Gucy1a1 (guanylate cyclase 1 soluble subunit alpha 1) - Rat Genome Database

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Gene: Gucy1a1 (guanylate cyclase 1 soluble subunit alpha 1) Rattus norvegicus
Analyze
Symbol: Gucy1a1
Name: guanylate cyclase 1 soluble subunit alpha 1
RGD ID: 68436
Description: Enables nitric oxide binding activity. Contributes to adenylate cyclase activity and cytidylate cyclase activity. Involved in response to herbicide. Part of guanylate cyclase complex, soluble. Biomarker of withdrawal disorder. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human GUCY1A1 (guanylate cyclase 1 soluble subunit alpha 1); PARTICIPATES IN long term depression; purine metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GCS-alpha-1; GCS-alpha-3; guanylate cyclase 1 soluble subunit alpha 3; guanylate cyclase 1, soluble, alpha 3; Guanylate cyclase soluble alpha 1 (GTP pyrophosphate - lyase); guanylate cyclase soluble subunit alpha-1; guanylate cyclase soluble subunit alpha-3; Guanylate cyclase, soluble, alpha 1 (GTP pyrophosphate - lyase); Gucy1a3; SGC; soluble guanylate cyclase; soluble guanylate cyclase large subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Gucy1a3em1Mcwi
Genetic Models: SS-Gucy1a3em1Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82169,716,684 - 169,780,360 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2169,716,709 - 169,779,737 (-)EnsemblGRCr8
mRatBN7.22167,418,615 - 167,482,293 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2167,418,640 - 167,481,671 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2174,618,756 - 174,679,844 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02172,639,998 - 172,701,086 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02167,227,585 - 167,288,671 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02181,045,694 - 181,103,321 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2181,045,703 - 181,102,918 (-)Ensemblrn6Rnor6.0
Rnor_5.02200,453,480 - 200,515,219 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42173,756,824 - 173,818,316 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2161,450,514 - 161,511,622 (-)NCBICelera
RGSC_v3.12173,705,122 - 173,768,506 (-)NCBI
Cytogenetic Map2q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3',5'-cyclic GMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
apocynin  (EXP)
aristolochic acid A  (ISO)
arotinoid acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
CHIR 99021  (ISO)
chloroprene  (EXP,ISO)
chlorpyrifos  (ISO)
cinaciguat  (EXP,ISO)
clobetasol  (ISO)
clotrimazole  (EXP)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
cyanocob(III)alamin  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
Dibutyl phosphate  (ISO)
diethyl malate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
ferroheme b  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
glafenine  (EXP)
GTP  (ISO)
heme b  (EXP)
hydrogen peroxide  (EXP)
hydroxocobalamin  (ISO)
isoflavones  (EXP)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
menadione  (EXP)
methimazole  (EXP)
methylseleninic acid  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel atom  (ISO)
nimesulide  (EXP)
nitric oxide  (ISO)
nitroglycerin  (EXP)
nitroprusside  (EXP)
NONOate(1-)  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-toluidine  (EXP)
panobinostat  (ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
potassium hexacyanoferrate(3-)  (ISO)
progesterone  (EXP)
protoporphyrin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-nitrosoglutathione  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
taurine  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
XAV939  (ISO)
zinc protoporphyrin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Modulation of voltage-gated Ca2+ current in vestibular hair cells by nitric oxide. Almanza A, etal., J Neurophysiol. 2007 Feb;97(2):1188-95. Epub 2006 Dec 20.
2. Genetic mapping of soluble guanylyl cyclase genes: implications for linkage to blood pressure in the Dahl rat. Azam M, etal., Hypertension 1998 Jul;32(1):149-54.
3. Beta-amyloid peptides decrease soluble guanylyl cyclase expression in astroglial cells. Baltrons MA, etal., Neurobiol Dis 2002 Jul;10(2):139-49.
4. Nucleotidyl cyclase activity of soluble guanylyl cyclase alpha1beta1. Beste KY, etal., Biochemistry. 2012 Jan 10;51(1):194-204. doi: 10.1021/bi201259y. Epub 2011 Dec 13.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
8. Post-transcriptional Regulation of Soluble Guanylyl Cyclase Expression in Rat Aorta. Kloss S, etal., J Biol Chem 2003 Jan 24;278(4):2377-83.
9. Diets high in selenium and isoflavones decrease androgen-regulated gene expression in healthy rat dorsolateral prostate. Legg RL, etal., Reprod Biol Endocrinol. 2008 Nov 24;6:57.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Effect of paraquat exposure on nitric oxide-responsive genes in rat mesencephalic cells. Moran JM, etal., Nitric Oxide. 2010 Apr 11.
12. Molecular cloning and expression of cDNAs coding for soluble guanylate cyclase from rat lung. Nakane M, etal., J Biol Chem 1990 Oct 5;265(28):16841-5.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Regional distribution of protein and activity of the nitric oxide receptor, soluble guanylyl cyclase, in rat brain suggests multiple mechanisms of regulation. Nedvetsky PI, etal., Brain Res 2002 Sep 20;950(1-2):148-54.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. Interaction between the 90-kDa heat shock protein and soluble guanylyl cyclase: physiological significance and mapping of the domains mediating binding. Papapetropoulos A, etal., Mol Pharmacol. 2005 Oct;68(4):1133-41. Epub 2005 Jul 15.
17. Content of mRNA for NMDA glutamate receptor subunits in the frontal cortex and striatum of rats after morphine withdrawal is related to the degree of abstinence. Peregud DI, etal., Bull Exp Biol Med. 2012 Oct;153(6):835-8. doi: 10.1007/s10517-012-1838-x.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. The alpha 1 subunit of soluble guanylyl cyclase is expressed prenatally in the rat brain. Smigrodzki R and Levitt P, Brain Res Dev Brain Res 1996 Dec 23;97(2):226-34.
23. Activation and up-regulation of spinal cord nitric oxide receptor, soluble guanylate cyclase, after formalin injection into the rat hind paw. Tao YX and Johns RA, Neuroscience 2002;112(2):439-46.
24. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
25. Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs. Winger JA, etal., J Biol Chem. 2007 Jan 12;282(2):897-907. Epub 2006 Nov 10.
Additional References at PubMed
PMID:12477932   PMID:14749300   PMID:14754757   PMID:16131543   PMID:16489110   PMID:16614755   PMID:17170090   PMID:18022154   PMID:18474600   PMID:18550612   PMID:18572161   PMID:18635821  
PMID:19141686   PMID:19466990   PMID:20009348   PMID:20023176   PMID:20353168   PMID:20459051   PMID:22806360   PMID:23093402   PMID:23505436   PMID:24982890   PMID:27009048   PMID:27923787  
PMID:28782641   PMID:30260287   PMID:32358060   PMID:35089807  


Genomics

Comparative Map Data
Gucy1a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82169,716,684 - 169,780,360 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2169,716,709 - 169,779,737 (-)EnsemblGRCr8
mRatBN7.22167,418,615 - 167,482,293 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2167,418,640 - 167,481,671 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2174,618,756 - 174,679,844 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02172,639,998 - 172,701,086 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02167,227,585 - 167,288,671 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02181,045,694 - 181,103,321 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2181,045,703 - 181,102,918 (-)Ensemblrn6Rnor6.0
Rnor_5.02200,453,480 - 200,515,219 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42173,756,824 - 173,818,316 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2161,450,514 - 161,511,622 (-)NCBICelera
RGSC_v3.12173,705,122 - 173,768,506 (-)NCBI
Cytogenetic Map2q34NCBI
GUCY1A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384155,666,848 - 155,737,059 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4155,666,707 - 155,737,059 (+)Ensemblhg38GRCh38
GRCh374156,588,000 - 156,658,211 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364156,807,328 - 156,871,232 (+)NCBIBuild 36Build 36hg18NCBI36
Build 344156,945,482 - 157,009,379NCBI
Celera4153,919,477 - 153,989,823 (+)NCBICelera
Cytogenetic Map4q32.1NCBI
HuRef4152,327,271 - 152,397,264 (+)NCBIHuRef
CHM1_14156,565,607 - 156,635,931 (+)NCBICHM1_1
T2T-CHM13v2.04158,999,647 - 159,069,856 (+)NCBIT2T-CHM13v2.0
Gucy1a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39381,999,734 - 82,053,253 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl381,999,734 - 82,053,096 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38382,092,427 - 82,145,946 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl382,092,427 - 82,145,789 (-)Ensemblmm10GRCm38
MGSCv37381,896,349 - 81,949,799 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36382,178,354 - 82,231,000 (-)NCBIMGSCv36mm8
Celera382,117,270 - 82,170,809 (-)NCBICelera
Cytogenetic Map3E3NCBI
cM Map335.97NCBI
Gucy1a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547111,367,282 - 11,424,273 (-)Ensembl
ChiLan1.0NW_00495547111,367,318 - 11,422,199 (-)NCBIChiLan1.0ChiLan1.0
GUCY1A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23153,578,326 - 153,648,905 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14153,933,876 - 154,004,517 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04148,032,167 - 148,102,757 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14159,850,092 - 159,920,159 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4159,850,107 - 159,913,338 (+)EnsemblpanPan2panpan1.1
GUCY1A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11553,172,914 - 53,236,200 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1553,174,157 - 53,234,533 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1553,510,720 - 53,570,219 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01553,880,516 - 53,943,086 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1553,881,077 - 53,942,856 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11553,134,895 - 53,194,847 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01553,244,742 - 53,304,495 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01553,557,797 - 53,618,055 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gucy1a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530137,135,116 - 37,192,728 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365762,353,761 - 2,411,425 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365762,353,874 - 2,411,747 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GUCY1A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl844,449,290 - 44,518,135 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1844,448,758 - 44,520,737 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2846,457,572 - 46,537,279 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GUCY1A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17102,206,438 - 102,310,535 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7102,238,477 - 102,303,673 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603781,715,008 - 81,968,286 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gucy1a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248482,525,153 - 2,560,025 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248482,522,935 - 2,588,758 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Gucy1a1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1371,414,408 - 71,471,104 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gucy1a1
406 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:550
Count of miRNA genes:260
Interacting mature miRNAs:337
Transcripts:ENSRNOT00000017190
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085178247591Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2154723085178247591Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085178247591Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085178247591Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085178247591Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2154723085178247591Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
631520Bp73Blood pressure QTL 730.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149806826170653323Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2145807215173074435Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat

Markers in Region
RH133297  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22167,418,677 - 167,418,858 (+)MAPPERmRatBN7.2
Rnor_6.02181,045,757 - 181,045,937NCBIRnor6.0
Rnor_5.02200,453,543 - 200,453,723UniSTSRnor5.0
RGSC_v3.42173,755,055 - 173,755,235UniSTSRGSC3.4
Celera2161,448,745 - 161,448,925UniSTS
RH 3.4 Map21090.1UniSTS
Cytogenetic Map2q33UniSTS


Genetic Models
This gene Gucy1a1 is modified in the following models/strains:
SS-Gucy1a3em1Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 159 91 90 59 92 59 6 352 192 11 137 77 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000017190   ⟹   ENSRNOP00000017190
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2169,716,709 - 169,779,737 (-)Ensembl
mRatBN7.2 Ensembl2167,418,640 - 167,481,671 (-)Ensembl
Rnor_6.0 Ensembl2181,045,703 - 181,102,918 (-)Ensembl
RefSeq Acc Id: NM_017090   ⟹   NP_058786
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82169,718,516 - 169,779,623 (-)NCBI
mRatBN7.22167,420,447 - 167,481,557 (-)NCBI
Rnor_6.02181,047,526 - 181,102,793 (-)NCBI
Rnor_5.02200,453,480 - 200,515,219 (-)NCBI
RGSC_v3.42173,756,824 - 173,818,316 (-)RGD
Celera2161,450,514 - 161,511,622 (-)RGD
Sequence:
RefSeq Acc Id: XM_006232518   ⟹   XP_006232580
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82169,716,684 - 169,780,360 (-)NCBI
mRatBN7.22167,418,615 - 167,482,293 (-)NCBI
Rnor_6.02181,045,694 - 181,103,321 (-)NCBI
Rnor_5.02200,453,480 - 200,515,219 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008761107   ⟹   XP_008759329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82169,716,684 - 169,780,360 (-)NCBI
mRatBN7.22167,418,615 - 167,482,293 (-)NCBI
Rnor_6.02181,045,694 - 181,074,131 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591011   ⟹   XP_017446500
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82169,716,684 - 169,779,297 (-)NCBI
mRatBN7.22167,418,615 - 167,481,222 (-)NCBI
Rnor_6.02181,045,694 - 181,103,321 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063282313   ⟹   XP_063138383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82169,716,684 - 169,779,678 (-)NCBI
RefSeq Acc Id: NP_058786   ⟸   NM_017090
- UniProtKB: P19686 (UniProtKB/Swiss-Prot),   A6J5U0 (UniProtKB/TrEMBL),   F7ESJ1 (UniProtKB/TrEMBL),   Q5U330 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232580   ⟸   XM_006232518
- Peptide Label: isoform X1
- UniProtKB: P19686 (UniProtKB/Swiss-Prot),   A6J5U0 (UniProtKB/TrEMBL),   F7ESJ1 (UniProtKB/TrEMBL),   Q5U330 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759329   ⟸   XM_008761107
- Peptide Label: isoform X1
- UniProtKB: P19686 (UniProtKB/Swiss-Prot),   A6J5U0 (UniProtKB/TrEMBL),   F7ESJ1 (UniProtKB/TrEMBL),   Q5U330 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446500   ⟸   XM_017591011
- Peptide Label: isoform X1
- UniProtKB: P19686 (UniProtKB/Swiss-Prot),   A6J5U0 (UniProtKB/TrEMBL),   F7ESJ1 (UniProtKB/TrEMBL),   Q5U330 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017190   ⟸   ENSRNOT00000017190
RefSeq Acc Id: XP_063138383   ⟸   XM_063282313
- Peptide Label: isoform X1
- UniProtKB: P19686 (UniProtKB/Swiss-Prot),   A6J5U0 (UniProtKB/TrEMBL),   F7ESJ1 (UniProtKB/TrEMBL),   Q5U330 (UniProtKB/TrEMBL)
Protein Domains
Guanylate cyclase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P19686-F1-model_v2 AlphaFold P19686 1-690 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691392
Promoter ID:EPDNEW_R1917
Type:multiple initiation site
Name:Gucy1a3_1
Description:guanylate cyclase 1 soluble subunit alpha 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02181,102,872 - 181,102,932EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68436 AgrOrtholog
BioCyc Gene G2FUF-52683 BioCyc
Ensembl Genes ENSRNOG00000012302 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000017190 ENTREZGENE
Gene3D-CATH 3.30.450.260 UniProtKB/Swiss-Prot
  3.30.70.1230 UniProtKB/Swiss-Prot
  3.90.1520.10 UniProtKB/Swiss-Prot
  6.10.250.780 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7190419 IMAGE-MGC_LOAD
InterPro A/G_cyclase UniProtKB/Swiss-Prot
  A/G_cyclase_CS UniProtKB/Swiss-Prot
  H-NOX_domain_sf UniProtKB/Swiss-Prot
  HNOB_dom_associated UniProtKB/Swiss-Prot
  HNOB_dom_associated_sf UniProtKB/Swiss-Prot
  NO_sig/Golgi_transp_ligand-bd UniProtKB/Swiss-Prot
  Nucleotide_cyclase UniProtKB/Swiss-Prot
MGC_CLONE MGC:93532 IMAGE-MGC_LOAD
NCBI Gene Gucy1a1 ENTREZGENE
PANTHER GUANYLATE CYCLASE SOLUBLE SUBUNIT ALPHA-1 UniProtKB/Swiss-Prot
  GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2 UniProtKB/Swiss-Prot
Pfam Guanylate_cyc UniProtKB/Swiss-Prot
  HNOBA UniProtKB/Swiss-Prot
PhenoGen Gucy1a1 PhenoGen
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/Swiss-Prot
  GUANYLATE_CYCLASE_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012302 RatGTEx
SMART CYCc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF111126 UniProtKB/Swiss-Prot
  SSF55073 UniProtKB/Swiss-Prot
TIGR TC230155
UniProt A6J5U0 ENTREZGENE, UniProtKB/TrEMBL
  F7ESJ1 ENTREZGENE, UniProtKB/TrEMBL
  GCYA1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5U330 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Gucy1a3  guanylate cyclase 1, soluble, alpha 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_drugs 3-(5-Hydroxymethyl-2-furyl)-1-benzyl indazole (YC1) decreases expression 628495
gene_expression expressed in lung and brain 61495
gene_expression expressed in lung and brain 68258
gene_function subunit of soluble guanylate cyclase, forms a heterodimer with Gucy1b3 that converts GTP to cGMP 61495
gene_function intracellular nitric oxide receptor in vascular smooth muscle cells 628495
gene_physical_interaction forms heterodimer with Gucy1b3 61495
gene_physical_interaction forms heterodimer with Gucy1b3 68258
gene_process may control salt-sensitive hypertension 61495
gene_process activates cGMP-dependent protein kinase that induces vascular smooth muscle relaxation and prevents contractile agonist-elicited intracellular free Ca2+ mobilization, dephosphorylates myosin light chain kinase 628495
gene_process hemoprotein mediating NO signaling by forming 3:5-cyclinc monophosphate (cGMP) 628495
gene_protein 76-81.5 kDa 628495
gene_regulation protected mRNA-stabilizing protein HuR which binds to the 3-UTR; increased Gucy1a3 levels results in downregulation of HuR expression and autoregulation as a negative feedback response 628495
gene_regulation mRNA and protein expression is decreased by beta-amyloid peptides in astroglial cells 1298937