,071,702 (-)NCBI
Rnor_5.01158,179,362 - 58,208,671 (-)NCBI
Celera1151,776,017 - 51,985,152 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001165561 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM11112 (Get FASTA)   NCBI Sequence Viewer  
  EDM11113 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000046114
  ENSRNOP00000046114.4
Reference Protein Sequences
RefSeq Acc Id: NP_001165561   ⟸   NM_001172090
- UniProtKB: D3ZKF3 (UniProtKB/TrEMBL),   A6IQV9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000046114   ⟸   ENSRNOT00000046330
Protein Domains
CW-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZKF3-F1-model_v2 AlphaFold D3ZKF3 1-957 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565610 AgrOrtholog
BioCyc Gene G2FUF-21419 BioCyc
Ensembl Genes ENSRNOG00000032101 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000046330 ENTREZGENE
  ENSRNOT00000046330.5 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.100 UniProtKB/TrEMBL
  3.30.565.10 UniProtKB/TrEMBL
InterPro HATPase_C_sf UniProtKB/TrEMBL
  Morc_S5 UniProtKB/TrEMBL
  Znf_CW UniProtKB/TrEMBL
KEGG Report rno:360712 UniProtKB/TrEMBL
NCBI Gene 360712 ENTREZGENE
PANTHER MORC FAMILY CW-TYPE ZINC FINGER PROTEIN 1 UniProtKB/TrEMBL
  ZINC FINGER CW-TYPE COILED-COIL DOMAIN PROTEIN 1 UniProtKB/TrEMBL
Pfam HATPase_c_3 UniProtKB/TrEMBL
  Morc6_S5 UniProtKB/TrEMBL
  zf-CW UniProtKB/TrEMBL
PhenoGen Morc1 PhenoGen
PROSITE ZF_CW UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032101 RatGTEx
Superfamily-SCOP ATP_bd_ATPase UniProtKB/TrEMBL
UniProt A6IQV9 ENTREZGENE, UniProtKB/TrEMBL
  D3ZKF3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-25 Morc1  MORC family CW-type zinc finger 1  Morc1  microrchidia 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Morc1  microrchidia 1  RGD1565610_predicted  similar to microrchidia (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1565610_predicted  similar to microrchidia (predicted)  LOC360712  similar to microrchidia  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC360712  similar to microrchidia      Symbol and Name status set to provisional 70820 PROVISIONAL