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Gene: Trhde (thyrotropin-releasing hormone degrading enzyme) Rattus norvegicus

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Symbol:

Trhde

Name:

thyrotropin-releasing hormone degrading enzyme

RGD ID:

728895

Description:

Predicted to enable metalloaminopeptidase activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be located in membrane. Predicted to be active in extracellular space. Orthologous to human TRHDE (thyrotropin releasing hormone degrading enzyme); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

PAP-II; pyroglutamyl-peptidase II; thyroliberinase; thyrotropin-releasing hormone degrading ectoenzyme; thyrotropin-releasing hormone-degrading ectoenzyme; TRH-DE; TRH-degrading ectoenzyme; TRH-specific aminopeptidase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TRHDE (thyrotropin releasing hormone degrading enzyme)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Trhde (TRH-degrading enzyme)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Trhde (thyrotropin releasing hormone degrading enzyme)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TRHDE (thyrotropin releasing hormone degrading enzyme)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TRHDE (thyrotropin releasing hormone degrading enzyme)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Trhde (thyrotropin releasing hormone degrading enzyme)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TRHDE (thyrotropin releasing hormone degrading enzyme)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TRHDE (thyrotropin releasing hormone degrading enzyme)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Trhde (thyrotropin releasing hormone degrading enzyme)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Trhde (thyrotropin releasing hormone degrading enzyme)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	NTRK3 (neurotrophic receptor tyrosine kinase 3)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	TRHDE (thyrotropin releasing hormone degrading enzyme)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Trhde (TRH-degrading enzyme)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	trhde.1 (thyrotropin releasing hormone degrading enzyme, tandem duplicate 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG2111	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Drosophila melanogaster (fruit fly):	CG31198	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Drosophila melanogaster (fruit fly):	CG31233	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Drosophila melanogaster (fruit fly):	CG31343	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Drosophila melanogaster (fruit fly):	CG3502	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	Y42A5A.1	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	Y42A5A.1	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	anp-1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG9806	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Drosophila melanogaster (fruit fly):	CG6071	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Drosophila melanogaster (fruit fly):	CG40470	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Danio rerio (zebrafish):	trhde.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	trhde.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG42335	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	TMA108	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	trhde	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	51,829,473 - 52,236,843 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	51,832,111 - 52,236,843 (-)	Ensembl				GRCr8
mRatBN7.2	7	49,943,271 - 50,350,613 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	49,945,766 - 50,367,371 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	51,852,771 - 52,257,524 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	54,055,893 - 54,460,654 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	53,833,748 - 54,238,531 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	57,253,023 - 57,679,795 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	57,253,023 - 57,679,795 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	57,265,684 - 57,693,174 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	53,591,770 - 54,021,219 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	46,740,631 - 47,161,218 (-)	NCBI		Celera
RGSC_v3.1	7	53,612,156 - 54,024,183 (-)	NCBI
Cytogenetic Map	7	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

long QT syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2-palmitoylglycerol (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

atrazine (EXP)

benzo[a]pyrene (EXP,ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP)

carbamazepine (ISO)

chlorpyrifos (ISO)

choline (ISO)

cisplatin (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

dorsomorphin (ISO)

endosulfan (EXP)

ethanol (ISO)

folic acid (ISO)

fonofos (ISO)

furan (EXP)

glycidol (EXP)

L-methionine (ISO)

lead diacetate (EXP)

methapyrilene (ISO)

mono(2-ethylhexyl) phthalate (ISO)

N-Nitrosopyrrolidine (ISO)

O-methyleugenol (ISO)

parathion (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenylmercury acetate (ISO)

phorbol 13-acetate 12-myristate (ISO)

piroxicam (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

terbufos (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

valproic acid (ISO)

vorinostat (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

peptide catabolic process (IBA)

proteolysis (IBA,IEA,TAS)

Cellular Component

extracellular space (IBA)

membrane (IEA)

Molecular Function

aminopeptidase activity (IEA,TAS)

hydrolase activity (IEA)

metal ion binding (IEA)

metalloaminopeptidase activity (IBA)

metallopeptidase activity (IEA)

peptidase activity (IEA)

pyroglutamyl-peptidase activity (IEA)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Purification and characterization of the thyrotropin-releasing hormone (TRH)-degrading serum enzyme and its identification as a product of liver origin.	Schmitmeier S, etal., Eur J Biochem 2002 Feb;269(4):1278-86.

Additional References at PubMed

PMID:7937801	PMID:10785382	PMID:16611635	PMID:19179432	PMID:21329657	PMID:22532627	PMID:22719053	PMID:23376485	PMID:23533145	PMID:25942072

Genomics

Comparative Map Data

Trhde
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	51,829,473 - 52,236,843 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	51,832,111 - 52,236,843 (-)	Ensembl				GRCr8
mRatBN7.2	7	49,943,271 - 50,350,613 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	49,945,766 - 50,367,371 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	51,852,771 - 52,257,524 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	54,055,893 - 54,460,654 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	53,833,748 - 54,238,531 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	57,253,023 - 57,679,795 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	57,253,023 - 57,679,795 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	57,265,684 - 57,693,174 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	53,591,770 - 54,021,219 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	46,740,631 - 47,161,218 (-)	NCBI		Celera
RGSC_v3.1	7	53,612,156 - 54,024,183 (-)	NCBI
Cytogenetic Map	7	q22	NCBI

TRHDE
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	72,087,266 - 72,670,758 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	72,087,266 - 72,670,758 (+)	Ensembl			hg38	GRCh38
GRCh37	12	72,666,150 - 73,064,538 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	70,952,730 - 71,345,689 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	70,952,729 - 71,345,688	NCBI
Celera	12	72,329,850 - 72,723,987 (+)	NCBI		Celera
Cytogenetic Map	12	q21.1	NCBI
HuRef	12	69,714,852 - 70,107,634 (+)	NCBI		HuRef
CHM1_1	12	72,632,089 - 73,024,946 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	72,063,195 - 72,646,521 (+)	NCBI		T2T-CHM13v2.0

Trhde
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	114,234,725 - 114,638,207 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	114,234,726 - 114,638,212 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	10	114,398,820 - 114,802,302 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	114,398,821 - 114,802,307 (-)	Ensembl			mm10	GRCm38
GRCm38.p6 Ensembl	10	114,398,823 - 114,802,307 (-)	Ensembl			mm10	GRCm38
MGSCv37	10	113,835,877 - 114,238,426 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	10	113,803,133 - 114,205,474 (-)	NCBI		MGSCv36	mm8
Celera	10	116,334,960 - 116,737,119 (-)	NCBI		Celera
Cytogenetic Map	10	D2	NCBI
cM Map	10	61.59	NCBI

Trhde
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955405	12,229,448 - 12,623,675 (+)	Ensembl
ChiLan1.0	NW_004955405	12,229,448 - 12,624,753 (+)	NCBI	ChiLan1.0	ChiLan1.0

TRHDE
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	80,300,714 - 80,696,949 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	80,297,114 - 80,693,349 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	69,795,208 - 70,191,298 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	72,652,776 - 73,047,182 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	72,652,958 - 73,073,418 (+)	Ensembl			panPan2	panpan1.1

TRHDE
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	13,744,907 - 14,118,023 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	13,744,591 - 14,115,437 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	13,685,019 - 14,055,891 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	13,883,046 - 14,254,797 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	13,883,046 - 14,249,827 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	13,743,941 - 14,115,272 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	13,995,000 - 14,365,815 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	14,116,319 - 14,488,005 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Trhde
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	44,067,297 - 44,437,562 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936568	1,290,774 - 1,662,542 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936568	1,290,758 - 1,660,520 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TRHDE
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	36,274,165 - 36,658,701 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	5	36,266,883 - 36,663,208 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	39,289,649 - 39,520,695 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TRHDE
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	67,912,122 - 68,313,509 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	67,912,138 - 68,315,962 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	177,295,134 - 177,727,707 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Trhde
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624750	25,007,540 - 25,419,433 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624750	25,000,907 - 25,419,628 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Trhde
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	192,523,290 - 192,927,101 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Trhde
1440 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	508
Count of miRNA genes:	267
Interacting mature miRNAs:	321
Transcripts:	ENSRNOT00000007461
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7411569	Bw137	Body weight QTL 137		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	23807606	68807606	Rat
10053722	Scort27	Serum corticosterone level QTL 27	2.41	0.0083	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	45113903	90113903	Rat
1578652	Bmd15	Bone mineral density QTL 15	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	7	10517086	62346019	Rat
9590102	Sffal5	Serum free fatty acids level QTL 5	8.62	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	7	7216097	52216097	Rat
1549840	Bss5	Bone structure and strength QTL 5	9.8		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	7	26638057	71638057	Rat
1357336	Gluco6	Glucose level QTL 6	3.4		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	7	51700643	96700643	Rat
1300127	Srn1	Serum renin concentration QTL 1	3.87		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	7	24179478	86817926	Rat
10059605	Kidm47	Kidney mass QTL 47	2.91	0.05	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	49137999	67614020	Rat
1358361	Sradr5	Stress Responsive Adrenal Weight QTL 5	5.55		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	7	31770293	110435881	Rat
2298547	Neuinf5	Neuroinflammation QTL 5	3.7		nervous system integrity trait (VT:0010566)	spinal cord Cd74 protein level (CMO:0002131)	7	10112916	60150541	Rat
631513	Scl7	Serum cholesterol level QTL 7	4.1		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	39845902	84845902	Rat
10059592	Kidm45	Kidney mass QTL 45	3.95	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	9460877	54460877	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	46307490	127866166	Rat
10755453	Coatc12	Coat color QTL 12		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	32998702	77998702	Rat
2317059	Aia15	Adjuvant induced arthritis QTL 15	2.46		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	7	49682832	63890004	Rat
7411605	Foco14	Food consumption QTL 14	24.1	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	36178764	81178764	Rat
738030	Anxrr8	Anxiety related response QTL 8	4.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	48475049	93475049	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	10112916	99900612	Rat
1300149	Cm6	Cardiac mass QTL 6	4.09		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	7	1	104117804	Rat
631534	Lnnr1	Liver neoplastic nodule remodeling QTL 1	3.85	0.001	liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)	7	36178764	81178764	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	1509236	116977875	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	40540077	123682549	Rat
2303629	Vencon3	Ventilatory control QTL 3	7.25		respiration trait (VT:0001943)	respiration rate (CMO:0000289)	7	42996226	58678836	Rat
70190	Mcs6	Mammary carcinoma susceptibility QTL 6	2.29		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	7	28624575	65788017	Rat
2316947	Rf58	Renal function QTL 58	7.8		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	7	49682832	115766396	Rat
1300132	Bp182	Blood pressure QTL 182	3.49		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	21541977	86817926	Rat
2316955	Stl24	Serum triglyceride level QTL 24	7.1		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	7	49682832	115766396	Rat
1300138	Hrtrt9	Heart rate QTL 9	4.72		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	7	10498820	55498820	Rat
738033	Anxrr6	Anxiety related response QTL 6	4.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	7	17460447	62460447	Rat
2316952	Pur22	Proteinuria QTL 22	5.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	7	49682832	115766396	Rat
2303582	Gluco53	Glucose level QTL 53	3		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	7	48603087	93603087	Rat
70207	Niddm31	Non-insulin dependent diabetes mellitus QTL 31	3.9		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	7	20057232	65057232	Rat
61439	Cia8	Collagen induced arthritis QTL 8	5.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	7	27182914	72182914	Rat

Markers in Region

D7Got80

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	50,032,914 - 50,033,085 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	57,340,069 - 57,340,239	NCBI	Rnor6.0
Rnor_5.0	7	57,352,464 - 57,352,634	UniSTS	Rnor5.0
RGSC_v3.4	7	53,679,915 - 53,680,086	RGD	RGSC3.4
RGSC_v3.4	7	53,679,916 - 53,680,086	UniSTS	RGSC3.4
Celera	7	46,827,288 - 46,827,458	UniSTS
RGSC_v3.1	7	53,700,549 - 53,700,719	RGD
RH 3.4 Map	7	440.1	UniSTS
RH 3.4 Map	7	440.1	RGD
RH 2.0 Map	7	403.5	RGD
Cytogenetic Map	7	q22	UniSTS

D7Wox33

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	7	51,833,723 - 51,833,851 (+)	Marker Load Pipeline
mRatBN7.2	7	49,947,519 - 49,947,647 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	57,254,777 - 57,254,902	NCBI	Rnor6.0
Rnor_5.0	7	57,267,438 - 57,267,563	UniSTS	Rnor5.0
RGSC_v3.4	7	53,593,524 - 53,593,651	UniSTS	RGSC3.4
Celera	7	46,742,385 - 46,742,510	UniSTS
Cytogenetic Map	7	q22	UniSTS

RH131058

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	50,368,172 - 50,368,392 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	57,680,597 - 57,680,816	NCBI	Rnor6.0
Rnor_5.0	7	57,693,976 - 57,694,195	UniSTS	Rnor5.0
RGSC_v3.4	7	54,022,021 - 54,022,240	UniSTS	RGSC3.4
Celera	7	47,162,017 - 47,162,236	UniSTS
RH 3.4 Map	7	442.8	UniSTS
Cytogenetic Map	7	q22	UniSTS

RH144062

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	50,352,592 - 50,352,699 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	57,665,019 - 57,665,125	NCBI	Rnor6.0
Rnor_5.0	7	57,678,398 - 57,678,504	UniSTS	Rnor5.0
RGSC_v3.4	7	54,006,445 - 54,006,551	UniSTS	RGSC3.4
Celera	7	47,146,450 - 47,146,556	UniSTS
RH 3.4 Map	7	442.21	UniSTS
Cytogenetic Map	7	q22	UniSTS

BI302213

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	50,068,604 - 50,068,813 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	57,375,691 - 57,375,899	NCBI	Rnor6.0
Rnor_5.0	7	57,388,086 - 57,388,294	UniSTS	Rnor5.0
RGSC_v3.4	7	53,715,604 - 53,715,812	UniSTS	RGSC3.4
Celera	7	46,862,952 - 46,863,160	UniSTS
RH 3.4 Map	7	442.6	UniSTS
Cytogenetic Map	7	q22	UniSTS

RH141425

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	49,946,078 - 49,946,258 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	57,253,336 - 57,253,515	NCBI	Rnor6.0
Rnor_5.0	7	57,265,997 - 57,266,176	UniSTS	Rnor5.0
RGSC_v3.4	7	53,592,083 - 53,592,262	UniSTS	RGSC3.4
Celera	7	46,740,944 - 46,741,123	UniSTS
RH 3.4 Map	7	440.8	UniSTS
Cytogenetic Map	7	q22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
9	11	65	149	79	78	47	54	47	6	276	151	11	127	61	90	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108991	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039079684	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039079685	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473960	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000007461 ⟹ ENSRNOP00000007461

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	51,832,111 - 52,236,843 (-)	Ensembl
mRatBN7.2 Ensembl	7	49,945,766 - 50,367,371 (-)	Ensembl
Rnor_6.0 Ensembl	7	57,253,023 - 57,679,795 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000109488 ⟹ ENSRNOP00000079029

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	51,834,559 - 52,236,843 (-)	Ensembl
mRatBN7.2 Ensembl	7	49,948,355 - 50,367,371 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000139848 ⟹ ENSRNOP00000106728

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	51,832,111 - 52,236,843 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000163342 ⟹ ENSRNOP00000111942

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	51,832,111 - 52,236,843 (-)	Ensembl

RefSeq Acc Id:

NM_001108991 ⟹ NP_001102461

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	51,832,111 - 52,236,843 (-)	NCBI
mRatBN7.2	7	49,945,907 - 50,350,613 (-)	NCBI
Rnor_6.0	7	57,253,023 - 57,679,795 (-)	NCBI
Rnor_5.0	7	57,265,684 - 57,693,174 (-)	NCBI
RGSC_v3.4	7	53,591,770 - 54,021,219 (-)	RGD
Celera	7	46,740,631 - 47,161,218 (-)	RGD

Sequence:

show sequence

CAGAGTACGGGAAGACAGTTTACGTTTTGAATACGTTCTCATGGTAGGGTAGATGGTGCTCCCG
AAAATGGACGCCCGGGCCGGACACTTCTTCACTTGTCTTCTCTGGAGGGCAGAGCAATATCGGA
ACGCGGAAGGCTTGCTGCCCAGTCCGCAACCTCACGCCTTTTACCGCCACCACTGCTTAAAGTG
TCCAGTGTGGAGAAGGCTTCTTCAGGACCGATGCTCCGCGGCCGTGGGACTTCCTCCGGCTAGC
TTACTCCCGTCCTTTCCTTGGTCCTCTGCTCCATCCTCTGCTCTCCCACAGCGAGGTGGAAGGC
ACCAGCGCCTTCCGGGCTGCCGCCGCCGCCGCAACTGTTTTTGCGACCACATCCCACCCAGAAG
ACCGAAAGCTGCTGGAGTGCGGGGAGCTGGGTGAAGCCCTAACTTGCCCCCCTGTTCAGTCGCT
CTCCCCAGCGCTCTCTGTCCTCCTGGCCGAGCCGCTGAGAGAGCTGCCGCCGCTAGCCTGGAAG
AGTGCGGCGCCCGGGAGGACACGCGAGCCGCAGGCGCACAGGGGCGGGGGCGGCGTGTGCCCGG
GCGCCCGGTGCTAGCCCGACGAGTAGCGCGCACCCGGCGAGCGACACGCTCCCCAAGTTGGGCG
CGTCCCAGAGCTGGTTGCCCCGCTATCCGCAGCTGGTGTCTGGAGAGAGGCGGGGCTGATGGGG
GTCGTCTCGGTCGTCACTAGCCTCCAGAGTCTGTCTTAAGAGAATCTGAGCTGGCCTTCCTAAG
GTCCCAGCCGGCGTCGCGCCCTCCGCCCGCGTGCGGTCTCTGATGACTGCGCTGGAGGTGGCCC
GGGTGGCCCGCCCGCTAGGGGTGTCGGAGGGGGCGGGGGAAGAGGAGGAGGCGGTGTGATGGCC
CTGGACGGCGAGAGGGGGGAGCAAGAGGAGGAGAAGAAAAAGAAGAAGAAGAAAAAGAAGAGGA
AGAAGAAGGAGGAGGAGGGGGCCGAGAAGAGCAGTTCACCGTTTGCGGCCACCATGGGAGAAGA
CGACGCCGCGCTCCGGGCAAGCGGCAGGGGGCTCTCGGACCCGTGGGCTGACTCGGTGGGAGTG
AGACCCCGCACCACGGAGCGCCACATCGCAGTGCACAAGAGGCTTGTGCTGGCTTTTGCCGTGT
CCATCGTGGCACTGCTGGCTGTCACCATGCTGGCCGTACTGCTCAGCCTGCGGTTCGACGAGTG
TGGAGCGAGCGCGGCGATGCCGGGCACCGACGGTGGCCTCGGAGGCTTCCCTGAGCGTGGTGGC
AACAGCAGCTACCCAGGATCTGCCCGGCGCAACCACCACGCGGGTGAGGAATCCTCGCAGCGTG
AGATCGGCGAGGTGGGCACCGCGGGGACCCCGTCTGCCCATCCGCCGTCGGAGGAAGAGCAGGA
GCAGTGGCAGCCCTGGACTCAGCTGCGCCTATCCGGCCACCTTAAGCCGCTGCACTACAATTTG
ATGCTCACCGCCTTCATGGAGAACTTCACCTTCTCTGGGGAGGTCAACGTGGAGATCGCGTGCC
AGAACGCCACCCGCTACGTGGTACTGCACGCCTCCCGGGTGGCGGTGGAGAAGGTGCAAGTAGC
GGAAGACCGGGCGTTCGGGGCTGTCCCGGTAGCAGGCTTTTTCCTCTACCCACAAACGCAGGTC
TTGGTGGTGGTGCTGAATAGAACCCTGGATGCGCAGAGGCACTACAATCTGAAGATTATCTACA
ATGCCCTGATAGAGAACGAGCTTTTGGGCTTCTTCCGCAGCTCCTACGTGATCCACGGGGAGAG
AAGATTCCTCGGTGTTACTCAGTTTTCACCTACACATGCCAGGAAGGCATTTCCATGTTTTGAT
GAACCAATCTACAAGGCCACTTTCAAAATCAGCATCAAACATCAAGCAACCTATTTGTCTCTCT
CCAACATGCCCGTGGAAACATCTGTGTTTGAGGAAGATGGATGGGTAACAGATCACTTTTCACA
GACCCCTCTCATGTCCACATATTATTTAGCCTGGGCGATTTGCAACTTCACATACAGAGAAACT
ACTACCAAGAGTGGGGTTGTAGTTCGATTATATGCAAGACCCGACGCTATCAGAAGAGGATCCG
GGGACTATGCTCTCCACATTACAAAGAGATTAATAGAATTTTATGAAGACTACTTTAAAGTGCC
CTATTCTTTGCCAAAACTAGATCTTTTAGCTGTGCCTAAGCATCCTTATGCTGCTATGGAGAAC
TGGGGACTAAGTATTTTTGTGGAACAAAGAATACTGCTGGATCCCAGTGTGTCATCTATTTCTT
ATTTGCTGGATGTCACCATGGTCATTGTTCATGAAATATGTCACCAGTGGTTTGGTGACCTTGT
GACCCCAGTGTGGTGGGAAGATGTGTGGTTGAAGGAAGGCTTTGCTCACTACTTTGAATTTGTG
GGTACAGACTACCTCTACCCTTCCTGGAACATGGAAAAGCAGAGGTTTCTGACAGATGTTCTGC
ATGAAGTGATGCTGCTTGACGGGTTGGCCAGTTCCCATCCAGTATCACAGGAAGTGCTACGGGC
AACAGATATTGACAAAGTGTTTGACTGGATCGCATACAAAAAGGGTGCTGCTTTAATAAGAATG
CTGGCTAATTTTATGGGCCATTCAGTTTTTCAGAGGGGATTGCAAGATTATTTAACCATTCACA
AGTATGGCAATGCAGCCAGAAATGATCTCTGGAATACATTATCAGAGGCTTTAAAAAGGAATGG
AAAATATGTGAACATACAAGAGGTAATGGATCAGTGGACACTCCAGATGGGATATCCTGTTATC
ACCATCCTGGGGAACATGACGGCAGAAAACAGAATACTCATCACCCAACAGCACTTCATTTACG
ATATCGGTGCTAAAACCAAAGCACTTCAACTTCAAAACAGCAGTTACCTGTGGCAGATTCCATT
AACCATCGTCGTAGGAAATAGAAGCCATGTGTCTTCAGAAGCAATTATTTGGGTGTCCAACAAA
TCAGAACATCACAGAATAACATACTTAGACAAAGGAAGCTGGATCCTTGGAAACATCAATCAAA
CTGGCTACTTCAGAGTCAACTATGACCTAAGGAACTGGAGATTACTGATCGATCAGTTAATCAG
GAACCATGAGGTACTTTCTGTCAGTAACCGTGCAGGCCTGATTGATGATGCCTTCAGCCTGGCC
AGGGCAGGCTATTTGCCTCAGAATATTCCCCTAGAGATCATCAGATACCTCTCTGAGGAAAAGG
ATTTTCTTCCTTGGCATGCTGCCAGCCGAGCTCTTTATCCTCTGGATAAATTACTGGACCGCAT
GGAAAACTACAATATCTTCAATGAATATATTCTAAAACAAGTGGCAACAACCTACAGCAAGCTT
GGATGGCCAAAGAACAACTTCAATGGCTCTGTCGTTCAAGCTTCCTATCAACATGAAGAGCTAC
GGAGGGAAGTGATAATGTTGGCCTGTAGCTTTGGGAACAAGCACTGTCACCAGCAGGCGTCAAC
TCTTATTTCAGACTGGATTTCCAGCAATAGAAACAGAATACCACTGAATGTTAGAGACATCGTC
TACTGCACAGGAGTGTCCCTGCTGGATGAGGATGTCTGGGAATTCATCTGGATGAAATTCCACT
CCACCACTGCAGTTTCTGAGAAAAAGATATTGCTGGAGGCGCTAACTTGCAGTGATGACAGGAA
TTTACTAAGTAGGCTTCTGAATCTGTCTCTGAATTCTGAGGTGGTGTTGGATCAAGATGCAATT
GATGTAATAATCCACGTAGCCAGAAATCCACATGGCCGAGACCTTGCCTGGAAGTTTTTCAGAG
ATAAATGGAAAATACTAAATACCAGGTATGGAGAAGCATTATTTATGAATTCCAAACTTATCAG
TGGAGTTACAGAATTTCTTAATACAGAAGGTGAACTTAAAGAGCTAAAGAACTTCATGAAGTCC
TATGATGGGGTAGCATCTGCTTCTTTCTCACGAGCCGTGGAAACCGTGGAAGCCAATGTGCGCT
GGAAAAGGCTTTATCAAGATGAGCTTTTCCAGTGGCTGGGAAAAGCCATGAGGCACTAATATCC
ATCAAATAGAGAATTCACCCCAGAACTGTGTAGGAGGACCTGCTTTTTGTGGGATGAGGAGGCT
AGCCAGAATGTCAGTGTTAACACGAGGGAGGATTTTTTCTTTCTTTTCTTTCTTTGTTGGGGGC
TATTTTTCTTGTTTCATCAACTCTACATTTGTGTTTCCACTGGATATTCCTCTGTAAAGAAACT
CTTGAAAGTGACACTTGCCCTGGTTACTTCAGCTGTACATTCCCCACTGTTCGGGACCAAGTAT
GATAGTGGTGCATGTTGATCTTGTTGTCAGTTTGGGAAATCCTATTCAGAATATTCTGTGCATG
GATATATGGTCCTGCCCGTGTTCCGGCATGCTTATTTAACATGTCCAATGTTGTATGTGAACAT
TTTATATGTACATCCAGAATGGGCATTATGCGAAAGCACAAAGATTACCTATGACAATCAGTGT
TGCAATGACAGTTAAAAAGAAAAAACGTTAGAAGGGAATTCTCTTCTTTGCCATGGACAACAGG
AGAGGTACAAGAGCTCTTATGCAATCTGTATCGATTGTTTCAGCACTCGGATTGTCTGGCAATG
ATTACTGTGTTGCTAACTCATTTTCTTTGAGTTAAAGCTGTGTATACACTTGCAAAGATGTATA
GATAGTGTGTACATATACATTATGTACATAGGGAAGCCCTATATGTATATAGTATGTTGTACAT
GCACCTGTTCAAAGAATCTCTTCAGATCAAAGGAAATTTAACTTTTTGGTTCTTTTTTAAATAT
ATATATATATATATATATATATATATATATATAAATGTGTGGACACACTGAAAAGGCTTCAAGA
AGTTGATCTCAACATTCCTACTTTGTATCTTGCTCTCTTAAGTGCTGTTCTTCTTGTCTATGTC
CTGAAGAATGATCTGTTCTATCACACGAAGCTGAATTCTAACAAAATATACATGTAAACTAACC
ACACTGCAAATCCTCTTAGGTCAGTGGCAATATTTTGTTGTTTTCTGTAATTATGTTGGTCAAC
ATTTTCTACTGCATAAAGCGATTTTGGGTAAACTTAGAATGATCGCTGCTAAGAAAATGTTTAT
GTACAGCTTCTCTGTCTTTCTAAGTTTCGCTACTGCAGAGTTAAACTCTCTCTGTGTGTTGATC
TTTGTGTGTACTCCTGTCCTCCATTAAGCGACCATACCTCAACAGGTCTATTAGTACTTAATGA
CCTTCTATGCCAGTTGTGCCCTCCCTTAAGACACAAAGTTGCTTTTATGCTATGTTACTGTACA
AAGCCTTTGGAAATTTGCACCCCCGTTCTACCTAGGAATTTTGAAGAGTCAGTTCTATGGCTGT
GTGTAACACAACTAGATTTCACTGCTTCTCTCACCCAATAGGCCTGCTCCCTGCTTCAGAATCA
ACATATCTTAAGTTTAACATTGTAAAATTCCTATATAATTATTATATTGAGTCAACTATTGTGT
AACCCCTTTTTGGTTTTCCTGTGATGTTCAGCTTTTCCAAATGTTGCAGTTCAGAGACTGTCAT
TCAATGCTGGAAAAAAATTCTTTATAAAATAGAGGTCATAGAATTATTTTTGTTTGTAGAAATG
AAAAGCAATTTCCCAATCCATAGACTACATAAAAACAAAATTTGATCCTGATCATGTAAGCAGT
TAATGTTCATTTCTTACAGCTATAATTTTCAATACTTCCGTCAATTAAAATACATGAATTTTAA
GTACTGTGTGGTACTAAAGAGTCATGGTCATGCCTAATGTGAAACCTGAGATTTAAGTCACTTA
CTGAAAGTGAGCAAGTTTTAAAAATATAATCTTCAAAACTAGTATACAGCCAGGAAGACCCTAA
ATATCTATGATAGCATTGGTGAATTCATTCATAGACTGAAACTGCCTAAAGGGGCAGACATAGG
TGTCTTGTTTTGCTCCCTGAAATATTGCAAATTTTTTGAGTTGGGGGTGGTGCTTTTCATTTTG
AGTGAGTGGTCGCTTCCGACTGACTTTGAGTTTGAAGGTCTTTCTTGTCTTTCTTAGTTCTCTT
TCCTCCCCATTTCTAACAGTTGTCATCCTCATTCAGTGTTTTAGTGGCCTTGAACACAACTGCT
TTAGCTATGATCTAAATCCTCAGTGTATAATTATGTGAAATGTTTATACCTCAGTCCTGTGGTA
CCAACGGCGTCGAGATGGCAGTTTTGCGCTACACATTTTTCAGTTATTGAACCTTTCCAACGTT
TAAATTATGCCAGGTTTGAAGTCTCCTTTTAGTTGTTTAAATAAGTAATATTTTCAAAATAATA
AAAAACAATGATATCTCTTGGAATATTCTGTAAAATGTAGCTATAAAATTATATTTTCTACTTT
AGAGTTTTTACCTTTTTCTCTTGTGTGTTTTACAAATCAATTATCTACATGAAATAACAATGTT
TTGAAAGTGTCCATGGTCTAGTCTCAAAATTTCCTTTATAATTATATGTATAAGAGCAAAGCTT
TGTTTTAATTAGAAAATATTATTATTTTCATCTTGGGTATTATTATCTCCATGTAACTTGTAAA
TATAACGTTTTGCCCAATTTTT

hide sequence

RefSeq Acc Id:

XM_039079684 ⟹ XP_038935612

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	51,829,473 - 52,236,096 (-)	NCBI
mRatBN7.2	7	49,943,271 - 50,349,819 (-)	NCBI

RefSeq Acc Id:

XM_039079685 ⟹ XP_038935613

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	51,970,855 - 52,236,096 (-)	NCBI
mRatBN7.2	7	50,098,062 - 50,349,819 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001102461	(Get FASTA)	NCBI Sequence Viewer
	XP_038935612	(Get FASTA)	NCBI Sequence Viewer
	XP_038935613	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM16698	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000007461
	ENSRNOP00000007461.4
	ENSRNOP00000111942
GenBank Protein	Q10836	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001102461 ⟸ NM_001108991

- UniProtKB:

Q10836 (UniProtKB/Swiss-Prot), G3V6Q2 (UniProtKB/Swiss-Prot), A0A8I5ZM45 (UniProtKB/TrEMBL), A6IGK0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MALDGERGEQEEEKKKKKKKKKRKKKEEEGAEKSSSPFAATMGEDDAALRASGRGLSDPWADSV
GVRPRTTERHIAVHKRLVLAFAVSIVALLAVTMLAVLLSLRFDECGASAAMPGTDGGLGGFPER
GGNSSYPGSARRNHHAGEESSQREIGEVGTAGTPSAHPPSEEEQEQWQPWTQLRLSGHLKPLHY
NLMLTAFMENFTFSGEVNVEIACQNATRYVVLHASRVAVEKVQVAEDRAFGAVPVAGFFLYPQT
QVLVVVLNRTLDAQRHYNLKIIYNALIENELLGFFRSSYVIHGERRFLGVTQFSPTHARKAFPC
FDEPIYKATFKISIKHQATYLSLSNMPVETSVFEEDGWVTDHFSQTPLMSTYYLAWAICNFTYR
ETTTKSGVVVRLYARPDAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAM
ENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFE
FVGTDYLYPSWNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLRATDIDKVFDWIAYKKGAALI
RMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYP
VITILGNMTAENRILITQQHFIYDIGAKTKALQLQNSSYLWQIPLTIVVGNRSHVSSEAIIWVS
NKSEHHRITYLDKGSWILGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGLIDDAFS
LARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYS
KLGWPKNNFNGSVVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRD
IVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLSRLLNLSLNSEVVLDQD
AIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFM
KSYDGVASASFSRAVETVEANVRWKRLYQDELFQWLGKAMRH

hide sequence

Ensembl Acc Id:

ENSRNOP00000007461 ⟸ ENSRNOT00000007461

RefSeq Acc Id:	XP_038935612 ⟸ XM_039079684
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZM45 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038935613 ⟸ XM_039079685
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSRNOP00000079029 ⟸ ENSRNOT00000109488

Ensembl Acc Id:

ENSRNOP00000106728 ⟸ ENSRNOT00000139848

Ensembl Acc Id:

ENSRNOP00000111942 ⟸ ENSRNOT00000163342

Protein Domains

Aminopeptidase N-like N-terminal ERAP1-like C-terminal Peptidase M1 membrane alanine aminopeptidase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q10836-F1-model_v2	AlphaFold	Q10836	1-1025	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:728895	AgrOrtholog
BioCyc Gene	G2FUF-34083	BioCyc
Ensembl Genes	ENSRNOG00000005278	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000007461	ENTREZGENE
	ENSRNOT00000007461.6	UniProtKB/Swiss-Prot
	ENSRNOT00000163342	ENTREZGENE
Gene3D-CATH	1.10.390.10	UniProtKB/Swiss-Prot
	1.25.50.20	UniProtKB/Swiss-Prot
	2.60.40.1730	UniProtKB/Swiss-Prot
	2.60.40.1910	UniProtKB/Swiss-Prot
InterPro	Aminopeptidase_N-like_N	UniProtKB/Swiss-Prot
	Aminopeptidase_N-like_N	UniProtKB/Swiss-Prot
	ERAP1-like_C_dom	UniProtKB/Swiss-Prot
	M1_APN-typ	UniProtKB/Swiss-Prot
	Peptidase_M1	UniProtKB/Swiss-Prot
	Peptidase_M1_aminopeptidases	UniProtKB/Swiss-Prot
	Peptidase_M1_dom	UniProtKB/Swiss-Prot
	Peptidase_M4/M1_CTD_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:366894	UniProtKB/Swiss-Prot
NCBI Gene	Trhde	ENTREZGENE
PANTHER	PROTEASE M1 ZINC METALLOPROTEASE	UniProtKB/Swiss-Prot
	THYROTROPIN-RELEASING HORMONE-DEGRADING ECTOENZYME	UniProtKB/Swiss-Prot
Pfam	ERAP1_C	UniProtKB/Swiss-Prot
	Peptidase_M1	UniProtKB/Swiss-Prot
	Peptidase_M1_N	UniProtKB/Swiss-Prot
PhenoGen	Trhde	PhenoGen
PRINTS	ALADIPTASE	UniProtKB/Swiss-Prot
PROSITE	ZINC_PROTEASE	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000005278	RatGTEx
Superfamily-SCOP	Metalloproteases ('zincins'), catalytic domain	UniProtKB/Swiss-Prot
	SSF63737	UniProtKB/Swiss-Prot
UniProt	A0A8I5ZM45	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LQ58_RAT	UniProtKB/TrEMBL
	A0ABK0LZE6_RAT	UniProtKB/TrEMBL
	A6IGK0	ENTREZGENE, UniProtKB/TrEMBL
	G3V6Q2	ENTREZGENE
	Q10836	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	G3V6Q2	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Trhde	thyrotropin-releasing hormone degrading enzyme			Symbol and Name status set to approved	1299863	APPROVED
2005-09-30	Trhde				Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in the brain, liver and serum	625628
gene_function	catalyzes the hydrolysis of hyrotropin-releasing hormone (TRH) at the pyroGlu-His bond	625628
gene_protein	97 kDa	625628

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar