Cdk7 (cyclin-dependent kinase 7) - Rat Genome Database

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Gene: Cdk7 (cyclin-dependent kinase 7) Rattus norvegicus
Analyze
Symbol: Cdk7
Name: cyclin-dependent kinase 7
RGD ID: 621124
Description: Enables cyclin-dependent protein serine/threonine kinase activity. Involved in protein phosphorylation and transcription by RNA polymerase II. Part of transcription factor TFIIH holo complex. Orthologous to human CDK7 (cyclin dependent kinase 7); PARTICIPATES IN RNA polymerase II transcription initiation pathway; RNA polymerase II transcription pathway; cell cycle pathway, mitotic; INTERACTS WITH 2,4-dinitrotoluene; ammonium chloride; dibutyl phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 39 protein kinase; CAK; CDK-activating kinase; CDK-activating kinase 1; cell division protein kinase 7; cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase); cyclin-dependent kinase 7 (MO15 homolog Xenopus laevis cdk-activating kinase); cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase); P39 Mo15; TFIIH basal transcription factor complex kinase subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8233,574,623 - 33,599,485 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl233,574,623 - 33,599,485 (-)EnsemblGRCr8
mRatBN7.2231,840,558 - 31,865,422 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl231,840,558 - 31,865,383 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx238,974,607 - 38,999,466 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0237,015,603 - 37,040,504 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0231,873,480 - 31,898,638 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd233,759,071 - 33,783,905 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive233,787,262 - 33,812,435 (-)NCBILyon_Normotensive
Lyon_Hypertensive233,691,489 - 33,716,662 (-)NCBILyon_Hypertensive
F344_StmMcwi233,553,497 - 33,578,288 (-)NCBIF344_StmMcwi
Rnor_6.0230,710,642 - 30,735,522 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl230,710,643 - 30,735,514 (-)Ensemblrn6Rnor6.0
Rnor_5.0249,869,631 - 49,894,108 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4231,500,629 - 31,525,590 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera227,854,542 - 27,879,123 (-)NCBICelera
RGSC_v3.1231,422,411 - 31,445,843 (-)NCBI
Cytogenetic Map2q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
caffeine  (ISO)
calycosin  (ISO)
carbamazepine  (ISO)
carbofuran  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chlorpromazine  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dicrotophos  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
divanadium pentaoxide  (ISO)
epoxiconazole  (ISO)
fipronil  (EXP)
flutamide  (EXP)
folpet  (ISO)
FR900359  (ISO)
gallic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GSK-J4  (ISO)
hydrogen peroxide  (ISO)
hypochlorous acid  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
lamivudine  (ISO)
lycopene  (ISO)
metformin  (ISO)
myristicin  (ISO)
N-acetyl-L-cysteine  (ISO)
nefazodone  (EXP)
okadaic acid  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
sodium arsenite  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
thapsigargin  (ISO)
thiram  (ISO)
triazoles  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
VX nerve agent  (ISO)
wogonin  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Updating the RNA polymerase CTD code: adding gene-specific layers. Egloff S, etal., Trends Genet. 2012 Jul;28(7):333-41. doi: 10.1016/j.tig.2012.03.007. Epub 2012 May 21.
2. A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor. Egly JM and Coin F, DNA Repair (Amst). 2011 Jul 15;10(7):714-21. doi: 10.1016/j.dnarep.2011.04.021. Epub 2011 May 17.
3. Changes in cyclin dependent kinase expression and activity accompanying lens fiber cell differentiation. Gao CY, etal., Exp Eye Res 1999 Dec;69(6):695-703.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. The writers, readers, and functions of the RNA polymerase II C-terminal domain code. Jeronimo C, etal., Chem Rev. 2013 Nov 13;113(11):8491-522. doi: 10.1021/cr4001397. Epub 2013 Jul 10.
7. An alliance between Ras GTPase-activating protein, filamin C, and Ras GTPase-activating protein SH3 domain-binding protein regulates myocyte growth. Lypowy J, etal., J Biol Chem. 2005 Jul 8;280(27):25717-28. Epub 2005 May 9.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. A mammalian RNA polymerase II holoenzyme containing all components required for promoter-specific transcription initiation. Ossipow V, etal., Cell. 1995 Oct 6;83(1):137-46.
11. An RNA polymerase II complex containing all essential initiation factors binds to the activation domain of PAR leucine zipper transcription factor thyroid embryonic factor. Ossipow V, etal., Mol Cell Biol. 1999 Feb;19(2):1242-50.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Association of Cdk-activating kinase subunits with transcription factor TFIIH. Serizawa H, etal., Nature. 1995 Mar 16;374(6519):280-2.
17. CR16, a novel proline-rich protein expressed in rat brain neurons, binds to SH3 domains and is a MAP kinase substrate. Weiler MC, etal., J Mol Neurosci 1996 Fall;7(3):203-15.
18. Neuronal CDK7 in hippocampus is related to aging and Alzheimer disease. Zhu X, etal., Neurobiol Aging. 2000 Nov-Dec;21(6):807-13.
Additional References at PubMed
PMID:8692841   PMID:9852112   PMID:10801852   PMID:11319144   PMID:12721286   PMID:12748294   PMID:16109376   PMID:17416350   PMID:21778139   PMID:23393140  


Genomics

Comparative Map Data
Cdk7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8233,574,623 - 33,599,485 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl233,574,623 - 33,599,485 (-)EnsemblGRCr8
mRatBN7.2231,840,558 - 31,865,422 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl231,840,558 - 31,865,383 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx238,974,607 - 38,999,466 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0237,015,603 - 37,040,504 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0231,873,480 - 31,898,638 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd233,759,071 - 33,783,905 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive233,787,262 - 33,812,435 (-)NCBILyon_Normotensive
Lyon_Hypertensive233,691,489 - 33,716,662 (-)NCBILyon_Hypertensive
F344_StmMcwi233,553,497 - 33,578,288 (-)NCBIF344_StmMcwi
Rnor_6.0230,710,642 - 30,735,522 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl230,710,643 - 30,735,514 (-)Ensemblrn6Rnor6.0
Rnor_5.0249,869,631 - 49,894,108 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4231,500,629 - 31,525,590 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera227,854,542 - 27,879,123 (-)NCBICelera
RGSC_v3.1231,422,411 - 31,445,843 (-)NCBI
Cytogenetic Map2q12NCBI
CDK7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38569,234,795 - 69,277,430 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl569,234,795 - 69,277,430 (+)Ensemblhg38GRCh38
GRCh37568,530,622 - 68,573,257 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36568,566,471 - 68,609,006 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34568,566,470 - 68,609,004NCBI
Celera565,533,029 - 65,575,634 (+)NCBICelera
Cytogenetic Map5q13.2NCBI
HuRef565,486,830 - 65,529,452 (+)NCBIHuRef
CHM1_1568,530,362 - 68,573,002 (+)NCBICHM1_1
T2T-CHM13v2.0570,060,554 - 70,103,173 (+)NCBIT2T-CHM13v2.0
Cdk7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913100,833,532 - 100,867,454 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13100,839,139 - 100,867,447 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3813100,697,024 - 100,730,942 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13100,702,631 - 100,730,939 (-)Ensemblmm10GRCm38
MGSCv3713101,466,979 - 101,500,897 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3613101,803,572 - 101,831,180 (-)NCBIMGSCv36mm8
Celera13104,306,673 - 104,340,748 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1353.23NCBI
Cdk7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544654,448 - 90,191 (+)Ensembl
ChiLan1.0NW_00495544654,401 - 87,884 (+)NCBIChiLan1.0ChiLan1.0
CDK7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2444,642,445 - 44,687,453 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1542,796,052 - 42,841,438 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0544,723,268 - 44,765,711 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1546,292,831 - 46,334,912 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl546,292,838 - 46,334,912 (-)EnsemblpanPan2panpan1.1
CDK7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1254,317,472 - 54,350,633 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl254,317,534 - 54,350,742 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha251,283,814 - 51,347,207 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0254,828,202 - 54,891,625 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl254,828,210 - 54,867,999 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1251,887,194 - 51,950,489 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0252,662,280 - 52,725,915 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0253,550,125 - 53,613,994 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cdk7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213191,370,593 - 191,403,111 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936480307,069 - 339,521 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936480307,089 - 339,515 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDK7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1647,410,145 - 47,449,364 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11647,410,136 - 47,445,795 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21651,303,672 - 51,329,266 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDK7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1465,329,490 - 65,375,269 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl465,329,585 - 65,374,989 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604914,060,456 - 14,106,755 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdk7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624905123,318 - 176,168 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624905123,365 - 175,776 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cdk7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13158,081,283 - 158,107,366 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cdk7
115 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:150
Count of miRNA genes:112
Interacting mature miRNAs:119
Transcripts:ENSRNOT00000025026, ENSRNOT00000071234
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21332504158325041Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2142977529Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
9590080Insglur4Insulin/glucose ratio QTL 428.70.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)2615276751152767Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21605188361051883Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
731166Mamtr2Mammary tumor resistance QTL 20.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358154623581Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22888999173889991Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21436870759368707Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358144538110Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266683465677Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)2573632550736325Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)23326999678269996Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266673652666Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 91 59 6 355 191 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000025026   ⟹   ENSRNOP00000025026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl233,574,623 - 33,599,485 (-)Ensembl
mRatBN7.2 Ensembl231,840,558 - 31,865,383 (-)Ensembl
Rnor_6.0 Ensembl230,710,643 - 30,735,514 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099935   ⟹   ENSRNOP00000091862
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl233,574,623 - 33,599,485 (-)Ensembl
mRatBN7.2 Ensembl231,840,558 - 31,865,383 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000130894   ⟹   ENSRNOP00000109241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl233,574,623 - 33,599,485 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000162417   ⟹   ENSRNOP00000110615
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl233,574,623 - 33,599,485 (-)Ensembl
RefSeq Acc Id: NM_001398656   ⟹   NP_001385585
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,574,623 - 33,599,485 (-)NCBI
mRatBN7.2231,840,558 - 31,865,422 (-)NCBI
Dahl_SR_JrHsd233,759,071 - 33,783,905 (-)NCBI
Lyon_Normotensive233,787,262 - 33,812,435 (-)NCBI
Lyon_Hypertensive233,691,489 - 33,716,662 (-)NCBI
F344_StmMcwi233,553,497 - 33,578,288 (-)NCBI
RefSeq Acc Id: NM_001398657   ⟹   NP_001385586
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,574,623 - 33,599,485 (-)NCBI
mRatBN7.2231,840,558 - 31,865,422 (-)NCBI
Dahl_SR_JrHsd233,759,071 - 33,783,905 (-)NCBI
Lyon_Normotensive233,787,262 - 33,812,435 (-)NCBI
Lyon_Hypertensive233,691,489 - 33,716,662 (-)NCBI
F344_StmMcwi233,553,497 - 33,578,288 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001385585 (Get FASTA)   NCBI Sequence Viewer  
  NP_001385586 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA58562 (Get FASTA)   NCBI Sequence Viewer  
  EDM10209 (Get FASTA)   NCBI Sequence Viewer  
  EDM10210 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025026
  ENSRNOP00000109241
GenBank Protein P51952 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSRNOP00000025026   ⟸   ENSRNOT00000025026
Ensembl Acc Id: ENSRNOP00000091862   ⟸   ENSRNOT00000099935
RefSeq Acc Id: NP_001385586   ⟸   NM_001398657
- Peptide Label: isoform 2
- UniProtKB: A6I5A2 (UniProtKB/TrEMBL),   F1LQC8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001385585   ⟸   NM_001398656
- Peptide Label: isoform 1
- UniProtKB: P51952 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000110615   ⟸   ENSRNOT00000162417
Ensembl Acc Id: ENSRNOP00000109241   ⟸   ENSRNOT00000130894
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51952-F1-model_v2 AlphaFold P51952 1-329 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691111
Promoter ID:EPDNEW_R1634
Type:initiation region
Name:Cdk7_1
Description:cyclin-dependent kinase 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0230,735,454 - 30,735,514EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621124 AgrOrtholog
BioCyc Gene G2FUF-54653 BioCyc
Ensembl Genes ENSRNOG00000018510 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000025026 ENTREZGENE
  ENSRNOT00000130894 ENTREZGENE
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro CDK UniProtKB/Swiss-Prot
  CDK7 UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
NCBI Gene 171150 ENTREZGENE
PANTHER CELL DIVISION PROTEIN KINASE UniProtKB/Swiss-Prot
  CYCLIN-DEPENDENT KINASE 7 UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Cdk7 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018510 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8I6ACJ6_RAT UniProtKB/TrEMBL
  A0ABK0LYA2_RAT UniProtKB/TrEMBL
  A0ABK0M280_RAT UniProtKB/TrEMBL
  A6I5A1_RAT UniProtKB/TrEMBL
  A6I5A2 ENTREZGENE, UniProtKB/TrEMBL
  CDK7_RAT UniProtKB/Swiss-Prot
  F1LQC8 ENTREZGENE, UniProtKB/TrEMBL
  P51952 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-09 Cdk7  cyclin-dependent kinase 7  Cdk7  cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Cdk7  cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase)    cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)  Name updated 1299863 APPROVED
2002-08-07 Cdk7  cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)      Symbol and Name status set to provisional 70820 PROVISIONAL