Clta (clathrin, light chain A) - Rat Genome Database

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Gene: Clta (clathrin, light chain A) Rattus norvegicus
Analyze
Symbol: Clta
Name: clathrin, light chain A
RGD ID: 70919
Description: Enables GTPase binding activity and peptide binding activity. Involved in synaptic vesicle endocytosis. Located in clathrin-coated pit and clathrin-coated vesicle. Part of clathrin coat. Is active in postsynaptic endocytic zone; presynaptic endocytic zone membrane; and synaptic vesicle membrane. Orthologous to human CLTA (clathrin light chain A); PARTICIPATES IN Arf family mediated signaling pathway; clathrin-dependent synaptic vesicle endocytosis; endocytosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-amino-2-deoxy-D-glucopyranose; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: clathrin light chain; clathrin light chain A; clathrin, light chain (Lca); clathrin, light polypeptide (Lca); lca; LCA1; LCA2; LCA3; MGC105384
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8563,022,046 - 63,059,223 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl563,041,184 - 63,059,215 (+)EnsemblGRCr8
mRatBN7.2558,244,253 - 58,263,480 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl558,245,442 - 58,263,472 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx560,227,391 - 60,245,248 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0562,046,199 - 62,064,056 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0562,015,336 - 62,033,490 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0559,490,689 - 59,509,139 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,491,096 - 59,509,138 (+)Ensemblrn6Rnor6.0
Rnor_5.0564,012,881 - 64,031,657 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4560,484,437 - 60,502,432 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera556,823,904 - 56,841,911 (+)NCBICelera
RGSC_v3.1560,484,615 - 60,502,611 (+)NCBI
Cytogenetic Map5q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Dynamics and nanoscale organization of the postsynaptic endocytic zone at excitatory synapses. Catsburg LA, etal., Elife. 2022 Jan 24;11:e74387. doi: 10.7554/eLife.74387.
2. Epsin binds to clathrin by associating directly with the clathrin-terminal domain. Evidence for cooperative binding through two discrete sites. Drake MT, etal., J Biol Chem. 2000 Mar 3;275(9):6479-89.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Non-stoichiometric relationship between clathrin heavy and light chains revealed by quantitative comparative proteomics of clathrin-coated vesicles from brain and liver. Girard M, etal., Mol Cell Proteomics. 2005 Aug;4(8):1145-54. Epub 2005 Jun 2.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Clathrin light chains LCA and LCB are similar, polymorphic, and share repeated heptad motifs. Kirchhausen T, etal., Science 1987 Apr 17;236(4799):320-4.
8. A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. Li H, etal., Nat Cell Biol. 2013 Jul;15(7):773-85. doi: 10.1038/ncb2791. Epub 2013 Jun 23.
9. Clathrin-coated vesicles in nervous tissue are involved primarily in synaptic vesicle recycling. Maycox PR, etal., J Cell Biol. 1992 Sep;118(6):1379-88.
10. Gene Data Set MGD Curation, June 12, 2002
11. Monitoring clathrin-mediated endocytosis during synaptic activity. Mueller VJ, etal., J Neurosci. 2004 Feb 25;24(8):2004-12.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. A motif in the clathrin heavy chain required for the Hsc70/auxilin uncoating reaction. Rapoport I, etal., Mol Biol Cell. 2008 Jan;19(1):405-13. Epub 2007 Oct 31.
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Comprehensive gene review and curation RGD comprehensive gene curation
18. The NECAP PHear domain increases clathrin accessory protein binding potential. Ritter B, etal., EMBO J. 2007 Sep 19;26(18):4066-77. Epub 2007 Aug 30.
19. Synaptic vesicle endocytosis. Saheki Y and De Camilli P, Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a005645. doi: 10.1101/cshperspect.a005645.
20. Possible involvement of clathrin in neuritogenesis induced by a protease inhibitor (benzyloxycarbonyl-Leu-Leu-Leu-aldehyde) in PC12 cells. Saito Y, etal., J Biochem. 1992 Oct;112(4):448-55.
Additional References at PubMed
PMID:4066749   PMID:8413590   PMID:9188501   PMID:10908605   PMID:11382783   PMID:11756460   PMID:12234931   PMID:12477932   PMID:16025302   PMID:16854843   PMID:17228368   PMID:17880892  
PMID:19144635   PMID:19946888   PMID:20231386   PMID:20730103   PMID:22871113   PMID:25002582   PMID:25427558   PMID:28131823   PMID:29476059   PMID:31672988  


Genomics

Comparative Map Data
Clta
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8563,022,046 - 63,059,223 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl563,041,184 - 63,059,215 (+)EnsemblGRCr8
mRatBN7.2558,244,253 - 58,263,480 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl558,245,442 - 58,263,472 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx560,227,391 - 60,245,248 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0562,046,199 - 62,064,056 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0562,015,336 - 62,033,490 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0559,490,689 - 59,509,139 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,491,096 - 59,509,138 (+)Ensemblrn6Rnor6.0
Rnor_5.0564,012,881 - 64,031,657 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4560,484,437 - 60,502,432 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera556,823,904 - 56,841,911 (+)NCBICelera
RGSC_v3.1560,484,615 - 60,502,611 (+)NCBI
Cytogenetic Map5q22NCBI
CLTA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38936,190,874 - 36,212,059 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl936,190,856 - 36,304,781 (+)Ensemblhg38GRCh38
GRCh37936,190,918 - 36,212,056 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36936,180,892 - 36,202,056 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34936,180,988 - 36,202,055NCBI
Celera936,124,438 - 36,145,644 (+)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef936,144,777 - 36,166,054 (+)NCBIHuRef
CHM1_1936,191,259 - 36,212,465 (+)NCBICHM1_1
T2T-CHM13v2.0936,212,880 - 36,234,065 (+)NCBIT2T-CHM13v2.0
Clta
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39444,003,816 - 44,032,846 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl444,004,452 - 44,032,846 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38444,003,816 - 44,032,846 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl444,004,452 - 44,032,846 (+)Ensemblmm10GRCm38
MGSCv37444,025,515 - 44,045,718 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36444,033,784 - 44,053,946 (+)NCBIMGSCv36mm8
Celera444,033,842 - 44,054,042 (+)NCBICelera
Cytogenetic Map4B1NCBI
cM Map423.09NCBI
Clta
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547297,235 - 117,144 (-)Ensembl
ChiLan1.0NW_00495547296,958 - 117,230 (-)NCBIChiLan1.0ChiLan1.0
CLTA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21188,377,550 - 88,398,727 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1988,383,487 - 88,404,664 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0936,040,566 - 36,061,744 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1936,841,477 - 36,862,528 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl936,840,868 - 36,862,528 (+)EnsemblpanPan2panpan1.1
CLTA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11152,636,328 - 52,681,258 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1152,615,039 - 52,681,270 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1151,227,019 - 51,271,906 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01153,742,643 - 53,787,381 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1153,765,885 - 53,789,703 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11152,245,564 - 52,290,214 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01152,267,619 - 52,312,459 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01152,969,170 - 53,014,020 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Clta
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947167,622,904 - 167,644,372 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365244,169,732 - 4,191,951 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365244,170,425 - 4,191,951 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLTA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,971,505 - 237,001,731 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11236,971,317 - 236,993,291 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21264,772,770 - 264,783,359 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CLTA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11244,346,169 - 44,367,626 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1244,344,395 - 44,367,619 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603841,437,200 - 41,458,568 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Clta
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248684,419,554 - 4,443,477 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248684,419,554 - 4,443,475 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Clta
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v112,485,442 - 2,504,772 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Clta
279 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:108
Count of miRNA genes:45
Interacting mature miRNAs:54
Transcripts:ENSRNOT00000019737, ENSRNOT00000036366
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)53275164977751649Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)55266537294894052Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)52367149379046465Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)53331167378311673Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)53275164977751649Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)53998594884985948Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53331167378311673Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)53952692484526924Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54852312391770353Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)560511627105511627Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52602321171023211Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)556546393101546393Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)52367149368671493Rat

Markers in Region
BI282730  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2558,263,218 - 58,263,407 (+)MAPPERmRatBN7.2
Rnor_6.0559,508,878 - 59,509,066NCBIRnor6.0
Rnor_5.0564,031,396 - 64,031,584UniSTSRnor5.0
RGSC_v3.4560,502,179 - 60,502,367UniSTSRGSC3.4
Celera556,841,658 - 56,841,846UniSTS
Cytogenetic Map5q22UniSTS
AV026556  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2558,263,354 - 58,263,444 (+)MAPPERmRatBN7.2
Rnor_6.0559,509,014 - 59,509,103NCBIRnor6.0
Rnor_5.0564,031,532 - 64,031,621UniSTSRnor5.0
RGSC_v3.4560,502,315 - 60,502,404UniSTSRGSC3.4
Celera556,841,794 - 56,841,883UniSTS
Cytogenetic Map5q22UniSTS
RH79677  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2558,263,164 - 58,263,443 (+)MAPPERmRatBN7.2
Rnor_6.0559,508,824 - 59,509,102NCBIRnor6.0
Rnor_5.0564,031,342 - 64,031,620UniSTSRnor5.0
RGSC_v3.4560,502,125 - 60,502,403UniSTSRGSC3.4
Celera556,841,604 - 56,841,882UniSTS
Cytogenetic Map5q22UniSTS
RH74929  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2558,263,201 - 58,263,434 (+)MAPPERmRatBN7.2
Rnor_6.0559,508,861 - 59,509,093NCBIRnor6.0
Rnor_5.0564,031,379 - 64,031,611UniSTSRnor5.0
RGSC_v3.4560,502,162 - 60,502,394UniSTSRGSC3.4
Celera556,841,641 - 56,841,873UniSTS
Cytogenetic Map5q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001436592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001436593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001436594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC127935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC087577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M15882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M19260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M19261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000019737   ⟹   ENSRNOP00000019737
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl563,041,201 - 63,059,215 (+)Ensembl
mRatBN7.2 Ensembl558,245,467 - 58,263,472 (+)Ensembl
Rnor_6.0 Ensembl559,491,096 - 59,509,138 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000036366   ⟹   ENSRNOP00000035138
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl563,041,184 - 63,059,215 (+)Ensembl
mRatBN7.2 Ensembl558,245,442 - 58,263,472 (+)Ensembl
Rnor_6.0 Ensembl559,491,103 - 59,509,131 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083068   ⟹   ENSRNOP00000070814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl563,041,184 - 63,059,215 (+)Ensembl
mRatBN7.2 Ensembl558,245,474 - 58,263,472 (+)Ensembl
Rnor_6.0 Ensembl559,491,136 - 59,509,131 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101159   ⟹   ENSRNOP00000089530
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl563,041,198 - 63,059,215 (+)Ensembl
mRatBN7.2 Ensembl558,245,467 - 58,263,472 (+)Ensembl
RefSeq Acc Id: NM_031974   ⟹   NP_114180
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8563,041,220 - 63,059,215 (+)NCBI
mRatBN7.2558,245,475 - 58,263,472 (+)NCBI
Rnor_6.0559,491,136 - 59,509,131 (+)NCBI
Rnor_5.0564,012,881 - 64,031,657 (+)NCBI
RGSC_v3.4560,484,437 - 60,502,432 (+)RGD
Celera556,823,904 - 56,841,911 (+)RGD
Sequence:
RefSeq Acc Id: XM_006238104   ⟹   XP_006238166
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8563,022,046 - 63,059,223 (+)NCBI
mRatBN7.2558,244,253 - 58,263,480 (+)NCBI
Rnor_6.0559,490,689 - 59,509,139 (+)NCBI
Rnor_5.0564,012,881 - 64,031,657 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006238105   ⟹   XP_006238167
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8563,022,046 - 63,059,223 (+)NCBI
mRatBN7.2558,244,253 - 58,263,480 (+)NCBI
Rnor_6.0559,490,689 - 59,509,139 (+)NCBI
Rnor_5.0564,012,881 - 64,031,657 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006238106   ⟹   XP_006238168
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8563,022,046 - 63,059,223 (+)NCBI
mRatBN7.2558,244,253 - 58,263,480 (+)NCBI
Rnor_6.0559,490,689 - 59,509,139 (+)NCBI
Rnor_5.0564,012,881 - 64,031,657 (+)NCBI
Sequence:
RefSeq Acc Id: NP_114180   ⟸   NM_031974
- UniProtKB: P08081 (UniProtKB/Swiss-Prot),   A6IJ63 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238166   ⟸   XM_006238104
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006238167   ⟸   XM_006238105
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006238168   ⟸   XM_006238106
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSRNOP00000070814   ⟸   ENSRNOT00000083068
Ensembl Acc Id: ENSRNOP00000035138   ⟸   ENSRNOT00000036366
Ensembl Acc Id: ENSRNOP00000019737   ⟸   ENSRNOT00000019737
Ensembl Acc Id: ENSRNOP00000089530   ⟸   ENSRNOT00000101159

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08081-F1-model_v2 AlphaFold P08081 1-248 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693690
Promoter ID:EPDNEW_R4212
Type:initiation region
Name:Clta_1
Description:clathrin, light chain A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0559,491,128 - 59,491,188EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70919 AgrOrtholog
BioCyc Gene G2FUF-41479 BioCyc
Ensembl Genes ENSRNOG00000014635 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019737 ENTREZGENE
  ENSRNOT00000019737.6 UniProtKB/Swiss-Prot
  ENSRNOT00000036366 ENTREZGENE
  ENSRNOT00000036366.7 UniProtKB/Swiss-Prot
  ENSRNOT00000083068 ENTREZGENE
  ENSRNOT00000101159 ENTREZGENE
IMAGE_CLONE IMAGE:7307624 IMAGE-MGC_LOAD
InterPro Clathrin_L-chain UniProtKB/Swiss-Prot
KEGG Report rno:83800 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105384 IMAGE-MGC_LOAD
NCBI Gene 83800 ENTREZGENE
PANTHER CLATHRIN LIGHT CHAIN A UniProtKB/Swiss-Prot
  PTHR10639 UniProtKB/Swiss-Prot
Pfam Clathrin_lg_ch UniProtKB/Swiss-Prot
PhenoGen Clta PhenoGen
PROSITE CLATHRIN_LIGHT_CHN_1 UniProtKB/Swiss-Prot
  CLATHRIN_LIGHT_CHN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014635 RatGTEx
UniProt A0A0G2JYW3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A7H3 ENTREZGENE, UniProtKB/TrEMBL
  A6IJ63 ENTREZGENE, UniProtKB/TrEMBL
  A6IJ64 ENTREZGENE, UniProtKB/TrEMBL
  A6IJ66_RAT UniProtKB/TrEMBL
  CLCA_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5PPP1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Clta  clathrin, light chain A  Clta  clathrin, light chain (Lca)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Clta  clathrin, light chain (Lca)  Clta  clathrin, light polypeptide (Lca)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Clta  clathrin, light polypeptide (Lca)      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains ten heptad elements that may form alpha-helical coiled coils 70686