Prps1l1 (phosphoribosyl pyrophosphate synthetase 1-like 1) - Rat Genome Database

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Gene: Prps1l1 (phosphoribosyl pyrophosphate synthetase 1-like 1) Rattus norvegicus
Analyze
Symbol: Prps1l1
Name: phosphoribosyl pyrophosphate synthetase 1-like 1
RGD ID: 1306328
Description: Predicted to enable ATP binding activity and ribose phosphate diphosphokinase activity. Involved in male gonad development. Predicted to be part of ribose phosphate diphosphokinase complex. Predicted to be active in cytoplasm. Orthologous to human PRPS1L1 (phosphoribosyl pyrophosphate synthetase 1 like 1); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH ammonium chloride; bisphenol A; trichloroethene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC298954; Prps3; ribose-phosphate pyrophosphokinase 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8657,412,331 - 57,414,021 (+)NCBIGRCr8
mRatBN7.2651,684,960 - 51,686,650 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl651,684,948 - 51,687,291 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx651,969,122 - 51,970,812 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0652,284,060 - 52,285,750 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0651,740,499 - 51,742,189 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0654,417,903 - 54,419,593 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl654,417,903 - 54,419,593 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0664,038,717 - 64,040,407 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4653,652,048 - 53,653,738 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1653,655,288 - 53,656,268 (+)NCBI
Celera650,843,329 - 50,845,019 (+)NCBICelera
Cytogenetic Map6q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Pediatric neurological syndromes and inborn errors of purine metabolism. Camici M, etal., Neurochem Int. 2010 Feb;56(3):367-78. Epub 2009 Dec 11.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. A human testis-specific mRNA for phosphoribosylpyrophosphate synthetase that initiates from a non-AUG codon. Taira M, etal., J Biol Chem. 1990 Sep 25;265(27):16491-7.

Genomics

Comparative Map Data
Prps1l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8657,412,331 - 57,414,021 (+)NCBIGRCr8
mRatBN7.2651,684,960 - 51,686,650 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl651,684,948 - 51,687,291 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx651,969,122 - 51,970,812 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0652,284,060 - 52,285,750 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0651,740,499 - 51,742,189 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0654,417,903 - 54,419,593 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl654,417,903 - 54,419,593 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0664,038,717 - 64,040,407 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4653,652,048 - 53,653,738 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1653,655,288 - 53,656,268 (+)NCBI
Celera650,843,329 - 50,845,019 (+)NCBICelera
Cytogenetic Map6q16NCBI
PRPS1L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38718,026,770 - 18,027,846 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl718,026,770 - 18,027,846 (-)EnsemblGRCh38hg38GRCh38
GRCh37718,066,393 - 18,067,469 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36718,032,922 - 18,034,011 (-)NCBINCBI36Build 36hg18NCBI36
Celera718,046,381 - 18,047,465 (-)NCBICelera
Cytogenetic Map7p21.1NCBI
HuRef717,951,884 - 17,952,968 (-)NCBIHuRef
CHM1_1718,067,488 - 18,068,577 (-)NCBICHM1_1
T2T-CHM13v2.0718,156,457 - 18,157,533 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2718,119,717 - 18,120,801 (-)NCBI
Prps1l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391235,034,760 - 35,036,435 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1235,034,760 - 35,036,435 (+)EnsemblGRCm39 Ensembl
GRCm381234,984,761 - 34,986,436 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1234,984,761 - 34,986,436 (+)EnsemblGRCm38mm10GRCm38
MGSCv371235,669,433 - 35,671,108 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361235,569,833 - 35,571,508 (+)NCBIMGSCv36mm8
Celera1236,410,649 - 36,412,324 (+)NCBICelera
Cytogenetic Map12A3NCBI
cM Map1215.64NCBI
Prps1l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541020,987,289 - 20,988,852 (-)NCBIChiLan1.0ChiLan1.0
PRPS1L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2622,859,141 - 22,860,249 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1771,183,865 - 71,184,973 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0718,680,579 - 18,681,655 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1718,006,809 - 18,007,885 (-)NCBIpanpan1.1PanPan1.1panPan2
Prps1l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511876,657,634 - 76,658,744 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365464,332,773 - 4,333,738 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRPS1L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl987,163,252 - 87,164,208 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1987,161,863 - 87,164,314 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2996,258,718 - 96,259,873 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRPS1L1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12140,120,251 - 40,121,975 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2140,120,963 - 40,121,919 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604264,405,873 - 64,407,128 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prps1l1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473912,406,278 - 12,407,234 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473912,406,148 - 12,407,861 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prps1l1
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:458
Count of miRNA genes:218
Interacting mature miRNAs:249
Transcripts:ENSRNOT00000052356
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63207442872227641Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63330954957730294Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63330954981132889Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63443413777102317Rat
1354632Scl29Serum cholesterol level QTL 293.74blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)63509870971636405Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)63569161857730540Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat

Markers in Region
UniSTS:488924  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2651,684,971 - 51,686,605 (+)MAPPERmRatBN7.2
Rnor_6.0654,417,915 - 54,419,548NCBIRnor6.0
Rnor_5.0664,038,729 - 64,040,362UniSTSRnor5.0
RGSC_v3.4653,652,060 - 53,653,693UniSTSRGSC3.4
Celera650,843,341 - 50,844,974UniSTS
Cytogenetic Map6q16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system hemolymphoid system integumental system musculoskeletal system nervous system reproductive system respiratory system appendage
High
Medium 7
Low 1
Below cutoff 1 4 2 3 3 2 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000052356   ⟹   ENSRNOP00000066940
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl651,684,948 - 51,687,291 (+)Ensembl
Rnor_6.0 Ensembl654,417,903 - 54,419,593 (+)Ensembl
RefSeq Acc Id: NM_001105678   ⟹   NP_001099148
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8657,412,331 - 57,414,021 (+)NCBI
mRatBN7.2651,684,960 - 51,686,650 (+)NCBI
Rnor_6.0654,417,903 - 54,419,593 (+)NCBI
Rnor_5.0664,038,717 - 64,040,407 (+)NCBI
RGSC_v3.4653,652,048 - 53,653,738 (+)RGD
Celera650,843,329 - 50,845,019 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099148 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM03299 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066940
  ENSRNOP00000066940.1
  ENSRNOP00000071101.2
Reference Protein Sequences
RefSeq Acc Id: NP_001099148   ⟸   NM_001105678
- UniProtKB: M0RBK1 (UniProtKB/TrEMBL),   A6HB94 (UniProtKB/TrEMBL),   A0A8L2R3X1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000066940   ⟸   ENSRNOT00000052356
Protein Domains
Ribose-phosphate pyrophosphokinase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RBK1-F1-model_v2 AlphaFold M0RBK1 1-318 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694554
Promoter ID:EPDNEW_R5079
Type:single initiation site
Name:Prps1l1_1
Description:phosphoribosyl pyrophosphate synthetase 1-like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0654,417,977 - 54,418,037EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306328 AgrOrtholog
BioCyc Gene G2FUF-37815 BioCyc
BioCyc Pathway PWY0-662 [PRPP biosynthesis] BioCyc
BioCyc Pathway Image PWY0-662 BioCyc
Ensembl Genes ENSRNOG00000032513 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000060262 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000052356 ENTREZGENE
  ENSRNOT00000052356.4 UniProtKB/TrEMBL
  ENSRNOT00000078582.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.2020 UniProtKB/TrEMBL
InterPro PRib_PP_synth_CS UniProtKB/TrEMBL
  Pribosyltran_N UniProtKB/TrEMBL
  PRibTrfase_dom UniProtKB/TrEMBL
  PRTase-like UniProtKB/TrEMBL
  Rib-P_diPkinase UniProtKB/TrEMBL
  Rib-P_diPkinase_bac UniProtKB/TrEMBL
KEGG Report rno:298954 UniProtKB/TrEMBL
NCBI Gene 298954 ENTREZGENE
PANTHER PTHR10210 UniProtKB/TrEMBL
  RIBOSE-PHOSPHATE DIPHOSPHOKINASE UniProtKB/TrEMBL
  RIBOSE-PHOSPHATE DIPHOSPHOKINASE UniProtKB/TrEMBL
Pfam Pribosyl_synth UniProtKB/TrEMBL
  Pribosyltran_N UniProtKB/TrEMBL
PhenoGen Prps1l1 PhenoGen
PROSITE PRPP_SYNTHASE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032513 RatGTEx
  ENSRNOG00000060262 RatGTEx
SMART Pribosyltran_N UniProtKB/TrEMBL
Superfamily-SCOP SSF53271 UniProtKB/TrEMBL
UniProt A0A8L2R3X1 ENTREZGENE, UniProtKB/TrEMBL
  A6HB94 ENTREZGENE, UniProtKB/TrEMBL
  M0RBK1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Prps1l1  phosphoribosyl pyrophosphate synthetase 1-like 1   Prps1l1_predicted  phosphoribosyl pyrophosphate synthetase 1-like 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Prps1l1_predicted  phosphoribosyl pyrophosphate synthetase 1-like 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED