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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69402
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acsl5
Name: acyl-CoA synthetase long-chain family member 5
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acsl5affects expressionISOACSL5 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the expression of ACSL5 mRNAPMID:20106945
Acsl5affects methylationISOACSL5 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of ACSL5 5' UTR; Benzo(a)pyrene affects the methylation of ACSL5 promoterPMID:27901495
Acsl5decreases expressionISOACSL5 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of ACSL5 mRNAPMID:22316170 PMID:32234424
Acsl5decreases expressionISOAcsl5 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of ACSL5 mRNAPMID:19770486 PMID:22228805
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