Frs2 (fibroblast growth factor receptor substrate 2) - Rat Genome Database

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Gene: Frs2 (fibroblast growth factor receptor substrate 2) Rattus norvegicus
Analyze
Symbol: Frs2
Name: fibroblast growth factor receptor substrate 2
RGD ID: 1308201
Description: Predicted to enable fibroblast growth factor receptor binding activity; neurotrophin TRKA receptor binding activity; and transmembrane receptor protein tyrosine kinase adaptor activity. Involved in cellular response to fibroblast growth factor stimulus and positive regulation of vascular associated smooth muscle cell proliferation. Predicted to be located in adherens junction and plasma membrane. Predicted to be active in cell-cell junction and cytoplasm. Orthologous to human FRS2 (fibroblast growth factor receptor substrate 2); PARTICIPATES IN brain-derived neurotrophic factor signaling pathway; fibroblast growth factor signaling pathway; neurotrophic factor signaling pathway; INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC314850
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8754,597,182 - 54,678,656 (-)NCBIGRCr8
mRatBN7.2752,711,255 - 52,792,738 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl752,711,257 - 52,792,743 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx754,617,996 - 54,699,472 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0756,821,102 - 56,902,578 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0756,599,002 - 56,680,483 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0760,128,506 - 60,210,482 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl760,128,508 - 60,210,518 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0760,128,589 - 60,210,278 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4756,409,863 - 56,490,535 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1756,435,173 - 56,446,435 (-)NCBI
Celera749,486,845 - 49,568,253 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MiR-339 inhibits proliferation of pulmonary artery smooth muscle cell by targeting FGF signaling. Chen J, etal., Physiol Rep. 2017 Sep;5(18). pii: 5/18/e13441. doi: 10.14814/phy2.13441.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. TrkB receptor signalling: implications in neurodegenerative, psychiatric and proliferative disorders. Gupta VK, etal., Int J Mol Sci. 2013 May 13;14(5):10122-42. doi: 10.3390/ijms140510122.
5. The impact of FGFR1 and FRS2alpha expression on sorafenib treatment in metastatic renal cell carcinoma. Ho TH, etal., BMC Cancer. 2015 Apr 18;15:304. doi: 10.1186/s12885-015-1302-1.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9182757   PMID:9660748   PMID:10196222   PMID:11585837   PMID:11729184   PMID:15488758   PMID:15569927   PMID:15736129   PMID:15738000   PMID:15870281   PMID:16239343   PMID:16573649  
PMID:17274988   PMID:17868091   PMID:18184727   PMID:19103595   PMID:20175207   PMID:23136392   PMID:23782834   PMID:23939491   PMID:25468996  


Genomics

Comparative Map Data
Frs2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8754,597,182 - 54,678,656 (-)NCBIGRCr8
mRatBN7.2752,711,255 - 52,792,738 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl752,711,257 - 52,792,743 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx754,617,996 - 54,699,472 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0756,821,102 - 56,902,578 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0756,599,002 - 56,680,483 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0760,128,506 - 60,210,482 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl760,128,508 - 60,210,518 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0760,128,589 - 60,210,278 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4756,409,863 - 56,490,535 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1756,435,173 - 56,446,435 (-)NCBI
Celera749,486,845 - 49,568,253 (-)NCBICelera
Cytogenetic Map7q22NCBI
FRS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381269,470,388 - 69,579,793 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1269,470,349 - 69,579,793 (+)EnsemblGRCh38hg38GRCh38
GRCh371269,864,168 - 69,973,573 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361268,150,396 - 68,259,829 (+)NCBINCBI36Build 36hg18NCBI36
Build 341268,150,452 - 68,255,011NCBI
Celera1269,527,782 - 69,637,211 (+)NCBICelera
Cytogenetic Map12q15NCBI
HuRef1266,913,617 - 67,023,032 (+)NCBIHuRef
CHM1_11269,832,586 - 69,941,996 (+)NCBICHM1_1
T2T-CHM13v2.01269,449,328 - 69,558,701 (+)NCBIT2T-CHM13v2.0
Frs2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910116,905,324 - 116,986,311 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10116,905,332 - 116,984,439 (-)EnsemblGRCm39 Ensembl
GRCm3810117,070,127 - 117,148,474 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10117,069,427 - 117,148,534 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710116,507,183 - 116,585,530 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610116,474,237 - 116,552,584 (-)NCBIMGSCv36mm8
Celera10119,013,278 - 119,091,626 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1065.09NCBI
Frs2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554059,843,925 - 9,884,220 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554059,785,857 - 9,884,220 (+)NCBIChiLan1.0ChiLan1.0
FRS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21077,497,563 - 77,613,316 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11277,493,983 - 77,609,107 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01266,992,207 - 67,107,313 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11269,767,526 - 69,878,293 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1269,829,435 - 69,878,293 (+)Ensemblpanpan1.1panPan2
FRS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11011,445,843 - 11,552,325 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1011,539,994 - 11,552,890 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1011,377,588 - 11,487,799 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01011,569,128 - 11,679,363 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1011,569,145 - 11,675,626 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11011,436,282 - 11,546,368 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01011,683,256 - 11,793,428 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01011,806,052 - 11,916,601 (+)NCBIUU_Cfam_GSD_1.0
Frs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494546,703,111 - 46,824,118 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365457,396,023 - 7,407,637 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365457,286,018 - 7,407,623 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FRS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl533,725,444 - 33,849,953 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1533,725,432 - 33,852,952 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2536,346,044 - 36,385,117 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FRS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11165,097,789 - 65,208,373 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1165,197,385 - 65,208,379 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037180,481,351 - 180,595,730 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Frs2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475028,224,289 - 28,359,473 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Frs2
251 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:655
Count of miRNA genes:294
Interacting mature miRNAs:394
Transcripts:ENSRNOT00000007472
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)71965431752888450Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)72940968353612950Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74110969256793354Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat

Markers in Region
AA996518  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2752,711,307 - 52,711,496 (+)MAPPERmRatBN7.2
Rnor_6.0760,128,559 - 60,128,747NCBIRnor6.0
Rnor_5.0760,128,648 - 60,128,836UniSTSRnor5.0
RGSC_v3.4756,409,914 - 56,410,102UniSTSRGSC3.4
Celera749,486,896 - 49,487,084UniSTS
RH 3.4 Map7483.0UniSTS
Cytogenetic Map7q22UniSTS
RH134714  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2752,711,994 - 52,712,179 (+)MAPPERmRatBN7.2
Rnor_6.0760,129,246 - 60,129,430NCBIRnor6.0
Rnor_5.0760,129,335 - 60,129,519UniSTSRnor5.0
RGSC_v3.4756,410,601 - 56,410,785UniSTSRGSC3.4
Celera749,487,583 - 49,487,767UniSTS
RH 3.4 Map7483.0UniSTS
Cytogenetic Map7q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 24 22 6 19 6 74 26 38 11
Low 2 19 35 35 35 8 11 9 3 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007472   ⟹   ENSRNOP00000007472
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl752,711,257 - 52,792,743 (-)Ensembl
Rnor_6.0 Ensembl760,128,508 - 60,210,482 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080983   ⟹   ENSRNOP00000071244
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl760,132,894 - 60,210,518 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108286   ⟹   ENSRNOP00000090102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl752,712,845 - 52,792,695 (-)Ensembl
RefSeq Acc Id: NM_001108097   ⟹   NP_001101567
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,597,182 - 54,678,656 (-)NCBI
mRatBN7.2752,711,255 - 52,792,738 (-)NCBI
Rnor_6.0760,128,508 - 60,210,482 (-)NCBI
Rnor_5.0760,128,589 - 60,210,278 (-)NCBI
RGSC_v3.4756,409,863 - 56,490,535 (-)RGD
Celera749,486,845 - 49,568,253 (-)RGD
Sequence:
RefSeq Acc Id: XM_039079125   ⟹   XP_038935053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,597,182 - 54,678,348 (-)NCBI
mRatBN7.2752,711,255 - 52,792,503 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001101567 (Get FASTA)   NCBI Sequence Viewer  
  XP_038935053 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM16632 (Get FASTA)   NCBI Sequence Viewer  
  EDM16633 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007472
  ENSRNOP00000007472.4
  ENSRNOP00000090102.1
Reference Protein Sequences
RefSeq Acc Id: NP_001101567   ⟸   NM_001108097
- UniProtKB: D4A244 (UniProtKB/TrEMBL),   A6IGR5 (UniProtKB/TrEMBL),   A0A8I6A9E6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071244   ⟸   ENSRNOT00000080983
RefSeq Acc Id: ENSRNOP00000007472   ⟸   ENSRNOT00000007472
RefSeq Acc Id: XP_038935053   ⟸   XM_039079125
- Peptide Label: isoform X1
- UniProtKB: D4A244 (UniProtKB/TrEMBL),   A6IGR5 (UniProtKB/TrEMBL),   A0A8I6A9E6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000090102   ⟸   ENSRNOT00000108286
Protein Domains
IRS-type PTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JZZ5-F1-model_v2 AlphaFold A0A0G2JZZ5 1-517 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695208
Promoter ID:EPDNEW_R5733
Type:initiation region
Name:Frs2_1
Description:fibroblast growth factor receptor substrate 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0760,210,438 - 60,210,498EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308201 AgrOrtholog
BioCyc Gene G2FUF-34015 BioCyc
Ensembl Genes ENSRNOG00000005642 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007472 ENTREZGENE
  ENSRNOT00000007472.7 UniProtKB/TrEMBL
  ENSRNOT00000108286.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
InterPro FRS2_PTB UniProtKB/TrEMBL
  Insln_rcpt_S1 UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
KEGG Report rno:314850 UniProtKB/TrEMBL
NCBI Gene 314850 ENTREZGENE
PANTHER DOCKING PROTEIN RELATED UniProtKB/TrEMBL
  FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2 UniProtKB/TrEMBL
Pfam IRS UniProtKB/TrEMBL
PhenoGen Frs2 PhenoGen
PROSITE IRS_PTB UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005642 RatGTEx
SMART IRS UniProtKB/TrEMBL
  PTBI UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
UniProt A0A8I6A9E6 ENTREZGENE, UniProtKB/TrEMBL
  A6IGR5 ENTREZGENE, UniProtKB/TrEMBL
  D4A244 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Frs2  fibroblast growth factor receptor substrate 2   Frs2_predicted  fibroblast growth factor receptor substrate 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Frs2_predicted  fibroblast growth factor receptor substrate 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED