Acsl5 (acyl-CoA synthetase long-chain family member 5) - Rat Genome Database

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Gene: Acsl5 (acyl-CoA synthetase long-chain family member 5) Rattus norvegicus
Analyze
Symbol: Acsl5
Name: acyl-CoA synthetase long-chain family member 5
RGD ID: 69402
Description: Enables arachidonate-CoA ligase activity. Involved in several processes, including long-chain fatty-acyl-CoA biosynthetic process; positive regulation of long-chain fatty acid import across plasma membrane; and positive regulation of triglyceride biosynthetic process. Predicted to be located in plasma membrane. Predicted to be active in endoplasmic reticulum; membrane; and mitochondrion. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human ACSL5 (acyl-CoA synthetase long chain family member 5); PARTICIPATES IN fatty acid beta degradation pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; fatty acid metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Acs5; arachidonate--CoA ligase; Facl5; fatty acid Coenzyme A ligase, long chain 5; LACS 5; long-chain acyl-CoA synthetase 5; long-chain fatty acid coenzyme A ligase 5; long-chain-fatty-acid--CoA ligase 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81264,294,851 - 264,341,943 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1264,294,864 - 264,341,943 (+)EnsemblGRCr8
mRatBN7.21254,289,513 - 254,336,608 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1254,292,521 - 254,336,607 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1262,494,531 - 262,541,592 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01269,200,609 - 269,247,672 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01261,848,340 - 261,895,280 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01276,240,703 - 276,290,012 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1276,240,703 - 276,290,008 (+)Ensemblrn6Rnor6.0
Rnor_5.01283,637,899 - 283,685,361 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41261,554,383 - 261,599,373 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1249,999,118 - 250,043,312 (+)NCBICelera
RGSC_v3.11261,765,427 - 261,810,418 (+)NCBI
Cytogenetic Map1q55NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
ATP  (ISO)
azathioprine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chlorpyrifos  (EXP)
cisplatin  (EXP)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
cortisol  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diethylstilbestrol  (EXP)
dioscin  (EXP,ISO)
doxorubicin  (ISO)
ethanol  (EXP,ISO)
farnesol  (ISO)
fenofibrate  (ISO)
flutamide  (EXP,ISO)
folic acid  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gentamycin  (EXP)
glutathione  (ISO)
glyphosate  (ISO)
GW 4064  (ISO)
GW 7647  (EXP,ISO)
hexadecanoic acid  (ISO)
indometacin  (EXP)
isoniazide  (ISO)
isotretinoin  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
levofloxacin  (EXP)
lithium atom  (EXP)
lithium hydride  (EXP)
methamphetamine  (EXP)
methidathion  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel sulfate  (ISO)
nimesulide  (EXP)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
oxybenzone  (EXP)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
picrotoxin  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
tolcapone  (ISO)
topotecan  (EXP)
trametinib  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
troglitazone  (EXP)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
XAV939  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Long chain fatty acyl-CoA synthetase 5 expression is induced by insulin and glucose: involvement of sterol regulatory element-binding protein-1c. Achouri Y, etal., Biochimie. 2005 Dec;87(12):1149-55. Epub 2005 Sep 20.
2. Rat long chain acyl-CoA synthetase 5, but not 1, 2, 3, or 4, complements Escherichia coli fadD. Caviglia JM, etal., J Biol Chem. 2004 Mar 19;279(12):11163-9. Epub 2004 Jan 7.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Expression and characterization of recombinant rat Acyl-CoA synthetases 1, 4, and 5. Selective inhibition by triacsin C and thiazolidinediones. Kim JH, etal., J Biol Chem 2001 Jul 6;276(27):24667-73.
6. Long-chain acyl-CoA synthetase isoforms differ in preferences for eicosanoid species and long-chain fatty acids. Klett EL, etal., J Lipid Res. 2017 May;58(5):884-894. doi: 10.1194/jlr.M072512. Epub 2017 Feb 16.
7. Rat liver acyl-CoA synthetase 4 is a peripheral-membrane protein located in two distinct subcellular organelles, peroxisomes, and mitochondrial-associated membrane. Lewin TM, etal., Arch Biochem Biophys. 2002 Aug 15;404(2):263-70.
8. Acyl-CoA synthetase isoforms 1, 4, and 5 are present in different subcellular membranes in rat liver and can be inhibited independently. Lewin TM, etal., J Biol Chem 2001 Jul 6;276(27):24674-9.
9. Rat long chain acyl-CoA synthetase 5 increases fatty acid uptake and partitioning to cellular triacylglycerol in McArdle-RH7777 cells. Mashek DG, etal., J Biol Chem. 2006 Jan 13;281(2):945-50. Epub 2005 Nov 1.
10. Rat long-chain acyl-CoA synthetase mRNA, protein, and activity vary in tissue distribution and in response to diet. Mashek DG, etal., J Lipid Res. 2006 Sep;47(9):2004-10. Epub 2006 Jun 13.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway. Nakahara K, etal., Mol Cell. 2012 May 25;46(4):461-71. doi: 10.1016/j.molcel.2012.04.033.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. A novel acyl-CoA synthetase, ACS5, expressed in intestinal epithelial cells and proliferating preadipocytes. Oikawa E, etal., J Biochem (Tokyo) 1998 Sep;124(3):679-85.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
21. Fatty acid transport by vectorial acylation in mammals: roles played by different isoforms of rat long-chain acyl-CoA synthetases. Tong F, etal., Arch Biochem Biophys. 2006 Mar 1;447(1):46-52. Epub 2006 Jan 23.
22. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. Watkins PA, etal., J Lipid Res. 2007 Dec;48(12):2736-50. Epub 2007 Aug 30.
Additional References at PubMed
PMID:12865426   PMID:14651853   PMID:17681178   PMID:18614015   PMID:19946888   PMID:20798351   PMID:22171129   PMID:24269233  


Genomics

Comparative Map Data
Acsl5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81264,294,851 - 264,341,943 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1264,294,864 - 264,341,943 (+)EnsemblGRCr8
mRatBN7.21254,289,513 - 254,336,608 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1254,292,521 - 254,336,607 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1262,494,531 - 262,541,592 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01269,200,609 - 269,247,672 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01261,848,340 - 261,895,280 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01276,240,703 - 276,290,012 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1276,240,703 - 276,290,008 (+)Ensemblrn6Rnor6.0
Rnor_5.01283,637,899 - 283,685,361 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41261,554,383 - 261,599,373 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1249,999,118 - 250,043,312 (+)NCBICelera
RGSC_v3.11261,765,427 - 261,810,418 (+)NCBI
Cytogenetic Map1q55NCBI
ACSL5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810112,374,116 - 112,428,376 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10112,372,400 - 112,428,381 (+)Ensemblhg38GRCh38
GRCh3710114,133,874 - 114,188,134 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610114,123,906 - 114,178,128 (+)NCBIBuild 36Build 36hg18NCBI36
Celera10107,861,444 - 107,915,662 (+)NCBICelera
Cytogenetic Map10q25.2NCBI
HuRef10107,761,898 - 107,815,784 (+)NCBIHuRef
CHM1_110114,415,634 - 114,469,870 (+)NCBICHM1_1
T2T-CHM13v2.010113,265,142 - 113,319,056 (+)NCBIT2T-CHM13v2.0
Acsl5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391955,240,298 - 55,285,060 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1955,240,370 - 55,286,152 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381955,251,861 - 55,296,628 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1955,251,938 - 55,297,720 (+)Ensemblmm10GRCm38
MGSCv371955,327,859 - 55,371,118 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361955,306,619 - 55,349,878 (+)NCBIMGSCv36mm8
Celera1957,444,332 - 57,487,767 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1951.3NCBI
Acsl5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543117,477,086 - 17,524,539 (+)Ensembl
ChiLan1.0NW_00495543117,477,113 - 17,524,539 (+)NCBIChiLan1.0ChiLan1.0
ACSL5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28124,252,488 - 124,305,741 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110124,257,822 - 124,307,922 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010108,965,559 - 109,019,240 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110112,405,069 - 112,457,892 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10112,407,161 - 112,457,892 (+)EnsemblpanPan2panpan1.1
ACSL5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12823,437,838 - 23,478,763 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2823,440,387 - 23,478,762 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2823,589,635 - 23,630,543 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02823,970,117 - 24,011,237 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2823,971,931 - 24,069,062 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12823,527,397 - 23,568,302 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02823,538,540 - 23,579,462 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02823,737,237 - 23,775,914 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Acsl5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721322,569,123 - 22,610,342 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364862,967,522 - 2,991,154 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364862,952,379 - 2,992,148 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACSL5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14122,777,130 - 122,828,052 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114122,777,135 - 122,828,054 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214133,689,844 - 133,751,494 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACSL5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19105,259,546 - 105,311,500 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9105,257,429 - 105,311,690 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604866,462,251 - 66,514,618 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acsl5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473734,038,518 - 34,091,661 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473734,038,610 - 34,091,579 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Acsl5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1260,864,899 - 60,907,301 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:179
Count of miRNA genes:129
Interacting mature miRNAs:145
Transcripts:ENSRNOT00000022126
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1263946994269633915Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1578775Iddm21Insulin dependent diabetes mellitus QTL 214.13blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1245782829270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1248619887269633915Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1247133834270518180Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1600390Niddm64Non-insulin dependent diabetes mellitus QTL 640.003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1257624997270518180Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
1598839Rf56Renal function QTL 56renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1255849111270518180Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1241569529269633915Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1243953669270518180Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat

Markers in Region
D1Rat456  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81264,309,900 - 264,310,107 (+)Marker Load Pipeline
mRatBN7.21254,304,565 - 254,304,772 (+)MAPPERmRatBN7.2
Rnor_6.01276,258,539 - 276,258,745NCBIRnor6.0
Rnor_5.01283,654,821 - 283,655,027UniSTSRnor5.0
RGSC_v3.41261,566,459 - 261,566,666RGDRGSC3.4
RGSC_v3.41261,566,460 - 261,566,666UniSTSRGSC3.4
Celera1250,011,271 - 250,011,477UniSTS
RGSC_v3.11261,777,504 - 261,777,711RGD
SHRSP x BN Map1143.5499UniSTS
SHRSP x BN Map1143.5499RGD
Cytogenetic Map1q55UniSTS
RH132400  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21254,336,366 - 254,336,571 (+)MAPPERmRatBN7.2
Rnor_6.01276,289,771 - 276,289,975NCBIRnor6.0
Rnor_5.01283,685,126 - 283,685,330UniSTSRnor5.0
RGSC_v3.41261,599,138 - 261,599,342UniSTSRGSC3.4
Celera1250,043,077 - 250,043,281UniSTS
RH 3.4 Map11650.3UniSTS
Cytogenetic Map1q55UniSTS
BE097769  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21254,294,052 - 254,294,206 (+)MAPPERmRatBN7.2
Rnor_6.01276,242,350 - 276,242,503NCBIRnor6.0
Rnor_5.01283,639,546 - 283,639,699UniSTSRnor5.0
RGSC_v3.41261,556,030 - 261,556,183UniSTSRGSC3.4
Celera1250,000,765 - 250,000,918UniSTS
RH 3.4 Map11651.5UniSTS
Cytogenetic Map1q55UniSTS
Acsl5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21254,331,296 - 254,331,569 (+)MAPPERmRatBN7.2
Rnor_6.01276,284,701 - 276,284,973NCBIRnor6.0
Rnor_5.01283,680,056 - 283,680,328UniSTSRnor5.0
RGSC_v3.41261,594,068 - 261,594,340UniSTSRGSC3.4
Celera1250,038,007 - 250,038,279UniSTS
Cytogenetic Map1q55UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000022126   ⟹   ENSRNOP00000022126
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1264,299,589 - 264,341,941 (+)Ensembl
mRatBN7.2 Ensembl1254,295,124 - 254,336,602 (+)Ensembl
Rnor_6.0 Ensembl1276,240,703 - 276,290,008 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098395   ⟹   ENSRNOP00000095186
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1264,299,589 - 264,341,941 (+)Ensembl
mRatBN7.2 Ensembl1254,294,252 - 254,336,605 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103067   ⟹   ENSRNOP00000092211
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1264,299,589 - 264,341,941 (+)Ensembl
mRatBN7.2 Ensembl1254,293,882 - 254,335,106 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103178   ⟹   ENSRNOP00000090718
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1264,297,913 - 264,341,943 (+)Ensembl
mRatBN7.2 Ensembl1254,292,521 - 254,336,607 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109824   ⟹   ENSRNOP00000078386
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1264,294,864 - 264,341,941 (+)Ensembl
mRatBN7.2 Ensembl1254,293,882 - 254,336,598 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110033   ⟹   ENSRNOP00000080415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1264,294,879 - 264,341,937 (+)Ensembl
mRatBN7.2 Ensembl1254,293,882 - 254,336,598 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112922   ⟹   ENSRNOP00000078938
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1264,299,589 - 264,341,941 (+)Ensembl
mRatBN7.2 Ensembl1254,293,882 - 254,336,598 (+)Ensembl
RefSeq Acc Id: NM_053607   ⟹   NP_446059
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,294,851 - 264,341,943 (+)NCBI
mRatBN7.21254,289,513 - 254,336,608 (+)NCBI
Rnor_6.01276,240,703 - 276,290,006 (+)NCBI
Rnor_5.01283,637,899 - 283,685,361 (+)NCBI
RGSC_v3.41261,554,383 - 261,599,373 (+)RGD
Celera1249,999,118 - 250,043,312 (+)RGD
Sequence:
RefSeq Acc Id: XM_039093157   ⟹   XP_038949085
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,299,780 - 264,341,943 (+)NCBI
mRatBN7.21254,293,624 - 254,336,601 (+)NCBI
RefSeq Acc Id: XM_039093168   ⟹   XP_038949096
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,298,853 - 264,341,943 (+)NCBI
mRatBN7.21254,294,762 - 254,336,601 (+)NCBI
RefSeq Acc Id: XM_039093173   ⟹   XP_038949101
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,314,176 - 264,341,943 (+)NCBI
mRatBN7.21254,308,841 - 254,336,601 (+)NCBI
RefSeq Acc Id: XM_039093177   ⟹   XP_038949105
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,313,179 - 264,341,943 (+)NCBI
mRatBN7.21254,307,850 - 254,336,601 (+)NCBI
RefSeq Acc Id: XM_063276003   ⟹   XP_063132073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,294,877 - 264,341,943 (+)NCBI
RefSeq Acc Id: NP_446059   ⟸   NM_053607
- UniProtKB: O88813 (UniProtKB/Swiss-Prot),   Q6IN15 (UniProtKB/TrEMBL),   A6JHY8 (UniProtKB/TrEMBL),   A6JHY9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022126   ⟸   ENSRNOT00000022126
RefSeq Acc Id: XP_038949085   ⟸   XM_039093157
- Peptide Label: isoform X1
- UniProtKB: O88813 (UniProtKB/Swiss-Prot),   Q6IN15 (UniProtKB/TrEMBL),   A6JHY8 (UniProtKB/TrEMBL),   A6JHY9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949096   ⟸   XM_039093168
- Peptide Label: isoform X1
- UniProtKB: O88813 (UniProtKB/Swiss-Prot),   Q6IN15 (UniProtKB/TrEMBL),   A6JHY8 (UniProtKB/TrEMBL),   A6JHY9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949105   ⟸   XM_039093177
- Peptide Label: isoform X3
- UniProtKB: O88813 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038949101   ⟸   XM_039093173
- Peptide Label: isoform X2
- UniProtKB: O88813 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000090718   ⟸   ENSRNOT00000103178
Ensembl Acc Id: ENSRNOP00000095186   ⟸   ENSRNOT00000098395
Ensembl Acc Id: ENSRNOP00000078938   ⟸   ENSRNOT00000112922
Ensembl Acc Id: ENSRNOP00000080415   ⟸   ENSRNOT00000110033
Ensembl Acc Id: ENSRNOP00000078386   ⟸   ENSRNOT00000109824
Ensembl Acc Id: ENSRNOP00000092211   ⟸   ENSRNOT00000103067
RefSeq Acc Id: XP_063132073   ⟸   XM_063276003
- Peptide Label: isoform X4
- UniProtKB: O88813 (UniProtKB/Swiss-Prot)
Protein Domains
AMP-dependent synthetase/ligase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88813-F1-model_v2 AlphaFold O88813 1-683 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690998
Promoter ID:EPDNEW_R1523
Type:initiation region
Name:Acsl5_1
Description:acyl-CoA synthetase long-chain family member 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01276,240,698 - 276,240,758EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69402 AgrOrtholog
BioCyc Gene G2FUF-55346 BioCyc
BioCyc Pathway FAO-PWY [fatty acid beta-oxidation I (generic)] BioCyc
  PWY-5143 [long-chain fatty acid activation] BioCyc
  PWY-5972 [stearate biosynthesis I (animals)] BioCyc
  PWY-6000 [gamma-linolenate biosynthesis II (animals)] BioCyc
  PWY-7049 [icosapentaenoate biosynthesis II (6-desaturase, mammals)] BioCyc
  PWY-8181 [2-methyl-branched fatty acid beta-oxidation] BioCyc
  PWY3DJ-11470 [sphingosine and sphingosine-1-phosphate metabolism] BioCyc
  PWY66-387 [3-methyl-branched fatty acid alpha-oxidation] BioCyc
  PWY66-388 [ceramide degradation by alpha-oxidation] BioCyc
  PWY66-389 [phytol degradation] BioCyc
  PWY66-391 [fatty acid beta-oxidation VI (mammalian peroxisome)] BioCyc
BioCyc Pathway Image FAO-PWY BioCyc
  PWY-5143 BioCyc
  PWY-5972 BioCyc
  PWY-6000 BioCyc
  PWY-7049 BioCyc
  PWY-8181 BioCyc
  PWY3DJ-11470 BioCyc
  PWY66-387 BioCyc
  PWY66-388 BioCyc
  PWY66-389 BioCyc
  PWY66-391 BioCyc
Ensembl Genes ENSRNOG00000016265 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000022126 ENTREZGENE
  ENSRNOT00000109824 ENTREZGENE
  ENSRNOT00000110033 ENTREZGENE
Gene3D-CATH 3.40.50.12780 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7096959 IMAGE-MGC_LOAD
InterPro AMP-binding_CS UniProtKB/Swiss-Prot
  AMP-dep_Synth/Lig UniProtKB/Swiss-Prot
  ANL_N_sf UniProtKB/Swiss-Prot
  LC-FACS_euk UniProtKB/Swiss-Prot
KEGG Report rno:94340 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91566 IMAGE-MGC_LOAD
NCBI Gene 94340 ENTREZGENE
PANTHER LONG-CHAIN-FATTY-ACID--COA LIGASE UniProtKB/Swiss-Prot
  LONG-CHAIN-FATTY-ACID--COA LIGASE 5 UniProtKB/Swiss-Prot
Pfam AMP-binding UniProtKB/Swiss-Prot
PhenoGen Acsl5 PhenoGen
PROSITE AMP_BINDING UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016265 RatGTEx
Superfamily-SCOP Acetyl-CoA synthetase-like UniProtKB/Swiss-Prot
TIGR TC216611
UniProt A0A8I5ZKT4_RAT UniProtKB/TrEMBL
  A0A8I5ZM08_RAT UniProtKB/TrEMBL
  A0A8I6AAN7_RAT UniProtKB/TrEMBL
  A0A8I6AHE5_RAT UniProtKB/TrEMBL
  A0A8I6GLI0_RAT UniProtKB/TrEMBL
  A0ABZ3NN85_RAT UniProtKB/TrEMBL
  A6JHY8 ENTREZGENE, UniProtKB/TrEMBL
  A6JHY9 ENTREZGENE, UniProtKB/TrEMBL
  A6JHZ0_RAT UniProtKB/TrEMBL
  A6JHZ1_RAT UniProtKB/TrEMBL
  A6JHZ2_RAT UniProtKB/TrEMBL
  ACSL5_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6IN15 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Acsl5  acyl-CoA synthetase long-chain family member 5  Facl5  fatty acid Coenzyme A ligase, long chain 5  Symbol and Name updated 1299863 APPROVED
2002-06-10 Facl5  fatty acid Coenzyme A ligase, long chain 5      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function catalyzes the ligation of long chain fatty acids with coenzyme A to produce long chain acyl-CoAs, has a broad substrate specificity for saturated fatty acids of 1218 carbon atoms and unsaturated fatty acids of 1620 carbon atoms 69375
gene_process involved in energy use via b-oxidation and the synthesis of triacylglycerol, phospholipids, cholesterol esters, and sphingomyelin 69375
gene_process may be critical for recycling arachidonate into phospholipids that are sources for signaling molecules related to intellect and coordination 69375