RGD Reference Report - Clathrin light chains LCA and LCB are similar, polymorphic, and share repeated heptad motifs. - Rat Genome Database

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Clathrin light chains LCA and LCB are similar, polymorphic, and share repeated heptad motifs.

Authors: Kirchhausen, T  Scarmato, P  Harrison, SC  Monroe, JJ  Chow, EP  Mattaliano, RJ  Ramachandran, KL  Smart, JE  Ahn, AH  Brosius, J 
Citation: Kirchhausen T, etal., Science 1987 Apr 17;236(4799):320-4.
RGD ID: 70686
Pubmed: PMID:3563513   (View Abstract at PubMed)

The clathrin light chains fall into two major classes, LCA and LCB. In an intact clathrin triskelion, one light chain, of either class, is bound to the proximal segment of a heavy chain leg. Analysis of rat brain and liver complementary DNA clones for LCA and LCB shows that the two light chain classes are closely related. There appear to be several members of each class having deletions of varying length aligned at the same position. A set of ten heptad elements, characteristic of alpha-helical coiled coils, is a striking feature of the central part of each derived amino acid sequence. These observations suggest a model in which the alpha-helical segment mediates binding to clathrin heavy chains and the amino- and carboxyl-terminal segments mediate interactions with other proteins. They also suggest an explanation for the observed tissue-dependent size variation for members of each class.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
neurotransmitter secretion involved_inNAS 70686PMID:3563513UniProt 
neurotransmitter transport involved_inNAS 70686PMID:3563513UniProt 
synaptic vesicle coating involved_inNAS 70686PMID:3563513UniProt 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
clathrin coat of coated pit  NAS 70686; 70686 RGD 
clathrin coat of coated pit part_ofNAS 70686PMID:3563513UniProt 
clathrin vesicle coat  NAS 70686; 70686 RGD 
clathrin vesicle coat part_ofNAS 70686PMID:3563513UniProt 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
neurotransmitter transmembrane transporter activity enablesNAS 70686PMID:3563513UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Clta  (clathrin, light chain A)
Cltb  (clathrin, light chain B)


Additional Information