TRHDE (thyrotropin releasing hormone degrading enzyme) - Rat Genome Database

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Gene: TRHDE (thyrotropin releasing hormone degrading enzyme) Chlorocebus sabaeus
Analyze
Symbol: TRHDE
Name: thyrotropin releasing hormone degrading enzyme
RGD ID: 18345098
Description: ENCODES a protein that exhibits aminopeptidase activity (inferred); metal ion binding (inferred); metalloaminopeptidase activity (inferred); INVOLVED IN peptide catabolic process (inferred); proteolysis (inferred); ASSOCIATED WITH long QT syndrome (ortholog); FOUND IN cytoplasm (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: thyrotropin-releasing hormone-degrading ectoenzyme
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11167,912,122 - 68,313,509 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1167,912,138 - 68,315,962 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037177,295,134 - 177,727,707 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
membrane  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TRHDE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11167,912,122 - 68,313,509 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1167,912,138 - 68,315,962 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037177,295,134 - 177,727,707 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
TRHDE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381272,087,266 - 72,670,758 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1272,087,266 - 72,670,758 (+)EnsemblGRCh38hg38GRCh38
GRCh371272,666,150 - 73,064,538 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361270,952,730 - 71,345,689 (+)NCBINCBI36Build 36hg18NCBI36
Build 341270,952,729 - 71,345,688NCBI
Celera1272,329,850 - 72,723,987 (+)NCBICelera
Cytogenetic Map12q21.1NCBI
HuRef1269,714,852 - 70,107,634 (+)NCBIHuRef
CHM1_11272,632,089 - 73,024,946 (+)NCBICHM1_1
T2T-CHM13v2.01272,063,195 - 72,646,521 (+)NCBIT2T-CHM13v2.0
Trhde
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910114,234,725 - 114,638,207 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10114,234,726 - 114,638,212 (-)EnsemblGRCm39 Ensembl
GRCm3810114,398,820 - 114,802,302 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10114,398,821 - 114,802,307 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl10114,398,823 - 114,802,307 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710113,835,877 - 114,238,426 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610113,803,133 - 114,205,474 (-)NCBIMGSCv36mm8
Celera10116,334,960 - 116,737,119 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1061.59NCBI
Trhde
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8751,829,473 - 52,236,843 (-)NCBIGRCr8
mRatBN7.2749,943,271 - 50,350,613 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl749,945,766 - 50,367,371 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx751,852,771 - 52,257,524 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0754,055,893 - 54,460,654 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0753,833,748 - 54,238,531 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0757,253,023 - 57,679,795 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl757,253,023 - 57,679,795 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0757,265,684 - 57,693,174 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4753,591,770 - 54,021,219 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1753,612,156 - 54,024,183 (-)NCBI
Celera746,740,631 - 47,161,218 (-)NCBICelera
Cytogenetic Map7q22NCBI
Trhde
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540512,229,448 - 12,623,675 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540512,229,448 - 12,624,753 (+)NCBIChiLan1.0ChiLan1.0
TRHDE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21080,300,714 - 80,696,949 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11280,297,114 - 80,693,349 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01269,795,208 - 70,191,298 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11272,652,776 - 73,047,182 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1272,652,958 - 73,073,418 (+)Ensemblpanpan1.1panPan2
TRHDE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11013,744,907 - 14,118,023 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1013,744,591 - 14,115,437 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1013,685,019 - 14,055,891 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01013,883,046 - 14,254,797 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1013,883,046 - 14,249,827 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11013,743,941 - 14,115,272 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01013,995,000 - 14,365,815 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01014,116,319 - 14,488,005 (+)NCBIUU_Cfam_GSD_1.0
Trhde
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494544,067,297 - 44,437,562 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365681,290,774 - 1,662,542 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365681,290,758 - 1,660,520 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRHDE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl536,274,165 - 36,658,701 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1536,266,883 - 36,663,208 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2539,289,649 - 39,520,695 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Trhde
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475025,007,540 - 25,419,433 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475025,000,907 - 25,419,628 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 9
Low 13 10 37
Below cutoff 23 9 14

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_008004042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000002101   ⟹   ENSCSAP00000000428
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1167,912,138 - 68,315,962 (+)Ensembl
RefSeq Acc Id: XM_008004042   ⟹   XP_008002233
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11167,912,122 - 68,313,509 (+)NCBI
Vero_WHO_p1.0NW_023666037177,295,134 - 177,727,707 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008002233 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000000428
  ENSCSAP00000000428.1
Reference Protein Sequences
RefSeq Acc Id: XP_008002233   ⟸   XM_008004042
- UniProtKB: A0A0D9QVN9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000000428   ⟸   ENSCSAT00000002101


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000004072 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000002101.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.390.10 UniProtKB/TrEMBL
  1.25.50.20 UniProtKB/TrEMBL
  2.60.40.1730 UniProtKB/TrEMBL
  2.60.40.1910 UniProtKB/TrEMBL
InterPro Aminopeptidase_N-like_N UniProtKB/TrEMBL
  Aminopeptidase_N-like_N UniProtKB/TrEMBL
  ERAP1-like_C_dom UniProtKB/TrEMBL
  M1_APN-typ UniProtKB/TrEMBL
  Peptidase_M1 UniProtKB/TrEMBL
  Peptidase_M1_dom UniProtKB/TrEMBL
  Peptidase_M4/M1_CTD_sf UniProtKB/TrEMBL
KEGG Report csab:103238733 UniProtKB/TrEMBL
NCBI Gene TRHDE ENTREZGENE
PANTHER PROTEASE M1 ZINC METALLOPROTEASE UniProtKB/TrEMBL
  PTHR11533:SF40 UniProtKB/TrEMBL
Pfam ERAP1_C UniProtKB/TrEMBL
  Peptidase_M1 UniProtKB/TrEMBL
  Peptidase_M1_N UniProtKB/TrEMBL
PRINTS ALADIPTASE UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF63737 UniProtKB/TrEMBL
UniProt A0A0D9QVN9 ENTREZGENE, UniProtKB/TrEMBL